Enzymatic deamination of cytosines in DNA plays key roles in various important biological processes, including innate immune responses against viruses and transposons, antibody diversification in adaptive immunity and the accumulation of somatic mutations in various human cancers1,2,3,4.
Jul 17, 2023
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Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B · Abstract · Publication types · MeSH terms · Substances · Grants and ...
Mar 3, 2021 · As a proof of concept, we analyzed the DNA cytosine deamination activity and chemical inhibition of human APOBEC3B (A3B) using pfuEndoQ to ...
Dec 19, 2016 · (a,b) DNA cytosine deamination by human A3A (WT, wild type) and the indicated mutant derivatives (S, substrate; P, product; TUB, tubulin). The ...
Term: DNA cytosine deamination. Definition: The removal of an amino group from a cytosine residue in DNA, forming a uracil residue.
Because the only known biochemical activity of A3B is single-stranded DNA cytosine deamination [for example, (7, 42, 45)] and the tamoxifen resistance phenotype ...
DNA cytosine deamination. Sources:Amigo / QuickGO · Orthologs. Species, Human, Mouse. Entrez · 57379 · 11628 · Ensembl · ENSG00000111732 · ENSMUSG00000040627 ...
Sep 1, 2016 · ... DNA–cytosine deamination activity. The study estimated that the total number of uracils in the genome of UNG–/– B cells was at least a few ...
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TERM, DNA cytosine deamination ; DEFINITION, The removal of an amino group from a cytosine residue in DNA, forming a uracil residue. ; RELATION, is a GO:0045006 ( ...
DNA cytosine deamination is associated with recurrent Somatic Copy ... DNA Cytosine Deamination, which may suggest the endogeneity of DNA Cytosine Deamination.