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Dec 16, 1993 · The division cycle of eukaryotic cells is regulated by a family of protein kinases known as the cyclin-dependent kinases (CDKs).
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What is the function of the cyclin CDK complex?
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p27Kip1 is a cyclin-CDK inhibitor that arrests the cell cycle at the G1 phase by blocking the activation of cyclin E-CDK2 complex, preventing the improper entry ...
Feb 12, 2008 · First identified as cell cycle inhibitors mediating the growth inhibitory cues of upstream signaling pathways, the cyclin-CDK inhibitors of ...
Abstract. p27 binds and inhibits cyclin-CDK to arrest the cell cycle. p27 also regulates other processes including cell migration and development.
Jul 19, 2022 · OGT decreases cell proliferation and induces cell cycle arrest through p21 independently of p53. We aimed to investigate if the effects of OGT ...
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We show that ATAC localizes to the mitotic spindle and controls cell cycle progression through direct acetylation of Cyclin A/Cdk2. Our data describes a new ...
DNA-dependent protein kinase requires Sp1 and the kinase to be bound to DNA (38). Since disruption of protein-DNA interaction with 50 μg/ml ethidium bromide (40) ...
It is regulated by cyclins, more specifically by Cyclin D proteins and Cyclin-dependent kinase inhibitor proteins. The protein encoded by this gene is a member ...
TRANSFERASE/TRANSFERASE INHIBITOR / protein kinase / phosphotransfer / peptidic inhibitor / TRANSFERASE-TRANSFERASE INHIBITOR complex. Function / homology.
Purpose: To determine the maximum-tolerated dose, toxicities, and pharmacokinetic profile of the far- nesyl protein transferase inhibitor R115777 when ad-.
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