Citrullination, which is also known as deimination, is one type of histone modification that leads to a reduction in hydrogen-bonding and a looser chromatin structure. The citrullination of histone H3, for example, has been shown to open up the chromatin and promote gene transcription.
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Jun 11, 2021 · Histone citrullination, a posttranscriptional modification catalyzed by peptidyl arginine deiminase (PAD) enzymes, is involved in human ...
Jan 11, 2018 · Histone citrullination is catalyzed by the enzyme peptidylarginine deiminase 4 (PAD4) [16], primarily located in the cytoplasm of immune ...
Additionally, because histone citrullination involves forming neutrophil extracellular traps (NETs), the relationship between NETs and tumors ...
Histone citrullination occurs by enzymatic conversion of arginine residue to citrulline. This leads to chromatin relaxation and enables activation of ...
Jan 26, 2014 · The ability of PADI4-mediated histone citrullination to induce chromatin decondensation in neutrophils prompted us to ask whether it can ...
Aug 27, 2021 · Hypoxia induces histone citrullination at HREs that is PADI4 and HIF dependent. RNA sequencing revealed that almost all HIF target genes in ...
Jul 29, 2020 · Histone Citrullination is an emerging chromatin-based biomarker of NETosis and inflammatory disease.
May 5, 2020 · Cl-amidine, a potent inhibitor of PADs, blocked histone citrullination effectively but failed to inhibit NET formation in human neutrophils ...
May 5, 2020 · Cl-ami- dine, a potent inhibitor of PADs, blocked histone citrullination effectively but failed to inhibit NET formation in human neutro ...