Nitrilase enzymes (nitrilases) catalyse the hydrolysis of nitrile compounds to the corresponding carboxylic acid and ammonia, and have a wide range of industrial and biotechnological applications, including the synthesis of industrially important carboxylic acids and bioremediation of cyanide and toxic nitriles.
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Nitrilases are involved in natural product biosynthesis and post translational modifications in plants, animals, fungi and certain prokaryotes. Nitrilases can ...
Nitrilase
Protein
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Nitrilase enzymes catalyse the hydrolysis of nitriles to carboxylic acids and ammonia, without the formation of "free" amide intermediates. Nitrilases are involved in natural product biosynthesis and post translational modifications in plants,... Wikipedia
NCBI gene: 4817
Abstract. The ability to catalyze highly chemo, regio, and enantioselective transformations under mild reaction conditions has generated a huge interest in ...
Oct 30, 2012 · Nitrilases are typically intracellular enzymes that are fragile and susceptible to outside environment. Therefore, purification of nitrilases ...
Jan 15, 2001 · The nitrilase superfamily consists of thiol enzymes involved in natural product biosynthesis and post-translational modification in plants, ...
Nitrilases catalyze a direct conversion of nitrile into carboxylic acid (Equation (11)), whereas nitrile hydratases catalyze formation of the amide, which can ...
Nov 2, 2018 · Our experiments show that nitrilases regulate substrate specificity in two ways, both by the usual means of changing active-site residues, but ...
Jul 17, 2019 · Nitrilases are helical enzymes that convert nitriles to acids and/or amides. All plants have a nitrilase 4 homolog specific for ...
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The nitrilase superfamily is a large and diverse superfamily of enzymes that catalyse the cleavage of various types of carbon-nitrogen bonds using a Cys-Glu-Lys ...
Oct 22, 2018 · Nitrilases are nitrile-converting enzymes commonly found within the plant kingdom that play diverse roles in nitrile detoxification, nitrogen ...