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Inhibition Of An Antibiotic Resistance Enzyme: Crystal Struc Aminoglycoside Phosphotransferase ... Structural Genomics, Center For Structural Genomics Of Infec ...
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These structural analyses demonstrated that despite sequence variation, AK enzymes adopt a common eukaryotic protein kinase (ePK)-like fold [22]. These ...
Structure of an Enzyme Required for Aminoglycoside Antibiotic Resistance Reveals Homology to Eukaryotic Protein Kinases ... protein kinase structures such as MAPK ...
Jun 20, 2012 · Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor pyrazolopyrimidine ...
Structurally, the APHs are similar to the eukaryotic protein kinase (ePK) catalytic domain, and although there is limited overall sequence identity, the ...
Home / Research / Research Centers / Structural Genomics Consortium / Science ... Pseudokinases: same fold as the protein kinases, but lack one or more canonical ...
Jun 8, 2012 · On May 30, the Center for Structural Genomics of Infectious Diseases deposited seven structures in the Protein Data Bank, pushing it past the ...
Using this observation, we identify PP derivatives that select against ePKs, attenuate APH(3′)-Ia activity and rescue aminoglycoside antibiotic activity against ...
Dec 11, 2014 · Here, we quantitatively define UbiB-specific sequence motifs and reveal their positions within the crystal structure of a UbiB protein, ADCK3.
structural genomics, center for structural genomics of infectious diseases, csgid, eukaryotic protein kinase-like fold, aminoglycoside phosphotransferase, ...