This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is diphthine:ammonia ligase (ADP-forming). Other names in common use include diphthamide synthase, and diphthamide synthetase.
This entry includes diphthine--ammonia ligases from eukaryotes and the uncharacterised protein MJ0570 from archaea. Diphthine--ammonia ligases are amidases ...
Function · Amidase that catalyzes the last step of diphthamide biosynthesis using ammonium and ATP. · Present with 2270 molecules/cell in log phase SD medium.
diphthine:ammonia ligase (AMP-forming). Class. Ligases; Forming carbon ... diphthine-ammonia ligase. Genes. HSA: 89978(DPH6). PTR: 735941(DPH6). PPS: 100988692 ...
Diphthine--ammonia ligase (EC 6.3.1.14) | Protein Target - PubChem
pubchem.ncbi.nlm.nih.gov › protein
This amidase catalyzes the last step in the conversion of an L-histidine residue in the translation elongation factor translation elongation factor 2 to ...
Amidase that may catalyze the last step of diphthamide biosynthesis using ammonium and ATP (PubMed:23169644). Diphthamide biosynthesis consists in the ...
Dec 3, 2023 · Enables diphthine-ammonia ligase activity. Involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine.
Catalysis of the reaction: ATP + diphthine + ammonia (ammonia) = ADP + phosphate + diphthamide. 2002-11-27, Added, DEFINITION, Catalysis of the reaction: ATP + ...
EC number. 6.3.1.14. Systematic name. diphthine:ammonia ligase (ADP-forming). Recommended name. diphthine-ammonia ligase. Synonyms. Diphthamide synthase.
Accession IDs, G-15503 (MetaCyc) YLR143W Q12429 (UniProt), Length. Location, cytosol. Reaction, a diphthine-[translation elongation factor 2] + ammonium + ...