It is as yet unclear how the activated RISC complex locates the mRNA targets in the cell, though it has been shown that the process can occur in situations ...
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Apr 2, 2013 · We postulated that the nuclear localization of the RISC proteins reconstituted a nuclear RISC complex and hypothesized that these proteins may ...
Sep 17, 2019 · Gene regulation in HCC via RISC complex ... The possible mechanism of RNA-induced silencing complex and its components as novel targets for ...
One strand is integrated into the RISC complex. This strand is known as the guide strand and is selected by the argonaute protein, the catalytically active ...
The RISC complex is thought to primarily exert posttranscriptional control of networks of protein-coding genes either by destabilizing mRNA transcripts or ...
Sep 21, 2018 · Drosophila AGO2, as a part of the RISC complex, is required for the unwinding of siRNA duplex and subsequent assembly of siRNA into RISC in ...
... RISC complex to catalyze endonucleolytic cleavage (Chen et al. 2004). Only 6–7 nt, usually nucleotides 2–8, the so-called 'seed sequence' of miRNAs, have ...
The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation.
Feb 20, 2007 · Tuschl and co-workers hypothesized that these smaller RNA species directed the activity of the RISC complex. Indeed, chemically ...