CA1118366A - Apparatus for dialysis of solution - Google Patents
Apparatus for dialysis of solutionInfo
- Publication number
- CA1118366A CA1118366A CA000306700A CA306700A CA1118366A CA 1118366 A CA1118366 A CA 1118366A CA 000306700 A CA000306700 A CA 000306700A CA 306700 A CA306700 A CA 306700A CA 1118366 A CA1118366 A CA 1118366A
- Authority
- CA
- Canada
- Prior art keywords
- housing
- hollow fibers
- dialysate
- fibers
- dialysis apparatus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000502 dialysis Methods 0.000 title claims description 20
- 239000012510 hollow fiber Substances 0.000 claims abstract description 79
- 239000007788 liquid Substances 0.000 claims abstract description 26
- 239000008280 blood Substances 0.000 claims description 39
- 210000004369 blood Anatomy 0.000 claims description 39
- 239000000835 fiber Substances 0.000 claims description 34
- 239000004814 polyurethane Substances 0.000 claims description 7
- 230000005465 channeling Effects 0.000 claims description 6
- 229920002635 polyurethane Polymers 0.000 claims description 6
- 239000006185 dispersion Substances 0.000 claims description 4
- 238000004891 communication Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 239000000243 solution Substances 0.000 description 8
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 7
- 239000004202 carbamide Substances 0.000 description 7
- 239000000463 material Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000009826 distribution Methods 0.000 description 5
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 3
- 239000000853 adhesive Substances 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 238000010276 construction Methods 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000004627 regenerated cellulose Substances 0.000 description 2
- 229920000742 Cotton Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 102400000830 Saposin-B Human genes 0.000 description 1
- 101800001697 Saposin-B Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical compound ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
- 229920001893 acrylonitrile styrene Polymers 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000007096 poisonous effect Effects 0.000 description 1
- 229920005668 polycarbonate resin Polymers 0.000 description 1
- 239000004431 polycarbonate resin Substances 0.000 description 1
- -1 polypropylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
- SCUZVMOVTVSBLE-UHFFFAOYSA-N prop-2-enenitrile;styrene Chemical compound C=CC#N.C=CC1=CC=CC=C1 SCUZVMOVTVSBLE-UHFFFAOYSA-N 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 229920002803 thermoplastic polyurethane Polymers 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000009827 uniform distribution Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/033—Specific distribution of fibres within one potting or tube-sheet
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2313/00—Details relating to membrane modules or apparatus
- B01D2313/21—Specific headers, end caps
Abstract
Abstract of the Disclosure A dialyzer comprises a housing, a plurality of hollow fibers extending in the housing parallel to one another, solution inlet and outlet ports provided at the ends of the housing through respective seal members, respectively and communicating with liquid passages inside the hollow fibers, and dialysate inlet and outlet ports provided near the ends of the housing, respectively,and communicating with a liquid passage outside the hollow fibers. The dialysate inlet port has a diameter of 1.5 to 3.5mm, and the dialysate outlet port has a diameter of 6 to 10mm.
Description
1~18366 Background of the Invention This invention relates to a dyalyzer using hollow fibers, in which a dialysate can flow uniformly through a space between any adjacent hollow fibers and which can be effectively worked when used as an artifical kidney.
Such a dialyzer as illustrated in Fig. 1 is known.
The known dialyzer comprises a bundle of about 10,000 hollow fibers 1 made of a semi-permeable material such as regenerated cellulose. The fibers 1 have an inner diameter of 200 to 300 microns and are arranged densely in a cylindrical housing 2 made of a synthetic resin and having both ends open. The fibers 1 are secured to the housing 2 in a liquid-tight fashion by a high molecular adhesive agent 3 such as poly-urethane resin. The hollow fibers 1 are made to communicate at one end with a solution inlet port 4 and at the other end with a solution outlet port 5. The peripheral wall of the housing 2 is provided with a dialysate inlet port 6 and a dialysate outlet port 7 near the respective ends of the housing 2. Through the dialysate inlet port 6 a dialysate ; 20 is introduced into the housing 2 to flow through the exterior of the hollow fibers 1. Through the dialysate outlet port 7 ; the dialysate is discharged from the housing 2. To elevate the dialysis efficiency, a dialyzer of this type is installed in a substantially vertical position, and the solution, e.g.
blood, and the dialysate are made to flow downwards and upwards, respectively.
.
jb/cz X
: .~ , ,...
` :
-` 1118366 In the above-described dialyzer, however, the dialysate flows only along particular portions of the hollow fibers 1, not uniformly along the entire fibers 1, as indi-cated by arrows in Fig. 1. This undesirable phenomenon is called "channeling". If channeling takes place, some portions of the fibers 1 indicated by "A" in Fig. 1 do not work for dialysis. That is, the dialysate comes into a good contact with those portions of the fibers 1 which are near dialysate ports 6 and 7, and as for the other portions of the fibers 1 it tends to flow where it meets less resis-tance. Further, the dialysate cannot come into a good contact with the innermost fibers, though it may be suffi-ciently contacted with the outermost fibers In order to avoid channeling, a dialyzer with a so-called "overflow mechanism" has been invented. The over-flow mechanism is constituted by two annular ribs which support the hollow fibers in the vicinity of the dialysate inlet port and the dialysate outlet port, respectively. In this type of dialyzer, the dialysate outlet port is provided below the upper edge of the annular rib, so that the dialy-sate is sucked up and uniformly flows over the edge of the rib and discharged through the dialysate outlet port. As a result, the dialysate can flow all along at least ~cz ~ - 2 -: ,.
:
.
36~i outermost ones of the hollow fibers. Indeed the overflow mechanism helps enhance the dialysis efficiency to some degree, but it fails to improve -the dialysis efficiency at the innermost hollow fibers.
Summary of the Invention Accordingly an object of this invention is to provide a dialyzer having hollow fibers, wherein a dialysate can come into as uniform a contact as possible with all the hollow fibers, thereby to elevate dialysis efficiency.
A dialyzer according to this invention comprises a cylindrical housing with both ends open, a plurality of elongated hollow fibers arranged within the housing substantially parallel to the axis thereof, a pair of seal members for securing the end portions of the hollow fibers to the housing in a liquid-tight fashion and for separating-liquid passages inside the hollow fibers from a liquid passage outside the hollow fibers, a dialy-- sate inlet port provided at one end of the housing near one of the seal members and communicating with one end of the liquid passage outside the hollow fibers, a dialysate outlet port pro-vided at the other end of the housin~ near the other seal member and communicating with the other end of the liquid passa~e outside the hollow fibers, a solution inlet port and a solution outlet port provided at the ends of the housing respectively and communi-cating with the liquid passages inside the hollow fibers, means for sealing the solution inlet and outlet ports to the respective ends of the housing so that they are out of communication with the dialysate inlet and outlet ports; and a dialysate deflection or dispersion member disposed in the vicinity of at least the dialy-sate inlet and outlet ports for dispersin~ a flow of dialysate.
The dialysate inlet port has a diameter of 1.5 to 3.5 mm, and the dialysate outlet port has a diameter of 6 to 10 mm.
ob/~,~ - 3 -,:
. ; '~ ' Brief Description of the Drawin~s Fig. 1 is a crcss sectional view of a prior art dialyzer having hollow fibers;
Fig. 2 is a partly broken away, perspective view of a dialyzer according to this invention; and Fig. 3 is an enlar~e~, cross sectional view of a part of another embodiment of this invention.
Detailed Description of the Preferred Embodiments .. .. _ . ..
Shown in Fig. 2 is one embodiment of this invention which is designed to function as a blood dialyzer. The upper and lower halves of this dialyzer are symmetrical to each other.
Except for dialysate ports and solution ports, all the consti-tuent members of the upper half are identical with the corres-pcnding members of the lower half. Every pair of identical members are therefore represented by the same reference numeral.
The dialyzer shown in Fig. 2 comprises a cylindrical housing 12 made of, for example, polycarbonate resin or acrylonitrile styrene resin. The housing 12 comprises a thin hollow cylinder 13 and a pair of thick hollow cylinders 14.
Both ends of the thin cylinder 13 are open and the respective ; ends are connected to respective thick cylinders 14. Two annular ribs 15 protrude from the ends of the thin cylinder 13 into the thick cylinders 14 to the same extent so that an identical annular space 16 is provided between each thick cylinder 14 and the respective annular rib 15. The lower thick cylinder 14 is provided with a dialysate inlet port 17, and the upper thick cylinder 14 ~th a dialysate ~nlet port 18. The dialysate ports 17 and 18 com~.unicate with the respective . annular spaces 16. The ob/j~, - 4 _ ..
:~
spaces 16. The housing 12 constituted by the thin cylinder 13, thick cylinders 14, annular ribs 15 and dialysate ports 17 and 18 can be integrally formed by injection mouldinq.
About 10,000 hollow fibers 19 are arranged densely in the housing 12, substantially parallel to the axis thereof.
The fibers 19 are long enough to extend beyond the annular ribs 15. They are held at one end by a seal member 20 and at the other end by a seal member 20. These fibers 19 extend beyond the annular ribs 15 for such a distance that between each rib 15 and the adjacent seal member 20 there is provided a qap throuqh which a dialysate can pass. The annular ribs 15 serve as deflec-tion or dispersion members for dialysate in the end portions of the cylinder 12.
The seal members 20 secure the end portions of the hollow fibers 19 to the housing 12 in a liquid-tight fashion.
Since both ends of the housing are closed by the seal members 20, the spaces amona the fibers 19 within the housina 12 act as a dialysate passage. The hollow fibers 19, which work as solu-tion passages, penetrate the seal members 20 and open at both ends outside the seal members 20. In order to prevent a blood-clot, it is preferred that the opposite open ends of each hollow fiber 19 should be on the same plane with the outer surface of the respective seal members 20. The so-called centrifugal injection method, for e~ample as described in U.S. Patent No.
3,339,341 is generally employed to secure the end portions of hollow fibers, wherein an adhesive agent such as polyurethane is applied into gaps among the hollow fibers and allowed to solidify, thus steadfastly holding the fibers. This technique of holding hollow fibers is known as "pottinq". After the ~; ob/~f' - 5 -3fi6 potting, those portions of the hollow fibers which protrude from the seal members 2Q, i.e. solified adhesive agent, are cut off.
The seal members 20 should be made of such material as would not be poisonous and as would not collapse the hollow fibers 19. Polyurethane is the best known material to meet both requirements and is most widely used to form seal members.
The dialysate inlet and outlet ports 17 and 18 are pro-vided on the wall portions of the housing 12 that face the respective annular rib deflection members 15. Thus, dialysate is introduced from the inlet port 17 and passes throuqh the exterior of the hollow fibers 19 toward the outlet port 18. The diameter of the dialysate inlet port 17 is made smaller than the dialysate outlet port 18. Preferably the diameter of the dialy-sate outlet port 18 is 6 to lOmm, and the diameter of the dialy-sate inlet port 17 is 1.5 to 3.5mm. If the dialysate ports 17 and 18 have such diameters, the dialysate can come into a uniform contact with every hollow fiber 19 and the pressure difference between the dialysate and blood can be kept below the permitted limit of, for example, about 50 mmHg.
The upper en~ o' the housin~ 12 is Provided with a ~nel-shaped blood inlet Port 21, and the lower end of the housinq 12 with a funnel-shaped blood outlet port 22. The blood ports 21 and 22 cover the seal members 20, respectively, and thus communicate with the interiors of the hollow fibers l9 or blood passa~es. They are made of, for example, polypropylene. Blood is introduced into the hollow fibers 19 throuqh the blood inlet port 21 and is collected in the blood outlet port 22. As shown In Fig. 3, each blood port comprises a pipe portion 23 and a cup portion 24. The pipe portion 23 is connected to a tube of a bloo~ circuit ~7 . .
ob~ 16 - 6 .
t I ~
" 11~83~
(not shown). Each blood port is secured onto the seal member 20 by m~ans of a cap 25 in screw engagement with the periphery of the thick cylinder 14. To prevent the blood from leakinq throuqh between the seal member 20 and the cup portion 24, an annular packing made of, for instance, silicon rubber should be interposed between the seal member 20 and the cup portion 24.
Fig. 3 shows a top part of another embodiment of this invention which is identical with the dialyzer shown in Fiq. 2 except that a support member 27 is provided to achieve a uniform distribution of blood to the hollow fibers 19 and a uniform con-tact of dialysate with all the hollow fibers 19.
As mentioned above, a dialyzer is usually installed to have the blood inlet port positioned above the blood outlet port for various reasons. In particular, a dialyzer provided with annular ribs (deflection members) is installed in a vertical position so that the blood inlet port is directed upwardly.
Otherwise, the annular ribs would not function properly.
tube of a blood circuit, when connected to the blood inlet port, is bent at some angle due to its flexibility (generally such a tube is made of soft vinyl chloride). As a result, the blood flows down through the blood inlet port in a direction deviated from the vertical axis of the blood inlet port. Consequently the blood cannot be distributed uniformly to the hollow fibers.
This phenomenon may take place in the dialyzer according to this invention.
In order to avoid an uneven blood distribution to the fibers 19 due to the above-mentioned reason, the length of "~ ob/)~ _ 7 _ . , . ,, , ~
~
,, .
' :
~1183~i the pipe portion 23 of the blood inlet port 21 should better be increased, so that the blood flows vertically down into the cup portion 24. It has been found that the flood flows vertically when the lenath of the pipe portion 23 is at least about 23mm.
However, an uneven blood distribution occurs due to not only non-vertical blood flow but also an improper ratio of the volume of the cup portion 24 to the inner diameter of the pipe portion 23 or the broadest cross sectional area of the cup portion 24. That is, an uneven blood distribution to the hollow fibers 19 will take place if the volume of the cup portion 24 is too larqe or too small. If the inner diameter L1 of the pipe portion 23 is about 4mm, the largest inner diameter L2 of the cup portion 24 is about 55mm, rl and r2 of curvature are about 3.5mm and about 8mm, respectively, and the lenath L of the pipe portion 23 is 23mm, there occurs no practical uneven blood distribution, provided that the tube connected to the pipe portion 23 is bent at 30 at most.
The support membex 27 of Fig. 3 is disposed at least in the area of the annular rib 15 near the dialysate inlet port 17 and in the midst of the hollow fibers 19. The member 27 there-fore pushes the fibers 19 onto the inner periphery of the annular rib 15. In other words, the member 27 secures the fibers 19 to the inner periphery of the annular rib 15. The hollow fibers 19 ; near the support member 27 are put together more densely than in the thin hollow cylinder and more densely than in the thick hollow cylinders 14.
Since the support member 27 pushes away the fibers 19 in the radial direction of the housinq 12, a columnar space 28 - is formed in the bundle of the fibers 19 between the seal member 20 and the support member 27. The dialysate ob/ik-'~' ~ 18366 from the dialysate inlet port 17 flows into the space 28, stays there temporarily and flows uniformly into the gap between any adjacent fibers 19, To facilitate this uniform dialysate distribution among the hollow fibers 19, the inner periphery of the annular rib 15 is tapered in such manner that the fibers 19 may be inclined toward the inner periphery of the thick cylinder 14. Further, the a~nular rib 15 may be provided at its edge with a plurality of notches 15a as shown in Fig. 2~ for example six notches 3mm wide and 4mm deep.
Then, through these notches 15a the dialysate can flow into and out of the columnar space 28 in any radial directions of the housing 12.
The hollow fibers 19 are flexible and may be easily permanently bent. The permanent curving of the fibers 19 can easily be eliminated by disposing one support member 27 in both annular ribs 15. But the support members 27 must be so arranged as not to form a columnar space extending between them. Should such a columnar space be formed, the dialysate would flow directly from the dialysate inlet port 17 to the dialysate outlet port 18, without flowing uniformly through the gaps between any adjacent fibers 19. In other words, ; it is desired that the hollow fibers 19 should be dispersed uniformly in the thin hollow cylinder 13 of the housing 12.
The support members 27 are made of foamed urethane, any other elastic material ! or cotton. Preferably, the ; material is light and would not make pinholes in the hollow fibers 19. It is desired that the members 27 are made in the form of a ball and made of a liquid-permeating material, b/ cz ~ _ g _ ' ~ ~ .
In view of this, foamed urethane is believed to be the best material of the support members 27.
Example 1 . _ _ A dialyzer of such construction as illustrated in Fig. 2 was manufactured to have a blood capacity of about 180ml and a dialysate capacity of about 300ml, using 7,000 regenerated cellulose hollow fibers (inner diameter: 300 microns, layer thickness: 16 microns). Dialysate outlet ports of various diameters ranging from 6mm to 10 mm were used and the diameter of the dialysate inlet port was changed as shown ln the Table 1 to see how the urea clearance will change. The blood was supplied at 200 ml/min, and the dialysate was supplied at 500 ml/min. The results were as shown in the following Table 1, wherein "pressure difference" means the difference between the pressure on the blood and the pressure on the ,! dialysate, i.e. negative pressure on the dialysate.
The numerals of urea clearance and pressure diff-erence indicate an average of ten test samples of the same diameter of the dialysate inlet port.
Table 1 . .~
- Dlameter of dialysate inlet Urea clearance Pressure difference port (mm) (ml/min) (mmHg) .. . .
~ 3.5 160 20 _ . .. . . . _ 3.0 164 23
Such a dialyzer as illustrated in Fig. 1 is known.
The known dialyzer comprises a bundle of about 10,000 hollow fibers 1 made of a semi-permeable material such as regenerated cellulose. The fibers 1 have an inner diameter of 200 to 300 microns and are arranged densely in a cylindrical housing 2 made of a synthetic resin and having both ends open. The fibers 1 are secured to the housing 2 in a liquid-tight fashion by a high molecular adhesive agent 3 such as poly-urethane resin. The hollow fibers 1 are made to communicate at one end with a solution inlet port 4 and at the other end with a solution outlet port 5. The peripheral wall of the housing 2 is provided with a dialysate inlet port 6 and a dialysate outlet port 7 near the respective ends of the housing 2. Through the dialysate inlet port 6 a dialysate ; 20 is introduced into the housing 2 to flow through the exterior of the hollow fibers 1. Through the dialysate outlet port 7 ; the dialysate is discharged from the housing 2. To elevate the dialysis efficiency, a dialyzer of this type is installed in a substantially vertical position, and the solution, e.g.
blood, and the dialysate are made to flow downwards and upwards, respectively.
.
jb/cz X
: .~ , ,...
` :
-` 1118366 In the above-described dialyzer, however, the dialysate flows only along particular portions of the hollow fibers 1, not uniformly along the entire fibers 1, as indi-cated by arrows in Fig. 1. This undesirable phenomenon is called "channeling". If channeling takes place, some portions of the fibers 1 indicated by "A" in Fig. 1 do not work for dialysis. That is, the dialysate comes into a good contact with those portions of the fibers 1 which are near dialysate ports 6 and 7, and as for the other portions of the fibers 1 it tends to flow where it meets less resis-tance. Further, the dialysate cannot come into a good contact with the innermost fibers, though it may be suffi-ciently contacted with the outermost fibers In order to avoid channeling, a dialyzer with a so-called "overflow mechanism" has been invented. The over-flow mechanism is constituted by two annular ribs which support the hollow fibers in the vicinity of the dialysate inlet port and the dialysate outlet port, respectively. In this type of dialyzer, the dialysate outlet port is provided below the upper edge of the annular rib, so that the dialy-sate is sucked up and uniformly flows over the edge of the rib and discharged through the dialysate outlet port. As a result, the dialysate can flow all along at least ~cz ~ - 2 -: ,.
:
.
36~i outermost ones of the hollow fibers. Indeed the overflow mechanism helps enhance the dialysis efficiency to some degree, but it fails to improve -the dialysis efficiency at the innermost hollow fibers.
Summary of the Invention Accordingly an object of this invention is to provide a dialyzer having hollow fibers, wherein a dialysate can come into as uniform a contact as possible with all the hollow fibers, thereby to elevate dialysis efficiency.
A dialyzer according to this invention comprises a cylindrical housing with both ends open, a plurality of elongated hollow fibers arranged within the housing substantially parallel to the axis thereof, a pair of seal members for securing the end portions of the hollow fibers to the housing in a liquid-tight fashion and for separating-liquid passages inside the hollow fibers from a liquid passage outside the hollow fibers, a dialy-- sate inlet port provided at one end of the housing near one of the seal members and communicating with one end of the liquid passage outside the hollow fibers, a dialysate outlet port pro-vided at the other end of the housin~ near the other seal member and communicating with the other end of the liquid passa~e outside the hollow fibers, a solution inlet port and a solution outlet port provided at the ends of the housing respectively and communi-cating with the liquid passages inside the hollow fibers, means for sealing the solution inlet and outlet ports to the respective ends of the housing so that they are out of communication with the dialysate inlet and outlet ports; and a dialysate deflection or dispersion member disposed in the vicinity of at least the dialy-sate inlet and outlet ports for dispersin~ a flow of dialysate.
The dialysate inlet port has a diameter of 1.5 to 3.5 mm, and the dialysate outlet port has a diameter of 6 to 10 mm.
ob/~,~ - 3 -,:
. ; '~ ' Brief Description of the Drawin~s Fig. 1 is a crcss sectional view of a prior art dialyzer having hollow fibers;
Fig. 2 is a partly broken away, perspective view of a dialyzer according to this invention; and Fig. 3 is an enlar~e~, cross sectional view of a part of another embodiment of this invention.
Detailed Description of the Preferred Embodiments .. .. _ . ..
Shown in Fig. 2 is one embodiment of this invention which is designed to function as a blood dialyzer. The upper and lower halves of this dialyzer are symmetrical to each other.
Except for dialysate ports and solution ports, all the consti-tuent members of the upper half are identical with the corres-pcnding members of the lower half. Every pair of identical members are therefore represented by the same reference numeral.
The dialyzer shown in Fig. 2 comprises a cylindrical housing 12 made of, for example, polycarbonate resin or acrylonitrile styrene resin. The housing 12 comprises a thin hollow cylinder 13 and a pair of thick hollow cylinders 14.
Both ends of the thin cylinder 13 are open and the respective ; ends are connected to respective thick cylinders 14. Two annular ribs 15 protrude from the ends of the thin cylinder 13 into the thick cylinders 14 to the same extent so that an identical annular space 16 is provided between each thick cylinder 14 and the respective annular rib 15. The lower thick cylinder 14 is provided with a dialysate inlet port 17, and the upper thick cylinder 14 ~th a dialysate ~nlet port 18. The dialysate ports 17 and 18 com~.unicate with the respective . annular spaces 16. The ob/j~, - 4 _ ..
:~
spaces 16. The housing 12 constituted by the thin cylinder 13, thick cylinders 14, annular ribs 15 and dialysate ports 17 and 18 can be integrally formed by injection mouldinq.
About 10,000 hollow fibers 19 are arranged densely in the housing 12, substantially parallel to the axis thereof.
The fibers 19 are long enough to extend beyond the annular ribs 15. They are held at one end by a seal member 20 and at the other end by a seal member 20. These fibers 19 extend beyond the annular ribs 15 for such a distance that between each rib 15 and the adjacent seal member 20 there is provided a qap throuqh which a dialysate can pass. The annular ribs 15 serve as deflec-tion or dispersion members for dialysate in the end portions of the cylinder 12.
The seal members 20 secure the end portions of the hollow fibers 19 to the housing 12 in a liquid-tight fashion.
Since both ends of the housing are closed by the seal members 20, the spaces amona the fibers 19 within the housina 12 act as a dialysate passage. The hollow fibers 19, which work as solu-tion passages, penetrate the seal members 20 and open at both ends outside the seal members 20. In order to prevent a blood-clot, it is preferred that the opposite open ends of each hollow fiber 19 should be on the same plane with the outer surface of the respective seal members 20. The so-called centrifugal injection method, for e~ample as described in U.S. Patent No.
3,339,341 is generally employed to secure the end portions of hollow fibers, wherein an adhesive agent such as polyurethane is applied into gaps among the hollow fibers and allowed to solidify, thus steadfastly holding the fibers. This technique of holding hollow fibers is known as "pottinq". After the ~; ob/~f' - 5 -3fi6 potting, those portions of the hollow fibers which protrude from the seal members 2Q, i.e. solified adhesive agent, are cut off.
The seal members 20 should be made of such material as would not be poisonous and as would not collapse the hollow fibers 19. Polyurethane is the best known material to meet both requirements and is most widely used to form seal members.
The dialysate inlet and outlet ports 17 and 18 are pro-vided on the wall portions of the housing 12 that face the respective annular rib deflection members 15. Thus, dialysate is introduced from the inlet port 17 and passes throuqh the exterior of the hollow fibers 19 toward the outlet port 18. The diameter of the dialysate inlet port 17 is made smaller than the dialysate outlet port 18. Preferably the diameter of the dialy-sate outlet port 18 is 6 to lOmm, and the diameter of the dialy-sate inlet port 17 is 1.5 to 3.5mm. If the dialysate ports 17 and 18 have such diameters, the dialysate can come into a uniform contact with every hollow fiber 19 and the pressure difference between the dialysate and blood can be kept below the permitted limit of, for example, about 50 mmHg.
The upper en~ o' the housin~ 12 is Provided with a ~nel-shaped blood inlet Port 21, and the lower end of the housinq 12 with a funnel-shaped blood outlet port 22. The blood ports 21 and 22 cover the seal members 20, respectively, and thus communicate with the interiors of the hollow fibers l9 or blood passa~es. They are made of, for example, polypropylene. Blood is introduced into the hollow fibers 19 throuqh the blood inlet port 21 and is collected in the blood outlet port 22. As shown In Fig. 3, each blood port comprises a pipe portion 23 and a cup portion 24. The pipe portion 23 is connected to a tube of a bloo~ circuit ~7 . .
ob~ 16 - 6 .
t I ~
" 11~83~
(not shown). Each blood port is secured onto the seal member 20 by m~ans of a cap 25 in screw engagement with the periphery of the thick cylinder 14. To prevent the blood from leakinq throuqh between the seal member 20 and the cup portion 24, an annular packing made of, for instance, silicon rubber should be interposed between the seal member 20 and the cup portion 24.
Fig. 3 shows a top part of another embodiment of this invention which is identical with the dialyzer shown in Fiq. 2 except that a support member 27 is provided to achieve a uniform distribution of blood to the hollow fibers 19 and a uniform con-tact of dialysate with all the hollow fibers 19.
As mentioned above, a dialyzer is usually installed to have the blood inlet port positioned above the blood outlet port for various reasons. In particular, a dialyzer provided with annular ribs (deflection members) is installed in a vertical position so that the blood inlet port is directed upwardly.
Otherwise, the annular ribs would not function properly.
tube of a blood circuit, when connected to the blood inlet port, is bent at some angle due to its flexibility (generally such a tube is made of soft vinyl chloride). As a result, the blood flows down through the blood inlet port in a direction deviated from the vertical axis of the blood inlet port. Consequently the blood cannot be distributed uniformly to the hollow fibers.
This phenomenon may take place in the dialyzer according to this invention.
In order to avoid an uneven blood distribution to the fibers 19 due to the above-mentioned reason, the length of "~ ob/)~ _ 7 _ . , . ,, , ~
~
,, .
' :
~1183~i the pipe portion 23 of the blood inlet port 21 should better be increased, so that the blood flows vertically down into the cup portion 24. It has been found that the flood flows vertically when the lenath of the pipe portion 23 is at least about 23mm.
However, an uneven blood distribution occurs due to not only non-vertical blood flow but also an improper ratio of the volume of the cup portion 24 to the inner diameter of the pipe portion 23 or the broadest cross sectional area of the cup portion 24. That is, an uneven blood distribution to the hollow fibers 19 will take place if the volume of the cup portion 24 is too larqe or too small. If the inner diameter L1 of the pipe portion 23 is about 4mm, the largest inner diameter L2 of the cup portion 24 is about 55mm, rl and r2 of curvature are about 3.5mm and about 8mm, respectively, and the lenath L of the pipe portion 23 is 23mm, there occurs no practical uneven blood distribution, provided that the tube connected to the pipe portion 23 is bent at 30 at most.
The support membex 27 of Fig. 3 is disposed at least in the area of the annular rib 15 near the dialysate inlet port 17 and in the midst of the hollow fibers 19. The member 27 there-fore pushes the fibers 19 onto the inner periphery of the annular rib 15. In other words, the member 27 secures the fibers 19 to the inner periphery of the annular rib 15. The hollow fibers 19 ; near the support member 27 are put together more densely than in the thin hollow cylinder and more densely than in the thick hollow cylinders 14.
Since the support member 27 pushes away the fibers 19 in the radial direction of the housinq 12, a columnar space 28 - is formed in the bundle of the fibers 19 between the seal member 20 and the support member 27. The dialysate ob/ik-'~' ~ 18366 from the dialysate inlet port 17 flows into the space 28, stays there temporarily and flows uniformly into the gap between any adjacent fibers 19, To facilitate this uniform dialysate distribution among the hollow fibers 19, the inner periphery of the annular rib 15 is tapered in such manner that the fibers 19 may be inclined toward the inner periphery of the thick cylinder 14. Further, the a~nular rib 15 may be provided at its edge with a plurality of notches 15a as shown in Fig. 2~ for example six notches 3mm wide and 4mm deep.
Then, through these notches 15a the dialysate can flow into and out of the columnar space 28 in any radial directions of the housing 12.
The hollow fibers 19 are flexible and may be easily permanently bent. The permanent curving of the fibers 19 can easily be eliminated by disposing one support member 27 in both annular ribs 15. But the support members 27 must be so arranged as not to form a columnar space extending between them. Should such a columnar space be formed, the dialysate would flow directly from the dialysate inlet port 17 to the dialysate outlet port 18, without flowing uniformly through the gaps between any adjacent fibers 19. In other words, ; it is desired that the hollow fibers 19 should be dispersed uniformly in the thin hollow cylinder 13 of the housing 12.
The support members 27 are made of foamed urethane, any other elastic material ! or cotton. Preferably, the ; material is light and would not make pinholes in the hollow fibers 19. It is desired that the members 27 are made in the form of a ball and made of a liquid-permeating material, b/ cz ~ _ g _ ' ~ ~ .
In view of this, foamed urethane is believed to be the best material of the support members 27.
Example 1 . _ _ A dialyzer of such construction as illustrated in Fig. 2 was manufactured to have a blood capacity of about 180ml and a dialysate capacity of about 300ml, using 7,000 regenerated cellulose hollow fibers (inner diameter: 300 microns, layer thickness: 16 microns). Dialysate outlet ports of various diameters ranging from 6mm to 10 mm were used and the diameter of the dialysate inlet port was changed as shown ln the Table 1 to see how the urea clearance will change. The blood was supplied at 200 ml/min, and the dialysate was supplied at 500 ml/min. The results were as shown in the following Table 1, wherein "pressure difference" means the difference between the pressure on the blood and the pressure on the ,! dialysate, i.e. negative pressure on the dialysate.
The numerals of urea clearance and pressure diff-erence indicate an average of ten test samples of the same diameter of the dialysate inlet port.
Table 1 . .~
- Dlameter of dialysate inlet Urea clearance Pressure difference port (mm) (ml/min) (mmHg) .. . .
~ 3.5 160 20 _ . .. . . . _ 3.0 164 23
2.5 165 26 ~ _ _ _ . _ _ . . . .
1.5 164 ~8 jb/cz - lO -.
. ::
,:
As Table 1 shows, when the`diameter of the dialysate outlet po-rt and that of the dialysate inlet port ranged from 6 to lOmm and from about 1,5 to 3.5mm, the pressure differ-ence did not exceed the permitted limit. It was also ascer-tained that the urea clearance was improved when the diameters of the dialysate ports were within said ranges.
Example 2 Another dialyzer of such construction as illustrated in Fig. 3 was manufactured. This dialyzer is identical with the dialyzer of Example 1 except that both dialysate ports have a diameter of 8mm and that a ball-like support member as shown in Fig. 3, made of foamed urethane is provided in both annular ribs. Support members of various diameters were alternatively used to see how the urea clearance will change. The blood was supplied at 200 ml/min, and the dialysate was supplied at 500 ml/min. The results were shown in the following table 2 Table 2 Diameter of support Urea clearancePressure members (mm) (ml/min) difference (mmHg) .. . . ~
156 16~ 30 158~159 30-45 _ _ No member used ~ (135-155) (10) . _ _ _ .. . . . .. ... . . . _ _ .
Note: Density of the hollow fibers was about 53~ in the thick hollow cylinder.
jb/CZ _ 1 ~ _ ' .
~'118~66 As Table 2 shows, the larger the elastic members were, the better the urea clearance became. But since the pressure difference became too high when the support members having a diameter of 60 or more were used, the optimum dia-meter of the support members is believed to be 40 to 50 mm.
~7hen support members having a diameter of 40mm and 50mm were used, the density of the fibers near the support members was 65% to 70%.
A dialyzer is used not only to remove waste materials from blood but also to remove water by ultrafiltration. The water is removed under a difference between the pressure on the blood and the pressure on the dialysate. The pressure difference is controlled in accordance with various physical conditions of the patient, thereby to remove a proper amount of water. This control consists chiefly in adjusting the negative pressure on the dialysate. A negative pressure (i.e.
pressure loss) on the dialysate is automatically created in a dialyzer using hollow fibers when the dialysate is supplied at a constant flow rate. As a result, water will be removed from ` 20 the blood even if no negative pressure is positively exerted on the dialysate. This phenomenon is undesirable when no water is required to be removed from the patient. Accordin~ly, a dialyzer having hollow fibers should be so designed as to minimizQ such pressure loss.
The dialyzer according to this invention can reduce such pressure loss to such extent that the pressure loss does not serve to remove water in an alarming amount. Further, the dialyzer can be supplied with a dialysate at a higher flow rate than a known dialyzer. Moreover, in the dialyzer of this invention, the channeling of dialysate b/cz - 12 -:
.
:
11183~
occurs but to a letter de~ree, and the dialysate can come into a uniform contact with all the hollow fibers to there-by elevate the dialysis efficiency.
ob/~ 13 -u .
'
1.5 164 ~8 jb/cz - lO -.
. ::
,:
As Table 1 shows, when the`diameter of the dialysate outlet po-rt and that of the dialysate inlet port ranged from 6 to lOmm and from about 1,5 to 3.5mm, the pressure differ-ence did not exceed the permitted limit. It was also ascer-tained that the urea clearance was improved when the diameters of the dialysate ports were within said ranges.
Example 2 Another dialyzer of such construction as illustrated in Fig. 3 was manufactured. This dialyzer is identical with the dialyzer of Example 1 except that both dialysate ports have a diameter of 8mm and that a ball-like support member as shown in Fig. 3, made of foamed urethane is provided in both annular ribs. Support members of various diameters were alternatively used to see how the urea clearance will change. The blood was supplied at 200 ml/min, and the dialysate was supplied at 500 ml/min. The results were shown in the following table 2 Table 2 Diameter of support Urea clearancePressure members (mm) (ml/min) difference (mmHg) .. . . ~
156 16~ 30 158~159 30-45 _ _ No member used ~ (135-155) (10) . _ _ _ .. . . . .. ... . . . _ _ .
Note: Density of the hollow fibers was about 53~ in the thick hollow cylinder.
jb/CZ _ 1 ~ _ ' .
~'118~66 As Table 2 shows, the larger the elastic members were, the better the urea clearance became. But since the pressure difference became too high when the support members having a diameter of 60 or more were used, the optimum dia-meter of the support members is believed to be 40 to 50 mm.
~7hen support members having a diameter of 40mm and 50mm were used, the density of the fibers near the support members was 65% to 70%.
A dialyzer is used not only to remove waste materials from blood but also to remove water by ultrafiltration. The water is removed under a difference between the pressure on the blood and the pressure on the dialysate. The pressure difference is controlled in accordance with various physical conditions of the patient, thereby to remove a proper amount of water. This control consists chiefly in adjusting the negative pressure on the dialysate. A negative pressure (i.e.
pressure loss) on the dialysate is automatically created in a dialyzer using hollow fibers when the dialysate is supplied at a constant flow rate. As a result, water will be removed from ` 20 the blood even if no negative pressure is positively exerted on the dialysate. This phenomenon is undesirable when no water is required to be removed from the patient. Accordin~ly, a dialyzer having hollow fibers should be so designed as to minimizQ such pressure loss.
The dialyzer according to this invention can reduce such pressure loss to such extent that the pressure loss does not serve to remove water in an alarming amount. Further, the dialyzer can be supplied with a dialysate at a higher flow rate than a known dialyzer. Moreover, in the dialyzer of this invention, the channeling of dialysate b/cz - 12 -:
.
:
11183~
occurs but to a letter de~ree, and the dialysate can come into a uniform contact with all the hollow fibers to there-by elevate the dialysis efficiency.
ob/~ 13 -u .
'
Claims (13)
1. A dialysis apparatus comprising:
a cylindrical housing with both ends open, a plurality of spaced apart elongated hollow fibers arranged within the housing substantially parallel to the longitudinal axis of the housing, each of said hollow fibers defining a liquid passage inside the respective hollow fibers and said hollow fibers being arranged to define a liquid passage outside said hollow fibers and between said hollow fibers, said hollow fibers forming a fiber bundle, a pair of seal members, one at each end portion of the housing, for securing the end portions of the hollow fibers to the housing in a liquid-tight fashion and for separating said liquid passages inside the hollow fibers from said liquid passage outside the hollow fibers, a dialysate inlet port provided at one end of the housing near one of the seal members and communicating with one end of said liquid passage outside the hollow fibers, a dialysate outlet port provided at the other end of the housing near the other seal member and communicating with the other end of said liquid passage outside the hollow fibers, a solution inlet port and solution outlet port provided at the ends of the housing, respectively and communicating with the liquid passages inside the hollow fibers, means for sealing said solution inlet and outlet ports to the housing and out of liquid communication with the dialysate inlet and outlet ports, and a dialysate deflection or dispersion member disposed at each end of the housing at least within the portion of the housing opposite to and spaced from the respective dialysate inlet and outlet ports for dispersing a flow of dialysate by said dialysate impinging thereagainst, said dialysate inlet port having a diameter of 1.5 to 3.5 mm and said dialysate outlet port having a diameter of 6 to 10 mm to prevent "channeling" among the hollow fibers in the housing.
a cylindrical housing with both ends open, a plurality of spaced apart elongated hollow fibers arranged within the housing substantially parallel to the longitudinal axis of the housing, each of said hollow fibers defining a liquid passage inside the respective hollow fibers and said hollow fibers being arranged to define a liquid passage outside said hollow fibers and between said hollow fibers, said hollow fibers forming a fiber bundle, a pair of seal members, one at each end portion of the housing, for securing the end portions of the hollow fibers to the housing in a liquid-tight fashion and for separating said liquid passages inside the hollow fibers from said liquid passage outside the hollow fibers, a dialysate inlet port provided at one end of the housing near one of the seal members and communicating with one end of said liquid passage outside the hollow fibers, a dialysate outlet port provided at the other end of the housing near the other seal member and communicating with the other end of said liquid passage outside the hollow fibers, a solution inlet port and solution outlet port provided at the ends of the housing, respectively and communicating with the liquid passages inside the hollow fibers, means for sealing said solution inlet and outlet ports to the housing and out of liquid communication with the dialysate inlet and outlet ports, and a dialysate deflection or dispersion member disposed at each end of the housing at least within the portion of the housing opposite to and spaced from the respective dialysate inlet and outlet ports for dispersing a flow of dialysate by said dialysate impinging thereagainst, said dialysate inlet port having a diameter of 1.5 to 3.5 mm and said dialysate outlet port having a diameter of 6 to 10 mm to prevent "channeling" among the hollow fibers in the housing.
2. A dialysis apparatus according to claim 1, wherein said deflection member is in a shape of a ring coaxial with said housing and spaced inwardly from the wall of said housing.
3. A dialysis apparatus according to claim 1, wherein said solution inlet port is funnel-shaped and comprises a cup portion sealed to said housing and a pipe portion extending from said cup portion and adapted to be connected to a tube, said pipe portion having a length of at least about 23mm to substantially prevent solution from flowing into said housing in a direction deviated from the axis of said housing.
4. A dialysis apparatus according to claim 2, wherein said dialysate outlet port is near an end of said fiber bundle, and further comprising a support member supported by the fibers within said housing, and within and near the end of said fiber bundle near said dialysate outlet port.
5. A dialysis apparatus according to claim 4, wherein said support memeber is a ball made of foamed polyurethane.
6. A dialysis apparatus according to claim 4, further comprising a further support member supported by the fibers within said housing, and within and near the other end of said fiber bundle near said dialysate inlet port.
7. A dialysis apparatus according to claim 6, wherein said further support member is a ball made of foamed polyurethane.
8. A dialysis apparatus for blood comprising:
a cylindrical housing with both ends open, a plurality of spaced apart elongated hollow fibers arranged within the housing substantially parallel to the longitudinal axis of the housing, each of said hollow fibers defining a liquid passage inside the respective hollow fibers and said hollow fibers being arranged to define a liquid passage outside said hollow fibers and between said hollow fibers, said hollow fibers forming a fiber bundle, a pair of seal members, one at each end portion of the housing, for securing the end portions of the hollow fibers to the housing in a liquid-tight fashion and for separating said liquid passages inside the hollow fibers from said liquid passage outside the hollow fibers, a dialysate inlet port provided at one end of the housing near one of the seal members and communicating with one end of said liquid passage outside the hollow fibers, a dialysate outlet port provided at the other end of the housing near the other seal member and communicating with the other end of said liquid passage outside the hollow fibers, said dialysate outlet port being near an end of said fiber bundle, a support member generally in the form of a ball and made of foamed polyurethane supported by the fibers within said housing, and within and near the end of said fiber bundle near said dialysate outlet port, a funnel-shaped blood inlet port provided at an end of the housing, and communicating with the liquid passages inside the hollow fibers for supplying blood to said liquid passages, a blood outlet port provided at the other end of the housing and communicating with the other ends of the liquid passages inside the hollow fibers for receiving blood from said liquid passages, means for sealing said solution inlet and outlet ports to the housing and out of liquid communication with the dialysate inlet and outlet ports, and a dialysate deflection or dispersion member disposed at each end of the housing at least within the portion of the housing opposite to and spaced from the respective dialysate inlet and outlet ports for dispersing a flow of dialysate by said dialysate impinging thereagainst, said deflection member being in the shape of a ring coaxial with said housing and spaced inwardly from the wall of said housing, said dialysate inlet port having a diameter of 1.5 to 3.5 mm and said dialysate outlet port having a diameter of 6 to 10 mm to prevent "channeling" among the hollow fibers in the housing.
a cylindrical housing with both ends open, a plurality of spaced apart elongated hollow fibers arranged within the housing substantially parallel to the longitudinal axis of the housing, each of said hollow fibers defining a liquid passage inside the respective hollow fibers and said hollow fibers being arranged to define a liquid passage outside said hollow fibers and between said hollow fibers, said hollow fibers forming a fiber bundle, a pair of seal members, one at each end portion of the housing, for securing the end portions of the hollow fibers to the housing in a liquid-tight fashion and for separating said liquid passages inside the hollow fibers from said liquid passage outside the hollow fibers, a dialysate inlet port provided at one end of the housing near one of the seal members and communicating with one end of said liquid passage outside the hollow fibers, a dialysate outlet port provided at the other end of the housing near the other seal member and communicating with the other end of said liquid passage outside the hollow fibers, said dialysate outlet port being near an end of said fiber bundle, a support member generally in the form of a ball and made of foamed polyurethane supported by the fibers within said housing, and within and near the end of said fiber bundle near said dialysate outlet port, a funnel-shaped blood inlet port provided at an end of the housing, and communicating with the liquid passages inside the hollow fibers for supplying blood to said liquid passages, a blood outlet port provided at the other end of the housing and communicating with the other ends of the liquid passages inside the hollow fibers for receiving blood from said liquid passages, means for sealing said solution inlet and outlet ports to the housing and out of liquid communication with the dialysate inlet and outlet ports, and a dialysate deflection or dispersion member disposed at each end of the housing at least within the portion of the housing opposite to and spaced from the respective dialysate inlet and outlet ports for dispersing a flow of dialysate by said dialysate impinging thereagainst, said deflection member being in the shape of a ring coaxial with said housing and spaced inwardly from the wall of said housing, said dialysate inlet port having a diameter of 1.5 to 3.5 mm and said dialysate outlet port having a diameter of 6 to 10 mm to prevent "channeling" among the hollow fibers in the housing.
9. A dialysis apparatus according to claim 8, further comprising a further support member supported by the fibers within said housing, and within and near the other end of said fiber bundle near said dialysate inlet port.
10. A dialysis apparatus according to claim 9, wherein said further support member is a ball made of foamed polyurethane.
11. A dialysis apparatus according to claim 8, wherein said dialysate inlet port comprises a cup portion sealed to said housing and a pipe portion extending from said cup portion and adapted to be connected to a tube, said pipe portion having a length of at least about 23 mm to substantially prevent solution from flowing into said housing in a direction deviated from the axis of said housing.
12. A dialysis apparatus according to claim 11, wherein the inner diameter of said pipe portion is about 4 mm and the largest inner diameter of said cup portion is about 55 mm.
13. A dialysis apparatus according to claim 3, wherein the inner diameter of said pipe portion is about 4 mm and the largest inner diameter of said cup portion is about 55 mm.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP7970977A JPS5415397A (en) | 1977-07-04 | 1977-07-04 | Hollow fiber material moving device |
JP52-79709 | 1977-07-04 | ||
JP52-104564 | 1977-08-04 | ||
JP1977104564U JPS5621399Y2 (en) | 1977-08-04 | 1977-08-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA1118366A true CA1118366A (en) | 1982-02-16 |
Family
ID=26420710
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA000306700A Expired CA1118366A (en) | 1977-07-04 | 1978-07-04 | Apparatus for dialysis of solution |
Country Status (5)
Country | Link |
---|---|
US (1) | US4201673A (en) |
EP (1) | EP0001736B1 (en) |
AU (1) | AU522156B2 (en) |
CA (1) | CA1118366A (en) |
DE (1) | DE2862116D1 (en) |
Families Citing this family (40)
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CA1092515A (en) * | 1976-07-23 | 1980-12-30 | Donald J. Bentley | Dialyzer and method of dialysis |
US4283284A (en) * | 1979-07-18 | 1981-08-11 | Baxter Travenol Laboratories, Inc. | Hollow fiber dialyzer end seal system |
US4334993A (en) * | 1979-12-05 | 1982-06-15 | Baxter Travenol Laboratories, Inc. | Potted-typed seal with stress relief and method of making same |
US4324662A (en) * | 1979-12-28 | 1982-04-13 | Baxter Travenol Laboratories, Inc. | Flow reversal in a dialyzer |
US4396510A (en) * | 1981-01-08 | 1983-08-02 | Bio-Med Corporation | Mass transfer device |
DE3105192A1 (en) * | 1981-02-13 | 1982-09-09 | Akzo Gmbh, 5600 Wuppertal | HOLLOW FIBER MODULE AND METHOD AND DEVICE FOR ITS PRODUCTION |
FR2514647B1 (en) * | 1981-10-21 | 1986-06-13 | Hospal Sa | HOLLOW FIBER HEMODIALYZER |
JPS5886172A (en) * | 1981-11-18 | 1983-05-23 | テルモ株式会社 | Medical substance moving apparatus |
US4637880A (en) * | 1981-11-30 | 1987-01-20 | Cordis Laboratories, Inc. | Apparatus and method for therapeutic immunodepletion |
US4378981A (en) * | 1981-12-21 | 1983-04-05 | Monsanto Company | Gas separation apparatus |
US4380460A (en) * | 1981-12-21 | 1983-04-19 | Monsanto Company | Gas separation apparatus |
JPS5928971A (en) * | 1982-08-06 | 1984-02-15 | 川澄化学工業株式会社 | Hollow yarn type mass transfer apparatus and production thereof |
US4707268A (en) * | 1982-10-18 | 1987-11-17 | Baxter Travenol Laboratories, Inc. | Hollow fiber potted microfilter |
IT8353037V0 (en) * | 1983-03-10 | 1983-03-10 | Sorin Biomedica Spa | QUARRY FIBER DIALIZER APPARATUS |
JPS6125903U (en) * | 1984-07-24 | 1986-02-15 | 株式会社 伊藤鉄工所 | filtration equipment |
JPS6163240U (en) * | 1984-09-29 | 1986-04-28 | ||
US4964976A (en) * | 1989-04-04 | 1990-10-23 | Lysaght Michael J | Optimized filter and method |
DE69130393T2 (en) * | 1990-04-20 | 1999-05-12 | Usf Filtration Ltd | MODULAR, MICROPOROUS FILTER SYSTEMS |
AU657265B2 (en) * | 1990-04-20 | 1995-03-09 | Siemens Water Technologies Corp. | Modular microporous filter |
EP0477966B1 (en) * | 1990-09-27 | 1995-12-06 | Terumo Kabushiki Kaisha | Hollow fiber mass transfer apparatus |
US5238561A (en) * | 1990-09-27 | 1993-08-24 | Terumo Kabushiki Kaisha | Hollow fiber mass transfer apparatus |
DK136192D0 (en) * | 1992-11-09 | 1992-11-09 | John Reipur | FILTER |
DE19857850C2 (en) * | 1998-12-15 | 2003-02-06 | Fresenius Medical Care De Gmbh | filter means |
US6623638B2 (en) | 2001-06-01 | 2003-09-23 | Baxter International Inc. | Hemodialyzer having improved dialysate perfusion |
US20030075498A1 (en) * | 2001-06-01 | 2003-04-24 | Watkins Randolph H. | Hemodialyzer headers |
US6702561B2 (en) | 2001-07-12 | 2004-03-09 | Nxstage Medical, Inc. | Devices for potting a filter for blood processing |
US20030010718A1 (en) * | 2001-07-12 | 2003-01-16 | Nxstage Medical, Inc. | Hemodilution cap and methods of use in blood-processing procedures |
CA2390214C (en) * | 2001-07-17 | 2009-09-08 | Fresenius Usa, Inc. | Dialyzer |
US6802821B2 (en) | 2001-10-01 | 2004-10-12 | Fresenius Usa, Inc. | Dialyzer |
JP4678776B2 (en) * | 2003-04-23 | 2011-04-27 | 旭化成クラレメディカル株式会社 | Hollow fiber membrane fluid processor |
WO2006049822A1 (en) * | 2004-10-28 | 2006-05-11 | Nxstage Medical, Inc | Blood treatment dialyzer/filter design to trap entrained air in a fluid circuit |
ES2475979T3 (en) | 2005-04-21 | 2014-07-11 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Breathing paracorporeal lung |
AU2006291582B2 (en) * | 2005-09-13 | 2012-03-29 | Gambro Lundia Ab | Arrangement for extracorporeal circulation of blood |
CN101262896B (en) * | 2005-09-13 | 2012-07-18 | 甘布罗伦迪亚股份公司 | Arrangement for extracorporeal circulation of blood |
US20070102340A1 (en) * | 2005-10-27 | 2007-05-10 | Nxstage Medical, Inc. | Blood treatment filter and method of manufacturing |
EP2156881A1 (en) * | 2008-08-22 | 2010-02-24 | Gambro Lundia AB | Cap for a diffusion and/or filtration device |
KR101881388B1 (en) * | 2012-07-25 | 2018-07-24 | 코오롱인더스트리 주식회사 | Pressurized-Type Hollow Fiber Membrane Module and Filtration System Comprising The Same |
US10369263B2 (en) | 2014-03-29 | 2019-08-06 | Novaflux Inc. | Blood processing cartridges and systems, and methods for extracorporeal blood therapies |
US10426884B2 (en) | 2015-06-26 | 2019-10-01 | Novaflux Inc. | Cartridges and systems for outside-in flow in membrane-based therapies |
WO2017053805A1 (en) | 2015-09-24 | 2017-03-30 | Labib Mohamed E | Cartridges for hollow fibre membrane-based therapies |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1601185A1 (en) * | 1968-01-13 | 1970-07-23 | Dietzsch Gmbh Hans Joachim | Exchange system |
US3503515A (en) * | 1968-10-03 | 1970-03-31 | Du Pont | Permeation separatory apparatus |
FR2234912B1 (en) * | 1973-06-27 | 1976-05-28 | Rhone Poulenc Ind | |
JPS5228519B2 (en) * | 1973-09-19 | 1977-07-27 | ||
FR2267138A1 (en) * | 1974-04-09 | 1975-11-07 | Rhone Poulenc Ind | Hollow fibre bundle for fluid treatment - partic. useful for dialysis or ultrafiltration |
US4031012A (en) * | 1975-09-17 | 1977-06-21 | Gics Pharmaceuticals, Inc. | Separatory apparatus |
NL7602880A (en) * | 1976-03-19 | 1976-05-31 | Organon Teknika Bv | Separator unit with membranes - has annular chambers at ends with passages through inner walls to outer chamber |
-
1978
- 1978-06-30 US US05/920,717 patent/US4201673A/en not_active Expired - Lifetime
- 1978-07-04 EP EP78100305A patent/EP0001736B1/en not_active Expired
- 1978-07-04 CA CA000306700A patent/CA1118366A/en not_active Expired
- 1978-07-04 DE DE7878100305T patent/DE2862116D1/en not_active Expired
- 1978-07-04 AU AU37767/78A patent/AU522156B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
AU522156B2 (en) | 1982-05-20 |
EP0001736A1 (en) | 1979-05-16 |
EP0001736B1 (en) | 1982-12-08 |
AU3776778A (en) | 1980-01-10 |
DE2862116D1 (en) | 1983-01-13 |
US4201673A (en) | 1980-05-06 |
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