scholar.google.com › citations
One strategy that targets the bacterial cell envelope involves the inhibition of the type II fatty acid biosynthesis pathway (FAS II), which is responsible for ...
People also ask
What is the extender unit in fatty acid biosynthesis?
What are the inhibitors of fatty acid biosynthesis?
What is bacterial fatty acid biosynthesis?
What is the function of enoyl reductase?
Bacterial fatty acid biosynthesis. There are two ... The substrate-binding loop (SBL) of mycobacterial FabIs like M. ... fatty acid synthesis inhibitors. Proc. Natl ...
Jan 15, 2021 · FabG from the bacterial fatty acid biosynthesis (FAS-II) system is a potential target for antibiotics. •. Inhibitors were identified by ...
Sep 2, 2008 · Cerulenin attacks the FAS ketoacyl synthase (KS) domain, forming a covalent bond to the active site cysteine C1305. The inhibitor binding causes ...
Feb 14, 2014 · Our findings indicate that the structural basis for slow-onset kinetics can be understood once the structures of both EI and EI* have been ...
People also search for
The stepwise characterization of the binding process provides mechanistic insights into the induced fit recognition in this system and serves as an excellent ...
Nov 22, 2017 · The membrane-integral glycerol 3-phosphate (G3P) acyltransferase PlsY catalyses the committed and essential step in bacterial phospholipid ...
Several of these fatty acid biosynthesis inhibitors have potential as lead compounds in the development of new antibacterials. This review encompasses the known ...
Apr 16, 2018 · HadD, a novel fatty acid synthase type II protein, is essential for alpha- and epoxy-mycolic acid biosynthesis and mycobacterial fitness. Cyril ...
... substrate. Enzyme changes shape by induced fit upon substrate binding to form enzyme-substrate complex. Hexokinase has a large induced fit motion that closes ...
Related searches