Trans-translation is a process found in all bacteria, which contributes to the release of ribosomes that are stalled through a variety of causes, for example when the 3′ end of a truncated mRNA lacking a stop codon is reached or at internal clusters of rare codons.
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trans-Translation is performed by a ribonucleoprotein complex composed of tmRNA, a specialized RNA with properties of both a tRNA and an mRNA, and the small ...
Nov 28, 2016 · Trans-translation is a ubiquitous bacterial mechanism for ribosome rescue in the event of translation stalling. Although trans-translation ...
It is based on the complex made by tmRNA and SmpB, and because trans-translation is absent in eukaryotes, but necessary for bacterial fitness or survival, it is ...
Trans-translation edit. trans-Translation stages A through F. A ribosome with its RNA binding sites, designated E, P, and A, is stuck near the 3' end of a ...
Taken together, trans-translation has been considered as the bacterial system that facilitates recycling of the ribosome stalled on a truncated mRNA lacking a ...
Mar 31, 2007 · The trans-translation model for tmRNA function (Figure 2) postulates that alanine-charged tmRNA recognizes stalled ribosomes (a), binds like a ...
Mar 19, 2021 · During trans-translation, transfer-messenger RNA (tmRNA) and the protein SmpB recognize non-stop ribosomes and use tRNA-like and mRNA-like ...
Acting both as a tRNA and an mRNA, in a process known as trans-translation, tmRNA adds a short peptide tag to undesirable proteins. Trans-translation plays ...
Sep 8, 2023 · Here, we show that KKL-55 inhibits trans-translation by binding elongation factor thermo-unstable (EF-Tu). EF-Tu is an essential and universally ...