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May 3, 2023 · We next describe the physical changes in the double helix that accompany platinum binding, and then we discuss the biological consequences that ...
Platinum binding to DNA: structural controls and consequences
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In recent years there have been numerous major advances in the understanding of the factors controlling all aspects of platinum binding to DNA and of the
The sequence specificity of platinum binding was mapped by exonuclease III digestion of 165 and 335 base pair restriction fragments from pBR322 DNA. Parallel ...
Nov 15, 2017 · ... platinum binding may cause conformation changes and finally the alteration of the structure and biological function. Cisplatin is known to ...
5.3 Platinum binding to DNA. Oligonucleotides are short sections of DNA (2 to 15 nucleotides long) used for model studies. They are often referred to as a ...
Platinum-binding (Pt-binding) peptides have been used for fabrication of complex platinum nanomaterials such as catalysts, metallopharmaceuticals, and ...
The lack of selective binding to AT-rich regions suggests the platinum binding was dominating the sequence selectivity, and is consistent with the pyrrole ...
... platinum binding base in dinucleotides has been determined on the basis of HPLC analysis of the enzymatic digestion products. References. 1). S. J. Lippard ...