Pacific Biosciences of California, Inc. is engaged in the developing, manufacturing and marketing tools for biological research. The Company has developed a technology to study the synthesis, composition, structure and regulation of DNA by combining advances in nanofabrication, biochemistry, molecular biology, surface chemistry and optics. Its SMRT technology enables real-time analysis of biomolecules with single molecule resolution, which has the potential to transform its understanding of biological systems by providing a window into these systems that has not previously been open for scientific study. The Company has developed PacBio RS II, which uses its SMRT technology. It consists of an instrument platform that uses its consumables including its SMRT Cell. The PacBio RS II is an instrument that conducts, monitors, and analyzes single molecule biochemical reactions in real time.