Arena Pharmaceuticals, Inc. (Arena) is a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing oral drugs that target G protein-coupled receptors (GPCRs), in four therapeutic areas: cardiovascular, central nervous system, inflammatory and metabolic diseases. After completing various studies, analyses and other activities in response to the lorcaserin CRL, in December 2011, the Company resubmitted the lorcaserin NDA. Its wholly owned subsidiary, Arena Pharmaceuticals GmbH (Arena GmbH), has granted Eisai Inc., rights to commercialize lorcaserin in the United States and its territories and possessions, subject to the United States Food and Drug Administration (FDA) approval of the lorcaserin NDA. As of December 31, 2011, the Company�s earlier-stage programs included APD811, an internally discovered, orally available agonist of the prostacyclin receptor intended for the treatment of pulmonary arterial hypertension.