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Accordingly, ER-resident lipid exchange proteins such as the microsomal triglyceride transfer protein (MTP) could fulfill this loading function (Dougan et al., ...
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May 28, 2021 · The proteins associated with lipid rafts belong to various distinct classes, including signalling proteins (Src-family kinases), G-protein- ...
Four human activator proteins, saposins A–D, are generated from one precursor protein, prosaposin consisting of 524 amino acids, by proteolysis possibly in ...
The four SAPs A–D, which are produced by proteolytic processing of a single precursor protein called prosaposin, are small proteins of about 80 amino acids.
Jun 4, 2014 · Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Med. 8, 1288–1295 ...
According to the “liftase” model, saposin C tightly binds to anionic phospholipids at low pH values, promoting a rearrangement of lipids in lysosomal ...
... saposin C ... bound lipid antigens by endosomal lipid transfer proteins ... activator protein-deficient mouse but not in fibroblasts of patients with Farber disease ...
May 3, 2021 · Thus, their degradation needs more complex cooperation between the hydrolases and other membrane-perturbing, and lipid-binding proteins, as well ...
Jan 22, 1993 · Sphingolipid activator protein (SAP) deficiency, previously described in two sibs and shown to be caused by the absence of the common saposin ...
Apr 24, 2018 · Saposins are small lysosomal “helper” proteins that can assume a globular closed conformation or an open V-shaped form capable of lipid ...