Zeltiq Aesthetics, Inc. operates as a medical device development company. It engages in the design, development, and commercialization of non-invasive procedures for the reduction of unwanted fat tissue. It develops Cryolipolysis, a technology that enables the reduction of fat tissue near nerves, muscle, and bones. The Company develops a non-invasive technology for aesthetic applications and plastic surgery. Its product is used as a skin cooling device to minimize pain and thermal injury during laser and dermatological treatments.