CA1232807A - Hypodermic injection apparatus - Google Patents
Hypodermic injection apparatusInfo
- Publication number
- CA1232807A CA1232807A CA000500154A CA500154A CA1232807A CA 1232807 A CA1232807 A CA 1232807A CA 000500154 A CA000500154 A CA 000500154A CA 500154 A CA500154 A CA 500154A CA 1232807 A CA1232807 A CA 1232807A
- Authority
- CA
- Canada
- Prior art keywords
- plunger
- shell
- gas
- pin
- ampule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/30—Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2053—Media being expelled from injector by pressurised fluid or vacuum
Abstract
Abstract of the Disclosure The present invention provides a pressure-operated hypodermic injection apparatus which is particularly suitable for needleless operation. The apparatus includes an elongate shell having an inwardly facing wall with a uniform configuration along a defined length thereof, with the shell further defining a discharge aperture adjacent one end thereof.
It further includes a plunger which is slideably disposed within the defined length of the shell, and which is shiftable between a ready position and a spent position, with the spent position being closer to the aperture than the ready position. With the plunger in its ready position, the shell and plunger collectively define an ampule chamber which is capable of containing a dischargeable medication. A pressurized-gas cartridge is mounted to the plunger to shift therewith, and has gas-releasing means which faces away from the discharge aperture. A body is further included which is sealingly and releasable joined to the other end of the shell. An actuator is mounted to the body and is manually operable for selectively operating the gas-releasing means to drive the plunger from its ready toward its spent position to discharge medication from the apparatus and into the patient.
It further includes a plunger which is slideably disposed within the defined length of the shell, and which is shiftable between a ready position and a spent position, with the spent position being closer to the aperture than the ready position. With the plunger in its ready position, the shell and plunger collectively define an ampule chamber which is capable of containing a dischargeable medication. A pressurized-gas cartridge is mounted to the plunger to shift therewith, and has gas-releasing means which faces away from the discharge aperture. A body is further included which is sealingly and releasable joined to the other end of the shell. An actuator is mounted to the body and is manually operable for selectively operating the gas-releasing means to drive the plunger from its ready toward its spent position to discharge medication from the apparatus and into the patient.
Description
~2:3~807 HYPODERMIC INJECTION APPARATUS
Background and Summary of the Invention This invention relates generally to a hypodermic injection apparatus, and more specifically to such an apparatus having a replaceable ampule unit carrying a plunger and a power source for administering intramuscular and subcutaneous injections without a needle.
Present needle less hypodermic injection apparatus involve the use of separately and independently replaceable ampule units and power source units containing COY cartridges.
An example of such a unit is described in US. Patent No.
3,688,765 issued to Gus on September 5, 1972. The device described in that patent includes a central body. On one end of the body is disposed an ampule unit having a generally cylindrical chamber and a plunger disposed in one end spaced away from a nozzle disposed in the other end. Abutting a side of the plunger opposite from the nozzle is the end of a piston which extends through a passageway to an opposite end of the body. A pressurized-gas cartridge is attached to the opposite end of the body with a frangible seal accessible from the center of the body. A firing pin is spring-loaded to be projected into the COY cartridge for release of the gas contained therein. The firing pin is hollow to conduct escaping gas into a cylinder which houses the plunger-driving piston described earlier. The piston thus drives the plunger toward the nozzle, expelling medication contained in the ampule unit.
Such a unit requires separate loading of the pressurized-gas cartridge and the medication-containing ampule.
Two members of the apparatus must be relatively rotated and axially pulled away from each other in order to cock the device.
Further, the piston which drives against the plunger during ~232807 ejection of the medication is exposed to the air during changing of an ampule unit. Such units thus require a fair amount of physical manipulation by the physician or other medical attendant. Also, there is some chance of infecting the ampule unit, either through its nozzle or through the plunger.
Another type of needle less hypodermic injection device is disclosed in US. Patent No. 4,089,334 to Shabbily et at.
This patent discloses a device which uses a pyrotechnic cap which, when detonated, provides an explosive charge of gas which drives medication through a discharge aperture in one end of the device. There are many drawbacks inherent in the use of this type of device, including danger to the patient, or at least apprehension of such danger. Because of this danger or at least the perception of such danger, this device will often not be usable in soft-tissue areas of the body, such as the mouth, where the patient may be particularly sensitive to use of an explosive device.
It is therefore a general object of the present invention to overcome the drawbacks and limitations of the prior art proposals. More particularly, the invention has as its objects, the following: (1) to provide a needle less hypodermic injection apparatus which requires only replacement of a single ampule unit containing a power source, plunger and medication ampule; (2) the provision of such an apparatus which may be operated by one having little expertise or training in the use of such devices; to) the provision of a needle less hypodermic injector which is automatically recooked after each use thereof; (4) to provide a hypodermic injection apparatus having a plurality of components, which is not usable unless the components are properly and fully assembled; (5) to develop a needle less hypodermic injection device which is usable in close proximity to the soft-tissue areas of the body, such as the mouth, due to the minimization of actuation noises and expulsion of gases during the injection process; (6) the provision of an injection device which is able to inject medication into the tongue so that the medication reaches the bloodstream at the earliest possible moment; and (7) to provide a needle less hypodermic injection apparatus which is simple in construction and therefore relatively easy and inexpensive to fabricate and assemble and which therefore may be marketed in both reusable and disposable embodiments.
Summary of the Invention The present invention meets the above objects by providing a pressure-operated hypodermic injection apparatus which includes an elongate shell having inwardly facing wall means with a uniform cross-sectional configuration along a defined length thereof, and having a discharge aperture adjacent one end thereof, a plunger slide ably disposed within such defined length, the plunger being shiftable between ready and spent positions disposed different distances from the aperture, a pressurized-gas cartridge mounted to the plunger to shift therewith and having gas-releasing means facing away from the aperture, a body mounted to the other end of the shell, and an actuator mounted to the body and manually operable for operating the gas releasing means to drive the plunger from the ready position toward the spent position. With the plunger in the ready position, the shell and plunger define an ampule chamber capable of containing a dischargeable medication.
The gas-releasing means typically includes a frangible portion, and the actuator normally includes a reciprocable firing pin with one end designed to break the frangible portion upon contact therewith. Thus, upon actuation of the device, the firing pin breaks the frangible portion, thereby releasing the gas and driving the cartridge and plunger mounted thereto toward ~L232~ 7 the aperture, discharging medication from the device and into the patient.
Means are also normally provided for selectively retaining and then releasing the firing pin so that the pin is only released upon actuation, and so that once the injector has been discharged, the pin is automatically recooked for subsequent use.
Another way to define the invention is as an ampule unit which is usable in a pressure-operated hypodermic injection device, but this and other aspects, features and objects of the present invention will become evident to those skilled in the art as this description continues.
Brief Description of the Drawings Fig. 1 is a side elevation perspective view of a hypodermic injection apparatus including an ampule unit made in accordance with the present invention;
Fig. 2 is an end view of the right side of the apparatus of Fig. l;
Fig. 3 is a side elevation sectional view taken along line 3--6 of Fig. 2, with the device in position ready to be activated;
Fig. 4 is a side elevation sectional view along 3--6 of Fig. 2, corresponding to Fist 3 except that the device is shown an instant after actuation, with a frangible seal of the cartridge being pierced, but prior to release of gas from the cartridge;
~X3~
Fig. 5 is a side elevation sectional view along line I
6 of Fig. 2, corresponding to that of Figs. 3 and 4 except that the apparatus is shown subsequent to discharge of gas from the cartridge, at the instant the cartridge and plunger reach their spent positions;
Fig. 6 is a side elevation sectional view along line 3-6 of Fig. 2, corresponding to that of Figs. 3-5, except that the apparatus is shown a moment after the cartridge and plunger reach their spent positions, and the gases within the ampule unit have driven the firing pin back to its initial, cocked position Fig. 7 is an end elevation view taken along line 7-7 of Fig. 6, except that the apparatus is rotated 90 degrees;
Fig. 8 is a fragmentary, partially sectioned side elevation view showing the detent safety mechanism;
Fig. 9 is a partially sectioned, side elevation view of the apparatus; and Fig. 10 is a side elevation view of the ampule assembly of the depicted embodiment.
Detailed Description of the Preferred Embodiment The drawings depict a preferred embodiment of the needle less hypodermic injection apparatus, which has been identified generally with the numeral 10. Apparatus 10 consists essentially of a body assembly 12, a removable ampule assembly 14 which is adapted to be mounted partially within the body assembly, a sliding collar 16 slide ably mounted to the exterior of the body assembly, and an actuator assembly 18. Ampule assembly 14 includes a shell 20 which defines a chamber having a compressed gas-containing cartridge 22 with a plunger 24 mounted to one end. Plunger 24 includes a Thea inch O-ring 25 in the 1:~32~307 depicted embodiment to ensure an adequate seal between the plunger and the inner walls of shell 20. The exposed or forward end of ampule 14 includes an aperture 26 which is typically about 1/2 mix in diameter. Cartridge 22 is typically filled with COY gas, although other gases may be alternatively used. A
frangible cartridge seal 28, sometimes referred to herein as a frangible member, is typically fabricated of polyurethane or a similar material, and is designed to seal cartridge 22 under pressure until that seal is broken by actuator assembly 18.
As shown in Fig. 10, ampule assembly 14 is mounted to body assembly 12 by a pair of L-shaped slots 23 defined in the rearward end of shell 20, the slots being designed to receive a pair of ampule engagement pins 27 which extend from the body assembly. This structure not only provides for adequate engagement between ampule assembly 14 and body assembly 12, but also provides means to prevent discharge of apparatus 10 unless the ampule assembly is completely engaged by the body assembly.
This means is depicted in Fig. 9 and includes a pair of collar pins 30 which extend inwardly through a corresponding pair of slotted or cut-out portions 32 is body assembly 12. When shell 20 of ampule assembly is pushed and then turned into body assembly 12, ampule engagement pins 27 first slide into longitudinally extending portions 23_ of slots 23, and then into transverse portions 23b. Only when ampule engagement pins 27 are in abutment with the end of the transverse portions 23_ will the longitudinal portions, aye be in longitudinal alignment with collar pins 30. As will be explained more fully below, only when this longitudinal alignment exists, is it possible to slide collar 16 forwardly to discharge the apparatus.
Actuator assembly 18 includes a reciprocable portion, depicted in the figures as a firing pin 34, which includes a seal-piercing pointed projection 36 at a forward end, an ~Z3Z~3Q7 axisymmetric annular groove 38 in its middle portion, and a spring seat 40 at its rearwardly disposed end. Spring seat 40 is mounted to a firing pin spring retainer 42 which encompasses and retains firing pin spring 44.
As shown in Figs. 3-6, a plurality of firing pin retaining balls 48 are positioned within actuator assembly 18 to selectively engage and release firing pin 34 at annular groove 38. These retaining balls 48, alternatively referred to herein as retaining members or retaining rollers, are held longitudinally or axially stationary by actuator sleeve 50, within which firing pin 34 is slide ably mounted. Retaining balls 48 are held against firing pin 34 by a ball retainer, which is shown generally at 52, and which sometimes will be referred to herein as inwardly facing wall means. Ball retainer 52 includes a narrowed race 54 and a broadened race 56.
Narrowed race 54 is sized such that retaining balls 48 may be disposed within annular groove 38 while in abutment with that race. Broadened race 56 is sized such that retaining balls 48 may be positioned between the remaining portion of firing pin 34 and that race.
In the depicted embodiment, firing pin annular groove 38 includes rounded walls which conform to the periphery of retaining balls 48, although any converging wall configuration would suffice as long as it conforms to the configuration of the retaining member which is included in that particular embodiment. Thus, when retaining balls 48 engage annular groove 38 and are held therein by narrowed race 54, firing pin 34 is not permitted to be displaced axially either through the action of pressure within shell 20 or by the urging of firing pin spring 44. When broadened race 56 is positioned adjacent retaining balls 48, the biasing of firing spring 44 urges the balls out of annular groove 38, thus causing firing pin 34 to be ~32~ it displaced axially in a forward direction toward ampule assembly 14.
Ball retainer 52 is biased rearwardly by a ball retainer spring 52 which seats against an annular ring 60 in actuator sleeve 50, The rearward end of ball retainer 52 is in contact with a pair of dowel pins 62 which extend inwardly from sliding collar 16. The opposite or rearward end of dowel pins 62 seat against an inner spring 64 so that sliding collar 16 is biased forwardly by inner spring 64 and rearwardly by ball retainer spring 58. Ball retainer spring 58 exerts more force than inner spring 64 when ball retainer 52 is in the position depicted in Figs. 3-5, for reasons which will become apparent as this description continues.
A bleed vent 70 through body assembly 12 and is positioned such that when ampule assembly 14 is properly engaged within the body assembly, the vent is in alignment with slot 23, as shown in Figs. 3-6. A safety detent slot 76 is depicted in Figs. 8 and 9. A pair of opposing slots 76 are actually provided to receive the two dowel pins 62, but only one of the slots appears in Figs. 8 and 9. As shown in Figs. 3-9, slot 76 includes a firing pin release portion 80 which causes actuator assembly 18 to discharge the apparatus, and a manual rearming portion I which recooks the actuator assembly prior to discharge. A centrally disposed detent portion 84 prevents collar 16 from being inadvertently rotated, because the force provided by ball retainer spring 58 is greater than inner spring 64, holding dowel pins 62 in their respective detent portions 84.
Operation of the Depicted Embodiment In order to use injection apparatus 10, the actuator assembly 18 is first cocked. This is normally done automatically immediately following injection of medication, but may be performed manually by slightly rotating sliding collar 16 and sliding it rearwardly until dowel pins 62 have passed through the entire length of manual rearming portions 82 of the safety detent slots 76. As dowel pins 62 are being slid rearwardly with collar 16, they contact the underside of the firing pin spring 42, which causes firing pin 34 to be moved rearwardly into its cocked position depicted in Fig. 3.
With actuator assembly 18 fully cocked, the previously-spent ampule assembly 14 (if any) is then removed and a replacement assembly, having a new supply of medication and a sealed and charged cartridge 22, may be mounted into place.
This is done by pushing shell 20 into body assembly 12 so that ampule engagement pins 27 slide through the longitudinally extending portions aye of slots 23. Shell 20 is then rotated to the position shown in Fig. 9 where the ampule engagement pins 27 are in abutment with the ends of the transverse slot portions 23b. As shown in Fig. 9, with shell 20 in this position, collar pins 30 will be in alignment with the longitudinal portions aye 80 that the collar is free to be subsequently slid forward to discharge the apparatus. If shell 20 has not been rotated all of the way and locked into place, such alignment will not exist.
To use the apparatus, it is positioned directly against the skin of the patient. It has been found that the depicted apparatus is particularly useful and effective when used to discharge medication into the tongue of the patient.
Prior art needle less devices were typically too large, too difficult to operate, or too explosively venting to be used within the mouth. Injectors having a needle would be so painful upon injection that the patient would be likely to move his tongue, presenting the possibility of laceration. Such 12328~7 lacerations can be very dangerous due to the vascular nature of the tongue. This vascularity is precisely why injection directly into the tongue is so beneficial. Within seconds of injection, the medication can be in the bloodstream. This can be of critical importance in many cases.
Fig. 3 depicts apparatus 10 in its ready-to-be-fired mode. In this mode, narrow race 54 of ball retainer 52 holds retaining balls 48 within annular groove 38 of firing pin 34.
This prevents firing pin 34 from being displaced forwardly by the biasing of firing pin spring 44.
To discharge the device, the operator slides sliding collar 16 slightly forwardly so that dowel pins 78 are directed to the end of firing pin release portions 80. Again, this is not possible unless the ampule assembly 14 is fully in place and the longitudinal portions aye of slots 23 are in alignment with the collar pins 30. This causes ball retainer 52 to be displaced forwardly against the urging of ball retainer spring 58, and positions broadened race 56 of ball retainer 52 adjacent retaining balls 48. The biasing of firing pin spring 44 causes retaining balls 48 to move radially outwardly from annular groove 38 until the are in abutment with broadened race 56, thereby freeing firing pin 34 to be axially displaced by the action of firing spring 44. This causes the projection 32 in the forward end of firing pin 34 to be driven into the frangible seal 28 in the rearward end of COY cartridge 22, as depicted in Fig. 4.
The compressed gases in cartridge 22 are then free to explode outwardly in a rearward direction, thereby driving cartridge 22 and plunger 24 forwardly from their so-called "ready" position, which forces the medication through discharge aperture 26 until all of the medication is discharged and plunger 24 is disposed against the forward end of shell 20, as 1232~3Q7 depicted in Fig. 5. At this point, cartridge 22 and plunger 24 are in a so-called "spent" position. With plunger 24 in this position, the pressure within shell 20 it approximately 400 psi, due to the fact that approximately 800 psi of charge is typically provided in cartridge 22. This 400 psi pressure then causes firing pin 34 to be driven rearwardly due to the action of the pressure on cartridge seal 28, against the biasing of firing pin spring 44. The force of this spring 44 is greater that the resistive force which the medication has to being driven through aperture 26, so that cartridge seal 28 remains stationary while the medication is being discharged. However, such force is substantially less than necessary to hold the firing pin in position once plunger 24 has been displaced from its ready position to its spent position depicted in Fig. 5.
Therefore, the action of the 40n psi on cartridge seal 28 causes firing pin 34 to be driven rearwardly to the position depicted in Fig. 6, thus automatically recooking actuator assembly 18.
The dislodgement of cartridge seal 28 is not immediate, due to the resistance provided by firing pin spring 44, so it is not typically fully effected until apparatus 10 would be removed from proximity to the patient's body. Once firing pin 34 is no-cocked, the pressurized gas within shell 20 is free to exit through one of the slots 23 in shell 20 and bleed vent 70 in body assembly 12, and then out to the atmosphere due to clearance between collar 16 and body assembly 12, all as shown in Fig. 6.
Thus, the device automatically recooks itself for the next operation. The ampule assembly 14 may then be removed, and be replaced with a freshly charged cartridge 22 and a new portion of medication, for the next use.
While the invention has been particularly shown and described with reference to the foregoing preferred embodiment, ~2328C37 it will be understood by those skilled in the art that other changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined in the following claims.
Background and Summary of the Invention This invention relates generally to a hypodermic injection apparatus, and more specifically to such an apparatus having a replaceable ampule unit carrying a plunger and a power source for administering intramuscular and subcutaneous injections without a needle.
Present needle less hypodermic injection apparatus involve the use of separately and independently replaceable ampule units and power source units containing COY cartridges.
An example of such a unit is described in US. Patent No.
3,688,765 issued to Gus on September 5, 1972. The device described in that patent includes a central body. On one end of the body is disposed an ampule unit having a generally cylindrical chamber and a plunger disposed in one end spaced away from a nozzle disposed in the other end. Abutting a side of the plunger opposite from the nozzle is the end of a piston which extends through a passageway to an opposite end of the body. A pressurized-gas cartridge is attached to the opposite end of the body with a frangible seal accessible from the center of the body. A firing pin is spring-loaded to be projected into the COY cartridge for release of the gas contained therein. The firing pin is hollow to conduct escaping gas into a cylinder which houses the plunger-driving piston described earlier. The piston thus drives the plunger toward the nozzle, expelling medication contained in the ampule unit.
Such a unit requires separate loading of the pressurized-gas cartridge and the medication-containing ampule.
Two members of the apparatus must be relatively rotated and axially pulled away from each other in order to cock the device.
Further, the piston which drives against the plunger during ~232807 ejection of the medication is exposed to the air during changing of an ampule unit. Such units thus require a fair amount of physical manipulation by the physician or other medical attendant. Also, there is some chance of infecting the ampule unit, either through its nozzle or through the plunger.
Another type of needle less hypodermic injection device is disclosed in US. Patent No. 4,089,334 to Shabbily et at.
This patent discloses a device which uses a pyrotechnic cap which, when detonated, provides an explosive charge of gas which drives medication through a discharge aperture in one end of the device. There are many drawbacks inherent in the use of this type of device, including danger to the patient, or at least apprehension of such danger. Because of this danger or at least the perception of such danger, this device will often not be usable in soft-tissue areas of the body, such as the mouth, where the patient may be particularly sensitive to use of an explosive device.
It is therefore a general object of the present invention to overcome the drawbacks and limitations of the prior art proposals. More particularly, the invention has as its objects, the following: (1) to provide a needle less hypodermic injection apparatus which requires only replacement of a single ampule unit containing a power source, plunger and medication ampule; (2) the provision of such an apparatus which may be operated by one having little expertise or training in the use of such devices; to) the provision of a needle less hypodermic injector which is automatically recooked after each use thereof; (4) to provide a hypodermic injection apparatus having a plurality of components, which is not usable unless the components are properly and fully assembled; (5) to develop a needle less hypodermic injection device which is usable in close proximity to the soft-tissue areas of the body, such as the mouth, due to the minimization of actuation noises and expulsion of gases during the injection process; (6) the provision of an injection device which is able to inject medication into the tongue so that the medication reaches the bloodstream at the earliest possible moment; and (7) to provide a needle less hypodermic injection apparatus which is simple in construction and therefore relatively easy and inexpensive to fabricate and assemble and which therefore may be marketed in both reusable and disposable embodiments.
Summary of the Invention The present invention meets the above objects by providing a pressure-operated hypodermic injection apparatus which includes an elongate shell having inwardly facing wall means with a uniform cross-sectional configuration along a defined length thereof, and having a discharge aperture adjacent one end thereof, a plunger slide ably disposed within such defined length, the plunger being shiftable between ready and spent positions disposed different distances from the aperture, a pressurized-gas cartridge mounted to the plunger to shift therewith and having gas-releasing means facing away from the aperture, a body mounted to the other end of the shell, and an actuator mounted to the body and manually operable for operating the gas releasing means to drive the plunger from the ready position toward the spent position. With the plunger in the ready position, the shell and plunger define an ampule chamber capable of containing a dischargeable medication.
The gas-releasing means typically includes a frangible portion, and the actuator normally includes a reciprocable firing pin with one end designed to break the frangible portion upon contact therewith. Thus, upon actuation of the device, the firing pin breaks the frangible portion, thereby releasing the gas and driving the cartridge and plunger mounted thereto toward ~L232~ 7 the aperture, discharging medication from the device and into the patient.
Means are also normally provided for selectively retaining and then releasing the firing pin so that the pin is only released upon actuation, and so that once the injector has been discharged, the pin is automatically recooked for subsequent use.
Another way to define the invention is as an ampule unit which is usable in a pressure-operated hypodermic injection device, but this and other aspects, features and objects of the present invention will become evident to those skilled in the art as this description continues.
Brief Description of the Drawings Fig. 1 is a side elevation perspective view of a hypodermic injection apparatus including an ampule unit made in accordance with the present invention;
Fig. 2 is an end view of the right side of the apparatus of Fig. l;
Fig. 3 is a side elevation sectional view taken along line 3--6 of Fig. 2, with the device in position ready to be activated;
Fig. 4 is a side elevation sectional view along 3--6 of Fig. 2, corresponding to Fist 3 except that the device is shown an instant after actuation, with a frangible seal of the cartridge being pierced, but prior to release of gas from the cartridge;
~X3~
Fig. 5 is a side elevation sectional view along line I
6 of Fig. 2, corresponding to that of Figs. 3 and 4 except that the apparatus is shown subsequent to discharge of gas from the cartridge, at the instant the cartridge and plunger reach their spent positions;
Fig. 6 is a side elevation sectional view along line 3-6 of Fig. 2, corresponding to that of Figs. 3-5, except that the apparatus is shown a moment after the cartridge and plunger reach their spent positions, and the gases within the ampule unit have driven the firing pin back to its initial, cocked position Fig. 7 is an end elevation view taken along line 7-7 of Fig. 6, except that the apparatus is rotated 90 degrees;
Fig. 8 is a fragmentary, partially sectioned side elevation view showing the detent safety mechanism;
Fig. 9 is a partially sectioned, side elevation view of the apparatus; and Fig. 10 is a side elevation view of the ampule assembly of the depicted embodiment.
Detailed Description of the Preferred Embodiment The drawings depict a preferred embodiment of the needle less hypodermic injection apparatus, which has been identified generally with the numeral 10. Apparatus 10 consists essentially of a body assembly 12, a removable ampule assembly 14 which is adapted to be mounted partially within the body assembly, a sliding collar 16 slide ably mounted to the exterior of the body assembly, and an actuator assembly 18. Ampule assembly 14 includes a shell 20 which defines a chamber having a compressed gas-containing cartridge 22 with a plunger 24 mounted to one end. Plunger 24 includes a Thea inch O-ring 25 in the 1:~32~307 depicted embodiment to ensure an adequate seal between the plunger and the inner walls of shell 20. The exposed or forward end of ampule 14 includes an aperture 26 which is typically about 1/2 mix in diameter. Cartridge 22 is typically filled with COY gas, although other gases may be alternatively used. A
frangible cartridge seal 28, sometimes referred to herein as a frangible member, is typically fabricated of polyurethane or a similar material, and is designed to seal cartridge 22 under pressure until that seal is broken by actuator assembly 18.
As shown in Fig. 10, ampule assembly 14 is mounted to body assembly 12 by a pair of L-shaped slots 23 defined in the rearward end of shell 20, the slots being designed to receive a pair of ampule engagement pins 27 which extend from the body assembly. This structure not only provides for adequate engagement between ampule assembly 14 and body assembly 12, but also provides means to prevent discharge of apparatus 10 unless the ampule assembly is completely engaged by the body assembly.
This means is depicted in Fig. 9 and includes a pair of collar pins 30 which extend inwardly through a corresponding pair of slotted or cut-out portions 32 is body assembly 12. When shell 20 of ampule assembly is pushed and then turned into body assembly 12, ampule engagement pins 27 first slide into longitudinally extending portions 23_ of slots 23, and then into transverse portions 23b. Only when ampule engagement pins 27 are in abutment with the end of the transverse portions 23_ will the longitudinal portions, aye be in longitudinal alignment with collar pins 30. As will be explained more fully below, only when this longitudinal alignment exists, is it possible to slide collar 16 forwardly to discharge the apparatus.
Actuator assembly 18 includes a reciprocable portion, depicted in the figures as a firing pin 34, which includes a seal-piercing pointed projection 36 at a forward end, an ~Z3Z~3Q7 axisymmetric annular groove 38 in its middle portion, and a spring seat 40 at its rearwardly disposed end. Spring seat 40 is mounted to a firing pin spring retainer 42 which encompasses and retains firing pin spring 44.
As shown in Figs. 3-6, a plurality of firing pin retaining balls 48 are positioned within actuator assembly 18 to selectively engage and release firing pin 34 at annular groove 38. These retaining balls 48, alternatively referred to herein as retaining members or retaining rollers, are held longitudinally or axially stationary by actuator sleeve 50, within which firing pin 34 is slide ably mounted. Retaining balls 48 are held against firing pin 34 by a ball retainer, which is shown generally at 52, and which sometimes will be referred to herein as inwardly facing wall means. Ball retainer 52 includes a narrowed race 54 and a broadened race 56.
Narrowed race 54 is sized such that retaining balls 48 may be disposed within annular groove 38 while in abutment with that race. Broadened race 56 is sized such that retaining balls 48 may be positioned between the remaining portion of firing pin 34 and that race.
In the depicted embodiment, firing pin annular groove 38 includes rounded walls which conform to the periphery of retaining balls 48, although any converging wall configuration would suffice as long as it conforms to the configuration of the retaining member which is included in that particular embodiment. Thus, when retaining balls 48 engage annular groove 38 and are held therein by narrowed race 54, firing pin 34 is not permitted to be displaced axially either through the action of pressure within shell 20 or by the urging of firing pin spring 44. When broadened race 56 is positioned adjacent retaining balls 48, the biasing of firing spring 44 urges the balls out of annular groove 38, thus causing firing pin 34 to be ~32~ it displaced axially in a forward direction toward ampule assembly 14.
Ball retainer 52 is biased rearwardly by a ball retainer spring 52 which seats against an annular ring 60 in actuator sleeve 50, The rearward end of ball retainer 52 is in contact with a pair of dowel pins 62 which extend inwardly from sliding collar 16. The opposite or rearward end of dowel pins 62 seat against an inner spring 64 so that sliding collar 16 is biased forwardly by inner spring 64 and rearwardly by ball retainer spring 58. Ball retainer spring 58 exerts more force than inner spring 64 when ball retainer 52 is in the position depicted in Figs. 3-5, for reasons which will become apparent as this description continues.
A bleed vent 70 through body assembly 12 and is positioned such that when ampule assembly 14 is properly engaged within the body assembly, the vent is in alignment with slot 23, as shown in Figs. 3-6. A safety detent slot 76 is depicted in Figs. 8 and 9. A pair of opposing slots 76 are actually provided to receive the two dowel pins 62, but only one of the slots appears in Figs. 8 and 9. As shown in Figs. 3-9, slot 76 includes a firing pin release portion 80 which causes actuator assembly 18 to discharge the apparatus, and a manual rearming portion I which recooks the actuator assembly prior to discharge. A centrally disposed detent portion 84 prevents collar 16 from being inadvertently rotated, because the force provided by ball retainer spring 58 is greater than inner spring 64, holding dowel pins 62 in their respective detent portions 84.
Operation of the Depicted Embodiment In order to use injection apparatus 10, the actuator assembly 18 is first cocked. This is normally done automatically immediately following injection of medication, but may be performed manually by slightly rotating sliding collar 16 and sliding it rearwardly until dowel pins 62 have passed through the entire length of manual rearming portions 82 of the safety detent slots 76. As dowel pins 62 are being slid rearwardly with collar 16, they contact the underside of the firing pin spring 42, which causes firing pin 34 to be moved rearwardly into its cocked position depicted in Fig. 3.
With actuator assembly 18 fully cocked, the previously-spent ampule assembly 14 (if any) is then removed and a replacement assembly, having a new supply of medication and a sealed and charged cartridge 22, may be mounted into place.
This is done by pushing shell 20 into body assembly 12 so that ampule engagement pins 27 slide through the longitudinally extending portions aye of slots 23. Shell 20 is then rotated to the position shown in Fig. 9 where the ampule engagement pins 27 are in abutment with the ends of the transverse slot portions 23b. As shown in Fig. 9, with shell 20 in this position, collar pins 30 will be in alignment with the longitudinal portions aye 80 that the collar is free to be subsequently slid forward to discharge the apparatus. If shell 20 has not been rotated all of the way and locked into place, such alignment will not exist.
To use the apparatus, it is positioned directly against the skin of the patient. It has been found that the depicted apparatus is particularly useful and effective when used to discharge medication into the tongue of the patient.
Prior art needle less devices were typically too large, too difficult to operate, or too explosively venting to be used within the mouth. Injectors having a needle would be so painful upon injection that the patient would be likely to move his tongue, presenting the possibility of laceration. Such 12328~7 lacerations can be very dangerous due to the vascular nature of the tongue. This vascularity is precisely why injection directly into the tongue is so beneficial. Within seconds of injection, the medication can be in the bloodstream. This can be of critical importance in many cases.
Fig. 3 depicts apparatus 10 in its ready-to-be-fired mode. In this mode, narrow race 54 of ball retainer 52 holds retaining balls 48 within annular groove 38 of firing pin 34.
This prevents firing pin 34 from being displaced forwardly by the biasing of firing pin spring 44.
To discharge the device, the operator slides sliding collar 16 slightly forwardly so that dowel pins 78 are directed to the end of firing pin release portions 80. Again, this is not possible unless the ampule assembly 14 is fully in place and the longitudinal portions aye of slots 23 are in alignment with the collar pins 30. This causes ball retainer 52 to be displaced forwardly against the urging of ball retainer spring 58, and positions broadened race 56 of ball retainer 52 adjacent retaining balls 48. The biasing of firing pin spring 44 causes retaining balls 48 to move radially outwardly from annular groove 38 until the are in abutment with broadened race 56, thereby freeing firing pin 34 to be axially displaced by the action of firing spring 44. This causes the projection 32 in the forward end of firing pin 34 to be driven into the frangible seal 28 in the rearward end of COY cartridge 22, as depicted in Fig. 4.
The compressed gases in cartridge 22 are then free to explode outwardly in a rearward direction, thereby driving cartridge 22 and plunger 24 forwardly from their so-called "ready" position, which forces the medication through discharge aperture 26 until all of the medication is discharged and plunger 24 is disposed against the forward end of shell 20, as 1232~3Q7 depicted in Fig. 5. At this point, cartridge 22 and plunger 24 are in a so-called "spent" position. With plunger 24 in this position, the pressure within shell 20 it approximately 400 psi, due to the fact that approximately 800 psi of charge is typically provided in cartridge 22. This 400 psi pressure then causes firing pin 34 to be driven rearwardly due to the action of the pressure on cartridge seal 28, against the biasing of firing pin spring 44. The force of this spring 44 is greater that the resistive force which the medication has to being driven through aperture 26, so that cartridge seal 28 remains stationary while the medication is being discharged. However, such force is substantially less than necessary to hold the firing pin in position once plunger 24 has been displaced from its ready position to its spent position depicted in Fig. 5.
Therefore, the action of the 40n psi on cartridge seal 28 causes firing pin 34 to be driven rearwardly to the position depicted in Fig. 6, thus automatically recooking actuator assembly 18.
The dislodgement of cartridge seal 28 is not immediate, due to the resistance provided by firing pin spring 44, so it is not typically fully effected until apparatus 10 would be removed from proximity to the patient's body. Once firing pin 34 is no-cocked, the pressurized gas within shell 20 is free to exit through one of the slots 23 in shell 20 and bleed vent 70 in body assembly 12, and then out to the atmosphere due to clearance between collar 16 and body assembly 12, all as shown in Fig. 6.
Thus, the device automatically recooks itself for the next operation. The ampule assembly 14 may then be removed, and be replaced with a freshly charged cartridge 22 and a new portion of medication, for the next use.
While the invention has been particularly shown and described with reference to the foregoing preferred embodiment, ~2328C37 it will be understood by those skilled in the art that other changes in form and detail may be made therein without departing from the spirit and scope of the invention as defined in the following claims.
Claims (29)
1. In a pressure-operated hypodermic injection apparatus including a body and an actuator mounted on the body, a replaceable, medication-discharging ampule unit comprising:
an elongate shell having inwardly facing wall means characterized by a substantially uniform cross-sectional configuration along a defined length portion of said shell, said shell further defining a discharge aperture adjacent a forward end thereof; a plunger slideably and sealingly disposed within said defined length portion in said shell, displaceable between a rearward, ready position, spaced one distance from said aperture, and a forward, spent position closer to said aperture than said ready position; said shell and plunger, with the latter in said ready position defining an ampule chamber capable of containing dischargeable medication; and a compressed-gas containing cartridge operable under the influence of the apparatus actuator to drive said plunger and reciprocate with said plunger from said ready position toward said spent position.
an elongate shell having inwardly facing wall means characterized by a substantially uniform cross-sectional configuration along a defined length portion of said shell, said shell further defining a discharge aperture adjacent a forward end thereof; a plunger slideably and sealingly disposed within said defined length portion in said shell, displaceable between a rearward, ready position, spaced one distance from said aperture, and a forward, spent position closer to said aperture than said ready position; said shell and plunger, with the latter in said ready position defining an ampule chamber capable of containing dischargeable medication; and a compressed-gas containing cartridge operable under the influence of the apparatus actuator to drive said plunger and reciprocate with said plunger from said ready position toward said spent position.
2. In a pressure-operated hypodermic injection apparatus including a body and an actuator mounted on the body, a replaceable, medication-discharging ampule unit comprising:
an elongate shell having inwardly facing wall means characterized by a substantially uniform cross-sectional configuration along a defined length portion of said shell, said shell further defining a discharge aperture adjacent a forward end thereof; a plunger slideably and sealingly disposed within said defined length portion in said shell, displaceable between a rearward, ready position, spaced one distance from said aperture, and a forward, spent position closer to said aperture than said ready position; said shell and plunger, with the latter in said ready position, defining an ampule chamber capable of containing dischargeable medication; and a compressed-gas containing cartridge including means for releasing its gas charge in a rearward direction upon actuation by the actuator to drive said plunger from said ready position toward said spent position.
an elongate shell having inwardly facing wall means characterized by a substantially uniform cross-sectional configuration along a defined length portion of said shell, said shell further defining a discharge aperture adjacent a forward end thereof; a plunger slideably and sealingly disposed within said defined length portion in said shell, displaceable between a rearward, ready position, spaced one distance from said aperture, and a forward, spent position closer to said aperture than said ready position; said shell and plunger, with the latter in said ready position, defining an ampule chamber capable of containing dischargeable medication; and a compressed-gas containing cartridge including means for releasing its gas charge in a rearward direction upon actuation by the actuator to drive said plunger from said ready position toward said spent position.
3. The ampule unit of claim 2 wherein said cartridge includes a frangible member which is broken upon actuation by the actuator.
4. The ampule unit of claim 2 wherein said cartridge is mounted to said plunger within said shell and slides therewith between said ready and spent positions.
5. The ampule unit of claim 2, further comprising:
means for being rotatable mounted to the apparatus; and means for preventing operation of the actuator and displacement of said plunger unless said ampule unit is all of the way turned into the apparatus.
means for being rotatable mounted to the apparatus; and means for preventing operation of the actuator and displacement of said plunger unless said ampule unit is all of the way turned into the apparatus.
6. The ampule unit of claim 5, wherein said means for preventing operation comprises longitudinally extending recess means defined in said shell for receiving, upon actuation, a complementing extension member of the actuator, said recess means being rotationally aligned with the extension member only when the ampule unit is turned all of the way into the apparatus.
7. A pressure-operated hypodermic injection apparatus comprising: an elongate shell having inwardly facing wall means characterized by a substantially uniform cross-sectional configuration along a defined length portion of said shell, said shell further defining a discharge aperture adjacent one end thereof; a plunger slideably and sealingly disposed within said defined length portion in said shell, shiftable from a ready position spaced one distance from said aperture toward a spent position closer to said aperture than said ready position;
said shell and plunger, with the latter in said ready position, defining an ampule chamber capable of containing dischargeable medication; a pressurized-gas cartridge mounted to said plunger to shift therewith and having gas-releasing means facing away from said discharge aperture; a body sealingly and releasably joined to another end of said shell; and an actuator mounted on said body and manually operable for selectively operating said gas-releasing means to drive said plunger from said ready position toward said spent position.
said shell and plunger, with the latter in said ready position, defining an ampule chamber capable of containing dischargeable medication; a pressurized-gas cartridge mounted to said plunger to shift therewith and having gas-releasing means facing away from said discharge aperture; a body sealingly and releasably joined to another end of said shell; and an actuator mounted on said body and manually operable for selectively operating said gas-releasing means to drive said plunger from said ready position toward said spent position.
8. The apparatus of claim 7 wherein said actuator includes a reciprocable portion which is displaceable between retracted and extended positions.
9. The apparatus of claim 8 wherein said reciprocable portion includes a reciprocable firing pin having one end which faces said gas-releasing means, and which comes into contact with said gas-releasing means upon being displaced to said extended position.
10. The apparatus of claim 9 wherein said gas-releasing means includes a frangible portion and said one end of said reciprocable firing pin includes means for breaking said frangible portion upon contact therewith.
11. The apparatus of claim 9 wherein said firing pin includes an annular groove therein, and wherein said actuator includes a plurality of retaining rollers which selectively enter into engagement with said firing pin annular groove, an inwardly facing portion with a narrow race and a broadened race for selectively holding said rollers in engagement with said groove, and permitting said rollers to move out of said groove, respectively, to hold and then release said firing pin.
12. A pressure-operated hypodermic injection apparatus comprising: an ampule unit having an elongate shell with wall means defining an internal chamber and a discharge aperture adjacent one end thereof, a plunger slideably and sealingly disposed within the chamber shiftable between a ready position spaced one distance from said aperture and a spent position closer to said aperture than the ready position, and a cartridge slidingly disposed in said shell fixed to said plunger opposite from said aperture, said cartridge having a frangible seal on a side opposite from said aperture and accessible from the other end of said shell; an elongate body releasably fixedly and sealingly joinable at one end to the other end of said shell of said ampule unit, said body having a longitudinal passageway having an opening disposed adjacent said cartridge seal; a firing pin slidingly disposed in said passageway with a seal-fracturing end disposed adjacent said one opening of said passageway, said pin being shiftable from a cocked position remote from said seal to a fired position with said one end of said pin extending through said seal when said ampule unit is joined to said body with said plunger in said ready position;
pin biasing means mounted in said body and joined to said pin for urging said pin from said cocked position toward said fired position; arming means for positioning said pin in said cocked position; and trigger means for retaining said pin in said cocked position and for selectively releasing said pin for traveling toward said fired position.
pin biasing means mounted in said body and joined to said pin for urging said pin from said cocked position toward said fired position; arming means for positioning said pin in said cocked position; and trigger means for retaining said pin in said cocked position and for selectively releasing said pin for traveling toward said fired position.
13. The apparatus of claim 12 wherein said body includes a longitudinally displaceable inwardly facing portion, and wherein said trigger means comprises: an annular groove defined in said pin; a plurality of pin retaining members positioned and sized to selectively enter into engagement with said pin annular groove, said members being in contact with said inwardly facing portion of said body, and wherein said inwardly facing portion includes narrowed race means for holding said members in engagement with said annular groove, and broadened race means for allowing said members to be displaced from said annular groove; and means for preventing longitudinal displacement of said members so that said pin is held from displacement in said cocked position when said members engage said annular groove and said pin is released to be displaced toward said fired position when said members release said pin.
14. The apparatus of claim 13 wherein said annular groove presents a centrally-converging, inclined abutment surface to said pin retaining members so that when field members are not held in engagement with said annular groove by said narrowed race means, the action of said spring means causes said retaining members to be displaced outwardly along said abutment surface until said pin is free to move toward said fired position.
15. The apparatus of claim 14 wherein said retaining members comprise generally spherical rollers.
16. The apparatus of claim 15 wherein said broadened race means is disposed remote from said ampule unit with respect to said narrowed race means, and further comprising race biasing means for urging said race means away from said ampule unit, and wherein said arming means includes a collar slidably mounted to said body, said collar contacting said inwardly facing body portion to permit said portion to be displaced against the urging of said race biasing means to thereby control the operation of said retaining members.
17. The apparatus of claim 12 wherein said firing pin includes means for engaging said frangible seal when said firing pin is in said fired position, and said pin biasing means urges said pin toward said fired position with a force less than that within said shell after said seal has been broken and said plunger has been driven to said spent position, so that after said plunger is driven to said spent position, said frangible seal and pin are driven toward said cocked position, and wherein said trigger means includes means for re-engaging said pin once it has been driven back to said cocked position.
18. The apparatus of claim 17 wherein said means for re-engaging said pin comprises said pin retaining members.
19. A pressure-operated, needleless hypodermic injection apparatus for injecting medication into the tongue of a patient, comprising: a replaceable, medication-discharging ampule unit which includes an elongate shell defining a discharge aperture adjacent a forward end thereof, a plunger slideably and sealingly disposed within said shell, displaceable between a ready position spaced one distance from said aperture and a spent position closer to said aperture than said ready position, said shell and plunger defining an ampule chamber capable of containing the medication when said plunger is in said ready position, and pressurized-gas means for driving said plunger and having gas-released means facing away from said discharge aperture; and means for manually actuating said ampule unit upon contact with the tongue of the patient, said means being mounted to said ampule unit and being operable for selectively operating said plunger-driving means to drive said plunger from said ready position toward said spent position.
20. The apparatus of claim 19, wherein said means for manually actuating said ampule unit comprises: a body sealingly and releasably joined to another end of said shell; and an actuator mounted on said body and manually operable for selectively operating said gas-releasing means to drive said plunger from said ready position toward said spent position, and including a reciprocable portion displaceable between retracted and extended positions, said reciprocable portion including a reciprocable firing pin having one end facing said gas-releasing means which comes into contact with said gas-releasing means upon being displaced to said extended position.
21. The apparatus of claim 20, wherein said gas-releasing means includes a frangible portion and said one end of said reciprocable firing pin includes means for breaking said frangible portion upon contact therewith.
22. The apparatus of claim 20, wherein said firing pin includes an annular groove therein, and wherein said actuator includes a plurality of retaining rollers which selectively enter into engagement with said firing pin annular groove, an inwardly facing portion with a narrow race and a broad race for selectively holding said rollers in engagement with said groove, and permitting said rollers to move out of said groove, respectively, to hold and then release said firing pin.
23. A pressure-operated hypodermic injection apparatus comprising: an elongate shell having inwardly facing wall means and defining a discharge aperture adjacent one end thereof; a plunger slideably and sealingly disposed within said shell, shiftable from a ready position spaced one distance from said aperture toward a spent position closer to said aperture;
said shell and plunger, with the latter in said ready position, defining an ampule chamber capable of containing dischargeable medication; and pressurized-gas means for driving said plunger and having gas-releasing means facing away from said discharge aperture.
said shell and plunger, with the latter in said ready position, defining an ampule chamber capable of containing dischargeable medication; and pressurized-gas means for driving said plunger and having gas-releasing means facing away from said discharge aperture.
24. The apparatus of claim 23, further comprising:
a body sealingly and releasably joined to another end of said shell; and an actuator mounted on said body and manually operable for selectively operating said gas-releasing means to drive said plunger from said ready position toward said spent position, and including a reciprocable portion displaceable between retracted and extended positions, said reciprocable portion including a reciprocable firing pin having one end facing said gas-releasing means which comes into contact with said gas releasing means upon being displaced to said extended position.
a body sealingly and releasably joined to another end of said shell; and an actuator mounted on said body and manually operable for selectively operating said gas-releasing means to drive said plunger from said ready position toward said spent position, and including a reciprocable portion displaceable between retracted and extended positions, said reciprocable portion including a reciprocable firing pin having one end facing said gas-releasing means which comes into contact with said gas releasing means upon being displaced to said extended position.
25. The apparatus of claim 24, wherein said gas-releasing means includes a frangible portion and said one end of said reciprocable firing pin includes means for breaking said frangible portion upon contact therewith.
26. The apparatus of claim 24, wherein said firing pin includes an annular groove therein, and wherein said actuator includes a plurality of retaining rollers which selectively enter into engagement with said firing pin annular groove, an inwardly facing portion with a narrow race and a broadened race for selectively holding said rollers in engagement with said groove, and permitting said rollers to move out of said groove, respectively, to hold and then release said firing pin.
27. A pressure-operated hypodermic injection apparatus for use with a medication-containing ampule having a discharge aperture adjacent a forward end thereof, and a pressurized-gas cartridge with a frangible gas-releasing portion facing away from said discharge aperture, wherein the injection apparatus comprises: a body for sealing and releasably engaging the ampule; and an actuator mounted to said body and manually operable for selectively operating the gas-releasing member, said actuator including a reciprocable portion which is displaceable between retracted and extended positions and includes a reciprocable firing member having one end for facing the ampule gas cartridge frangible portion, and which comes into contact with the frangible gas-releasing portion upon being displaced to said extended portion, said reciprocable firing member including means for breaking the frangible gas-releasing portion upon contact therewith.
28. The apparatus of claim 27, wherein said firing member includes an annual groove therein, and wherein said actuator includes a plurality of retaining rollers which selectively enter into engagement with said firing member annular groove, an inwardly facing portion with a narrow race and a broad race for selectively holding said rollers in engagement with said groove, and permitting said rollers to move out of said groove, respectively, to hold and then release said firing member.
29. The apparatus of claim 27, further comprising the medication-containing ampule.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/715,930 US4596556A (en) | 1985-03-25 | 1985-03-25 | Hypodermic injection apparatus |
| US06/715,930 | 1985-03-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1232807A true CA1232807A (en) | 1988-02-16 |
Family
ID=24876044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000500154A Expired CA1232807A (en) | 1985-03-25 | 1986-01-23 | Hypodermic injection apparatus |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US4596556A (en) |
| EP (1) | EP0197625A1 (en) |
| JP (1) | JPS61268265A (en) |
| CA (1) | CA1232807A (en) |
Families Citing this family (992)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4680027A (en) * | 1985-12-12 | 1987-07-14 | Injet Medical Products, Inc. | Needleless hypodermic injection device |
| CA1283827C (en) * | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
| US4941880A (en) * | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4790824A (en) * | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4940460A (en) * | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| JPH01198561A (en) * | 1987-11-16 | 1989-08-10 | Medhi Tek Internatl Ltd | Liquid injection apparatus |
| US4913699A (en) * | 1988-03-14 | 1990-04-03 | Parsons James S | Disposable needleless injection system |
| US5024656A (en) * | 1988-08-30 | 1991-06-18 | Injet Medical Products, Inc. | Gas-pressure-regulated needleless injection system |
| US5064413A (en) * | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) * | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5062830A (en) * | 1990-04-04 | 1991-11-05 | Derata Corporation | Dry disposable nozzle assembly for medical jet injector |
| GB9118204D0 (en) * | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| US5383851A (en) * | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| AU675702B2 (en) * | 1993-01-26 | 1997-02-13 | Leslie R. Coney | Compositions and methods for delivery of genetic material |
| US7001759B1 (en) | 1993-01-26 | 2006-02-21 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| US5981505A (en) * | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| US5746714A (en) * | 1993-04-05 | 1998-05-05 | P.A.T.H. | Air powered needleless hypodermic injector |
| TW404844B (en) * | 1993-04-08 | 2000-09-11 | Oxford Biosciences Ltd | Needleless syringe |
| KR100223616B1 (en) * | 1993-07-31 | 1999-10-15 | 웨스톤 테렌스 에드워드 | Needleless injector |
| FR2718357B1 (en) | 1994-04-06 | 1997-10-03 | Defarges Alain Moreau | Improvements made to a needleless jet injection device. |
| US5899880A (en) * | 1994-04-08 | 1999-05-04 | Powderject Research Limited | Needleless syringe using supersonic gas flow for particle delivery |
| GB9416663D0 (en) | 1994-08-17 | 1994-10-12 | Oxford Bioscience Limited | Particle delivery |
| GB9426379D0 (en) | 1994-12-23 | 1995-03-01 | Oxford Biosciences Ltd | Particle delivery |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| AU4494196A (en) * | 1995-02-06 | 1996-08-27 | Weston Medical Limited | Needle-less injector |
| GB9502879D0 (en) * | 1995-02-14 | 1995-04-05 | Oxford Biosciences Ltd | Particle delivery |
| US5503628A (en) | 1995-03-15 | 1996-04-02 | Jettek, Inc. | Patient-fillable hypodermic jet injector |
| DE29507987U1 (en) * | 1995-05-15 | 1996-09-19 | Ferton Holding | Ejection device for high pressure ejection of a liquid |
| US5730723A (en) * | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| US6013050A (en) * | 1995-10-20 | 2000-01-11 | Powderject Research Limited | Particle delivery |
| US5899879A (en) * | 1995-12-19 | 1999-05-04 | Genesis Medical Technologies, Inc. | Spring-actuated needleless injector |
| US5697917A (en) | 1996-02-29 | 1997-12-16 | Medi-Ject Corporation | Nozzle assembly with adjustable plunger travel gap |
| US5643211A (en) | 1996-02-29 | 1997-07-01 | Medi-Ject Corporation | Nozzle assembly having a frangible plunger |
| US5722953A (en) | 1996-02-29 | 1998-03-03 | Medi-Ject Corporation | Nozzle assembly for injection device |
| US5921967A (en) | 1996-02-29 | 1999-07-13 | Medi-Ject Corporation | Plunger for nozzle assembly |
| US5865795A (en) | 1996-02-29 | 1999-02-02 | Medi-Ject Corporation | Safety mechanism for injection devices |
| US5800388A (en) | 1996-02-29 | 1998-09-01 | Medi-Ject Corporation | Plunger/ram assembly adapted for a fluid injector |
| GB9607549D0 (en) * | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| US5875976A (en) | 1996-12-24 | 1999-03-02 | Medi-Ject Corporation | Locking mechanism for nozzle assembly |
| WO1998032397A1 (en) | 1997-01-24 | 1998-07-30 | Biostar Inc. | Pharmaceutical delivery system |
| US6261281B1 (en) * | 1997-04-03 | 2001-07-17 | Electrofect As | Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells |
| US5993412A (en) * | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| US5947928A (en) * | 1997-06-19 | 1999-09-07 | Mile Creek Capital, Llc | Drug delivery system |
| US6610042B2 (en) | 1997-12-05 | 2003-08-26 | Felton Medical, Inc. | Disposable unit-dose jet-injection syringe for pre-filled and/or transfilled liquid injectable medical drug or vaccine products and method thereof |
| US6541606B2 (en) * | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
| GB9802508D0 (en) | 1998-02-05 | 1998-04-01 | Boc Group Plc | Needleless medical device |
| US6369201B1 (en) | 1998-02-19 | 2002-04-09 | Metamorphix International, Inc. | Myostatin multimers |
| JP2002511396A (en) | 1998-04-14 | 2002-04-16 | メルク エンド カムパニー インコーポレーテッド | Needleless administration of polynucleotide preparations |
| US6063054A (en) * | 1998-05-13 | 2000-05-16 | Mark L. Anderson | Injector pump |
| JP2002521147A (en) * | 1998-07-27 | 2002-07-16 | メディ−ジェクト コーポレイション | Loading mechanism for use in medical syringe assemblies |
| KR100622160B1 (en) * | 1998-07-27 | 2006-09-07 | 안타레스 팔마, 인코퍼레이티드 | Injection-assisting probe for medical injector assembly |
| GB9818110D0 (en) * | 1998-08-19 | 1998-10-14 | Weston Medical Ltd | Needleless injectors and other devices |
| US6783509B1 (en) | 1998-11-18 | 2004-08-31 | Bioject Inc. | Single-use needle-less hypodermic jet injection apparatus and method |
| US6264629B1 (en) * | 1998-11-18 | 2001-07-24 | Bioject, Inc. | Single-use needle-less hypodermic jet injection apparatus and method |
| US6689093B2 (en) | 1998-11-18 | 2004-02-10 | Bioject, Inc. | Single-use needle-less hypodermic jet injection apparatus and method |
| US6406455B1 (en) * | 1998-12-18 | 2002-06-18 | Biovalve Technologies, Inc. | Injection devices |
| WO2000064514A1 (en) | 1999-04-22 | 2000-11-02 | Gilbert Garitano | Needleless permanent makeup and tattoo device |
| US6689103B1 (en) | 1999-05-07 | 2004-02-10 | Scimed Life System, Inc. | Injection array apparatus and method |
| US6319230B1 (en) | 1999-05-07 | 2001-11-20 | Scimed Life Systems, Inc. | Lateral needle injection apparatus and method |
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| CA2589418A1 (en) | 1999-08-24 | 2001-03-01 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| US6802826B1 (en) | 1999-10-11 | 2004-10-12 | Felton International, Inc. | Universal anti-infectious protector for needleless injectors |
| US7074210B2 (en) * | 1999-10-11 | 2006-07-11 | Felton International, Inc. | Universal protector cap with auto-disable features for needle-free injectors |
| US20020193740A1 (en) | 1999-10-14 | 2002-12-19 | Alchas Paul G. | Method of intradermally injecting substances |
| US6569123B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Prefillable intradermal injector |
| US6843781B2 (en) * | 1999-10-14 | 2005-01-18 | Becton, Dickinson And Company | Intradermal needle |
| US20020198509A1 (en) * | 1999-10-14 | 2002-12-26 | Mikszta John A. | Intradermal delivery of vaccines and gene therapeutic agents via microcannula |
| US6494865B1 (en) | 1999-10-14 | 2002-12-17 | Becton Dickinson And Company | Intradermal delivery device including a needle assembly |
| US6569143B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Method of intradermally injecting substances |
| US6776776B2 (en) * | 1999-10-14 | 2004-08-17 | Becton, Dickinson And Company | Prefillable intradermal delivery device |
| US7029457B2 (en) * | 1999-11-23 | 2006-04-18 | Felton International, Inc. | Jet injector with hand piece |
| US6770054B1 (en) | 1999-11-23 | 2004-08-03 | Felton International, Inc. | Injector assembly with driving means and locking means |
| US7887506B1 (en) | 1999-11-23 | 2011-02-15 | Pulse Needlefree Systems, Inc. | Safety mechanism to prevent accidental patient injection and methods of same |
| US6344027B1 (en) | 1999-12-08 | 2002-02-05 | Scimed Life Systems, Inc. | Needle-less injection apparatus and method |
| US6613026B1 (en) | 1999-12-08 | 2003-09-02 | Scimed Life Systems, Inc. | Lateral needle-less injection apparatus and method |
| DK1242132T3 (en) * | 1999-12-23 | 2004-02-23 | Arnold Neracher | Injection device and propulsion system therefore |
| WO2001051109A1 (en) * | 2000-01-07 | 2001-07-19 | Biovalve Technologies, Inc. | Injection device |
| US6210359B1 (en) | 2000-01-21 | 2001-04-03 | Jet Medica, L.L.C. | Needleless syringe |
| US7137968B1 (en) * | 2000-03-13 | 2006-11-21 | Nucryst Pharmaceuticals Corp. | Transcutaneous medical device dressings and method of use |
| US6719987B2 (en) | 2000-04-17 | 2004-04-13 | Nucryst Pharmaceuticals Corp. | Antimicrobial bioabsorbable materials |
| CA2415186A1 (en) * | 2000-07-10 | 2002-01-17 | Peter M. Wild | Woody plant injection method and apparatus |
| US20030180379A1 (en) * | 2000-07-27 | 2003-09-25 | Burrell Robert E. | Solutions and aerosols of metal-containing compounds |
| US20040191329A1 (en) * | 2000-07-27 | 2004-09-30 | Burrell Robert E. | Compositions and methods of metal-containing materials |
| US20030185901A1 (en) | 2000-07-27 | 2003-10-02 | Burrell Robert E. | Methods of treating conditions with a metal-containing material |
| US20030206966A1 (en) * | 2000-07-27 | 2003-11-06 | Burrell Robert E. | Methods of inducing apoptosis and modulating metalloproteinases |
| US7001617B2 (en) | 2001-04-23 | 2006-02-21 | Nueryst Pharmaceuticals Corp. | Method of induction of apoptosis and inhibition of matrix metalloproteinases using antimicrobial metals |
| US7427416B2 (en) * | 2000-07-27 | 2008-09-23 | Nucryst Pharmaceuticals Corp. | Methods of treating conditions using metal-containing materials |
| US7008647B2 (en) | 2001-04-23 | 2006-03-07 | Nucryst Pharmaceuticals Corp. | Treatment of acne |
| US7255881B2 (en) * | 2000-07-27 | 2007-08-14 | Nucryst Pharmaceuticals Corp. | Metal-containing materials |
| AU7832201A (en) | 2000-07-27 | 2002-02-13 | Nucryst Pharm Corp | Treatment of hyperproliferative skin disorders and diseases |
| US6989157B2 (en) * | 2000-07-27 | 2006-01-24 | Nucryst Pharmaceuticals Corp. | Dry powders of metal-containing compounds |
| GB0022742D0 (en) | 2000-09-15 | 2000-11-01 | Smithkline Beecham Biolog | Vaccine |
| KR100831139B1 (en) | 2000-10-18 | 2008-05-20 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | Vaccines |
| KR20030071780A (en) * | 2000-11-30 | 2003-09-06 | 바이오밸브 테크놀로지스, 인코포레이티드 | Injection systems |
| AU2002222371A1 (en) * | 2000-12-21 | 2002-07-01 | Arnold Neracher | Injection device with re-usable pressure generating means. |
| CA2433792C (en) | 2001-01-04 | 2012-03-27 | University Of Saskatchewan | Enterohemorragic escherichia coli vaccine |
| GB0100756D0 (en) | 2001-01-11 | 2001-02-21 | Powderject Res Ltd | Needleless syringe |
| EP2269639B1 (en) | 2001-02-23 | 2018-11-28 | GlaxoSmithKline Biologicals s.a. | Influenza vaccine formulations for intradermal delivery |
| US6471669B2 (en) | 2001-03-05 | 2002-10-29 | Bioject Medical Technologies Inc. | Disposable needle-free injection apparatus and method |
| US6645170B2 (en) | 2001-03-05 | 2003-11-11 | Bioject Medical Technologies, Inc. | Simplified disposable needle-free injection apparatus and method |
| CA2440983A1 (en) | 2001-03-14 | 2002-09-26 | Penjet Corporation | System and method for removing dissolved gas from a solution |
| GB0109297D0 (en) | 2001-04-12 | 2001-05-30 | Glaxosmithkline Biolog Sa | Vaccine |
| US7795218B2 (en) | 2001-04-12 | 2010-09-14 | Bioaxone Therapeutique Inc. | ADP-ribosyl transferase fusion variant proteins |
| US6613010B2 (en) | 2001-04-13 | 2003-09-02 | Penjet Corporation | Modular gas-pressured needle-less injector |
| US20050192530A1 (en) * | 2001-04-13 | 2005-09-01 | Penjet Corporation | Method and apparatus for needle-less injection with a degassed fluid |
| ATE322274T1 (en) | 2001-04-23 | 2006-04-15 | Nucryst Pharm Corp | MEDICINAL PRODUCTS OR PLASTERS CONTAINING A METAL SUCH AS SILVER GOLD, PLATINUM OR PALLADIUM AS AN ANTIMICROBIAL ACTIVE AND THEIR USE IN THE TREATMENT OF SKIN INFLAMMATION |
| WO2002087663A2 (en) | 2001-04-27 | 2002-11-07 | Penjet Corporation | Method and apparatus for filling or refilling a needle-less injector |
| TWI228420B (en) | 2001-05-30 | 2005-03-01 | Smithkline Beecham Pharma Gmbh | Novel vaccine composition |
| US20100221284A1 (en) | 2001-05-30 | 2010-09-02 | Saech-Sisches Serumwerk Dresden | Novel vaccine composition |
| US6752781B2 (en) * | 2001-06-08 | 2004-06-22 | Sergio Landau | Durable hypodermic jet injector apparatus and method |
| US20060018877A1 (en) * | 2001-06-29 | 2006-01-26 | Mikszta John A | Intradermal delivery of vacccines and therapeutic agents |
| US8061006B2 (en) * | 2001-07-26 | 2011-11-22 | Powderject Research Limited | Particle cassette, method and kit therefor |
| US6824526B2 (en) | 2001-10-22 | 2004-11-30 | Penjet Corporation | Engine and diffuser for use with a needle-less injector |
| US6607510B2 (en) | 2001-11-09 | 2003-08-19 | Bioject Medical Technologies Inc. | Disposable needle-free injection apparatus and method |
| IL162844A0 (en) * | 2002-01-18 | 2005-11-20 | Inovio As | Use of an expression vector for preparing pharmaceutical compositions |
| GB0206560D0 (en) | 2002-03-20 | 2002-05-01 | Glaxo Group Ltd | Novel device |
| JP4594623B2 (en) | 2002-04-12 | 2010-12-08 | シェーリング コーポレイション | G protein-coupled receptor ligand and method |
| US20040025420A1 (en) * | 2002-05-09 | 2004-02-12 | Peter M. Wild | Injection needle for injecting woody plants |
| JP4563171B2 (en) | 2002-05-24 | 2010-10-13 | シェーリング コーポレイション | Neutralizing human anti-IGFR antibody |
| US6942638B1 (en) * | 2002-05-30 | 2005-09-13 | Kerry Quinn | Needleless injector and ampule system |
| US7156823B2 (en) * | 2002-06-04 | 2007-01-02 | Bioject Inc. | High workload needle-free injection system |
| US7238167B2 (en) * | 2002-06-04 | 2007-07-03 | Bioject Inc. | Needle-free injection system |
| US6676630B2 (en) | 2002-06-04 | 2004-01-13 | Bioject Medical Technologies, Inc. | Needle-free injection system |
| US20030229308A1 (en) * | 2002-06-05 | 2003-12-11 | Israil Tsals | Injector adapter and combination thereof |
| DE10226537A1 (en) * | 2002-06-14 | 2004-01-08 | Peter Eichhorst | pre-injection device |
| AU2003247707A1 (en) * | 2002-07-03 | 2004-01-23 | Peter M. Wild | Plant injection method and apparatus |
| US20040132058A1 (en) | 2002-07-19 | 2004-07-08 | Schering Corporation | NPC1L1 (NPC3) and methods of use thereof |
| US6883222B2 (en) * | 2002-10-16 | 2005-04-26 | Bioject Inc. | Drug cartridge assembly and method of manufacture |
| CA3029035C (en) | 2002-10-17 | 2023-03-07 | Genmab A/S | Human monoclonal antibodies against cd20 |
| AU2003286575A1 (en) * | 2002-10-22 | 2004-05-13 | Nucryst Pharmaceuticals Corp. | Prophylactic treatment methods |
| US7018356B2 (en) | 2002-10-31 | 2006-03-28 | Wise Roger R | Method and apparatus for adjusting the contents of a needle-less injector |
| PT1587907E (en) | 2003-01-07 | 2011-04-08 | Dyax Corp | Kunitz domain library |
| US6935384B2 (en) * | 2003-02-19 | 2005-08-30 | Bioject Inc. | Needle-free injection system |
| US20060184101A1 (en) * | 2003-04-21 | 2006-08-17 | Ravi Srinivasan | Microjet devices and methods for drug delivery |
| CA2559330A1 (en) * | 2003-04-21 | 2004-11-04 | Stratagent Life Sciences | Apparatus and methods for repetitive microjet drug delivery |
| CA2523142A1 (en) | 2003-04-23 | 2004-11-04 | Medarex, Inc. | Humanized antibodies to interferon alpha receptor-1 (ifnar-1) |
| AU2004272972A1 (en) | 2003-05-22 | 2005-03-24 | Fraunhofer Usa, Inc. | Recombinant carrier molecule for expression, delivery and purification of target polypeptides |
| BRPI0411649A (en) * | 2003-06-20 | 2006-08-08 | Allergan Inc | needleless injectors |
| DK1648931T3 (en) | 2003-07-21 | 2011-03-07 | Transgene Sa | Multifunctional cytokines |
| HU225252B1 (en) * | 2003-08-21 | 2006-08-28 | S Istvan Lindmayer | Needleless injection apparatus |
| WO2005034949A1 (en) * | 2003-09-09 | 2005-04-21 | University Of Florida | Desferrithiocin derivatives and their use as iron chelators |
| US7131961B2 (en) * | 2003-10-01 | 2006-11-07 | Bioject, Inc. | Needle-free injection system |
| GB0325836D0 (en) * | 2003-11-05 | 2003-12-10 | Celltech R&D Ltd | Biological products |
| HUE026260T2 (en) | 2003-11-21 | 2016-06-28 | Ucb Biopharma Sprl | Method for the treatment of multiple sclerosis by inhibiting IL-17 activity |
| US7776007B2 (en) * | 2003-12-05 | 2010-08-17 | Zogenix, Inc. | Device for readying a needle free injector for delivery |
| JP4942487B2 (en) | 2003-12-10 | 2012-05-30 | メダレックス インコーポレーティッド | IP-10 antibody and use thereof |
| EP2418220B1 (en) | 2003-12-10 | 2017-08-02 | E. R. Squibb & Sons, L.L.C. | Interferon alpha antibodies and their uses |
| US8147426B2 (en) * | 2003-12-31 | 2012-04-03 | Nipro Diagnostics, Inc. | Integrated diagnostic test system |
| EP1713900A4 (en) * | 2004-01-27 | 2009-06-17 | Compugen Ltd | Methods and systems for annotating biomolecular sequences |
| US20050209553A1 (en) * | 2004-03-19 | 2005-09-22 | Sergio Landau | Needle-free single-use cartridge and injection system |
| US20050209554A1 (en) * | 2004-03-19 | 2005-09-22 | Sergio Landau | Needle-free single-use cartridge and injection system |
| DE102004024617A1 (en) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentially expressed in tumors gene products and their use |
| EP1753458A4 (en) * | 2004-05-19 | 2009-07-22 | Wyeth Corp | Modulation of immunoglobulin production and atopic disorders |
| US7717874B2 (en) * | 2004-05-28 | 2010-05-18 | Bioject, Inc. | Needle-free injection system |
| WO2006002177A2 (en) | 2004-06-21 | 2006-01-05 | Medarex, Inc. | Interferon alpha receptor 1 antibodies and their uses |
| US7329737B2 (en) | 2004-08-03 | 2008-02-12 | Dyax Corp. | Antibodies that bind hK-1 |
| GB0417852D0 (en) | 2004-08-11 | 2004-09-15 | Biotica Tech Ltd | Production of polyketides and other natural products |
| CA2478458A1 (en) * | 2004-08-20 | 2006-02-20 | Michael Panzara | Treatment of pediatric multiple sclerosis |
| ES2540770T3 (en) | 2004-09-22 | 2015-07-13 | Glaxosmithkline Biologicals Sa | Immunogenic composition for use in staphylococcal vaccination |
| US20060089593A1 (en) * | 2004-10-26 | 2006-04-27 | Sergio Landau | Needle-free injection device for individual users |
| US20060089594A1 (en) * | 2004-10-26 | 2006-04-27 | Sergio Landau | Needle-free injection device |
| US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| EP1817590A2 (en) | 2004-11-08 | 2007-08-15 | Schering Corporation | Tumor association of mdl-1 and methods |
| CA2629751A1 (en) | 2004-11-12 | 2006-05-18 | The University Of British Columbia | Antimicrobial peptides |
| US20090202527A1 (en) | 2004-11-19 | 2009-08-13 | Biogen Idec Ma Inc. | Treatment for multiple sclerosis |
| JP4960252B2 (en) | 2004-11-22 | 2012-06-27 | インテリジェクト，インコーポレイテッド | Device, system and method for drug delivery |
| US7648482B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
| US11590286B2 (en) | 2004-11-22 | 2023-02-28 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
| US7947017B2 (en) * | 2004-11-22 | 2011-05-24 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| US10737028B2 (en) | 2004-11-22 | 2020-08-11 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
| US7648483B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| EP2532378B1 (en) * | 2004-12-01 | 2016-04-27 | AcuShot, Inc. | Needle-free injector |
| DE602005025685D1 (en) | 2004-12-03 | 2011-02-10 | Schering Corp | BIOLOGICAL MARKERS FOR THE PRESELECTION OF PATIENTS FOR ANTI-IGF1R THERAPY |
| CA2589379A1 (en) * | 2004-12-03 | 2006-06-08 | Biogen Idec Ma Inc. | Delaying or preventing onset of multiple sclerosis |
| US20060183893A1 (en) * | 2005-01-25 | 2006-08-17 | North Don A | Nucleic acids for apoptosis of cancer cells |
| KR20070095452A (en) * | 2005-01-25 | 2007-09-28 | 스카이 제네틱스, 인코포레이티드 | Nucleic acids for apoptosis of cancer cells |
| US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
| US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
| US8361026B2 (en) | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
| ES2396745T3 (en) | 2005-02-01 | 2013-02-25 | Intelliject, Inc. | Devices for medication administration |
| US7731686B2 (en) * | 2005-02-01 | 2010-06-08 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| EP2332408B1 (en) | 2005-02-17 | 2013-11-13 | Biogen Idec MA Inc. | Treating neurological disorders |
| SG170006A1 (en) | 2005-02-18 | 2011-04-29 | Medarex Inc | Monoclonal antibodies against cd30 lacking fucosyl residues |
| GB0504994D0 (en) | 2005-03-11 | 2005-04-20 | Biotica Tech Ltd | Novel compounds |
| US20100061994A1 (en) * | 2005-03-11 | 2010-03-11 | Rose Mary Sheridan | Medical uses of 39-desmethoxyrapamycin and analogues thereof |
| US7829673B2 (en) | 2005-03-23 | 2010-11-09 | Genmab A/S | Antibodies against CD38 for treatment of multiple myeloma |
| AU2006226543B2 (en) | 2005-03-23 | 2011-10-06 | Glaxosmithkline Biologicals S.A. | Use of an influenza virus an oil-in-water emulsion adjuvant to induce CD4 T-cell and/or improved B-memory cell response |
| CN102989012B (en) | 2005-03-31 | 2015-05-13 | 通用医疗公司 | Monitoring and modulating hgf/hgfr activity |
| ES2614086T3 (en) | 2005-04-04 | 2017-05-29 | University Of Florida Research Foundation, Inc. | Desferritiocin polyether analogs |
| US20070027428A1 (en) * | 2005-05-03 | 2007-02-01 | Pharmajet, Inc. | Vial system and method for needle-less injector |
| US7699802B2 (en) | 2005-05-03 | 2010-04-20 | Pharmajet, Inc. | Needle-less injector |
| US7618393B2 (en) | 2005-05-03 | 2009-11-17 | Pharmajet, Inc. | Needle-less injector and method of fluid delivery |
| EP1896582A4 (en) | 2005-05-09 | 2009-04-08 | Ono Pharmaceutical Co | Human monoclonal antibodies to programmed death 1(pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| HUE030701T2 (en) | 2005-05-27 | 2017-05-29 | Biogen Ma Inc | Tweak binding antibodies |
| US20070118093A1 (en) * | 2005-06-20 | 2007-05-24 | Von Muhlen Marcio G | High-speed jet devices for drug delivery |
| GB0513248D0 (en) * | 2005-06-29 | 2005-08-03 | Boc Group Plc | Gas dispenser |
| CN101248089A (en) | 2005-07-01 | 2008-08-20 | 米德列斯公司 | Human monoclonal antibodies to programmed death ligand 1(PD-L1) |
| EP1919504B1 (en) * | 2005-08-03 | 2013-10-16 | iBio, Inc. | Antibody to bacillus anthracis protective antigen |
| US20070055199A1 (en) * | 2005-08-10 | 2007-03-08 | Gilbert Scott J | Drug delivery device for buccal and aural applications and other areas of the body difficult to access |
| EP1762575A1 (en) | 2005-09-12 | 2007-03-14 | Ganymed Pharmaceuticals AG | Identification of tumor-associated antigens for diagnosis and therapy |
| AU2006294663B2 (en) | 2005-09-26 | 2012-03-22 | Medarex, Inc. | Human monoclonal antibodies to CD70 |
| AR058104A1 (en) | 2005-10-21 | 2008-01-23 | Novartis Ag | ORGANIC COMPOUNDS |
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| CN101356195B (en) | 2005-12-08 | 2013-04-03 | 米德列斯公司 | Human monoclonal antibodies to fucosyl-GM1 and methods for using anti-fucosyl-GM1 |
| TWI457133B (en) * | 2005-12-13 | 2014-10-21 | Glaxosmithkline Biolog Sa | Novel composition |
| WO2007070682A2 (en) | 2005-12-15 | 2007-06-21 | Massachusetts Institute Of Technology | System for screening particles |
| CN101378778B (en) | 2005-12-22 | 2013-02-06 | 葛兰素史密丝克莱恩生物有限公司 | Vaccine comprising streptococcus pneumoniae capsular polyaccharide conjugates |
| GB0607088D0 (en) | 2006-04-07 | 2006-05-17 | Glaxosmithkline Biolog Sa | Vaccine |
| US20070166774A1 (en) * | 2006-01-17 | 2007-07-19 | Groman Ernest V | Functional immunoassay |
| US20080161755A1 (en) * | 2006-01-27 | 2008-07-03 | Bioject Inc. | Needle-free injection device and priming system |
| JP5364382B2 (en) | 2006-02-07 | 2013-12-11 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | Stabilized composition of a protein having a free thiol moiety |
| CA2642056A1 (en) * | 2006-02-13 | 2007-08-23 | Fraunhofer Usa, Inc. | Hpv antigens, vaccine compositions, and related methods |
| EP1984405A4 (en) * | 2006-02-13 | 2010-06-30 | Fraunhofer Usa Inc | Influenza antigens, vaccine compositions, and related methods |
| WO2008048344A2 (en) * | 2006-02-13 | 2008-04-24 | Fraunhofer Usa, Inc. | Bacillus anthracis antigens, vaccine compositions, and related methods |
| WO2007106415A2 (en) * | 2006-03-10 | 2007-09-20 | Massachusetts Institute Of Technology | Triggered self-assembly conjugates and nanosystems |
| WO2007111806A2 (en) | 2006-03-23 | 2007-10-04 | Massachusetts Eye And Ear Infirmary | Cyclopentane heptanoic acid compounds for reducing body fat |
| US20080045471A1 (en) * | 2006-03-27 | 2008-02-21 | North Don A | Nucleic Acids For Apoptosis Of Cancer Cells |
| EA015833B1 (en) | 2006-03-30 | 2011-12-30 | Глаксосмитклайн Байолоджикалс С.А. | Immunogenic composition |
| CA2648099C (en) | 2006-03-31 | 2012-05-29 | The Brigham And Women's Hospital, Inc | System for targeted delivery of therapeutic agents |
| WO2007120638A2 (en) * | 2006-04-12 | 2007-10-25 | President And Fellows Of Harvard College | Methods and compositions for modulating glycosylation |
| WO2007124082A2 (en) * | 2006-04-21 | 2007-11-01 | Amgen, Inc. | Buffering agents for biopharmaceutical formulations |
| WO2007133807A2 (en) | 2006-05-15 | 2007-11-22 | Massachusetts Institute Of Technology | Polymers for functional particles |
| EP2034830B1 (en) | 2006-05-25 | 2014-09-03 | Biogen Idec MA Inc. | Anti-vla-1 antibody for treating stroke |
| EP2492684B1 (en) | 2006-06-02 | 2016-12-28 | President and Fellows of Harvard College | Protein surface remodeling |
| WO2007150030A2 (en) | 2006-06-23 | 2007-12-27 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| ES2427924T3 (en) | 2006-06-30 | 2013-11-04 | Merck Sharp & Dohme Corp. | IGFBP2 biomarker |
| CA2656620C (en) | 2006-07-04 | 2018-03-13 | Genmab A/S | Cd20 binding molecules for the treatment of copd |
| DK2043682T3 (en) | 2006-07-17 | 2014-06-02 | Glaxosmithkline Biolog Sa | INFLUENZA VACCINE |
| JP5244785B2 (en) | 2006-08-11 | 2013-07-24 | 小野薬品工業株式会社 | Monoclonal antibody against stroma-derived factor-1 (SDF-1) |
| US9115358B2 (en) * | 2006-08-11 | 2015-08-25 | President And Fellows Of Harvard College | Moenomycin biosynthesis-related compositions and methods of use thereof |
| US20090269342A1 (en) * | 2006-08-14 | 2009-10-29 | Massachusetts Institute Of Technology | Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto |
| US20100061990A1 (en) * | 2006-08-14 | 2010-03-11 | Massachusetts Institute Of Technology | Hemagglutinin Polypeptides, and Reagents and Methods Relating Thereto |
| KR20090088852A (en) | 2006-09-05 | 2009-08-20 | 메다렉스, 인코포레이티드 | Antibodies to bone morphogenic proteins and receptors therefor and methods for their use |
| US7942845B2 (en) * | 2006-09-19 | 2011-05-17 | Bioject, Inc. | Needle-free injector and process for providing serial injections |
| PL2066351T3 (en) | 2006-10-02 | 2016-02-29 | Squibb & Sons Llc | Human antibodies that bind cxcr4 and uses thereof |
| US7547293B2 (en) | 2006-10-06 | 2009-06-16 | Bioject, Inc. | Triggering mechanism for needle-free injector |
| WO2008045373A2 (en) * | 2006-10-06 | 2008-04-17 | Amgen Inc. | Stable antibody formulations |
| JO3598B1 (en) | 2006-10-10 | 2020-07-05 | Infinity Discovery Inc | Boronic acids and esters as inhibitors of fatty acid amide hydrolase |
| BRPI0717219B8 (en) | 2006-10-12 | 2021-05-25 | Glaxosmithkline Biologicals Sa | immunogenic composition, and, use of an immunogenic composition |
| SI2086582T1 (en) | 2006-10-12 | 2013-02-28 | Glaxosmithkline Biologicals S.A. | Vaccine comprising an oil in water emulsion adjuvant |
| CA2666682C (en) | 2006-10-19 | 2014-07-08 | Merck & Co., Inc. | Anti-il-13r.alpha.1 antibodies and their uses thereof |
| ES2925992T3 (en) * | 2006-10-20 | 2022-10-20 | Amgen Inc | Stable formulations of polypeptides |
| BRPI0718283A2 (en) | 2006-10-20 | 2013-11-12 | Biogen Idec Inc | TREATMENT OF DEMELINIZING DISORDERS |
| US8618248B2 (en) | 2006-10-31 | 2013-12-31 | President And Fellows Of Harvard College | Phosphopeptide compositions and anti-phosphopeptide antibody compositions and methods of detecting phosphorylated peptides |
| CL2007003291A1 (en) | 2006-11-15 | 2008-07-04 | Medarex Inc | ISOLATED HUMAN MONOCLONAL ANTIBODY THAT LINKS THE BTLA PROTEIN OR FRAGMENTS OF THE SAME; NUCLEIC ACID THAT CODIFIES IT; METHOD OF PRODUCTION; COMPOSITION AND IMMUNOCUJUGADO THAT UNDERSTANDS THEM; AND METHOD TO INHIBIT THE GROWTH OF TUMOR CELLS AND |
| BRPI0719756A2 (en) | 2006-12-01 | 2014-01-21 | Anterios Inc | Amphiphilic Nanoparticles |
| NZ578064A (en) | 2006-12-01 | 2012-01-12 | Medarex Inc | Human antibodies that bind cd22 and uses thereof |
| US20080213377A1 (en) * | 2006-12-08 | 2008-09-04 | Bhatia Sangeeta N | Delivery of Nanoparticles and/or Agents to Cells |
| CL2007003622A1 (en) | 2006-12-13 | 2009-08-07 | Medarex Inc | Human anti-cd19 monoclonal antibody; composition comprising it; and tumor cell growth inhibition method. |
| KR20090088946A (en) | 2006-12-14 | 2009-08-20 | 메다렉스, 인코포레이티드 | Human antibodies that bind cd70 and uses thereof |
| WO2008079290A2 (en) * | 2006-12-21 | 2008-07-03 | Amgen Inc | Stable buffered formulations containing polypeptides |
| DK2474525T3 (en) | 2006-12-26 | 2020-07-13 | Lantheus Medical Imaging Inc | Ligands for imaging cardiac innervation |
| US20080171968A1 (en) * | 2007-01-15 | 2008-07-17 | Bioject, Inc. | Methods of administering injectables to a joint with a needle-free injection system |
| WO2008091838A2 (en) | 2007-01-22 | 2008-07-31 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
| ES2558928T3 (en) | 2007-01-31 | 2016-02-09 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| WO2008098165A2 (en) | 2007-02-09 | 2008-08-14 | Massachusetts Institute Of Technology | Oscillating cell culture bioreactor |
| KR101598229B1 (en) | 2007-02-16 | 2016-02-26 | 메리맥 파마슈티컬즈, 인크. | 3 antibodies against erbb3 and uses thereof |
| WO2008103997A2 (en) * | 2007-02-23 | 2008-08-28 | Bioject Inc. | Needle-free injection devices and drug delivery systems therefor |
| EP1970384A1 (en) | 2007-03-14 | 2008-09-17 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
| JP5439193B2 (en) | 2007-03-15 | 2014-03-12 | ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． | Desferrithiocin polyether analogue |
| US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
| WO2008118970A2 (en) | 2007-03-27 | 2008-10-02 | Sea Lane Biotechnologies, Llc | Constructs and libraries comprising antibody surrogate light chain sequences |
| KR101623985B1 (en) | 2007-03-28 | 2016-05-25 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Stitched polypeptides |
| WO2008124634A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Polymer-encapsulated reverse micelles |
| WO2008124632A1 (en) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Amphiphilic compound assisted nanoparticles for targeted delivery |
| US8778348B2 (en) * | 2007-04-28 | 2014-07-15 | Ibio Inc. | Trypanosoma antigens, vaccine compositions, and related methods |
| EP2152304B1 (en) | 2007-05-02 | 2018-08-22 | The Regents of the University of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
| GB0708758D0 (en) | 2007-05-04 | 2007-06-13 | Powderject Res Ltd | Particle cassettes and process thereof |
| EP1997832A1 (en) | 2007-05-29 | 2008-12-03 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against Claudin-18 for treatment of cancer |
| JP2010529127A (en) | 2007-06-05 | 2010-08-26 | イエール ユニバーシティ | Inhibitor of receptor tyrosine kinase and method of using the same |
| AU2008266051B2 (en) * | 2007-06-14 | 2014-07-31 | Biogen Ma Inc. | Antibody formulations |
| JP2010529166A (en) * | 2007-06-14 | 2010-08-26 | クルセル スウィツァーランド アーゲー | Intradermal influenza vaccine |
| US8524444B2 (en) | 2007-06-15 | 2013-09-03 | President And Fellows Of Harvard College | Methods and compositions for detections and modulating O-glycosylation |
| JP2010531330A (en) | 2007-06-26 | 2010-09-24 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | Vaccine containing Streptococcus pneumoniae capsular polysaccharide conjugate |
| EP2178558B1 (en) | 2007-07-11 | 2014-04-30 | iBio, Inc. | Yersinia pestis antigens, vaccine compositions, and related methods |
| JP5588866B2 (en) | 2007-08-10 | 2014-09-10 | メダレックス エル．エル．シー． | HCO 32 and HCO 27 and related examples |
| US20110059130A1 (en) * | 2007-08-20 | 2011-03-10 | Fraunhofer Usa, Inc. | Prophylactic and therapeutic influenza vaccines, antigens, compositions and methods |
| PL2769729T3 (en) | 2007-09-04 | 2019-09-30 | Compugen Ltd. | Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
| GB0717337D0 (en) | 2007-09-06 | 2007-10-17 | Ucb Pharma Sa | Method of treatment |
| EP2205074A4 (en) * | 2007-10-04 | 2013-07-31 | Harvard College | Moenomycin analogs, methods of synthesis, and uses thereof |
| AR068767A1 (en) | 2007-10-12 | 2009-12-02 | Novartis Ag | ANTIBODIES AGAINST SCLEROSTIN, COMPOSITIONS AND METHODS OF USE OF THESE ANTIBODIES TO TREAT A PATHOLOGICAL DISORDER MEDIATIONED BY SCLEROSTIN |
| EP3424525A1 (en) | 2007-10-12 | 2019-01-09 | Massachusetts Institute Of Technology | Vaccine nanotechnology |
| AU2008320823B2 (en) | 2007-11-02 | 2013-01-17 | Novartis Ag | Molecules and methods for modulating low-density-lipoprotein receptor-related protein 6 (LRP6) |
| US8236318B2 (en) | 2007-11-07 | 2012-08-07 | Celldex Therapeutics Inc. | Antibodies that bind human dendritic and epithelial cell 205 (DEC-205) |
| US20090137949A1 (en) * | 2007-11-26 | 2009-05-28 | Bioject Inc. | Needle-free injection device with nozzle auto-disable |
| US8617099B2 (en) * | 2007-11-26 | 2013-12-31 | Bioject Inc. | Injection device plunger auto-disable |
| JP5737944B2 (en) | 2007-12-17 | 2015-06-17 | ファイザー・リミテッドＰｆｉｚｅｒ Ｌｉｍｉｔｅｄ | Treatment of interstitial cystitis |
| WO2009086250A1 (en) | 2007-12-21 | 2009-07-09 | Aesthetic Sciences Corporation | Self-contained pressurized injection device |
| CN101951927A (en) * | 2008-01-03 | 2011-01-19 | 麻省理工学院 | Decoy influenza therapies |
| US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
| US20090187135A1 (en) * | 2008-01-18 | 2009-07-23 | Eilaz Babaev | Ultrasonic syringe |
| ES2559195T3 (en) | 2008-01-22 | 2016-02-10 | Fundação De Amparo À Pesquisa Do Estado De São Paulo - Fapesp | Peptides, compositions, and their uses |
| US20110052501A1 (en) * | 2008-01-31 | 2011-03-03 | Liat Dassa | Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics |
| WO2009100110A1 (en) | 2008-02-05 | 2009-08-13 | Medarex, Inc. | Alpha 5 - beta 1 antibodies and their uses |
| PT2250279E (en) | 2008-02-08 | 2016-06-03 | Medimmune Llc | Anti-ifnar1 antibodies with reduced fc ligand affinity |
| TW201000107A (en) * | 2008-04-09 | 2010-01-01 | Infinity Pharmaceuticals Inc | Inhibitors of fatty acid amide hydrolase |
| MX2010011412A (en) | 2008-04-16 | 2010-11-12 | Glaxosmithkline Biolog Sa | Vaccine. |
| JP2011523353A (en) * | 2008-04-28 | 2011-08-11 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | Overcharged protein for cell penetration |
| PT2274331E (en) | 2008-05-02 | 2014-02-27 | Novartis Ag | Improved fibronectin-based binding molecules and uses thereof |
| USD994111S1 (en) | 2008-05-12 | 2023-08-01 | Kaleo, Inc. | Medicament delivery device cover |
| US8021344B2 (en) | 2008-07-28 | 2011-09-20 | Intelliject, Inc. | Medicament delivery device configured to produce an audible output |
| AU2009260527A1 (en) | 2008-05-30 | 2009-12-23 | Dana-Farber Cancer Institute Inc. | Methods of treating a meiotic kinesin-associated disease |
| WO2009150623A1 (en) | 2008-06-13 | 2009-12-17 | Pfizer Inc | Treatment of chronic prostatitis |
| JP6146949B2 (en) | 2008-06-20 | 2017-06-21 | ノバルティス アーゲー | Immunoglobulin with reduced aggregation |
| US20110212157A1 (en) | 2008-06-26 | 2011-09-01 | Anterios, Inc. | Dermal delivery |
| US8680020B2 (en) | 2008-07-15 | 2014-03-25 | Academia Sinica | Glycan arrays on PTFE-like aluminum coated glass slides and related methods |
| EP2356139A4 (en) | 2008-07-23 | 2013-01-09 | Harvard College | Ligation of stapled polypeptides |
| CA2734991A1 (en) * | 2008-07-23 | 2010-01-28 | Massachusetts Institute Of Technology | Activation of histone deacetylase 1 (hdac1) protects against dna damage and increases neuronal survival |
| EP3629022A1 (en) | 2008-07-25 | 2020-04-01 | Richard W. Wagner | Protein screening methods |
| AR072999A1 (en) | 2008-08-11 | 2010-10-06 | Medarex Inc | HUMAN ANTIBODIES THAT JOIN GEN 3 OF LYMPHOCYTARY ACTIVATION (LAG-3) AND THE USES OF THESE |
| EP2166021A1 (en) * | 2008-09-16 | 2010-03-24 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
| CN102196834B (en) * | 2008-09-18 | 2013-10-30 | 贝克顿·迪金森公司 | Medical injector with slidable sleeve activation |
| EP3530672A1 (en) | 2008-09-26 | 2019-08-28 | Dana Farber Cancer Institute, Inc. | Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses thereof |
| EP2349209A2 (en) | 2008-09-26 | 2011-08-03 | Nanobio Corporation | Nanoemulsion therapeutic compositions and methods of using the same |
| US8734803B2 (en) | 2008-09-28 | 2014-05-27 | Ibio Inc. | Humanized neuraminidase antibody and methods of use thereof |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8277812B2 (en) | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US8343498B2 (en) | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| AR073997A1 (en) | 2008-10-29 | 2010-12-15 | Wyeth Corp | FORMULATIONS OF MOLECULES OF UNION TO ANTIGENO OF UNIQUE DOMAIN. METHOD. KIT |
| CA2743904A1 (en) | 2008-11-17 | 2010-05-20 | The Regents Of The University Of Michigan | Cancer vaccine compositions and methods of using the same |
| EP2193817A1 (en) * | 2008-12-02 | 2010-06-09 | Sanofi-Aventis Deutschland GmbH | Drive assembly suitable for use in a medication delivery device and medication delivery device |
| AU2009322967B2 (en) * | 2008-12-05 | 2015-06-11 | Ams Research Corporation | Devices, systems and methods for delivering fluid to tissue |
| EP2373690B1 (en) | 2008-12-08 | 2015-02-11 | Compugen Ltd. | Antibodies specific for tmem154 |
| WO2010077806A1 (en) | 2008-12-15 | 2010-07-08 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways |
| EP2380023A2 (en) | 2008-12-19 | 2011-10-26 | Medirista Biotechnologies AB | Oxidized cardiolipin as a novel pro-inflammatory factor |
| CN105132387A (en) * | 2008-12-22 | 2015-12-09 | 绿光生物科学公司 | Compositions and methods for the production of a compound |
| BRPI1009232B1 (en) | 2009-03-05 | 2022-05-03 | E.R. Squibb & Sons, Llc. | Isolated monoclonal antibody or an antigen-binding portion thereof, or an antibody fragment, composition comprising them, nucleic acid molecule, hybridoma and methods for preparing an anti-cadm1 antibody |
| GB0904540D0 (en) | 2009-03-17 | 2009-04-29 | Biotica Tech Ltd | Novel compounds and methods for their production |
| WO2010118159A1 (en) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| WO2010118155A1 (en) | 2009-04-07 | 2010-10-14 | Infinity Pharmaceuticals, Inc. | Inhibitors of fatty acid amide hydrolase |
| WO2010121141A1 (en) * | 2009-04-17 | 2010-10-21 | Biogen Idec Ma Inc. | Compositions and methods to treat acute myelogenous leukemia |
| SG10201401604VA (en) | 2009-04-20 | 2014-08-28 | Oxford Biotherapeutics Ltd | Antibodies Specific To Cadherin-17 |
| AR076402A1 (en) | 2009-04-27 | 2011-06-08 | Novartis Ag | COMPOSITIONS AND METHODS TO INCREASE MUSCLE GROWTH |
| EA201101572A1 (en) | 2009-04-27 | 2012-05-30 | Новартис Аг | COMPOSITIONS AND METHODS OF APPLICATION OF THERAPEUTIC ANTIBODIES SPECIFIC TO THE SUB-UNIT OF BETA1 IL-12 RECEPTOR |
| WO2010129023A2 (en) | 2009-04-28 | 2010-11-11 | President And Fellows Of Harvard College | Supercharged proteins for cell penetration |
| TWI486171B (en) | 2009-05-04 | 2015-06-01 | 亞培研究公司 | Antibodies against nerve growth factor (ngf) with enhanced in vivo stability |
| AU2010249046A1 (en) | 2009-05-13 | 2011-12-01 | Sea Lane Biotechnologies, Llc | Neutralizing molecules to influenza viruses |
| US9149465B2 (en) * | 2009-05-18 | 2015-10-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| US8927551B2 (en) * | 2009-05-18 | 2015-01-06 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| US8765735B2 (en) * | 2009-05-18 | 2014-07-01 | Infinity Pharmaceuticals, Inc. | Isoxazolines as inhibitors of fatty acid amide hydrolase |
| JP2012528858A (en) | 2009-06-01 | 2012-11-15 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | O-GlcNAc transferase inhibitor and use thereof |
| CA2769999C (en) | 2009-06-01 | 2020-02-18 | Shriners Hospitals For Children | A cloned transmembrane receptor for 24-hydroxylated vitamin d compounds and uses thereof |
| US8974423B2 (en) * | 2009-06-01 | 2015-03-10 | Sanofi-Aventis Deutschland Gmbh | Resettable drug delivery device |
| US8834885B2 (en) | 2009-06-04 | 2014-09-16 | Novartis Ag | Methods for identification of sites for IgG conjugation |
| US20100316673A1 (en) | 2009-06-16 | 2010-12-16 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
| WO2010146511A1 (en) | 2009-06-17 | 2010-12-23 | Pfizer Limited | Treatment of overactive bladder |
| US9163330B2 (en) | 2009-07-13 | 2015-10-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| SG177689A1 (en) | 2009-07-31 | 2012-02-28 | Organon Nv | Fully human antibodies to btla |
| US8394922B2 (en) | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
| GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB0914589D0 (en) | 2009-08-20 | 2009-09-30 | Biotica Tech Ltd | Novel compounds and methods for their production |
| WO2011029823A1 (en) | 2009-09-09 | 2011-03-17 | Novartis Ag | Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells |
| CA2774973A1 (en) | 2009-09-22 | 2011-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| GB0916630D0 (en) | 2009-09-22 | 2009-11-04 | Secr Defence | Antibody |
| WO2011041391A1 (en) | 2009-09-29 | 2011-04-07 | Fraunhofer Usa, Inc. | Influenza hemagglutinin antibodies, compositions, and related methods |
| GB0917817D0 (en) | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
| GB0917816D0 (en) | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
| WO2011047083A1 (en) | 2009-10-13 | 2011-04-21 | Oxford Biotherapeutics Ltd. | Antibodies against epha10 |
| WO2011047180A1 (en) | 2009-10-14 | 2011-04-21 | Merrimack Pharmaceuticals, Inc. | Bispecific binding agents targeting igf-1r and erbb3 signalling and uses thereof |
| WO2011051327A2 (en) | 2009-10-30 | 2011-05-05 | Novartis Ag | Small antibody-like single chain proteins |
| WO2011051466A1 (en) | 2009-11-02 | 2011-05-05 | Novartis Ag | Anti-idiotypic fibronectin-based binding molecules and uses thereof |
| CN102640001A (en) | 2009-11-05 | 2012-08-15 | 诺瓦提斯公司 | Biomarkers predictive of progression of fibrosis |
| US9428586B2 (en) | 2009-12-01 | 2016-08-30 | Compugen Ltd | Heparanase splice variant |
| US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
| CN102686729B (en) | 2009-12-18 | 2015-09-23 | 箭头研究公司 | Be used for the treatment of the organic composite of HSF1 relative disease |
| AU2010334974A1 (en) | 2009-12-22 | 2012-07-12 | Novartis Ag | Tetravalent CD47-antibody constant region fusion protein for use in therapy |
| CA2784807C (en) | 2009-12-29 | 2021-12-14 | Dana-Farber Cancer Institute, Inc. | Type ii raf kinase inhibitors |
| AU2011210840B2 (en) | 2010-01-27 | 2014-12-11 | Massachusetts Institute Of Technology | Engineered polypeptide agents for targeted broad spectrum influenza neutralization |
| WO2011092233A1 (en) | 2010-01-29 | 2011-08-04 | Novartis Ag | Yeast mating to produce high-affinity combinations of fibronectin-based binders |
| RU2015143910A (en) * | 2010-02-03 | 2018-12-28 | Инфинити Фармасьютикалз, Инк. | FATTY ACID AMID HYDROLASE INHIBITORS |
| MX2012009318A (en) | 2010-02-10 | 2012-09-07 | Novartis Ag | Methods and compounds for muscle growth. |
| WO2011112635A1 (en) | 2010-03-08 | 2011-09-15 | Sloan-Kettering Institute For Cancer Research | Cdc7 kinase inhibitors and uses thereof |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| GB201003920D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Method of treatment |
| US20110256135A1 (en) | 2010-03-17 | 2011-10-20 | Wolfgang Fraunhofer | Anti-nerve growth factor (ngf) antibody compositions |
| US9102697B2 (en) | 2010-03-22 | 2015-08-11 | President And Fellows Of Harvard College | Trioxacarcins and uses thereof |
| EP2371864A1 (en) | 2010-03-23 | 2011-10-05 | Ganymed Pharmaceuticals AG | Monoclonal antibodies for treatment of cancer |
| US10745467B2 (en) | 2010-03-26 | 2020-08-18 | The Trustees Of Dartmouth College | VISTA-Ig for treatment of autoimmune, allergic and inflammatory disorders |
| US20150231215A1 (en) | 2012-06-22 | 2015-08-20 | Randolph J. Noelle | VISTA Antagonist and Methods of Use |
| WO2011120013A2 (en) | 2010-03-26 | 2011-09-29 | Trustees Of Dartmouth College | Vista regulatory t cell mediator protein, vista binding agents and use thereof |
| WO2011130332A1 (en) | 2010-04-12 | 2011-10-20 | Academia Sinica | Glycan arrays for high throughput screening of viruses |
| NZ602892A (en) | 2010-04-13 | 2014-08-29 | Celldex Therapeutics Inc | Antibodies that bind human cd27 and uses thereof |
| SG10201502967RA (en) | 2010-04-16 | 2015-05-28 | Biogen Ma Inc | Anti-vla-4 antibodies |
| EA034363B1 (en) | 2010-04-23 | 2020-01-30 | Эрроухед Фармасьютикалс, Инк. | PHARMACEUTICAL COMPOSITION FOR INHIBITING BETA-ENaC GENE EXPRESSION AND USE THEREOF |
| CA2798273A1 (en) | 2010-05-04 | 2011-11-10 | Merrimack Pharmaceuticals, Inc. | Antibodies against epidermal growth factor receptor (egfr) and uses thereof |
| WO2011140151A1 (en) | 2010-05-04 | 2011-11-10 | Dyax Corp. | Antibodies against epidermal growth factor receptor (egfr) |
| WO2011140296A1 (en) | 2010-05-05 | 2011-11-10 | Infinity Pharmaceuticals | Triazoles as inhibitors of fatty acid synthase |
| EP2566853B1 (en) | 2010-05-05 | 2017-01-25 | Infinity Pharmaceuticals, Inc. | Tetrazolones as inhibitors of fatty acid synthase |
| EP2566953B1 (en) | 2010-05-07 | 2019-01-02 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through enzyme relocation |
| BR122020018186B1 (en) | 2010-05-11 | 2021-07-27 | Lantheus Medical Imaging, Inc | USE OF IMAGING AGENTS TO PREPARE A COMPOSITION FOR DETECTION OF THE NOREPINEPHRIN CONVEYOR (NET) AND METHOD FOR THE DETECTION OF NET |
| US8658603B2 (en) | 2010-06-16 | 2014-02-25 | The Regents Of The University Of Michigan | Compositions and methods for inducing an immune response |
| ES2664872T3 (en) | 2010-06-18 | 2018-04-23 | Taiho Pharmaceutical Co., Ltd | PRPK-TPRKB modulators and their uses |
| US10045911B2 (en) * | 2010-06-25 | 2018-08-14 | Genetronics, Inc. | Intradermal injection device |
| CA2805024A1 (en) | 2010-06-30 | 2012-01-05 | Compugen Ltd. | Polypeptides and uses thereof as a drug for treatment of multiples sclerosis, rheumatoid arthritis and other autoimmune disorders |
| WO2016030888A1 (en) | 2014-08-26 | 2016-03-03 | Compugen Ltd. | Polypeptides and uses thereof as a drug for treatment of autoimmune disorders |
| CA2804154C (en) | 2010-07-01 | 2021-06-01 | The Texas A&M University System | Perlecan domain v protects, repairs and restores ischemic brain stroke injury and motor function |
| WO2012007880A2 (en) | 2010-07-16 | 2012-01-19 | Ablynx Nv | Modified single domain antigen binding molecules and uses thereof |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DK2603600T3 (en) | 2010-08-13 | 2019-03-04 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES |
| WO2012022734A2 (en) | 2010-08-16 | 2012-02-23 | Medimmune Limited | Anti-icam-1 antibodies and methods of use |
| EP2611922A1 (en) | 2010-08-31 | 2013-07-10 | Greenlight Biosciences, Inc. | Methods for control of flux in metabolic pathways through protease manipulation |
| WO2012035518A1 (en) | 2010-09-17 | 2012-03-22 | Compugen Ltd. | Compositions and methods for treatment of drug resistant multiple myeloma |
| US8802110B2 (en) | 2010-09-21 | 2014-08-12 | Massachusetts Institute Of Technology | Influenza treatment and/or characterization, human-adapted HA polypeptides; vaccines |
| WO2012040459A2 (en) | 2010-09-22 | 2012-03-29 | President And Fellows Of Harvard College | Beta-catenin targeting peptides and uses thereof |
| EP2621514B1 (en) | 2010-09-28 | 2016-09-21 | KAHR Medical (2005) Ltd | Compositions and methods for treatment of hematological malignancies |
| EP4108671A1 (en) | 2010-10-01 | 2022-12-28 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| WO2012044684A2 (en) | 2010-10-01 | 2012-04-05 | Biogen Idec Ma Inc. | Interferon-beta for use as monotherapy or in combination with other cancer therapies |
| US9228023B2 (en) | 2010-10-01 | 2016-01-05 | Oxford Biotherapeutics Ltd. | Anti-ROR1 antibodies and methods of use for treatment of cancer |
| BR112013007946B1 (en) | 2010-10-04 | 2022-07-12 | Massachusetts Institute Of Technology | PHARMACEUTICAL AND IMMUNOGENIC COMPOSITIONS COMPRISING HEMAGGLUTININ POLYPEPTIDES |
| EP2625203A1 (en) | 2010-10-05 | 2013-08-14 | Novartis AG | Anti-il12rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders |
| WO2012064973A2 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| SG190321A1 (en) | 2010-11-24 | 2013-06-28 | Novartis Int Pharm Ltd | Fusion enzymes having n-acetylglucosaminyltransferase activity |
| GB201100282D0 (en) | 2011-01-07 | 2011-02-23 | Ucb Pharma Sa | Biological methods |
| US10208349B2 (en) | 2011-01-07 | 2019-02-19 | Ucb Biopharma Sprl | Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy |
| UA115767C2 (en) | 2011-01-10 | 2017-12-26 | Інфініті Фармасьютікалз, Інк. | Processes for preparing isoquinolinones and solid forms of isoquinolinones |
| US9089579B2 (en) | 2011-01-19 | 2015-07-28 | Topokine Therapeutics, Inc. | Methods and compositions for treating metabolic syndrome |
| KR20140005998A (en) | 2011-01-24 | 2014-01-15 | 안테리오스, 인코퍼레이티드 | Nanoparticle compositions, formulations thereof, and uses therefor |
| WO2012103037A1 (en) | 2011-01-24 | 2012-08-02 | Anterios, Inc. | Oil compositions |
| DK2667854T3 (en) | 2011-01-24 | 2019-04-23 | Anterios Inc | NANO PARTICLE FORMATIONS |
| US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| US9084849B2 (en) | 2011-01-26 | 2015-07-21 | Kaleo, Inc. | Medicament delivery devices for administration of a medicament within a prefilled syringe |
| US8627816B2 (en) | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| US8703818B2 (en) | 2011-03-03 | 2014-04-22 | Tersus Pharmaceuticals, LLC | Compositions and methods comprising C16:1n7-palmitoleate |
| WO2012119989A2 (en) | 2011-03-04 | 2012-09-13 | Oryzon Genomics, S.A. | Methods and antibodies for the diagnosis and treatment of cancer |
| GB201103836D0 (en) | 2011-03-07 | 2011-04-20 | Glaxosmithkline Biolog Sa | Conjugation process |
| US9193767B2 (en) | 2011-03-30 | 2015-11-24 | Brown University | Enopeptins, uses thereof, and methods of synthesis thereto |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| WO2012140627A1 (en) | 2011-04-15 | 2012-10-18 | Compugen Ltd. | Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer |
| CN103533953A (en) | 2011-05-17 | 2014-01-22 | 葛兰素史密丝克莱恩生物有限公司 | Vaccine against streptococcus pneumoniae |
| US8691231B2 (en) | 2011-06-03 | 2014-04-08 | Merrimack Pharmaceuticals, Inc. | Methods of treatment of tumors expressing predominantly high affinity EGFR ligands or tumors expressing predominantly low affinity EGFR ligands with monoclonal and oligoclonal anti-EGFR antibodies |
| US20140193408A1 (en) | 2011-06-16 | 2014-07-10 | Novartis Ag | Soluble proteins for use as therapeutics |
| WO2012177997A1 (en) | 2011-06-22 | 2012-12-27 | The General Hospital Corporation | Treatment of proteinopathies |
| NZ618503A (en) | 2011-06-28 | 2016-03-31 | Oxford Biotherapeutics Ltd | Antibodies to adp-ribosyl cyclase 2 |
| WO2013001517A1 (en) | 2011-06-30 | 2013-01-03 | Compugen Ltd. | Polypeptides and uses thereof for treatment of autoimmune disorders and infection |
| HUE040276T2 (en) | 2011-07-01 | 2019-02-28 | Novartis Ag | Method for treating metabolic disorders |
| AU2012284091B2 (en) | 2011-07-19 | 2015-11-12 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| US8969363B2 (en) | 2011-07-19 | 2015-03-03 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| PT2734510T (en) | 2011-07-22 | 2019-02-13 | Massachusetts Inst Technology | Activators of class i histone deacetlyases (hdacs) and uses thereof |
| CA2842860A1 (en) | 2011-07-28 | 2013-01-31 | Sea Lane Biotechnologies, Llc | Sur-binding proteins |
| US9408972B2 (en) | 2011-08-02 | 2016-08-09 | Pharmajet, Inc. | Needle-free injection device |
| WO2013032591A1 (en) | 2011-08-29 | 2013-03-07 | Infinity Pharmaceuticals Inc. | Heterocyclic compounds and uses thereof |
| EP3521432A1 (en) | 2011-09-02 | 2019-08-07 | Arrowhead Pharmaceuticals, Inc. | Organic compositions to treat hsf1-related diseases |
| CA2846893A1 (en) | 2011-09-09 | 2013-03-14 | Greenlight Biosciences, Inc. | Cell-free preparation of carbapenems |
| CN104159890B (en) | 2011-09-09 | 2018-04-10 | 蓝瑟斯医学影像公司 | Composition, method and system for synthesizing and using developer |
| EP2755693A4 (en) | 2011-09-12 | 2015-05-20 | Moderna Therapeutics Inc | Engineered nucleic acids and methods of use thereof |
| WO2013043569A1 (en) | 2011-09-20 | 2013-03-28 | Vical Incorporated | Synergistic anti-tumor efficacy using alloantigen combination immunotherapy |
| SG10201800158XA (en) | 2011-09-22 | 2018-02-27 | Amgen Inc | Cd27l antigen binding proteins |
| US9630979B2 (en) | 2011-09-29 | 2017-04-25 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
| CN103974724B (en) | 2011-10-03 | 2019-08-30 | 现代泰克斯公司 | Nucleosides, nucleotide and nucleic acid of modification and application thereof |
| US9096684B2 (en) | 2011-10-18 | 2015-08-04 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| JP6106685B2 (en) | 2011-11-17 | 2017-04-05 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | Inhibitors of C-JUN-N-terminal kinase (JNK) |
| GB201119999D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| GB201120000D0 (en) | 2011-11-20 | 2012-01-04 | Glaxosmithkline Biolog Sa | Vaccine |
| RU2627632C2 (en) | 2011-12-13 | 2017-08-09 | Фармаджет Инк. | Needle-free intradermal injection device |
| CA3029492C (en) | 2011-12-15 | 2019-09-10 | Socpra Sciences Et Genie S.E.C. | Mechanism for puncturing a gas cartridge |
| CA2859387A1 (en) | 2011-12-16 | 2013-06-20 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| WO2013090750A1 (en) | 2011-12-16 | 2013-06-20 | University Of Florida Research Foundation, Inc. | Uses of 4'-desferrithiocin analogs |
| US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
| EP2793940B1 (en) | 2011-12-22 | 2018-11-14 | i2 Pharmaceuticals, Inc. | Surrogate binding proteins |
| GB201122305D0 (en) | 2011-12-23 | 2012-02-01 | Biotica Tech Ltd | Novel compound |
| US9567596B2 (en) | 2012-01-05 | 2017-02-14 | Glykos Finland Oy | Protease deficient filamentous fungal cells and methods of use thereof |
| CA2860676A1 (en) | 2012-01-09 | 2013-07-18 | Novartis Ag | Organic compositions to treat beta-catenin-related diseases |
| SG2014008304A (en) | 2012-02-01 | 2014-06-27 | Compugen Ltd | C10rf32 antibodies, and uses thereof for treatment of cancer |
| AU2013221873B2 (en) | 2012-02-13 | 2016-11-17 | Bristol-Myers Squibb Company | Enediyne compounds, conjugates thereof, and uses and methods therefor |
| AU2013221432B2 (en) | 2012-02-15 | 2018-01-18 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2013123267A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| US20150079100A1 (en) | 2012-03-23 | 2015-03-19 | Bristol-Myers Squibb Company | Methods of treatments using ctla-4 antibodies |
| EP2830659A1 (en) | 2012-03-27 | 2015-02-04 | Novartis AG | Treatment of fibrosis |
| EP2850091A1 (en) | 2012-04-06 | 2015-03-25 | President and Fellows of Harvard College | Methods and compounds for identifying glycosyltransferase inhibitors |
| EP2850090B1 (en) | 2012-04-06 | 2018-10-03 | President and Fellows of Harvard College | Chemoenzymatic methods for synthesizing moenomycin analogs |
| WO2013152277A2 (en) | 2012-04-06 | 2013-10-10 | President And Fellows Of Harvard College | Moenomycin analogs, methods of synthesis, and uses thereof |
| US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| EP2841098A4 (en) | 2012-04-23 | 2016-03-02 | Allertein Therapeutics Llc | Nanoparticles for treatment of allergy |
| WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| KR102122618B1 (en) | 2012-05-10 | 2020-06-29 | 메사츄세츠 인스티튜트 어브 테크놀로지 | Agents for influenza neutralization |
| US9399672B2 (en) | 2012-05-17 | 2016-07-26 | The United States Of America, As Represented By The Secretary Department Of Health And Human Services | Hepatitis C virus neutralizing antibody |
| JO3623B1 (en) | 2012-05-18 | 2020-08-27 | Amgen Inc | St2 antigen binding proteins |
| US9522235B2 (en) | 2012-05-22 | 2016-12-20 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
| DK2852610T3 (en) | 2012-05-23 | 2018-09-03 | Glykos Finland Oy | PRODUCTION OF FUCOSYLED GLYCOPROTEIN |
| WO2013176754A1 (en) | 2012-05-24 | 2013-11-28 | Abbvie Inc. | Novel purification of antibodies using hydrophobic interaction chromatography |
| US9890215B2 (en) | 2012-06-22 | 2018-02-13 | King's College London | Vista modulators for diagnosis and treatment of cancer |
| AR091649A1 (en) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | OPTIMIZATION OF ANTIBODIES THAT FIX THE LYMPHOCYTE ACTIVATION GEN 3 (LAG-3) AND ITS USES |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| WO2014024026A1 (en) | 2012-08-06 | 2014-02-13 | Glaxosmithkline Biologicals S.A. | Method for eliciting in infants an immune response against rsv and b. pertussis |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| JP6302909B2 (en) | 2012-08-18 | 2018-03-28 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | Cell-permeable probes for sialidase identification and imaging |
| CN109793893B (en) | 2012-09-07 | 2023-05-26 | 达特茅斯大学理事会 | VISTA modulators for diagnosis and treatment of cancer |
| CA3113959A1 (en) | 2012-09-26 | 2014-04-03 | President And Fellows Of Harvard College | Proline-locked stapled peptides and uses thereof |
| US20150225471A1 (en) | 2012-10-01 | 2015-08-13 | President And Fellows Of Harvard College | Stabilized polypeptide insulin receptor modulators |
| RS58700B1 (en) | 2012-10-12 | 2019-06-28 | Broad Inst Inc | Gsk3 inhibitors and methods of use thereof |
| WO2014063068A1 (en) | 2012-10-18 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (cdk7) |
| US10000483B2 (en) | 2012-10-19 | 2018-06-19 | Dana-Farber Cancer Institute, Inc. | Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof |
| WO2014063061A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
| CN104870477B (en) | 2012-10-23 | 2018-10-09 | 爱默蕾大学 | GM-CSF and IL-4 conjugates, composition and relative method |
| US9982034B2 (en) | 2012-10-24 | 2018-05-29 | Platelet Targeted Therapeutics, Llc | Platelet targeted treatment |
| US9751931B2 (en) | 2012-10-26 | 2017-09-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hepatitis C virus neutralizing antibodies and methods |
| CN105102000B (en) | 2012-11-01 | 2021-10-22 | 无限药品公司 | Cancer therapy using PI3 kinase subtype modulators |
| MX2015005244A (en) | 2012-11-01 | 2015-07-14 | Aileron Therapeutics Inc | Disubstituted amino acids and methods of preparation and use thereof. |
| WO2014071247A1 (en) | 2012-11-02 | 2014-05-08 | Dana-Farber Cancer Institute, Inc. | Pyrrol-1 -yl benzoic acid derivates useful as myc inhibitors |
| EP2922542A4 (en) | 2012-11-21 | 2016-10-05 | Topokine Therapeutics Inc | Methods and compositions for locally increasing body fat |
| JP6144355B2 (en) | 2012-11-26 | 2017-06-07 | モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． | Chemically modified mRNA |
| US9775915B2 (en) | 2012-11-26 | 2017-10-03 | President And Fellows Of Harvard College | Trioxacarcins, trioxacarcin-antibody conjugates, and uses thereof |
| PT2928923T (en) | 2012-12-10 | 2020-03-27 | Biogen Ma Inc | Anti-blood dendritic cell antigen 2 antibodies and uses thereof |
| MY174820A (en) | 2012-12-18 | 2020-05-17 | Novartis Ag | Stabilized insulin-like growth factor polypeptides |
| US9908887B2 (en) | 2012-12-21 | 2018-03-06 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| EP2935222B1 (en) | 2012-12-21 | 2018-09-05 | Epizyme, Inc. | Prmt5 inhibitors and uses thereof |
| US9365555B2 (en) | 2012-12-21 | 2016-06-14 | Epizyme, Inc. | PRMT5 inhibitors and uses thereof |
| JP2016505002A (en) | 2012-12-21 | 2016-02-18 | エピザイム，インコーポレイティド | PRMT5 inhibitors containing dihydroisoquinoline or tetrahydroisoquinoline and uses thereof |
| WO2014106096A1 (en) | 2012-12-27 | 2014-07-03 | Kaleo, Inc. | Devices, systems and methods for locating and interacting with medicament delivery systems |
| WO2014113089A2 (en) | 2013-01-17 | 2014-07-24 | Moderna Therapeutics, Inc. | Signal-sensor polynucleotides for the alteration of cellular phenotypes |
| ES2728936T3 (en) | 2013-01-25 | 2019-10-29 | Amgen Inc | Antibodies directed against CDH19 for melanoma |
| JO3519B1 (en) | 2013-01-25 | 2020-07-05 | Amgen Inc | Antibody constructs for CDH19 and CD3 |
| EP2953638B1 (en) | 2013-02-07 | 2023-07-05 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| US20140335504A1 (en) | 2013-02-07 | 2014-11-13 | Massachusetts Institute Of Technology | Human adaptation of h5 influenza |
| PT2953969T (en) | 2013-02-08 | 2019-12-03 | Novartis Ag | Anti-il-17a antibodies and their use in treating autoimmune and inflammatory disorders |
| EP2956173B1 (en) | 2013-02-14 | 2017-03-29 | Bristol-Myers Squibb Company | Tubulysin compounds, methods of making and use |
| CA3175634A1 (en) | 2013-02-28 | 2014-09-04 | Caprion Proteomics Inc. | Tuberculosis biomarkers and uses thereof |
| EP2991665A4 (en) | 2013-03-13 | 2016-11-09 | Harvard College | Stapled and stitched polypeptides and uses thereof |
| WO2014159813A1 (en) | 2013-03-13 | 2014-10-02 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| EP2970375A1 (en) | 2013-03-14 | 2016-01-20 | AbbVie Inc. | Low acidic species compositions and methods for producing the same using displacement chromatography |
| CA2926301A1 (en) | 2013-03-14 | 2014-10-02 | Abbvie Inc. | Low acidic species compositions and methods for producing and using the same |
| US9580486B2 (en) | 2013-03-14 | 2017-02-28 | Amgen Inc. | Interleukin-2 muteins for the expansion of T-regulatory cells |
| US9308236B2 (en) | 2013-03-15 | 2016-04-12 | Bristol-Myers Squibb Company | Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions |
| US20160122436A1 (en) | 2013-03-15 | 2016-05-05 | Amgen Research (Munich) Gmbh | Single chain binding molecules comprising n-terminal abp |
| WO2014143739A2 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
| WO2014151386A1 (en) | 2013-03-15 | 2014-09-25 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
| WO2014144466A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
| CN105392801A (en) | 2013-03-15 | 2016-03-09 | 比奥根Ma公司 | Treatment and prevention of acute kidney injury using anti-alpha v beta 5 antibodies |
| WO2014140368A1 (en) | 2013-03-15 | 2014-09-18 | Amgen Research (Munich) Gmbh | Antibody constructs for influenza m2 and cd3 |
| EP3760223A1 (en) | 2013-04-03 | 2021-01-06 | N-Fold Llc | Nanoparticle composition for desensitizing a subject to peanut allergens |
| US9982005B2 (en) | 2013-04-04 | 2018-05-29 | President And Fellows Of Harvard College | Macrolides and methods of their preparation and use |
| ES2774330T3 (en) | 2013-04-09 | 2020-07-20 | Massachusetts Inst Technology | Drug supply polymer and uses thereof |
| US10301359B2 (en) | 2013-04-30 | 2019-05-28 | Massachusetts Institute Of Technology | Human adaptation of H3 influenza |
| WO2014179562A1 (en) | 2013-05-01 | 2014-11-06 | Massachusetts Institute Of Technology | 1,3,5-triazinane-2,4,6-trione derivatives and uses thereof |
| NO2753788T3 (en) | 2013-05-10 | 2018-06-16 | ||
| PL3004167T3 (en) | 2013-05-30 | 2019-01-31 | Kiniksa Pharmaceuticals, Ltd. | Oncostatin m receptor antigen binding proteins |
| RU2705204C2 (en) | 2013-05-30 | 2019-11-06 | Инфинити Фармасьютикалз, Инк. | Treating malignant tumors using piz-kinase isoform modulators |
| US10526375B2 (en) | 2013-06-05 | 2020-01-07 | Massachusetts Institute Of Technology | Human Adaptation of H7 HA |
| JP6469661B2 (en) | 2013-06-11 | 2019-02-13 | カラ ファーマシューティカルズ インコーポレイテッド | Urea derivatives and uses thereof |
| KR20160019547A (en) | 2013-06-14 | 2016-02-19 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | Stabilized polypeptide insulin receptor modulators |
| WO2014210397A1 (en) | 2013-06-26 | 2014-12-31 | Academia Sinica | Rm2 antigens and use thereof |
| EP4001275A1 (en) | 2013-06-26 | 2022-05-25 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | (s)-enantiomer of mepazine as paracaspase (malt1) inhibitor for the treatment of cancer |
| US9981030B2 (en) | 2013-06-27 | 2018-05-29 | Academia Sinica | Glycan conjugates and use thereof |
| BR112016001457A2 (en) | 2013-07-25 | 2017-08-29 | Dana Farber Cancer Inst Inc | TRANSCRIPTION FACTOR INHIBITORS AND THEIR USES |
| WO2015021058A2 (en) | 2013-08-05 | 2015-02-12 | Greenlight Biosciences, Inc. | Engineered proteins with a protease cleavage site |
| CN105555304A (en) | 2013-08-05 | 2016-05-04 | 葛兰素史密丝克莱恩生物有限公司 | Combination immunogenic compositions |
| CN105682666B (en) | 2013-09-06 | 2021-06-01 | 中央研究院 | Activation of human iNKT cells using glycolipids |
| AR097648A1 (en) | 2013-09-13 | 2016-04-06 | Amgen Inc | COMBINATION OF EPIGENETIC FACTORS AND BIESPECTIVE COMPOUNDS THAT HAVE LIKE DIANA CD33 AND CD3 IN THE TREATMENT OF MYELOID LEUKEMIA |
| WO2015050959A1 (en) | 2013-10-01 | 2015-04-09 | Yale University | Anti-kit antibodies and methods of use thereof |
| US20160271265A1 (en) | 2013-10-02 | 2016-09-22 | Novartis Ag | Insulin-like growth factor mimetics for use in therapy |
| WO2015051234A2 (en) | 2013-10-04 | 2015-04-09 | Biogen Idec Ma Inc. | Tweak antagonists for treating lupus nephritis and muscle atrophy |
| US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| TWI657085B (en) | 2013-10-04 | 2019-04-21 | 英菲尼提製藥股份有限公司 | Heterocyclic compounds and uses thereof |
| EA036927B1 (en) | 2013-10-11 | 2021-01-15 | Оксфорд Биотерепьютикс Лтд | Conjugated antibodies against ly75 for the treatment of cancer |
| US9982009B2 (en) | 2013-10-15 | 2018-05-29 | Massachusetts Institute Of Technology | Methods for treating polycystic kidney disease and polycystic liver disease |
| US9902986B2 (en) | 2013-10-16 | 2018-02-27 | Massachusetts Institute Of Technology | Enterobactin conjugates and uses thereof |
| WO2015057939A1 (en) | 2013-10-18 | 2015-04-23 | Biogen Idec Ma Inc. | Anti-s1p4 antibodies and uses thereof |
| WO2015058140A1 (en) | 2013-10-18 | 2015-04-23 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7) |
| CA2927917C (en) | 2013-10-18 | 2022-08-09 | Syros Pharmaceuticals, Inc. | Heteroaromatic compounds useful for the treatment of proliferative diseases |
| WO2015061204A1 (en) | 2013-10-21 | 2015-04-30 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| EP3063171B1 (en) | 2013-11-01 | 2019-07-24 | University Of Oslo | Albumin variants and uses thereof |
| US9458169B2 (en) | 2013-11-01 | 2016-10-04 | Kala Pharmaceuticals, Inc. | Crystalline forms of therapeutic compounds and uses thereof |
| US9993541B2 (en) | 2013-11-13 | 2018-06-12 | University Of Oslo | Outer membrane vesicles and uses thereof |
| US11452767B2 (en) | 2013-11-15 | 2022-09-27 | Oslo Universitetssykehus Hf | CTL peptide epitopes and antigen-specific t cells, methods for their discovery, and uses thereof |
| UY35874A (en) | 2013-12-12 | 2015-07-31 | Novartis Ag | A PROCESS FOR THE PREPARATION OF A COMPOSITION OF PEGILATED PROTEINS |
| CN106029697B (en) | 2013-12-20 | 2021-06-04 | 英特维特国际股份有限公司 | Canine antibodies with modified CH2-CH3 sequences |
| TWI728373B (en) | 2013-12-23 | 2021-05-21 | 美商建南德克公司 | Antibodies and methods of use |
| CA2935378C (en) | 2013-12-24 | 2023-04-18 | Janssen Pharmaceutica Nv | Anti-vista antibodies and fragments |
| AU2014369834B2 (en) | 2013-12-24 | 2018-12-20 | President And Fellows Of Harvard College | Cortistatin analogues and syntheses and uses thereof |
| US11014987B2 (en) | 2013-12-24 | 2021-05-25 | Janssen Pharmaceutics Nv | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| EP3094352B1 (en) | 2014-01-16 | 2020-09-23 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| WO2015117087A1 (en) | 2014-01-31 | 2015-08-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| EP3119415A4 (en) | 2014-03-07 | 2017-11-29 | The Arizona Board of Regents on behalf of the University of Arizona | Non-narcotic crmp2 peptides targeting sodium channels for chronic pain |
| JP6701088B2 (en) | 2014-03-19 | 2020-05-27 | インフィニティー ファーマシューティカルズ， インコーポレイテッド | Heterocyclic compounds for use in the treatment of PI3K-gamma mediated disorders |
| EP3129767B1 (en) | 2014-03-27 | 2021-09-01 | Academia Sinica | Reactive labelling compounds and uses thereof |
| US10293035B2 (en) | 2014-03-28 | 2019-05-21 | University Of Washington Through Its Center For Commercialization | Breast and ovarian cancer vaccines |
| US9862688B2 (en) | 2014-04-23 | 2018-01-09 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged janus kinase inhibitors and uses thereof |
| WO2015164614A1 (en) | 2014-04-23 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Janus kinase inhibitors and uses thereof |
| WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
| WO2015168380A1 (en) | 2014-04-30 | 2015-11-05 | Massachusetts Institute Of Technology | Siderophore-based immunization against gram-negative bacteria |
| JP6759109B2 (en) | 2014-05-21 | 2020-09-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | RAS inhibitory peptides and their use |
| KR20170003720A (en) | 2014-05-27 | 2017-01-09 | 아카데미아 시니카 | Anti-cd20 glycoantibodies and uses thereof |
| TWI679020B (en) | 2014-05-27 | 2019-12-11 | 中央研究院 | Anti-her2 glycoantibodies and uses thereof |
| US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
| TWI717319B (en) | 2014-05-27 | 2021-02-01 | 中央研究院 | Fucosidase from bacteroides and methods using the same |
| KR102494193B1 (en) | 2014-05-28 | 2023-01-31 | 아카데미아 시니카 | Anti-tnf-alpha glycoantibodies and uses thereof |
| RS59643B1 (en) | 2014-06-06 | 2020-01-31 | Bristol Myers Squibb Co | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof |
| MX2016016310A (en) | 2014-06-11 | 2017-10-20 | A Green Kathy | Use of vista agonists and antagonists to suppress or enhance humoral immunity. |
| CA2951430A1 (en) | 2014-06-13 | 2015-12-17 | Glaxosmithkline Biologicals Sa | Immunogenic combinations |
| CR20170011A (en) | 2014-06-19 | 2017-04-04 | Ariad Pharma Inc | HETEROARILO COMPOUNDS FOR INHIBITION OF CINASA |
| US20170291939A1 (en) | 2014-06-25 | 2017-10-12 | Novartis Ag | Antibodies specific for il-17a fused to hyaluronan binding peptide tags |
| WO2015200425A1 (en) | 2014-06-27 | 2015-12-30 | Topokine Therapeutics, Inc. | Topical dosage regimen |
| WO2016004202A1 (en) | 2014-07-02 | 2016-01-07 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| US20170226552A1 (en) | 2014-07-03 | 2017-08-10 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using cobalt |
| US20160185848A1 (en) | 2014-07-09 | 2016-06-30 | Abbvie Inc. | Methods for modulating the glycosylation profile of recombinant proteins using sugars |
| US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
| WO2016011386A1 (en) | 2014-07-18 | 2016-01-21 | University Of Washington | Cancer vaccine compositions and methods of use thereof |
| AR101936A1 (en) | 2014-07-31 | 2017-01-25 | Amgen Res (Munich) Gmbh | SPECIFIC BIESPECIFIC CHAIN ANTIBODY CONSTRUCTS SPECIFIED FOR OPTIMIZED CROSSED SPECIES |
| AR101669A1 (en) | 2014-07-31 | 2017-01-04 | Amgen Res (Munich) Gmbh | ANTIBODY CONSTRUCTS FOR CDH19 AND CD3 |
| AU2015295242B2 (en) | 2014-07-31 | 2020-10-22 | Amgen Research (Munich) Gmbh | Bispecific single chain antibody construct with enhanced tissue distribution |
| EP4108256A1 (en) | 2014-08-11 | 2022-12-28 | University of Massachusetts | Anti-ospa antibodies and methods of use |
| US10736966B2 (en) | 2014-08-12 | 2020-08-11 | Massachusetts Institute Of Technology | Brush-poly (glycoamidoamine)-lipids and uses thereof |
| JO3663B1 (en) | 2014-08-19 | 2020-08-27 | Merck Sharp & Dohme | Anti-lag3 antibodies and antigen-binding fragments |
| TWI790593B (en) | 2014-08-19 | 2023-01-21 | 美商默沙東有限責任公司 | Anti-tigit antibodies |
| CN107001404B (en) | 2014-09-08 | 2021-06-29 | 中央研究院 | Activation of human iNKT cells using glycolipids |
| EP2993174A1 (en) | 2014-09-08 | 2016-03-09 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Pyrazolopyridine derivatives and their use in therapy |
| WO2016049359A1 (en) | 2014-09-24 | 2016-03-31 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| MX2017003819A (en) | 2014-09-24 | 2017-06-15 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and formulations thereof. |
| SG10201902924RA (en) | 2014-10-03 | 2019-05-30 | Massachusetts Inst Technology | Antibodies that bind ebola glycoprotein and uses thereof |
| US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
| EP3204039B1 (en) | 2014-10-10 | 2022-06-08 | The Regents Of The University Of Michigan | Nanoemulsion compositions for preventing, suppressing or eliminating allergic and inflammatory disease |
| US9732119B2 (en) | 2014-10-10 | 2017-08-15 | Bristol-Myers Squibb Company | Immunomodulators |
| EA035145B1 (en) | 2014-10-21 | 2020-05-06 | Ариад Фармасьютикалз, Инк. | Crystalline forms of 5-chloro-n4-[-2-(dimethylphosphoryl)phenyl]-n2-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]pyrimidine-2,4-diamine |
| US20180015101A1 (en) | 2014-10-28 | 2018-01-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compositions and methods for antigen-specific tolerance |
| AU2015252119A1 (en) | 2014-11-07 | 2016-05-26 | Takeda Vaccines, Inc. | Hand, foot, and mouth vaccines and methods of manufacture and use thereof |
| MA40920A (en) | 2014-11-07 | 2017-09-12 | Takeda Vaccines Inc | VACCINES OF THE HAND, FOOT AND MOUTH, AND METHODS OF MANUFACTURING AND USE THEREOF |
| EP3217982A1 (en) | 2014-11-10 | 2017-09-20 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Spiropyrazine derivatives as inhibitors of non-apoptotic regulated cell-death |
| US10077287B2 (en) | 2014-11-10 | 2018-09-18 | Bristol-Myers Squibb Company | Tubulysin analogs and methods of making and use |
| EP3461904A1 (en) | 2014-11-10 | 2019-04-03 | ModernaTX, Inc. | Alternative nucleic acid molecules containing reduced uracil content and uses thereof |
| US9856292B2 (en) | 2014-11-14 | 2018-01-02 | Bristol-Myers Squibb Company | Immunomodulators |
| CN113773388A (en) | 2014-11-21 | 2021-12-10 | 百时美施贵宝公司 | anti-CD 73 antibodies and uses thereof |
| CN107250157B (en) | 2014-11-21 | 2021-06-29 | 百时美施贵宝公司 | Antibodies comprising modified heavy chain constant regions |
| WO2016086026A1 (en) | 2014-11-26 | 2016-06-02 | Kala Pharmaceuticals, Inc. | Crystalline forms of a therapeutic compound and uses thereof |
| US20170269092A1 (en) | 2014-12-02 | 2017-09-21 | Cemm - Forschungszentrum Fuer Molekulare Medizin Gmbh | Anti-mutant calreticulin antibodies and their use in the diagnosis and therapy of myeloid malignancies |
| JP2018505911A (en) | 2014-12-05 | 2018-03-01 | イミュネクスト，インコーポレーテッド | Identification of VSIG8 as a putative VISTA receptor and its use to produce a VISTA / VSIG8 modulator |
| EP3230272B1 (en) | 2014-12-10 | 2020-08-19 | Kala Pharmaceuticals, Inc. | 1-amino-triazolo(1,5-a)pyridine-substituted urea derivative and uses thereof |
| US9861680B2 (en) | 2014-12-18 | 2018-01-09 | Bristol-Myers Squibb Company | Immunomodulators |
| CA2971542A1 (en) | 2014-12-19 | 2016-06-23 | Regenesance B.V. | Antibodies that bind human c6 and uses thereof |
| TWI708786B (en) | 2014-12-23 | 2020-11-01 | 美商必治妥美雅史谷比公司 | Antibodies to tigit |
| AU2015369707B2 (en) | 2014-12-23 | 2020-07-23 | Sloan-Kettering Institute For Cancer Research | Polymorph of granaticin B |
| AU2015371251B2 (en) | 2014-12-23 | 2020-06-11 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
| HRP20220860T1 (en) | 2015-01-09 | 2022-10-14 | Adalta Limited | Cxcr4 binding molecules |
| MX2017009144A (en) | 2015-01-14 | 2017-11-22 | Bristol Myers Squibb Co | Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using. |
| US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
| US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
| JP6779887B2 (en) | 2015-01-24 | 2020-11-04 | アカデミア シニカＡｃａｄｅｍｉａ Ｓｉｎｉｃａ | New glycan conjugate and how to use it |
| US20160222060A1 (en) | 2015-02-04 | 2016-08-04 | Bristol-Myers Squibb Company | Immunomodulators |
| US10983128B2 (en) | 2015-02-05 | 2021-04-20 | Bristol-Myers Squibb Company | CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy |
| CN107530416A (en) | 2015-03-05 | 2018-01-02 | 西北大学 | Virus that non-nerve infects and application thereof |
| WO2016144773A1 (en) | 2015-03-06 | 2016-09-15 | Abbvie Inc. | Arabinosylated glycoproteins |
| US20180044429A1 (en) | 2015-03-09 | 2018-02-15 | Celldex Therapeutics, Inc. | Cd27 agonists |
| US9809625B2 (en) | 2015-03-18 | 2017-11-07 | Bristol-Myers Squibb Company | Immunomodulators |
| WO2016154058A1 (en) | 2015-03-20 | 2016-09-29 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| US10695495B2 (en) | 2015-03-24 | 2020-06-30 | Kaleo, Inc. | Devices and methods for delivering a lyophilized medicament |
| WO2016160617A2 (en) | 2015-03-27 | 2016-10-06 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
| JP6843065B2 (en) | 2015-03-30 | 2021-03-17 | グリーンライト バイオサイエンシーズ インコーポレーテッドＧｒｅｅｎｌｉｇｈｔ Ｂｉｏｓｃｉｅｎｃｅｓ，Ｉｎｃ． | Cell-free production of ribonucleic acid |
| CA2980087A1 (en) | 2015-04-02 | 2016-10-06 | Intervet International B.V. | Antibodies to canine interleukin-4 receptor alpha |
| MY188430A (en) | 2015-04-10 | 2021-12-08 | Amgen Inc | Interleukin-2 muteins for the expansion of t-regulatory cells |
| EP3280705B1 (en) | 2015-04-10 | 2021-07-21 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Pyrone derivatives for use as antiviral agents |
| EP3283524B1 (en) | 2015-04-17 | 2023-04-05 | Amgen Research (Munich) GmbH | Bispecific antibody constructs for cdh3 and cd3 |
| AU2016255770A1 (en) | 2015-04-27 | 2017-11-16 | University Of Florida Research Foundation, Incorporated | Metabolically programmed metal chelators and uses thereof |
| JP2018515082A (en) | 2015-04-30 | 2018-06-14 | プレジデント アンド フェローズ オブ ハーバード カレッジ | Anti-AP2 antibody and antigen binding agent for treating metabolic disorders |
| WO2016178591A2 (en) | 2015-05-05 | 2016-11-10 | Gene Predit, Sa | Genetic markers and treatment of male obesity |
| FI3447075T3 (en) | 2015-05-15 | 2023-11-07 | Massachusetts Gen Hospital | Antagonistic anti-tumor necrosis factor receptor superfamily antibodies |
| EP3297676A2 (en) | 2015-05-22 | 2018-03-28 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Combination of trpm8-agonist and nachr-agonist for treatment of obesity and related disorders and for weight reduction |
| MY195000A (en) | 2015-05-27 | 2022-12-30 | Ucb Biopharma Sprl | Method for the treatment of neurological disease |
| CA2986441A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| CA2990172A1 (en) | 2015-06-19 | 2016-12-22 | Massachusetts Institute Of Technology | Alkenyl substituted 2,5-piperazinediones and their use in compositions for delivering an agent to a subject or cell |
| CN107922497B (en) | 2015-06-24 | 2022-04-12 | 詹森药业有限公司 | anti-VISTA antibodies and fragments |
| JOP20200312A1 (en) | 2015-06-26 | 2017-06-16 | Novartis Ag | Factor xi antibodies and methods of use |
| MX2017016502A (en) | 2015-06-29 | 2018-03-12 | Univ Rockefeller | Antibodies to cd40 with enhanced agonist activity. |
| WO2017004345A1 (en) | 2015-06-30 | 2017-01-05 | Kaleo, Inc. | Auto-injectors for administration of a medicament within a prefilled syringe |
| US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| EP3971211A1 (en) | 2015-07-13 | 2022-03-23 | Compugen Ltd. | Hide1 compositions and methods |
| TWI744242B (en) | 2015-07-31 | 2021-11-01 | 德商安美基研究（慕尼黑）公司 | Antibody constructs for egfrviii and cd3 |
| US10369572B2 (en) | 2015-07-31 | 2019-08-06 | Point Of Care Diagnostics, Llc | Reagent dispensing apparatus |
| TWI717375B (en) | 2015-07-31 | 2021-02-01 | 德商安美基研究（慕尼黑）公司 | Antibody constructs for cd70 and cd3 |
| TWI793062B (en) | 2015-07-31 | 2023-02-21 | 德商安美基研究（慕尼黑）公司 | Antibody constructs for dll3 and cd3 |
| TWI829617B (en) | 2015-07-31 | 2024-01-21 | 德商安美基研究（慕尼黑）公司 | Antibody constructs for flt3 and cd3 |
| TWI796283B (en) | 2015-07-31 | 2023-03-21 | 德商安美基研究（慕尼黑）公司 | Antibody constructs for msln and cd3 |
| JO3620B1 (en) | 2015-08-05 | 2020-08-27 | Amgen Res Munich Gmbh | Immune-checkpoint inhibitors for use in the treatment of blood-borne cancers cancers |
| JP7028766B2 (en) | 2015-09-09 | 2022-03-02 | ダナ－ファーバー キャンサー インスティテュート， インコーポレイテッド | Inhibitor of cyclin-dependent kinase |
| CN108368161A (en) | 2015-09-10 | 2018-08-03 | 艾瑞朗医疗公司 | Peptidomimetic macrocyclic compound as MCL-1 conditioning agents |
| LT3350157T (en) | 2015-09-17 | 2022-02-25 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| DK3350333T3 (en) | 2015-09-17 | 2022-01-31 | Modernatx Inc | POLYNUCLEOTIDES CONTAINING A STABILIZING TAIL REGION |
| RU2638457C2 (en) | 2015-09-28 | 2017-12-13 | Общество С Ограниченной Ответственностью "Онкомакс" | Antibodies specifically binding type 1 receptor of fibroblast growth factor, antibodies application for oncological disease treatment, method for antibodies production |
| US11266730B2 (en) | 2015-09-29 | 2022-03-08 | The General Hospital Corporation | Methods of treating and diagnosing disease using biomarkers for BCG therapy |
| MX2018003983A (en) | 2015-09-30 | 2018-11-09 | Rhythm Pharmaceuticals Inc | Method of treating melanocortin-4 receptor pathway-associated disorders. |
| WO2017059389A1 (en) | 2015-10-01 | 2017-04-06 | Kythera Biopharmaceuticals, Inc. | Compositions comprising a statin for use in methods of adipolysis |
| GB201518684D0 (en) | 2015-10-21 | 2015-12-02 | Glaxosmithkline Biolog Sa | Vaccine |
| JO3555B1 (en) | 2015-10-29 | 2020-07-05 | Merck Sharp & Dohme | Antibody neutralizing human respiratory syncytial virus |
| CN108602884A (en) | 2015-11-08 | 2018-09-28 | 豪夫迈·罗氏有限公司 | The method for screening multi-specificity antibody |
| EP3374390A1 (en) | 2015-11-13 | 2018-09-19 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| CN108738324B (en) | 2015-11-19 | 2022-06-21 | 百时美施贵宝公司 | Anti-glucocorticoid-induced tumor necrosis factor receptor (GITR) antibodies and uses thereof |
| UY36990A (en) | 2015-11-21 | 2017-11-30 | Fundació Privada Inst De Recerca De La Sida-Caixa (Irsicaixa) | DERIVATIVES OF ANTIBODIES AGAINST HIV WITH DUAL ANTIVIRAL AND IMMUNOMODULATORY ACTIVITY |
| WO2017095823A1 (en) | 2015-11-30 | 2017-06-08 | The Regents Of The University Of California | Tumor-specific payload delivery and immune activation using a human antibody targeting a highly specific tumor cell surface antigen |
| EP3383903A1 (en) | 2015-11-30 | 2018-10-10 | Bristol-Myers Squibb Company | Anti human ip-10 antibodies and their uses |
| JP7114465B2 (en) | 2015-12-22 | 2022-08-08 | モデルナティエックス インコーポレイテッド | Compounds and compositions for intracellular delivery of drugs |
| EP3405498A1 (en) | 2016-01-22 | 2018-11-28 | Merck Sharp & Dohme Corp. | Anti-coagulation factor xi antibodies |
| TWI797073B (en) | 2016-01-25 | 2023-04-01 | 德商安美基研究（慕尼黑）公司 | Pharmaceutical composition comprising bispecific antibody constructs |
| MD3411402T2 (en) | 2016-02-03 | 2022-05-31 | Amgen Res Munich Gmbh | BCMA and CD3 bispecific T cell engaging antibody constructs |
| SG11201806150RA (en) | 2016-02-03 | 2018-08-30 | Amgen Res Munich Gmbh | Psma and cd3 bispecific t cell engaging antibody constructs |
| EA039859B1 (en) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Bispecific antibody constructs binding egfrviii and cd3 |
| TWI756204B (en) | 2016-02-12 | 2022-03-01 | 比利時商楊森製藥公司 | Anti-vista antibodies and fragments, uses thereof, and methods of identifying same |
| RU2018131123A (en) | 2016-02-17 | 2020-03-17 | Новартис Аг | ANTIBODIES TO TGF-BETA2 |
| CN109195629A (en) | 2016-02-24 | 2019-01-11 | 威特拉公司 | Influenza antibody molecular preparation |
| AU2017228470A1 (en) | 2016-03-04 | 2018-08-30 | Bristol-Myers Squibb Company | Combination therapy with anti-CD73 antibodies |
| US10143746B2 (en) | 2016-03-04 | 2018-12-04 | Bristol-Myers Squibb Company | Immunomodulators |
| EA201891925A1 (en) | 2016-03-04 | 2019-02-28 | Зэ Рокфеллер Юниверсити | ANTIBODIES TO CD40 WITH STRENGTHENED AGONISTIC ACTIVITY |
| CA3016170A1 (en) | 2016-03-08 | 2017-09-14 | Academia Sinica | Methods for modular synthesis of n-glycans and arrays thereof |
| WO2017161116A1 (en) | 2016-03-17 | 2017-09-21 | Infinity Pharmaceuticals, Inc. | Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as pi3k kinase inhibitors |
| US10358463B2 (en) | 2016-04-05 | 2019-07-23 | Bristol-Myers Squibb Company | Immunomodulators |
| CR20180525A (en) | 2016-04-06 | 2019-02-14 | Greenlight Biosciences Inc | RIBONUCLEIC ACID PRODUCTION FREE OF CELLS |
| SG11201808633RA (en) | 2016-04-15 | 2018-10-30 | Immunext Inc | Anti-human vista antibodies and use thereof |
| MA44723A (en) | 2016-04-18 | 2019-02-27 | Celldex Therapeutics Inc | HUMAN CD40 BINDING AGONIST ANTIBODIES AND THEIR USES |
| US20190255143A1 (en) | 2016-04-18 | 2019-08-22 | The Trustees Of Columbia University In The City Of New York | Therapeutic targets involved in the progression of nonalcoholic steatohepatitis (nash) |
| JOP20170091B1 (en) | 2016-04-19 | 2021-08-17 | Amgen Res Munich Gmbh | Administration of a bispecific construct binding to CD33 and CD3 for use in a method for the treatment of myeloid leukemia |
| CN109072232B (en) | 2016-04-22 | 2022-11-15 | 生物技术公司 | Method for providing single-stranded RNA |
| CN115073581A (en) | 2016-05-04 | 2022-09-20 | 美国安进公司 | Interleukin-2 muteins for expansion of T regulatory cells |
| WO2017196663A1 (en) | 2016-05-09 | 2017-11-16 | Bristol-Myers Squibb Company | Tl1a antibodies and uses thereof |
| WO2017201390A1 (en) | 2016-05-19 | 2017-11-23 | The Regents Of The University Of Michigan | Novel adjuvant compositions |
| TW201802121A (en) | 2016-05-25 | 2018-01-16 | 諾華公司 | Reversal binding agents for anti-factor XI/XIa antibodies and uses thereof |
| US11116832B2 (en) | 2016-06-03 | 2021-09-14 | Sanofi Pasteur Inc. | Modification of engineered influenza hemagglutinin polypeptides |
| WO2017214337A1 (en) | 2016-06-07 | 2017-12-14 | Massachusetts Institute Of Technology | Drug delivery polymers and uses thereof |
| WO2017214269A1 (en) | 2016-06-08 | 2017-12-14 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
| AU2017286606A1 (en) | 2016-06-14 | 2018-12-13 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| WO2017218371A1 (en) | 2016-06-14 | 2017-12-21 | Merck Sharp & Dohme Corp. | Anti-coagulation factor xi antibodies |
| US20180002417A1 (en) | 2016-06-15 | 2018-01-04 | Celimmune Llc | Methods and Compositions for the Treatment of Celiac Disease, Non-Celiac Gluten Sensitivity, and Refractory Celiac Disease |
| GB201610599D0 (en) | 2016-06-17 | 2016-08-03 | Glaxosmithkline Biologicals Sa | Immunogenic Composition |
| PE20190418A1 (en) | 2016-07-14 | 2019-03-19 | Bristol Myers Squibb Co | ANTIBODIES AGAINST PROTEIN 3 CONTAINING THE MUCIN AND IMMUNOGLOBULIN T-LYMPHOCYTE DOMAIN (TIM3) AND THEIR USES |
| NL2017267B1 (en) | 2016-07-29 | 2018-02-01 | Aduro Biotech Holdings Europe B V | Anti-pd-1 antibodies |
| NL2017270B1 (en) | 2016-08-02 | 2018-02-09 | Aduro Biotech Holdings Europe B V | New anti-hCTLA-4 antibodies |
| EP3494141A4 (en) | 2016-08-03 | 2020-04-08 | Bio-Techne Corporation | Identification of vsig3/vista as a novel immune checkpoint and use thereof for immunotherapy |
| MX2019001341A (en) | 2016-08-05 | 2019-07-04 | Sanofi Pasteur Inc | Multivalent pneumococcal polysaccharide-protein conjugate composition. |
| JP7001687B2 (en) | 2016-08-05 | 2022-02-04 | サノフィ パスツール インコーポレイティッド | Polyvalent pneumococcal polysaccharide-protein conjugate composition |
| ES2902179T3 (en) | 2016-08-19 | 2022-03-25 | Bristol Myers Squibb Co | Seco-cyclopropapyrroloindole compounds, antibody-drug conjugates thereof, and methods of making and use |
| JP7213549B2 (en) | 2016-08-22 | 2023-01-27 | シーエイチオー ファーマ インコーポレイテッド | Antibodies, Binding Fragments, and Methods of Use |
| WO2018035710A1 (en) | 2016-08-23 | 2018-03-01 | Akeso Biopharma, Inc. | Anti-ctla4 antibodies |
| US10981976B2 (en) | 2016-08-31 | 2021-04-20 | University Of Rochester | Human monoclonal antibodies to human endogenous retrovirus K envelope (HERV-K) and use thereof |
| JOP20190055A1 (en) | 2016-09-26 | 2019-03-24 | Merck Sharp & Dohme | Anti-cd27 antibodies |
| EP3305781A1 (en) | 2016-10-07 | 2018-04-11 | Deutsches Krebsforschungszentrum | Chemical substances which inhibit the enzymatic activity of human kallikrein-related peptidase 6 (klk6) |
| CA3040189A1 (en) | 2016-10-13 | 2018-04-19 | Massachusetts Institute Of Technology | Antibodies that bind zika virus envelope protein and uses thereof |
| AU2017348365A1 (en) | 2016-10-28 | 2019-05-23 | Astute Medical, Inc. | Use of antibodies to TIMP-2 for the improvement of renal function |
| WO2018085750A2 (en) | 2016-11-07 | 2018-05-11 | Bristol-Myers Squibb Company | Immunomodulators |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| US11434301B2 (en) | 2016-11-11 | 2022-09-06 | The Regents Of The University Of California | Anti-CD46 antibodies and methods of use |
| CA3043131A1 (en) | 2016-11-18 | 2018-05-24 | Neurovive Pharmaceutical Ab | Use of sanglifehrin macrocyclic analogues as anticancer compounds |
| WO2018096396A1 (en) | 2016-11-22 | 2018-05-31 | University Of Oslo | Albumin variants and uses thereof |
| WO2018106738A1 (en) | 2016-12-05 | 2018-06-14 | Massachusetts Institute Of Technology | Brush-arm star polymers, conjugates and particles, and uses thereof |
| JP7050335B2 (en) | 2016-12-21 | 2022-04-08 | メレオ バイオファーマ ３ リミテッド | Use of anti-sclerostin antibody in the treatment of osteogenesis imperfecta |
| JP2020502218A (en) | 2016-12-21 | 2020-01-23 | メレオ バイオファーマ ３ リミテッド | Use of anti-sclerostin antibodies in the treatment of osteogenesis imperfecta |
| IL308980A (en) | 2016-12-23 | 2024-01-01 | Novartis Ag | Factor xi antibodies and methods of use |
| JP7014797B2 (en) | 2016-12-23 | 2022-02-01 | カレオ，インコーポレイテッド | Drug delivery devices and methods for delivering drugs to babies and children |
| PL3565828T3 (en) | 2017-01-05 | 2022-04-04 | Kahr Medical Ltd. | A sirp1 alpha-41bbl fusion protein and methods of use thereof |
| AU2018205888B2 (en) | 2017-01-05 | 2021-09-02 | Kahr Medical Ltd. | A PD1-41BBL fusion protein and methods of use thereof |
| TW201833140A (en) | 2017-01-09 | 2018-09-16 | 美商莫瑞麥克製藥公司 | Anti-fgfr antibodies and methods of use |
| WO2018136413A2 (en) | 2017-01-17 | 2018-07-26 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and event detection |
| JP7252526B2 (en) | 2017-01-23 | 2023-04-05 | スチョー アルファマブ カンパニー リミテッド | PD-L1 binding polypeptide or compound |
| WO2018140510A1 (en) | 2017-01-25 | 2018-08-02 | Biogen Ma Inc. | Compositions and methods for treatment of stroke and other cns disorders |
| JOP20190189A1 (en) | 2017-02-02 | 2019-08-01 | Amgen Res Munich Gmbh | Low ph pharmaceutical composition comprising t cell engaging antibody constructs |
| WO2018141234A1 (en) * | 2017-02-02 | 2018-08-09 | 黄国伦 | Pressurized gas injection device and method |
| GB201702144D0 (en) | 2017-02-09 | 2017-03-29 | Annexin Pharmaceuticals Ab | Therapeutic compositions |
| JP2020507632A (en) | 2017-02-10 | 2020-03-12 | マウント タム セラピューティクス, インコーポレイテッドMount Tam Therapeutics, Inc. | Rapamycin analog |
| SG11201906947SA (en) | 2017-02-17 | 2019-08-27 | Bristol Myers Squibb Co | Antibodies to alpha-synuclein and uses thereof |
| GB201703876D0 (en) | 2017-03-10 | 2017-04-26 | Berlin-Chemie Ag | Pharmaceutical combinations |
| WO2018170336A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Lipid nanoparticle formulation |
| RS63953B1 (en) | 2017-03-15 | 2023-02-28 | Modernatx Inc | Compound and compositions for intracellular delivery of therapeutic agents |
| WO2018175324A1 (en) | 2017-03-20 | 2018-09-27 | The Broad Institute, Inc. | Compounds and methods for regulating insulin secretion |
| BR112019020810A2 (en) | 2017-04-05 | 2020-04-28 | Biogen Ma Inc | tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof |
| TWI788340B (en) | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | Anti-icos agonist antibodies and uses thereof |
| TWI796329B (en) | 2017-04-07 | 2023-03-21 | 美商默沙東有限責任公司 | Anti-ilt4 antibodies and antigen-binding fragments |
| SG11201908813QA (en) | 2017-04-13 | 2019-10-30 | Aduro Biotech Holdings Europe B V | Anti-sirp alpha antibodies |
| AR111773A1 (en) | 2017-05-05 | 2019-08-21 | Amgen Inc | PHARMACEUTICAL COMPOSITION THAT INCLUDES CONSTRUCTS OF BISPECTIFIC ANTIBODIES FOR STORAGE AND ADMINISTRATION |
| US20200157192A1 (en) | 2017-05-10 | 2020-05-21 | Albajuna Therapeutics, S.L. | Fc-fusion protein derivatives with high dual hiv antiviral and immunomodulatory activity |
| CN111094335B (en) | 2017-05-15 | 2022-08-23 | 罗切斯特大学 | Broadly neutralizing anti-influenza monoclonal antibodies and uses thereof |
| CN116333129A (en) | 2017-05-25 | 2023-06-27 | 百时美施贵宝公司 | Antibodies comprising modified heavy chain constant regions |
| WO2018232120A1 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| WO2018237153A1 (en) | 2017-06-23 | 2018-12-27 | Bristol-Myers Squibb Company | Immunomodulators acting as antagonists of pd-1 |
| BR112019027387A8 (en) | 2017-06-23 | 2022-12-06 | Univ Maryland | IMMUNOGENIC COMPOSITIONS |
| WO2018233333A1 (en) | 2017-06-23 | 2018-12-27 | 苏州博聚华生物医药科技有限公司 | Monoclonal antibody of targeted human tumor stem cells and application of monoclonal antibody |
| WO2019013789A1 (en) | 2017-07-12 | 2019-01-17 | Curza Global, Llc | Antimicrobial compounds |
| WO2019013790A1 (en) | 2017-07-12 | 2019-01-17 | Curza Global, Llc | Antimicrobial compounds and uses thereof |
| WO2019040608A1 (en) | 2017-08-22 | 2019-02-28 | Biogen Ma Inc. | Pharmaceutical compositions and dosage regimens containing anti-alpha(v)beta(6) antibodies |
| WO2019046126A1 (en) | 2017-08-28 | 2019-03-07 | Achaogen, Inc. | Aminoglycosides and uses thereof |
| CA3073211A1 (en) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| EP3678699A1 (en) | 2017-09-07 | 2020-07-15 | University Of Oslo | Vaccine molecules |
| US20220118076A1 (en) | 2017-09-07 | 2022-04-21 | University Of Oslo | Vaccine molecules |
| JP7257393B2 (en) | 2017-10-03 | 2023-04-13 | ブリストル－マイヤーズ スクイブ カンパニー | Immunomodulator |
| CA3076630A1 (en) | 2017-10-04 | 2019-04-11 | Amgen Inc. | Transthyretin immunoglobulin fusions |
| WO2019075090A1 (en) | 2017-10-10 | 2019-04-18 | Tilos Therapeutics, Inc. | Anti-lap antibodies and uses thereof |
| WO2019075167A1 (en) | 2017-10-11 | 2019-04-18 | Greenlight Biosciences, Inc. | Methods and compositions for nucleoside triphosphate and ribonucleic acid production |
| CN117106096A (en) | 2017-10-26 | 2023-11-24 | 盛禾(中国)生物制药有限公司 | Novel recombinant fusion proteins, their preparation and use |
| CN111542544A (en) | 2017-11-01 | 2020-08-14 | 百时美施贵宝公司 | Immunostimulatory antibodies for the treatment of cancer |
| EP3703739A2 (en) | 2017-11-03 | 2020-09-09 | Takeda Vaccines, Inc. | Zika vaccines and immunogenic compositions, and methods of using the same |
| EP3710479A2 (en) | 2017-11-17 | 2020-09-23 | Merck Sharp & Dohme Corp. | Antibodies specific for immunoglobulin-like transcript 3 (ilt3) and uses thereof |
| WO2019109079A1 (en) | 2017-12-01 | 2019-06-06 | North Carolina State University | Fibrin particles and methods of making the same |
| JP7344206B2 (en) | 2017-12-11 | 2023-09-13 | アムジェン インコーポレイテッド | Continuous manufacturing process for bispecific antibody products |
| JP2021507944A (en) | 2017-12-21 | 2021-02-25 | グリアファーム エスエー | Compositions and treatments for neuropathy, including motor neuron disease |
| GB201721576D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | Hla antigens and glycoconjugates thereof |
| EP3728201A1 (en) | 2017-12-21 | 2020-10-28 | Gliapharm SA | Compositions and methods of treatment for neurological disorders comprising a dementia |
| GB201721582D0 (en) | 2017-12-21 | 2018-02-07 | Glaxosmithkline Biologicals Sa | S aureus antigens and immunogenic compositions |
| KR20200103761A (en) | 2017-12-27 | 2020-09-02 | 브리스톨-마이어스 스큅 컴퍼니 | Anti-CD40 antibody and uses thereof |
| TW201940518A (en) | 2017-12-29 | 2019-10-16 | 美商安進公司 | Bispecific antibody construct directed to MUC17 and CD3 |
| CN111886255A (en) | 2018-01-12 | 2020-11-03 | 百时美施贵宝公司 | anti-TIM 3 antibodies and uses thereof |
| WO2019148412A1 (en) | 2018-02-01 | 2019-08-08 | Merck Sharp & Dohme Corp. | Anti-pd-1/lag3 bispecific antibodies |
| EP3746477A1 (en) | 2018-02-02 | 2020-12-09 | Bio-Techne Corporation | Compounds that modulate the interaction of vista and vsig3 and methods of making and using |
| AU2019216759A1 (en) | 2018-02-08 | 2020-08-06 | Amgen Inc. | Low pH pharmaceutical antibody formulation |
| NL2020520B1 (en) | 2018-03-02 | 2019-09-12 | Labo Bio Medical Invest B V | Multispecific binding molecules for the prevention, treatment and diagnosis of neurodegenerative disorders |
| US20210363172A1 (en) | 2018-03-15 | 2021-11-25 | Biontech Rna Pharmaceuticals Gmbh | 5'-cap-trinucleotide- or higher oligonucleotide compounds and their use in stabilizing rna, expressing proteins in therapy |
| TW202003565A (en) | 2018-03-23 | 2020-01-16 | 美商必治妥美雅史谷比公司 | Antibodies against MICA and/or MICB and uses thereof |
| JOP20200240A1 (en) | 2018-04-02 | 2020-09-27 | Bristol Myers Squibb Co | Anti-trem-1 antibodies and uses thereof reference to sequence listing submitted electronically via efs-web |
| WO2019194858A1 (en) | 2018-04-03 | 2019-10-10 | Achaogen, Inc. | Modular synthesis of aminoglycosides |
| WO2019195756A1 (en) | 2018-04-06 | 2019-10-10 | Rhythm Pharmaceuticals, Inc. | Compositions for treating kidney disease |
| KR20200142542A (en) | 2018-04-12 | 2020-12-22 | 브리스톨-마이어스 스큅 컴퍼니 | Anticancer combination therapy with CD73 antagonist antibody and PD-1/PD-L1 axis antagonist antibody |
| MX2020010913A (en) | 2018-04-17 | 2021-01-08 | Celldex Therapeutics Inc | Anti-cd27 and anti-pd-l1 antibodies and bispecific constructs. |
| US20210179602A1 (en) | 2018-04-20 | 2021-06-17 | Iomx Therapeutics Ag | A 5-thiazolecarboxamide kinase inhibitor and uses thereof |
| JP7402541B2 (en) | 2018-05-03 | 2023-12-21 | ユニバーシティ オブ ロチェスター | Anti-influenza neuraminidase monoclonal antibody and its use |
| PE20211598A1 (en) | 2018-05-25 | 2021-08-18 | Primmune Therapeutics Inc | TLR7 AGONISTS |
| WO2019236417A1 (en) | 2018-06-04 | 2019-12-12 | Biogen Ma Inc. | Anti-vla-4 antibodies having reduced effector function |
| GB201809746D0 (en) | 2018-06-14 | 2018-08-01 | Berlin Chemie Ag | Pharmaceutical combinations |
| US11241417B2 (en) | 2018-06-21 | 2022-02-08 | Yumanity Therapeutics, Inc. | Compositions and methods for the treatment and prevention of neurological disorders |
| CA3104780A1 (en) | 2018-07-11 | 2020-01-16 | Kahr Medical Ltd. | Sirpalpha-4-1bbl variant fusion protein and methods of use thereof |
| WO2020018433A1 (en) | 2018-07-16 | 2020-01-23 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and compliance detection |
| JP2021532140A (en) | 2018-07-30 | 2021-11-25 | アムジェン リサーチ （ミュニック） ゲゼルシャフト ミット ベシュレンクテル ハフツング | Long-term administration of bispecific antibody constructs that bind to CD33 and CD3 |
| AU2019316164A1 (en) | 2018-07-31 | 2021-01-21 | Amgen Inc. | Dosing regimen for BCMA-CD3 bispecific antibodies |
| WO2020028401A1 (en) | 2018-07-31 | 2020-02-06 | Amgen Inc. | Pharmaceutical formulations of masked antibodies |
| KR20210042117A (en) | 2018-08-03 | 2021-04-16 | 암젠 리서치 (뮌헨) 게엠베하 | Antibody constructs against CLDN18.2 and CD3 |
| CN112533954A (en) | 2018-08-08 | 2021-03-19 | 宜明昂科生物医药技术（上海）有限公司 | Recombinant bifunctional protein targeting CD47 and HER2 |
| WO2020049208A1 (en) | 2018-09-09 | 2020-03-12 | Fundacio Privada Institut De Recerca De La Sida - Caixa | Aurora kinase as target for treating, preventing or curing hiv infection or aids |
| AU2019342017A1 (en) | 2018-09-18 | 2021-05-13 | Merrimack Pharmaceuticals, Inc. | Anti-TNFR2 antibodies and uses thereof |
| US20220409536A1 (en) | 2018-09-19 | 2022-12-29 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| EP3852728A1 (en) | 2018-09-20 | 2021-07-28 | Modernatx, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| WO2020076969A2 (en) | 2018-10-10 | 2020-04-16 | Tilos Therapeutics, Inc. | Anti-lap antibody variants and uses thereof |
| SG11202103275YA (en) | 2018-10-11 | 2021-04-29 | Amgen Inc | Downstream processing of bispecific antibody constructs |
| WO2020084005A1 (en) | 2018-10-23 | 2020-04-30 | Myelopro Diagnostics And Research Gmbh | Compounds targeting mutant calreticulin |
| EP3643713A1 (en) | 2018-10-23 | 2020-04-29 | iOmx Therapeutics AG | Heterocyclic kinase inhibitors and uses thereof |
| EP3876989A4 (en) | 2018-11-09 | 2022-12-07 | University of Massachusetts | Anti-cfae antibodies and methods of use |
| PE20211284A1 (en) | 2018-11-16 | 2021-07-19 | Bristol Myers Squibb Co | ANTI-NKG2A ANTIBODIES AND USES OF THEM |
| WO2020112781A1 (en) | 2018-11-28 | 2020-06-04 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
| US20220098310A1 (en) | 2018-12-06 | 2022-03-31 | Alexion Pharmaceuticals, Inc. | Anti-alk2 antibodies and uses thereof |
| KR20210104744A (en) | 2018-12-18 | 2021-08-25 | 리제너론 파마슈티칼스 인코포레이티드 | Compositions and methods for improving body weight and lean muscle mass using antagonists for the leptin receptor, GDF8 and activin A |
| WO2020128863A1 (en) | 2018-12-19 | 2020-06-25 | Novartis Ag | Anti-tnf-alpha antibodies |
| WO2020132378A2 (en) | 2018-12-22 | 2020-06-25 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising depression |
| WO2020144535A1 (en) | 2019-01-08 | 2020-07-16 | Aduro Biotech Holdings, Europe B.V. | Methods and compositions for treatment of multiple myeloma |
| WO2020150372A1 (en) | 2019-01-16 | 2020-07-23 | Curza Global, Llc | Antimicrobial compounds and methods |
| AU2020209170A1 (en) | 2019-01-16 | 2021-08-12 | Curza Global, Llc | Antimicrobial compounds and methods |
| CN109762067B (en) | 2019-01-17 | 2020-02-28 | 北京天广实生物技术股份有限公司 | Antibodies that bind human Claudin18.2 and uses thereof |
| EP3914622A1 (en) | 2019-01-22 | 2021-12-01 | Bristol-Myers Squibb Company | Antibodies against il-7r alpha subunit and uses thereof |
| KR20210118881A (en) | 2019-01-22 | 2021-10-01 | 제넨테크, 인크. | Immunoglobulin A Antibodies and Methods of Production and Use |
| CA3127448A1 (en) | 2019-01-22 | 2020-07-30 | Aeovian Pharmaceuticals, Inc. | Mtorc modulators and uses thereof |
| CA3128215A1 (en) | 2019-01-31 | 2020-08-06 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| WO2020168466A1 (en) | 2019-02-19 | 2020-08-27 | Stemirna Therapeutics Co., Ltd. | Modified nucleoside and synthetic methods thereof |
| CN113874083A (en) | 2019-03-01 | 2021-12-31 | 梅里麦克制药股份有限公司 | anti-TNFR 2 antibodies and uses thereof |
| TW202103732A (en) | 2019-03-11 | 2021-02-01 | 美商百健Ｍａ公司 | Pharmaceutical compositions containing anti-lingo-1 antibodies |
| AU2020248404A1 (en) | 2019-03-25 | 2021-09-30 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| KR20220005471A (en) | 2019-04-08 | 2022-01-13 | 바이오젠 엠에이 인코포레이티드 | Anti-integrin antibodies and uses thereof |
| US20220251141A1 (en) | 2019-05-21 | 2022-08-11 | Bristol-Myers Squibb Company | Immunomodulators |
| EA202192810A1 (en) | 2019-06-11 | 2022-03-05 | Регенерон Фармасьютикалз, Инк. | ANTIBODIES TO PcrV THAT BIND PcrV, COMPOSITIONS CONTAINING ANTIBODIES TO PcrV AND METHODS OF THEIR APPLICATION |
| TW202045711A (en) | 2019-06-13 | 2020-12-16 | 美商安進公司 | Automated biomass-based perfusion control in the manufacturing of biologics |
| KR20220032065A (en) | 2019-07-08 | 2022-03-15 | 암젠 인크 | Multispecific Transtyretin Immunoglobulin Fusion |
| WO2021005599A1 (en) | 2019-07-11 | 2021-01-14 | Kahr Medical Ltd. | Heterodimers and methods of use thereof |
| CN114174536A (en) | 2019-07-15 | 2022-03-11 | 百时美施贵宝公司 | anti-TREM-1 antibodies and uses thereof |
| EP3999539A1 (en) | 2019-07-15 | 2022-05-25 | Intervet International B.V. | Caninized antibodies to human and canine ctla-4 |
| CN114144435A (en) | 2019-07-15 | 2022-03-04 | 百时美施贵宝公司 | Antibodies against human TREM-1 and uses thereof |
| CN114174337A (en) | 2019-07-15 | 2022-03-11 | 英特维特国际股份有限公司 | Caninized antibodies against canine CTLA-4 |
| CN114728050A (en) | 2019-07-31 | 2022-07-08 | 圣诺菲·帕斯图尔公司 | Multivalent pneumococcal polysaccharide-protein conjugate compositions and methods of use thereof |
| US20220280639A1 (en) | 2019-07-31 | 2022-09-08 | Modernatx, Inc. | Compositions and methods for delivery of rna interference agents to immune cells |
| EP4009936A4 (en) | 2019-08-09 | 2023-08-09 | Kaleo, Inc. | Devices and methods for delivery of substances within a prefilled syringe |
| CR20220111A (en) | 2019-08-13 | 2022-05-04 | Amgen Inc | Interleukin-2 muteins for the expansion of t-regulatory cells |
| WO2021050970A1 (en) | 2019-09-13 | 2021-03-18 | Rutgers, The State University Of New Jersey | Aav-compatible laminin-linker polymerization proteins |
| KR20220088868A (en) | 2019-10-30 | 2022-06-28 | 브리스톨-마이어스 스큅 컴퍼니 | immunomodulators |
| EP3819007A1 (en) | 2019-11-11 | 2021-05-12 | Amgen Research (Munich) GmbH | Dosing regimen for anti-bcma agents |
| EP4058485A1 (en) | 2019-11-13 | 2022-09-21 | Amgen Inc. | Method for reduced aggregate formation in downstream processing of bispecific antigen-binding molecules |
| WO2021097061A1 (en) | 2019-11-13 | 2021-05-20 | Curza Global, Llc | Antimicrobial compounds and methods |
| KR20220100950A (en) | 2019-11-19 | 2022-07-18 | 브리스톨-마이어스 스큅 컴퍼니 | Macrocyclic Peptides as PD-L1 Inhibitors and Immunomodulators for the Treatment of Cancer and Infectious Diseases |
| CN115551885A (en) | 2019-12-11 | 2022-12-30 | 威特拉公司 | Compositions and methods for treating and preventing influenza |
| AU2020407208A1 (en) | 2019-12-17 | 2022-06-02 | Amgen Inc. | Dual interleukin-2 /tnf receptor agonist for use in therapy |
| CN114929746A (en) | 2019-12-20 | 2022-08-19 | 英特维特国际股份有限公司 | Canine interleukin-4 receptor alpha antibodies |
| US11926672B2 (en) | 2019-12-20 | 2024-03-12 | Amgen Inc. | Mesothelin-targeted CD40 agonistic multispecific antibody constructs for the treatment of solid tumors |
| BR112022011629A2 (en) | 2019-12-20 | 2022-09-13 | Intervet Int Bv | CANINIZED BISPECIFIC ANTIBODIES TO TREAT ATOPIC DERMATITIS |
| US20230063238A1 (en) | 2020-01-06 | 2023-03-02 | Bristol-Myers Squibb Company | Immunomodulators |
| WO2021141684A1 (en) | 2020-01-06 | 2021-07-15 | Bristol-Myers Squibb Company | Immunomodulators |
| CN110818795B (en) | 2020-01-10 | 2020-04-24 | 上海复宏汉霖生物技术股份有限公司 | anti-TIGIT antibodies and methods of use |
| EP4093771A1 (en) | 2020-01-22 | 2022-11-30 | Amgen Research (Munich) GmbH | Combinations of antibody constructs and inhibitors of cytokine release syndrome and uses thereof |
| US20230285297A1 (en) | 2020-01-31 | 2023-09-14 | Modernatx, Inc. | Methods of preparing lipid nanoparticles |
| AU2021228061A1 (en) | 2020-02-27 | 2022-10-13 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Antibodies binding IL4R and uses thereof |
| WO2021173965A1 (en) | 2020-02-28 | 2021-09-02 | Massachusetts Institute Of Technology | Identification of variable influenza residues and uses thereof |
| US20230140384A1 (en) | 2020-03-09 | 2023-05-04 | Bristol-Myers Squibb Company | Antibodies to cd40 with enhanced agonist activity |
| JP2023517736A (en) | 2020-03-16 | 2023-04-26 | ブリストル－マイヤーズ スクイブ カンパニー | Immunomodulator |
| MX2022011632A (en) | 2020-03-19 | 2022-10-13 | Amgen Inc | Antibodies against mucin 17 and uses thereof. |
| EP4126902B1 (en) | 2020-03-30 | 2023-12-06 | Bristol-Myers Squibb Company | Immunomodulators |
| CA3170570A1 (en) | 2020-04-01 | 2021-10-07 | James J. KOBIE | Monoclonal antibodies against the hemagglutinin (ha) and neuraminidase (na) of influenza h3n2 viruses |
| EP4132971A1 (en) | 2020-04-09 | 2023-02-15 | Merck Sharp & Dohme LLC | Affinity matured anti-lap antibodies and uses thereof |
| EP3901151A1 (en) | 2020-04-21 | 2021-10-27 | iOmx Therapeutics AG | Halogenated-heteroaryl and other heterocyclic kinase inhibitors, and uses thereof |
| US11834485B2 (en) | 2020-04-21 | 2023-12-05 | Regeneron Pharmaceuticals, Inc. | IL-2 variants with reduced binding to IL-2 receptor alpha and uses thereof |
| WO2021219731A2 (en) | 2020-04-28 | 2021-11-04 | Iomx Therapeutics Ag | Bicyclic kinase inhibitors and uses thereof |
| WO2021222935A2 (en) | 2020-04-28 | 2021-11-04 | The Rockefeller University | Neutralizing anti-sars-cov-2 antibodies and methods of use thereof |
| EP4142789A1 (en) | 2020-04-29 | 2023-03-08 | Amgen Inc. | Pharmaceutical formulation |
| CN115484980A (en) | 2020-04-29 | 2022-12-16 | 安进公司 | Pharmaceutical formulations |
| EP4143227A2 (en) | 2020-04-30 | 2023-03-08 | Sairopa B.V. | Anti-cd103 antibodies |
| WO2021226460A1 (en) | 2020-05-08 | 2021-11-11 | Bristol-Myers Squibb Company | Immunomodulators |
| WO2021231729A1 (en) | 2020-05-13 | 2021-11-18 | Sanofi | Adjuvanted stabilized stem hemagglutinin nanoparticles and methods of using the same to induce broadly neutralizing antibodies against influenza |
| US20230192867A1 (en) | 2020-05-15 | 2023-06-22 | Bristol-Myers Squibb Company | Antibodies to garp |
| AU2021275049A1 (en) | 2020-05-19 | 2022-12-22 | Amgen Inc. | MAGEB2 binding constructs |
| US20230277524A1 (en) | 2020-05-22 | 2023-09-07 | Trailhead Biosystems Inc. | Combination therapy for treatment of viral infections |
| JP2023527972A (en) | 2020-05-29 | 2023-07-03 | アムジエン・インコーポレーテツド | Reduced Adverse Effect Administration of Bispecific Constructs that Bind CD33 and CD3 |
| WO2021252708A1 (en) | 2020-06-11 | 2021-12-16 | President And Fellows Of Harvard College | Stabilized trioxacarcin antibody drug conjugates and uses thereof |
| FR3112939B1 (en) | 2020-07-31 | 2024-01-05 | Univ Montpellier | Universal cell therapy product and its use |
| CN116419747A (en) | 2020-08-07 | 2023-07-11 | 福蒂斯治疗公司 | CD46 targeting immunoconjugates and methods of use thereof |
| EP4200333A1 (en) | 2020-08-24 | 2023-06-28 | Amgen Inc. | Pharmaceutical formulation comprising a bite, bispecific antibody, and methionine |
| CN116322735A (en) | 2020-10-02 | 2023-06-23 | 百时美施贵宝公司 | Macrocyclic peptide borate immunomodulators |
| JP2023546020A (en) | 2020-10-08 | 2023-11-01 | ブリストル－マイヤーズ スクイブ カンパニー | Novel dimeric immunomodulator |
| WO2022076796A1 (en) | 2020-10-09 | 2022-04-14 | Bristol-Myers Squibb Company | Macrocyclic immunomodulators |
| MX2023004439A (en) | 2020-10-15 | 2023-05-08 | Intervet Int Bv | CANINIZED ANTIBODIES TO CANINE INTERLEUKIN-31 RECEPTOR <i>ALPHA. |
| CN116710116A (en) | 2020-10-30 | 2023-09-05 | Ｘｅｎｏ－Ｉｎｔｅｒｆａｃｅ株式会社 | Beta-sheet femoral bridge peptide |
| US20230390296A1 (en) | 2020-10-30 | 2023-12-07 | Keio University | Novel treatment and prevention of sarcopenia-related diseases |
| JP2023548878A (en) | 2020-11-04 | 2023-11-21 | ザ ロックフェラー ユニバーシティー | Neutralizing anti-SARS-COV-2 antibody |
| AU2021374036A1 (en) | 2020-11-06 | 2023-06-08 | Amgen Inc. | Polypeptide constructs selectively binding to cldn6 and cd3 |
| WO2022096698A1 (en) | 2020-11-06 | 2022-05-12 | Amgen Inc. | Polypeptide constructs binding to cd3 |
| KR20230104256A (en) | 2020-11-06 | 2023-07-07 | 암젠 인크 | Multitargeting bispecific antigen binding molecules of increased selectivity |
| WO2022096704A1 (en) | 2020-11-06 | 2022-05-12 | Amgen Inc. | Antigen binding domain with reduced clipping rate |
| WO2022103781A1 (en) | 2020-11-10 | 2022-05-19 | Amgen Inc. | Methods for administering a bcma x cd3 binding molecule |
| KR20230107281A (en) | 2020-11-11 | 2023-07-14 | 비온테크 에스이 | Monoclonal Antibodies to Programmed Death-1 Protein and Uses in Medicine |
| TW202237068A (en) | 2020-12-09 | 2022-10-01 | 美商建南德克公司 | High-throughput methods for preparing lipid nanoparticles and uses thereof |
| CN114685669A (en) | 2020-12-30 | 2022-07-01 | 和铂医药(苏州)有限公司 | Antibodies that bind TROP2 and uses thereof |
| WO2022155324A1 (en) | 2021-01-15 | 2022-07-21 | The Rockefeller University | Neutralizing anti-sars-cov-2 antibodies |
| WO2022192176A1 (en) | 2021-03-09 | 2022-09-15 | Massachusetts Institute Of Technology | Branched poly(-amino esters) for the delivery of nucleic acids |
| AU2022232523A1 (en) | 2021-03-12 | 2023-11-16 | Bristol-Myers Squibb Company | Kras g12d inhibitors |
| CA3210383A1 (en) | 2021-03-12 | 2022-09-15 | Bristol-Myers Squibb Company | Kras inhibitors |
| CN117157306A (en) | 2021-03-24 | 2023-12-01 | 百时美施贵宝公司 | Immunomodulators |
| EP4320159A1 (en) | 2021-04-09 | 2024-02-14 | Celldex Therapeutics, Inc. | Antibodies against ilt4, bispecific anti-ilt4/pd-l1 antibody and uses thereof |
| EP4323380A2 (en) | 2021-04-12 | 2024-02-21 | Bristol-Myers Squibb Company | Cyclic peptide immunomodulators |
| EP4334358A1 (en) | 2021-05-06 | 2024-03-13 | Amgen Research (Munich) GmbH | Cd20 and cd22 targeting antigen-binding molecules for use in proliferative diseases |
| EP4333805A1 (en) | 2021-05-06 | 2024-03-13 | Amgen Inc. | Etelcalcetide formulations |
| EP4334343A2 (en) | 2021-05-06 | 2024-03-13 | The Rockefeller University | Neutralizing anti-sars- cov-2 antibodies and methods of use thereof |
| KR20240017813A (en) | 2021-05-10 | 2024-02-08 | 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. | Pharmaceutical composition for treating neurological diseases |
| KR20240013732A (en) | 2021-05-26 | 2024-01-30 | 옥스포드 바이오테라퓨틱스 리미티드 | Pharmaceutical combination comprising an anti-CD205 antibody and an immune checkpoint inhibitor |
| TW202313065A (en) | 2021-05-28 | 2023-04-01 | 美商季卡尼醫療公司 | Compounds for treating genetic diseases |
| EP4351553A1 (en) | 2021-06-09 | 2024-04-17 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH | Novel anti-fibrotic drugs |
| CN117425666A (en) | 2021-06-09 | 2024-01-19 | 百时美施贵宝公司 | Cyclic peptide immunomodulators |
| WO2023278585A1 (en) | 2021-06-30 | 2023-01-05 | Amgen Inc. | Method of reconstituting lyophilized formulation |
| WO2023288213A1 (en) | 2021-07-12 | 2023-01-19 | Bristol-Myers Squibb Company | Macrocyclic immunomodulators |
| KR20240035843A (en) | 2021-07-19 | 2024-03-18 | 브리스톨-마이어스 스큅 컴퍼니 | Macrocyclic immunomodulators |
| WO2023004344A1 (en) | 2021-07-20 | 2023-01-26 | Regeneron Pharmaceuticals, Inc. | Butyrophilin-like 2 for treating inflammatory disorders |
| WO2023018817A1 (en) | 2021-08-11 | 2023-02-16 | Sanofi Pasteur Inc. | Truncated influenza neuraminidase and methods of using the same |
| CA3227716A1 (en) | 2021-08-20 | 2023-02-23 | Intervet International B.V. | Antibodies and igg fusion proteins with an extended half-life |
| WO2023021170A2 (en) | 2021-08-20 | 2023-02-23 | Intervet International B.V. | Fusion proteins for treating atopic dermatitis |
| WO2023039108A1 (en) | 2021-09-08 | 2023-03-16 | Affinivax, Inc. | Coronavirus vaccine |
| CN113773401B (en) | 2021-09-15 | 2023-06-20 | 宜明昂科生物医药技术（上海）股份有限公司 | Recombinant fusion protein targeting CD47 and PD-L1 and preparation and application thereof |
| WO2023059857A1 (en) | 2021-10-08 | 2023-04-13 | Sanofi Pasteur Inc. | Multivalent influenza vaccines |
| CN113831412B (en) | 2021-10-13 | 2023-06-20 | 宜明昂科生物医药技术（上海）股份有限公司 | Antibodies targeting CD24, their preparation and use |
| CN113754769B (en) | 2021-10-13 | 2023-06-06 | 宜明昂科生物医药技术（上海）股份有限公司 | CD 70-targeting antibodies, their preparation and use |
| CN113956363B (en) | 2021-10-13 | 2023-03-31 | 宜明昂科生物医药技术（上海）股份有限公司 | Recombinant fusion protein targeting CD47 and CD24 and preparation and application thereof |
| WO2023069994A1 (en) | 2021-10-20 | 2023-04-27 | Bristol-Myers Squibb Company | Immunomodulators |
| TW202334221A (en) | 2021-11-03 | 2023-09-01 | 德商安富美德有限公司 | Bispecific cd16a binders |
| WO2023079493A1 (en) | 2021-11-03 | 2023-05-11 | Affimed Gmbh | Bispecific cd16a binders |
| WO2023079113A1 (en) | 2021-11-05 | 2023-05-11 | Sanofi | Hybrid multivalent influenza vaccines comprising hemagglutinin and neuraminidase and methods of using the same |
| WO2023081798A1 (en) | 2021-11-05 | 2023-05-11 | Sanofi Pasteur Inc. | Multivalent influenza vaccines comprising recombinant hemagglutinin and neuraminidase and methods of using the same |
| WO2023077521A1 (en) | 2021-11-08 | 2023-05-11 | Celldex Therapeutics, Inc | Anti-ilt4 and anti-pd-1 bispecific constructs |
| WO2023089314A1 (en) | 2021-11-18 | 2023-05-25 | Oxford Biotherapeutics Limited | Pharmaceutical combinations |
| WO2023096904A2 (en) | 2021-11-24 | 2023-06-01 | President And Fellows Of Harvard College | C-16 modified trioxacarcins, antibody drug conjugates, and uses thereof |
| WO2023102507A1 (en) | 2021-12-03 | 2023-06-08 | Bristol-Myers Squibb Company | Macrocyclic immunomodulators |
| WO2023105281A1 (en) | 2021-12-11 | 2023-06-15 | Fundaciò Privada Institut De Recerca De La Sida-Caixa | Soluble tigit recombinant proteins |
| TW202334405A (en) | 2021-12-15 | 2023-09-01 | 美商英特瑞斯生物療法公司 | Pseudotyped viral particles, compositions comprising the same, and uses thereof |
| WO2023111148A1 (en) | 2021-12-16 | 2023-06-22 | Intervet International B.V. | Caninized antibodies to canine interleukin-31 receptor alpha 1 |
| WO2023111153A1 (en) | 2021-12-16 | 2023-06-22 | Intervet International B.V. | Caninized antibodies to human ngf |
| TW202333654A (en) | 2021-12-16 | 2023-09-01 | 美商現代公司 | Processes for preparing lipid nanoparticles |
| WO2023129963A1 (en) | 2021-12-30 | 2023-07-06 | Curza Global, Llc | Antimicrobial compounds and methods |
| WO2023147399A1 (en) | 2022-01-27 | 2023-08-03 | The Rockefeller University | Broadly neutralizing anti-sars-cov-2 antibodies targeting the n-terminal domain of the spike protein and methods of use thereof |
| WO2023144206A1 (en) | 2022-01-27 | 2023-08-03 | Sanofi Pasteur | Modified vero cells and methods of using the same for virus production |
| WO2023166488A1 (en) | 2022-03-04 | 2023-09-07 | Revagenix, Inc. | Broad spectrum aminoglycosides and uses thereof |
| WO2023177579A1 (en) | 2022-03-14 | 2023-09-21 | Sanofi Pasteur Inc. | Machine-learning techniques in protein design for vaccine generation |
| WO2023175171A1 (en) | 2022-03-18 | 2023-09-21 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Bk polyomavirus antibodies and uses thereof |
| WO2023192873A1 (en) | 2022-03-28 | 2023-10-05 | Bristol-Myers Squibb Company | Macrocyclic immunomodulators |
| WO2023193002A1 (en) | 2022-04-01 | 2023-10-05 | Modernatx, Inc. | Cross mixers for lipid nanoparticle production, and methods of operating the same |
| EP4257132A1 (en) | 2022-04-08 | 2023-10-11 | iOmx Therapeutics AG | Sik3 inhibitors for treating diseases resistant to death receptor signalling |
| EP4257609A1 (en) | 2022-04-08 | 2023-10-11 | iOmx Therapeutics AG | Combination therapies based on pd-1 inhibitors and sik3 inhibitors |
| WO2023212559A1 (en) | 2022-04-26 | 2023-11-02 | Amgen Inc. | Lyophilization method |
| US11932693B2 (en) | 2022-05-12 | 2024-03-19 | BioNTech SE | Monoclonal antibodies directed against programmed death-1 protein and their use in medicine |
| TW202346368A (en) | 2022-05-12 | 2023-12-01 | 德商安美基研究（慕尼黑）公司 | Multichain multitargeting bispecific antigen-binding molecules of increased selectivity |
| GB202207263D0 (en) | 2022-05-18 | 2022-06-29 | Annexin Pharmaceuticals Ab | Therapeutic compositions |
| WO2023225661A1 (en) | 2022-05-20 | 2023-11-23 | Bristol-Myers Squibb Company | Macrocyclic immunomodulators |
| WO2023235380A1 (en) | 2022-06-01 | 2023-12-07 | Zikani Therapeutics, Inc. | Macrolides for treating genetic diseases |
| US20240067662A1 (en) | 2022-06-10 | 2024-02-29 | Bristol-Myers Squibb Company | Kras inhibitors |
| WO2023240189A1 (en) | 2022-06-10 | 2023-12-14 | Bristol-Myers Squibb Company | Tetrahydropyrido 3,4-d pyrimidine derivatives as kras inhibitors |
| WO2023250513A1 (en) | 2022-06-24 | 2023-12-28 | Zikani Therapeutics, Inc. | 13-membered macrolide compounds for treating diseases mediated by abnormal protein translation |
| WO2024026475A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Compositions for delivery to hematopoietic stem and progenitor cells (hspcs) and related uses |
| WO2024026482A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Lipid nanoparticle compositions comprising surface lipid derivatives and related uses |
| WO2024026487A1 (en) | 2022-07-29 | 2024-02-01 | Modernatx, Inc. | Lipid nanoparticle compositions comprising phospholipid derivatives and related uses |
| WO2024036270A1 (en) | 2022-08-11 | 2024-02-15 | Bristol-Myers Squibb Company | Kras inhibitors |
| WO2024040109A2 (en) | 2022-08-16 | 2024-02-22 | Bristol-Myers Squibb Company | Kras inhibitors |
| WO2024049994A1 (en) | 2022-09-01 | 2024-03-07 | Zikani Therapeutics, Inc. | Treatment of familial adenomatous polyopsis using a 13-membered macrolide |
| WO2024054926A1 (en) | 2022-09-07 | 2024-03-14 | Bristol-Myers Squibb Company | Kras g12d inhibitors |
| WO2024059472A1 (en) | 2022-09-12 | 2024-03-21 | Bristol-Myers Squibb Company | Macrocyclic immunomodulators |
| WO2024059675A2 (en) | 2022-09-14 | 2024-03-21 | Amgen Inc. | Bispecific molecule stabilizing composition |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2737946A (en) * | 1949-09-01 | 1956-03-13 | Jr George N Hein | Hypodermic injection apparatus |
| US2764977A (en) * | 1951-05-24 | 1956-10-02 | Becton Dickinson Co | Hypodermic injection mechanism |
| US3115133A (en) * | 1962-05-15 | 1963-12-24 | Morando Emilio Donald | Needleless prefilled disposable hypodermic injector |
| US3403679A (en) * | 1964-12-11 | 1968-10-01 | Secr Defence Brit | Hypodermic injection apparatus with a secondary capsule-collapsing means |
| US3688765A (en) * | 1969-10-03 | 1972-09-05 | Jack S Gasaway | Hypodermic injection device |
| US3695266A (en) * | 1970-06-18 | 1972-10-03 | Maurice G Lussier | Needleless sequential dosing syringe |
| US3853125A (en) * | 1971-10-05 | 1974-12-10 | W Clark | Disposable needleless injector |
| US3802430A (en) * | 1972-06-30 | 1974-04-09 | L Arnold | Disposable pyrotechnically powered injector |
| US4089334A (en) * | 1976-10-07 | 1978-05-16 | Schwebel Paul R | Pyrotechnically powered needleless injector |
| US4329988A (en) * | 1980-12-23 | 1982-05-18 | Survival Technology, Inc. | Plural injection assembly |
| US4403989A (en) * | 1981-09-14 | 1983-09-13 | Syntex (U.S.A.) Inc. | Injection device |
-
1985
- 1985-03-25 US US06/715,930 patent/US4596556A/en not_active Expired - Fee Related
-
1986
- 1986-01-23 EP EP86300442A patent/EP0197625A1/en not_active Withdrawn
- 1986-01-23 CA CA000500154A patent/CA1232807A/en not_active Expired
- 1986-03-11 JP JP61051627A patent/JPS61268265A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS61268265A (en) | 1986-11-27 |
| EP0197625A1 (en) | 1986-10-15 |
| US4596556A (en) | 1986-06-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1232807A (en) | Hypodermic injection apparatus | |
| EP0404818B1 (en) | Disposable needleless injection system | |
| US11471603B2 (en) | Needle-free injector | |
| US5865795A (en) | Safety mechanism for injection devices | |
| USRE35986E (en) | Multiple chamber automatic injector | |
| US5041088A (en) | Multiple chamber automatic injector | |
| US5891086A (en) | Needle-less injector | |
| US3802430A (en) | Disposable pyrotechnically powered injector | |
| EP1877117B1 (en) | Needle-less injector | |
| US5073165A (en) | Hypodermic jet injector and cartridge therefor | |
| US20120302989A1 (en) | Two-stage reconstituting injector | |
| US5697917A (en) | Nozzle assembly with adjustable plunger travel gap | |
| WO1994009839A1 (en) | Automatic two-chamber injector | |
| JPH10512165A (en) | Medical infusion system with gas spring | |
| EP3481464B1 (en) | Drug delivery device with pneumatic power pack | |
| EP0956059A1 (en) | Nozzle assembly with adjustable plunger travel gap | |
| EP1596908A1 (en) | Needle-free mass injection device | |
| CA2368611A1 (en) | Hypodermic injection system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |