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Sep 2, 2021 · This suggests that the inhibition of MCL1 can either induce apoptosis or autophagy, which depends on the parallel expression levels of Beclin-1 ...
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... caspase‐3 ... Mcl‐1.Bim complex in granzyme B‐mediated mitochondrial apoptosis. ... apoptosis in HCT116 cells is determined by Mcl‐1's inhibitory effect on Bak.
Apr 21, 2021 · Complex 14 was able to selectively inhibit MCL-1 and disrupt MCL-1/BAX and MCL-1/BAK complexes in tumor cells, inducing BAX/BAK-dependent ...
Dec 11, 2020 · Melphalan-induced apoptosis in multiple myeloma cells is associated with a cleavage of Mcl-1 and Bim and a decrease in the Mcl-1/Bim complex.
Apr 21, 2021 · Here, we discuss the mechanism by which MCL-1 regulates cancer cell apoptosis and review the progress related to MCL-1 small molecule inhibitors ...
Combined inhibition of MCL-1 and BCL-XL resulted in synergistic effects with relevant loss of colony-forming hematopoietic stem and progenitor cells already at ...
MCL1 is an anti-apoptotic BCL2 family member that is essential for the inhibition of the apoptotic pathway through the inhibition of BCL2 associated X (BAX) and ...
Nov 2, 2023 · In this study, we assessed the efficacy of the highly potent and selective MCL-1 inhibitor AZD5991 in various therapy-resistant MCL cell models.
Aug 20, 2021 · We tested two promising targeted therapies, trametinib (MEK inhibitor) and sunitinib (multi-target tyrosine kinase inhibitor), currently ...
Jan 15, 2021 · Cytochrome c and deoxyadenosine triphosphate (dATP) bind to APAF-1 to form a multimeric complex that recruits and activates pro-caspase-9, that ...