Osiris Therapeutics, Inc. (Osiris) is a stem cell company. The Company is an integrated company, having developed capabilities in research, development, manufacturing, marketing and distribution of stem cell products. The Company has developed an intellectual property portfolio to protect its technology and commercial interests. Its Biosurgery business works to harness the ability of cells and constructs to promote the body's natural healing with the goals of improving surgical outcomes and offering better treatment options for patients and physicians. The Company�s Biosurgery products includes Grafix, Ovation, Cartiform, and OvationOS, each of which it developed and manufacture. Grafix is a three-dimensional placental tissue matrix for use as a wound covering for application directly to acute and chronic wounds, including diabetic foot ulcers, venous leg ulcers, and burns.