Integra LifeSciences Holdings Corporation operates in medical technology. Integra offers solutions in orthopedic extremity surgery, neurosurgery, spine surgery, and reconstructive and general surgery. Integra was founded on a technology platform to repair and regenerate tissue with engineered collagen devices. The Company develops product lines for applications ranging from burn and deep tissue wounds to regeneration of Dura mater in the brain and repair of nerve and tendon. The Company manufactures and sells products in five business segments: U.S. Neurosurgery, U.S. Extremities, U.S. Instruments, U.S. Spine and Other, and International. The Company’s products include regenerative medicine implants, metal implants, instruments and equipment for orthopedic surgery, neurosurgery and general surgery. The U.S. Neurosurgery segment sells a line of products for neurosurgery and neuro critical care. The U.S. Instruments segment is a surgical instrument supplier in the United States.