The CBM complex forms an essential molecular link between the triggering of cell surface antigen receptors and NF-κB activation. Germline mutations ...
The CBM complex: A growing multiplicity of cellular functions, regulatory mechanisms and connections to human disease.
May 15, 2019 · Targeting the CBM complex in Treg cells may thus be highly effective at enhancing the potency of immune checkpoint therapy (ICT) in patients ...
Oct 2, 2018 · The CARD11-BCL10-MALT1 (CBM) complex triggers the adaptive immune response in lymphocytes and lymphoma cells.
Aug 15, 2022 · ... (CBM) complex. Dysfunction or dysregulation of CBM proteins has been linked to numerous clinical manifestations known as “CBM-opathies.” The ...
... (CBM) complex. Dysfunction or dysregulation of CBM proteins has been linked to numerous clinical manifestations known as “CBM-opathies.” The CBM-opathy ...
This positions the CBM complex as a critical regulator of lymphocyte activation, proliferation, survival, and metabolism. Inborn errors in each of the CBM ...
Jun 29, 2022 · Numerous studies have shown that the activation of the CBM complex/NF-κB signaling pathway results in the expression of hypoxia-inducible factor ...
Mar 5, 2023 · The CBM complex is a caspase-recruitment domain that contains (CARD) membrane-associated guanylate kinase (MAGUK) protein 1 (CARMA1, also ...
Jan 30, 2018 · The CARMA1–BCL10–MALT1 (CBM) complex is the central mediator of T cell receptor and B cell receptor-induced NF-κB activation in lymphocytes.