Aptose Biosciences Inc is a clinical-stage biotechnology company. The Company is engaged in discovering and developing personalized therapies addressing unmet medical needs in oncology. The Company’s drugs include APTO-253, IL-17E and APTO-500. APTO-253 is a small molecule with potent anti-tumor activity in cancer cells via tumor suppressor induction leading to cell cycle inhibition and programmed cell death. The Company discovered IL-17E, which has potent anticancer properties against a range of solid tumors in vivo, including human melanoma, pancreatic, colon, lung, ovarian and breast tumor models. APTO-500 program focuses on discovering and developing potent small molecule inhibitors of maternal embryonic leucine zipper kinase (MELK).