Base excision repair plays an important role in preventing mutations associated with the common product of oxidative damage, 8-oxoguanine.
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Jan 16, 2024 · The NER (nucleotide excision repair) mechanism is employed to repair the damage by creating large adducts and intra-strand crosslinks when UV ...
Most damage to bases in DNA is repaired by the base excision repair (BER) pathway [1]. BER is initiated by DNA glycosylases, enzymes that recognize specific ...
Sep 7, 2020 · Efficient search for DNA damage embedded in vast expanses of the DNA genome presents one of the greatest challenges to DNA repair enzymes.
Here we ponder the question of how. DNA repair proteins, and in particular DNA glycosylases, locate their target lesions amidst the vast excess of normal.
Dec 1, 2020 · This methodology may be broadly applicable to studies of otherwise unstable or transient complexes of proteins with RNA and RNA/DNA. Graphical ...
Feb 24, 2006 · DNA glycosylases must interrogate millions of base pairs of undamaged DNA in order to locate and then excise one damaged nucleobase.
First, a number of antitumor agents such as cisplatin or temozolomide cause cytotoxicity by inflicting DNA damage to tumor cells and the damage is processed by ...
Sep 1, 2021 · Here PDI is recruited directly to sites of DNA damage, implying that it has a direct role in DNA repair. This study therefore identifies a novel ...
Crosslinking is used to stabilize the interaction of two weakly bound biomolecules using covalent bonds. Click here to explore our DNA crosslink repair ...
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