Ionizing radiation stimulates generation of nitric oxide (NO). NO stimulates genomic instability by inhibiting BRCA1 protein expression. NO can diffuse and stimulate genomic instability in the bystander cells.
This study investigated the role of nitric oxide in radiation-induced damage by examining changes in mouse serum nitrate concentrations after irradiation.
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NO produced in irradiated tissues mediates cellular regulation through posttranslational modification of a number of regulatory proteins. The best studied of ...
Jun 8, 2022 · Evidence suggests that exposure to UV-A radiation can liberate nitric oxide from skin cells eliciting vasodilation in-vivo.
Nitric oxide (NO) is a crucial mediator of several survival mechanisms in tumor cells. Previous studies demonstrated that ionizing radiation (IR) stimulates ...
This close relationship suggests that nitric oxide donors can play an important role as radiosensitizers, and that manipulation of the balance of nitric oxide ...
Sep 11, 2017 · Our observations are consistent with a bi-phasic mechanism by which UV-A can trigger vasodilatory effects. Analyses of NO-production spectra ...
May 4, 2020 · Nitric oxide (NO) is a potent tumor-cell radiosensitizer but it can be readily scavenged by hemoglobin (Hb) in vivo.
NO (or RNS) generated by ionizing radiation has been demonstrated to activate a number of stress proteins, including MAPK and JNK [12,13]. At low doses of IR or ...
Jul 1, 1994 · Perturbations of NO levels have profound effects on in vivo radiosensitivity of normal tissues. We hypothesize that alterations in regional ...