Nov 13, 2020 · This autoinhibitory activity contrasts GRF-ZF domains of other DNA-processing enzymes, which typically use ssDNA binding to enhance catalytic ...
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Aug 1, 2017 · A DNA-binding protein containing two widely separated zinc finger motifs that recognize the same DNA sequence. Genes Dev. 1990;4:29–42. doi ...
Mar 12, 2024 · These interactions are dependent on two clusters of C2H2 zinc finger motifs within ZNF827. We find that ZNF827 accumulates at stalled forks and ...
The individual NEIL3 GRF motifs have been shown to bind ssDNA (28), but the DNA binding specificity of the tandem GRF domain (GRF12), has not been investigated.
Nov 12, 2021 · The repair of DSBs by cNHEJ depends on the binding of the Ku70/Ku80 heterodimer to broken DNA ends, followed by the recruitment of the DNA-PKcs ...
This entry represents DNA glycosylase/AP lyase enzymes that are involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. These ...
It remains to be established whether the binding of ZnF domains to RNA and methylated DNA has functional relevance for DSB repair (?). 3. ZnF proteins ...
Jun 9, 2000 · In proteins such as those with ßßa zinc fingers, however, a chain contains several binding domains; in such cases, therefore, the subunits were ...
Eukaryotic replication protein A (RPA) is a single- stranded DNA-binding protein with multiple functions in DNA replication, repair, ...
2TX interacts with the zinc finger (ZnF) DNA binding domain of the enzyme. This explains why the zincless hNEIL1 enzyme is resistant to 2TX. Crystal structures ...