Global Blood Therapeutics, Inc. is a biopharmaceutical company that engages in discovering, developing and commercializing therapeutics to treat blood-based disorders. The Company is engaged in developing initial product candidate, GBT440, oral prophylactic therapy for sickle cell disease (SCD). The Company offers randomized, placebo-controlled, double-blind, single and multiple ascending dose Phase 1/2 clinical trial of GBT440 in healthy subjects and patients with SCD. It is also developing hemoglobin modifiers for pulmonary disorders, such as acute respiratory distress syndrome, in which increased oxygen delivery is needed. The Company, through its GBT440 or analog, also focuses on chemical and biological mechanisms of blood-based disorders to target hypoxemic pulmonary disorders and hereditary angioedema (HAE), which is in pre-clinical trials. In addition, the Company develops TBD, an oral kallikrein inhibitor, which are in Phase 1/2 clinical trials.