Tobira Therapeutics, Inc., formerly Regado BioSciences, Inc., is a clinical-stage biopharmaceutical company focused on developing and commercializing therapies to treat liver disease, inflammation, fibrosis and human immunodeficiency virus (HIV). The Company’s lead product candidate, cenicriviroc (CVC), is an immunomodulator that can be used to treat a number of diseases, including non-alcoholic steatohepatitis (NASH), kidney fibrosis, HIV-1 and others. The Company is engaged in clinical studies for CVC, including the CENTAUR Study, an international, randomized Phase IIb study of CVC, and placebo in patients with NASH and liver fibrosis (NCT02217475). The Company has initiated ORION, a Phase IIa Study of Cenicriviroc in obese patients with fatty liver disease. It is also engaged in the Phase I pioglitazone safety combination study. NASH is a type of non-alcoholic fatty liver disease, or NAFLD. NAFLD is a liver disease and is associated with obesity and type-2 diabetes.