Columbia Laboratories, Inc. (Columbia) is engaged in the business of developing, manufacturing and selling pharmaceutical products that utilize its bioadhesive drug delivery technologies to treat various medical conditions. As of December 31, 2011, Columbia developed and brought to market five bioadhesive vaginal gel products that provide solutions for infertility, pregnancy support, amenorrhea and other gynecologic conditions. All of the products Columbia has developed utilize its bioadhesive delivery system (BDS), which consists principally of a polymer (polycarbophil) and an active ingredient. The Company�s Progesterone products include CRINONE and PROCHIEVE. Its CRINONE and PROCHIEVE vaginal gel products are manufactured in bulk by Fleet Laboratories Limited, Watford, Herts, United Kingdom (Fleet) and filled into overwrapped single-use disposable applicators by Maropack AG, Zell, Switzerland (Maropack).