Integrated chemical and genetic screens unveil FSP1 mechanisms ...
www.ncbi.nlm.nih.gov › PMC10643123
Nov 13, 2023 · Conclusively, our study provides new insights into the molecular functions of FSP1 and enables the rational design of FSP1 inhibitors targeting ...
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Sep 22, 2023 · Our structures reveal that FSP1 contains a unique CTD that mediates the FSP1 functional dimerization (Fig. ... 30% w/v PEG8000, 0.1 M MES pH6.0, ...
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iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM.
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