CA1272917A - Devices for administering medicaments to patients - Google Patents
Devices for administering medicaments to patientsInfo
- Publication number
- CA1272917A CA1272917A CA000514908A CA514908A CA1272917A CA 1272917 A CA1272917 A CA 1272917A CA 000514908 A CA000514908 A CA 000514908A CA 514908 A CA514908 A CA 514908A CA 1272917 A CA1272917 A CA 1272917A
- Authority
- CA
- Canada
- Prior art keywords
- container
- tray
- plunger
- housing
- support
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/0045—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters
- A61M15/0046—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier
- A61M15/0048—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using multiple prepacked dosages on a same carrier, e.g. blisters characterized by the type of carrier the dosages being arranged in a plane, e.g. on diskettes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
Abstract
ABSTRACT
Devices for administering medicaments to patients A device is provided for administering medicaments in solid finely divided form to patients. The device comprises a housing (1, 101), a tray (2, 102) mounted in the housing (1, 101) and movable between first and second positions relative to the housing, a support disc (3, 103) provided on the tray and adapted to receive a carrier (5) provided with at least one medicament container. A plunger (18, 118) is operable to penetrate a container registered therewith to open the container, movement of the tray (2, 102) from its first to its second position being such as to cause the support to bring a container into registration with the plunger (18, 118).
Air enters through an air inlet (17, 117), and there is an outlet (27,127) through which a patient can inhale air having medicament therein.
Devices for administering medicaments to patients A device is provided for administering medicaments in solid finely divided form to patients. The device comprises a housing (1, 101), a tray (2, 102) mounted in the housing (1, 101) and movable between first and second positions relative to the housing, a support disc (3, 103) provided on the tray and adapted to receive a carrier (5) provided with at least one medicament container. A plunger (18, 118) is operable to penetrate a container registered therewith to open the container, movement of the tray (2, 102) from its first to its second position being such as to cause the support to bring a container into registration with the plunger (18, 118).
Air enters through an air inlet (17, 117), and there is an outlet (27,127) through which a patient can inhale air having medicament therein.
Description
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Devices for Administering Medicarnents to Patients ~ his invention relates to devices by which a medicament in solid finely divided form can be administered to or by patients inhaling through the devices. Such devices are now quite well Isnown for administering medicaments contained in capsules to patients suffering from bronchial conditions such asj for examplej bronchial as-thma. It is well known for Medicament in powder or other finely divided form to be supplied in capsules which are loaded by a patient 10 into such a device. ~he medicament is then released from the capsule and inhaled by the patient, usually through the mouthj but sometimes through the nose.
~ he specification of PC~ Application Publication No. W082/01470j GB-A-1387954 and GB-A-2061735 all 15 describe devices for dispensing medicament in finely divided form from capsules. In each of these previously described devicesj the capsules are mounted on a rotat-able support member on which each capsule in turn can be brought to a position in which it is opened 20 to enable medicament to exit from the capsule to permit it to be inhaled by a patient inhaling through a mouthpiece of the devlce.
~ here are disadvantages in the use of capsules;
which~are made of gelatinj to contain medicaments.
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Gelatin is relatively unstable and is lacking in physical strength so that the capsules need to be pro-tected by packagingj for example in glass bottles.
Environmental degradation of both the capsules and their contents may occur in a re,latively short time.
In the device described in UK Patent Specification 13~7954 the capsules are ~ounted in what is referred to therein as a blister packj and is in fact a plurality of capsules mounted in a blister pack on a rotor which is designed to spin during exhalation by the patient to throw medicament out of an opened capsule whereafter the patient inhales. ~his has a number of disadvantages, including the fact that the exhalation which is required is more~difficult for some patlents;
fo~ example asthma patients~ than inhalation.
In our patent specification GB-A-2129691 we provided a more convenient way of administering medicament to such patients than had been possible hitherto and which avoided the need to pack medicaments in capsules. ~he device there described makes use of the technique of packaging a medicament by loading the medlcament directly lnto a blister pack comprising a sheetj~which may be laminated, of foil or plastics material which acts as a carrier and which is provided ; with a number of breakable or openable containers called "bllsters"~incorporatlng a sheet secured on a first sheet to form a cover or lid. Such blister packs ::
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are in common use with tablets of one kind or another, but we have discovered that ~hey can also be used with medicaments in finely divided solid form. GB-A-21296~1 provides a device for administering to patients medicaments in blister pack form.
However, the embodiments described in GB-A-2129691 are more bulky than is desirable. It is an object of the present invention to provide a device which avoids or mitigates this problem.
Attention is also directed to our specification GB-A-2142246 which describes various alternative devices for administering medicaments held in solid finely divided form in blister packs.
According to the present invention there is provided a device for administering medicaments in solid finely divided form to patients, comprising a housing; a tray mounted in the housing and movable between first and second positions relative to the housing; a support provided on the tray and adapted to receivej in use, a carrier provided with at least one - medicament container; a plunger operable, in use, to penetrate a container registered therewith to open the container, movement of the tray from its first to its second position being such as to cause in use, the support to bring a container into registration with the plunger; an air inlet through which in use, air can ,.~
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enter the device, and an outlet through which a patient can inhale~ whereby medicament will be released from an opened container and entrained in an air flow produced by the patient, air entering the air inlet and passing out through the outlet having entrained medicament therein.
In an embodiment of the invention the support is rotatably mounted on the tray and the carrier has a plurality of medicament contain0rs arranged in a circle.
Indexing means are preferably provided so that movement of the tray from its first to its second position causes the support to be indexed to bring the next container into registration with the plunger, ~he housing of the device preferably has a base 15 member and a lid pivo-tally mounted thereon for movement between a closed position and an open position. ~he plunger can then be carried by -the lid and arranged to penetrate a container when the lid is moved to its open :
position.
~he device of the invention is suitable for , administering a variety of medicaments such as, for example, salbutamol, beclomethasone dipropionate and sodium cromoglycate.
A significant number of asthma patients suffer from asthma with a severity such that they need to take ~ : ' ... . :
-': . ', : ' -, not one but two medicaments. rhese are, respectively, a ~-stimulant, for example salbutamol or sadium cromoglycate, and an anti-inflammatory steroid, for example beclomethasone dipropionate. ~ypically a patient needing both these medicaments will take alternate doses of the two medicaments at prescribed intervals during the day.
It is an object of one aspect of the present invention to provide a single device from which two medicaments can be administered. ~he two medicaments concerned may be a ~-stimulant and an anti-inflammatory steroid respectively, or some other pair of medicaments used in treating asthma, or some other pair of medicaments inhaled for the purpose of tr~atinL~ some other condition.
~he reference to two medicaments is to be understood as including not only a pair of medicaments containing two different active ingredients~ but also a pair of medicaments containing the same active ingredient in different dosages.
~0 According to this aspect of the present inventlon there is provided a device according to the invention in `~ tandem with another such device to form a single article.
Some embodiments of the invention are illustrated in the accompanylng schematic drawings in which:
Figure 1 is an exploded perspective view of a ~ device according to one embodiment of the invention;
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Figure 2 is a perspective view of' the device of Figure 1 with a cover thereof removed:
Figure 3 is a view similar to that of Figure 2 but with a tray portion thereof in an outward position;
Figure 4 is a plan view of the device with a portion broken away;
Figure 5 is a section taken~on line X-X in Figure 4;
Figure 6 is a section taken on line Y-Y in Figure 4;
Figure 7 is an exploded perspective view of a second embodiment of the invention;
Figure 8 is an underplan view of the rotatable support used in the device of Figure 7;
Figure 9 is a perspective view of a third embodiment of the invention with the cover removed;
Figure 10 is a perspective YieW of a fourth embodiment of the invention, for use in dispensing two medicaments;
Figure 11 is a perspective view of t~e article of Figure 10 with a cover thereof removed and with a tray portion thereof in an outward position;
Figure 12 is:a perspective view of the article of Figure~10 wlth one of the covers~thereof removed and with a lid thereof in a raised position;~ and Figures 13 to 15 show a fourth embodiment of the ~` lnvention, also ~or use in dispensing two medicaments, in positions~correspondlng to those Figures 10 to 12, : ~ : ' '`
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? ` . ~ : ' ' , ' ~ ', ' ' '' ' : ' ' ' ~ ' . : ' . ' ~ he device shown in Figures 1 to 6 comprise four principal components, namely a housing 1, a tray 2, a rotatable support 3 and a cover ~. I'he support 3 is designed to receive a circular blister pack 5, as described in more detail below.
Considering first the housing lj this comprises a base member 10 and a lid 11 hinged thereto by pivots 12. ~he base member 10 has a base wall 13, upstanding side and rear walls 14 and 15 and a top wall 16 which extends over only the forward portion of the base member to form a kind of bridge. ~he top wall 16 has an aperture 17 formed therein. Extending forwardly from the front edge of the lid 11 is an elongated plunger 18. ~his is so positioned that when the lid 11 is raised the plunger passes through the aperture 17 which also acts as an air inlet into the device. ~he plunger is conveniently tapered at the tlp to form a relatively sharp point, but this is not essen-tial and a blunter plunger would serve the intended purpose which is described below. When~the lld is ln its lowered position the plunger 18 is protected from damage by up-standing walIs 19 formed on the upper wall 16.
The tray 2 defines a shallow chamber 20 for receivlng the rotatable support 3. In the centre of the chamber 20 is an upstanding lug 21 on which the support 3 is mounted fnr rotatlon. ~he lug 21 is shown . :: . ..
. .. , ` : : . :,, , as being cruciform in cross-section, but need not be; a lug of circular cross-section, for examplej could be used instead. ~he tray 2 can be moved in the housing between an inward position, as shown in Eigure 2j and an outward positionj as shown in Figures 3 and ~. Further outward movement beyond the above mentioned outward position is normally prevented by a lug 23 which is formed on the end of an arm 22 and which engages behind an inwardly directed protrusion on one of the side walls 14 of the housing 1. ~he arm 22 is secured to the rest of the tray only at its forward end and is substantially separated from the rest of the tray by a slot 2 ~he arm 22 is resilient, and when it is desired to remove the tray completely from the housing this can be achieved by pressing the arm 22 inwardly and then withdrawing the tray. Withdrawal is assisted~by the provision of thumb grips 33j in the form of ribs, on both sides of the tray. ~he tray also has a tongue 25 which can be depressed downwardly as described belowj and which has an open slot 26.
Extending from the front of the tray~2 is a mouth-piece 27. ~ It is through this mouthpiece that medicament ~ leaves the devlce as it is inhaled by a patient. ~o ; improve airflow through the mouthpiece it may be provided :: :
with a pair of apertures 2S.
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~he rotatable support 3 is in the form of a disc .. . . ~ . ., ~ . . : , . . .... .. ..
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3,~.7 in which is formed a circular array of circular openings 30. A central opening 31 enables the carrier to be mounted for rotativn on the lug 21. A corresponding plurality of ribs 32 are formed on the underside of the support 3, with one rib extending between each two adjacent openings 30.
In use, the cover 4 is removed and the tray with the support 3 mounted thereon, is then removed completely from the housing 1 after the arm 22 has been depressed.
A blister pack 5 is then mounted on the support 3 with one blister extending into each of the openings 30. ~he tray, support and blister pack are then inserted together into the housing. ~he cover 4 is then replaced. When a patient desires to inhale medicament he removes the cover and raises the lid ll so as to cause the plunger 1~
to pass through the aperture 17 and puncture a respective blister loca-ted immediately below the aperture 17. ~he lid is then lowered to withdraw the plunger from the blister, leaving a hole therein, and the patient inhales the medicament through the mouthpiece 27. It should be noted that the plunger is positively withdrawn from the blister by the patlent rather than being left to withdraw under spring pressure (as in GB-A-212,9691 ~mentioned above) which avoids any risk of the plunger remaining jammed in the blister. Either before replacing .
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the cover, or on the next occasion when the patient deslres to use the device, the support 3 is rotated to bring the next blister beneath the aperture 17.
~his is achieved as follows. ~he tray 2 is withdrawn to its outward position and then pushed back to its inward position. During the latter movement an arm 60 which extends forwardly in the casing 1 and is secured to the base wall 13 thereof engages one of the ribs on the underside of the support 3. ~his causes the support to rotate in a clockwise direction, as viewed in Figure 4j by an amount sufficient to bring the next blister beneath the aperture 17. During this rotational movement another of the ribs bears againstj and progressively depresses, the tongue 25 until that rib 15 engages in the slot 26 which retains the support in its deslred position and prevents further rotation. It will be seen from Figure 5 that on either side of the slot 26 are a pair of sloping shouldersj the larger of which prevents anticlockwise rotation of the 20 support 3j and the smaller of which is sufficient to normally retain the rib in the slot 26 but which is not such as to prevent the rib leaving the slot on the next occasion when the support 3 is rotated as described above.
: 25 ~he upper surface of the blister pack 5 carries a series of numbers, arranged in a circlej corresponding : . ,. ~ :..
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--ll--to the number o~ blisters in the pack (in this case the numbers 1 to 8). ~he top wall 16 of the housing l has an aperture 3~ through which a respective one of the numbers is visible to indicate the nurnber of the blister then aligned with the aperture 17j and hence to indicate how many blisters are left for use or alternatively how ~any blisters have been used.
In order to assist in providing ma~i~um efficiency of powder entrainment, r.leans are provided for ensuring an air flow path through the device which is substantially isolated from the surrounding environment. ~o this endj the tray 2 is provided adjacent the mouthpiece with a pair of upstanding walls 35 which converge towards the centre of the tray~ the radially inner ends of the walls 35 being interconnected by a wall 35a. When the support 3 is in a posi-tion in which a blister is aligned with the plungerj two adjacent ribs 32 of the support are allgned with the wall 35 and in close contact therewith. Alsoj the bllster pack 5 is in close cont~ct with the underside of the top wall 16 of the trayj at least~in the vicinlty of the aperture 17.
~hus when the patlent inhales through the mouthpiece 27 substantially the only air fIow which is produced lS one which passes through the aperture 17, through the hole~formed in the blister aligned therewithj throllgh a chamber defined by the wall 35 and the ribs 32 in ~: , ,, ,. , .~
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contact therewith and thence through the mouthpiece 27, optionally supplemented by air flowing into the mouthpiece through the aper-tures 28 if these are provided.
~here is thus no requirement for airtightness in other parts of the device> for example, airtightness between the housing parts 10 and ll or between the housing and the trayj and such airtightness is not provided.
Although not visible in the drawingsj the device shown in Figures l to 6 is preferably provided with a recessj located inwardly of the rear wall 15 and extending parallel thereto, for removably receiving a brush whlch the patient can use to clean the device of powdered medicament spilt therein.
~he device shown in Figures 1 to 6 may be modified in various ways. For example, the plunger 18 may be curved, asvie~vedin side elevation so that as it pierces a blister it produces ln it a hole which is smaller and more nearly circular than that which is produced if the plunger is straight as illustrated. ~his provides for lmproved entrainment of powdered medicament in the ai~r flow produced by inhalation and helps to avoid powder belng trapped ln the blister. ~his and other modifications are shown in Figures 7 and 8 which illustrate a second~embodlment~of the invention.
~ he~embodlment of Figures 7 and 8 is broadly slmllar to that of Figures 1 to 6j and the reference ' :
numerals in Figures 7 and 8 are the same as in Figures 1 to 6, where appropriate, but with the addition of a prime. Because of the similarities between the two embodiments the following description deals only with features of Figures 7 and 8 which differ from the corresponding features of Figures 1 to 6.
(a) ~he arm 22 is replaced by a pair of resilient arms 22'~ one on either side. ~he symmetry thus achieved makes it easier to slide the tray 2' in and out.
(b) ~here is no slot 26. Instead, the ribs 32 on the underside of the disc 3' engage behind the rear edge of tongue 25'.
(c) ~he walls 35 and 35a are replaced by a smoothly continuous wall 35' in which straight wall 35a is replaced by an arcuate wall portion the ends of which merge into the radially inner ends of the walls 35. A
corresponding modification is required in the ribs on the underside of the rotatable supportj and Figure 8 is an underplan view of such a modified support.
(d) ~he lug 21' is circular in cross-section, rather than being cruciform as shown in Figure 1.
(e) ~hethumb grips 33 are replaced by thumb grips 33a' on the arms 22' and additional thumb grips 33b' are provlded on the cover 4'.
(f) ~he aperture 34, through which numbers on the blister pack are visible is replaced by a slot 34'.
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Most of the slot is covered by the lid 11', but the forward portion is notj and it is through this forward portion that the numbers are visible.
(g) ~he brushj which is referred to above but is not shown in ~igures 1 to 6 is shown in Figure 7 and denoted by reference numeral 40. -Figure 9 shows a second embodiment of theinvention, which instead of using a blister pack comprising a plurality of blistersj uses a plurality of individual packs each containing a single blister.
In Figure 9 components which are comparable in function to those of Figures 1 to 6 are denoted by the same reference numerals plus 100.
~he device of ~igure 9 comprises a housing lOl a tray 102 with an integral support 103j a cover 104j and a plurality of individual blister packs 105. ~he housing 101 comprises a base member 110 and a lid 111 hinged thereto by pivots 112. ~he base member 110 includes side walls 114 and a top wall 116 which extends over only the forward portion of the base member to form a kind of bridge. Extending forwardly from the . :: , ; .: ;. .. . . .
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lid 111 is an elongate plunger 118 which is so positioned that when the lid 111 is raised the plunger passes through an aperture 117 formed in the top wall 116. I~hen the lid is in its lowered position the plunger 118 is protected from damage by ups-tanding walls 119 formed on the top walI 11~.
~ he blister packs are removably contained in a magazine 151 which is fixed or removable and is located at the rear of the housing 101 and normally covered by the lid 111. In the illustrated embodiment the magazine is arranged to contain four packsj but other sizes of magazine could be used instead.
~he tray 102 defines a recess 150 adapted to receive one of the blister packs 105. ~he recess communlcates at its forward end with a mouthpiece 127.
~he tray is slidable between the outward position illustrated and an inward position in which a flange 152 thereof rests against the forward end of the h~using 101. ~liding movement is achieved by means of a palr~ofrunners ~whlch pa~ss down the inside of the housing adjacent the side walls 114 thereof. ~he sides of the magazine 151 stop short of the side walls ll~ to permi-t the runners to pass.
In use~ the patient removes the cover 104 and, with the tray iD either its inward or outward position, , - : - ~
raises the lid 111, and removes a blister pack 10~ ~rom the magazine 151. With the tray in its out~ard position, the patient then places the blister pack on -the tray with blister thereof extending downwardly into the recess 150.
~he lid is then lowered. ~he tray is then pushed to its inward position and the lid raisedj to cause the plunger 118 to puncture the blisterj and then lowered. ~he patient then inhales through the mouthpiece 127j medicament from the blister being entrained in the air flow thus produced. ~he blister pack is in close contact with the underside of the top wall 116 so that substantially the only air flow is that which passes through the aperture 117, through the hole formed in the blister aligned therewithj through the recess 150 and thence through the mouthpiece 127.
If desiredj the mouthpiece 127 could be provided with apertures corresponding to the apertures 28 of ~igure 1.
~ he embodiment of Eigures 10 to 12 comprises a pair of ide~tical inhalation devices arranged back to back to form a single article. Each device comprises a housing 201, a tray 202, a rotatable support 203 and a cover 204. ~he support 203 is designed to receive a circular blister pack whichj for use in the embodiment illustrated in Figures I0 to 12j comprises four blisters arranged in a circle. It is to be understoodj however;
that blister packs with other numbers of blisters cou].d be used insteadj given appropriate modification to the ~, . .: , ,,,~ . , :
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~Z7Z~7 rotatable support 203.
Considering first the housing 201, this comprises a base mer;lber 210 which is common to each of the devices.
~he housing further comprises a lid 211 hinged to the base member 210 by pivots 212. Each device has its own lid. ~he lid 211 has a recess 211' in the upper surface thereof; the recess in one side making it easier for a patient to lift the other lid.
~he recesses of the two lids are offset from one another on opposite sides of the article. ~he base member 210 has a base wall (not visible in the drawings), upstanding side walls 214j and a pair of top walls 216j one in each devicej each top wall 216 being arranged to form a bridge between the side walls. Each top wall 216 has an aperture 217 ~ormed therein. E~-tending forwardly from the front edge of each lid 211 is an elongate plunger 218. ~his is so positioned that when the lid 211 is raised (see Figure 11) the plunger passes through the aperture 217 which also acts as an air inlet lnto the device. When the lid is in its lowered pOSitiOIl the plunger 218 is protected from damage by upstanding walls 219 formed on the upper wall 216.
As can be seenj the plunger 218 is curvedj as viewed in side elevation, for reasons set out above.
~he tray 202 ~efines a shallow chamber for receiving j , - :, ,, :
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the rotatable support 203. The tray 202 can be moved in the housing between an inward position~ as shown in Figure 12, and an outward positionj as shown in Figure 11. Further outward movement beyond the above mentioned outward position is possible only on releasing a lug mechanism which, when releasedj ~al~es it possible to remove the tray completely fror.l the housing. ~he lug mechanism can be the same as that described above with rei~erence to Fi~ures 1 to ~, or ~igures 7 and ~, and including a lug 23 as are details of the other internal components of the devices, and these are not therefore described in more detail here.
Extending from the front of the tray 202 is a mouth-piece 227. ~he mouthpiece is provided with a pair of apertures 22~,though these are optional.
~he remaining constructional details ~nd the Mænner of use of the devices shown in Figures lOto 12can be ascertained from the above description of Figures 1 to ~, and Figures 7~and 8.
It will be apparent that two separate blister pacl~s may be held in the article, one in each of the two devices.
~hese two blister packs may contain different medicaments, and thus a patient needing two different medicaments can use a slngle artlcle wlthout the problem of needing repeatedly to change over the blister pacl~ from one medicament to the other.
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~ he embodiment shown in ~igures13 to 15 is identical to that shown in Figures lOto 12 except as regards the lids. In the embodiment of Figures 13 to 1~ the lidsj denoted by reference numeral 311j each have the general shape of an L~ with the ster.ls of the two L's each occupying half the width of the article and being side by side with one another. ~his makes it possible for the distance between the distal end of each lid and the pivot thereof to be greater than is the case ~qith the er.lbodiment of Figures lOto 1.~, ~his in turn means that for a given upward force applied by the patient to a lid the downward force of the tip of the plunger 218 will be greater in the embodiment of Flgures 13 to 15 than it ~is in the embodiment of Figures IOto ~. This ln turn makes it easier for a patient to puncture a bllster, a fact which may be of considerable significance to some patients, particularly the elderly :
and infirm.
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Devices for Administering Medicarnents to Patients ~ his invention relates to devices by which a medicament in solid finely divided form can be administered to or by patients inhaling through the devices. Such devices are now quite well Isnown for administering medicaments contained in capsules to patients suffering from bronchial conditions such asj for examplej bronchial as-thma. It is well known for Medicament in powder or other finely divided form to be supplied in capsules which are loaded by a patient 10 into such a device. ~he medicament is then released from the capsule and inhaled by the patient, usually through the mouthj but sometimes through the nose.
~ he specification of PC~ Application Publication No. W082/01470j GB-A-1387954 and GB-A-2061735 all 15 describe devices for dispensing medicament in finely divided form from capsules. In each of these previously described devicesj the capsules are mounted on a rotat-able support member on which each capsule in turn can be brought to a position in which it is opened 20 to enable medicament to exit from the capsule to permit it to be inhaled by a patient inhaling through a mouthpiece of the devlce.
~ here are disadvantages in the use of capsules;
which~are made of gelatinj to contain medicaments.
.
~, . . ~................ :
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Gelatin is relatively unstable and is lacking in physical strength so that the capsules need to be pro-tected by packagingj for example in glass bottles.
Environmental degradation of both the capsules and their contents may occur in a re,latively short time.
In the device described in UK Patent Specification 13~7954 the capsules are ~ounted in what is referred to therein as a blister packj and is in fact a plurality of capsules mounted in a blister pack on a rotor which is designed to spin during exhalation by the patient to throw medicament out of an opened capsule whereafter the patient inhales. ~his has a number of disadvantages, including the fact that the exhalation which is required is more~difficult for some patlents;
fo~ example asthma patients~ than inhalation.
In our patent specification GB-A-2129691 we provided a more convenient way of administering medicament to such patients than had been possible hitherto and which avoided the need to pack medicaments in capsules. ~he device there described makes use of the technique of packaging a medicament by loading the medlcament directly lnto a blister pack comprising a sheetj~which may be laminated, of foil or plastics material which acts as a carrier and which is provided ; with a number of breakable or openable containers called "bllsters"~incorporatlng a sheet secured on a first sheet to form a cover or lid. Such blister packs ::
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are in common use with tablets of one kind or another, but we have discovered that ~hey can also be used with medicaments in finely divided solid form. GB-A-21296~1 provides a device for administering to patients medicaments in blister pack form.
However, the embodiments described in GB-A-2129691 are more bulky than is desirable. It is an object of the present invention to provide a device which avoids or mitigates this problem.
Attention is also directed to our specification GB-A-2142246 which describes various alternative devices for administering medicaments held in solid finely divided form in blister packs.
According to the present invention there is provided a device for administering medicaments in solid finely divided form to patients, comprising a housing; a tray mounted in the housing and movable between first and second positions relative to the housing; a support provided on the tray and adapted to receivej in use, a carrier provided with at least one - medicament container; a plunger operable, in use, to penetrate a container registered therewith to open the container, movement of the tray from its first to its second position being such as to cause in use, the support to bring a container into registration with the plunger; an air inlet through which in use, air can ,.~
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enter the device, and an outlet through which a patient can inhale~ whereby medicament will be released from an opened container and entrained in an air flow produced by the patient, air entering the air inlet and passing out through the outlet having entrained medicament therein.
In an embodiment of the invention the support is rotatably mounted on the tray and the carrier has a plurality of medicament contain0rs arranged in a circle.
Indexing means are preferably provided so that movement of the tray from its first to its second position causes the support to be indexed to bring the next container into registration with the plunger, ~he housing of the device preferably has a base 15 member and a lid pivo-tally mounted thereon for movement between a closed position and an open position. ~he plunger can then be carried by -the lid and arranged to penetrate a container when the lid is moved to its open :
position.
~he device of the invention is suitable for , administering a variety of medicaments such as, for example, salbutamol, beclomethasone dipropionate and sodium cromoglycate.
A significant number of asthma patients suffer from asthma with a severity such that they need to take ~ : ' ... . :
-': . ', : ' -, not one but two medicaments. rhese are, respectively, a ~-stimulant, for example salbutamol or sadium cromoglycate, and an anti-inflammatory steroid, for example beclomethasone dipropionate. ~ypically a patient needing both these medicaments will take alternate doses of the two medicaments at prescribed intervals during the day.
It is an object of one aspect of the present invention to provide a single device from which two medicaments can be administered. ~he two medicaments concerned may be a ~-stimulant and an anti-inflammatory steroid respectively, or some other pair of medicaments used in treating asthma, or some other pair of medicaments inhaled for the purpose of tr~atinL~ some other condition.
~he reference to two medicaments is to be understood as including not only a pair of medicaments containing two different active ingredients~ but also a pair of medicaments containing the same active ingredient in different dosages.
~0 According to this aspect of the present inventlon there is provided a device according to the invention in `~ tandem with another such device to form a single article.
Some embodiments of the invention are illustrated in the accompanylng schematic drawings in which:
Figure 1 is an exploded perspective view of a ~ device according to one embodiment of the invention;
:. . . . :. .
. .
: .
Figure 2 is a perspective view of' the device of Figure 1 with a cover thereof removed:
Figure 3 is a view similar to that of Figure 2 but with a tray portion thereof in an outward position;
Figure 4 is a plan view of the device with a portion broken away;
Figure 5 is a section taken~on line X-X in Figure 4;
Figure 6 is a section taken on line Y-Y in Figure 4;
Figure 7 is an exploded perspective view of a second embodiment of the invention;
Figure 8 is an underplan view of the rotatable support used in the device of Figure 7;
Figure 9 is a perspective view of a third embodiment of the invention with the cover removed;
Figure 10 is a perspective YieW of a fourth embodiment of the invention, for use in dispensing two medicaments;
Figure 11 is a perspective view of t~e article of Figure 10 with a cover thereof removed and with a tray portion thereof in an outward position;
Figure 12 is:a perspective view of the article of Figure~10 wlth one of the covers~thereof removed and with a lid thereof in a raised position;~ and Figures 13 to 15 show a fourth embodiment of the ~` lnvention, also ~or use in dispensing two medicaments, in positions~correspondlng to those Figures 10 to 12, : ~ : ' '`
` ~ ' .
? ` . ~ : ' ' , ' ~ ', ' ' '' ' : ' ' ' ~ ' . : ' . ' ~ he device shown in Figures 1 to 6 comprise four principal components, namely a housing 1, a tray 2, a rotatable support 3 and a cover ~. I'he support 3 is designed to receive a circular blister pack 5, as described in more detail below.
Considering first the housing lj this comprises a base member 10 and a lid 11 hinged thereto by pivots 12. ~he base member 10 has a base wall 13, upstanding side and rear walls 14 and 15 and a top wall 16 which extends over only the forward portion of the base member to form a kind of bridge. ~he top wall 16 has an aperture 17 formed therein. Extending forwardly from the front edge of the lid 11 is an elongated plunger 18. ~his is so positioned that when the lid 11 is raised the plunger passes through the aperture 17 which also acts as an air inlet into the device. ~he plunger is conveniently tapered at the tlp to form a relatively sharp point, but this is not essen-tial and a blunter plunger would serve the intended purpose which is described below. When~the lld is ln its lowered position the plunger 18 is protected from damage by up-standing walIs 19 formed on the upper wall 16.
The tray 2 defines a shallow chamber 20 for receivlng the rotatable support 3. In the centre of the chamber 20 is an upstanding lug 21 on which the support 3 is mounted fnr rotatlon. ~he lug 21 is shown . :: . ..
. .. , ` : : . :,, , as being cruciform in cross-section, but need not be; a lug of circular cross-section, for examplej could be used instead. ~he tray 2 can be moved in the housing between an inward position, as shown in Eigure 2j and an outward positionj as shown in Figures 3 and ~. Further outward movement beyond the above mentioned outward position is normally prevented by a lug 23 which is formed on the end of an arm 22 and which engages behind an inwardly directed protrusion on one of the side walls 14 of the housing 1. ~he arm 22 is secured to the rest of the tray only at its forward end and is substantially separated from the rest of the tray by a slot 2 ~he arm 22 is resilient, and when it is desired to remove the tray completely from the housing this can be achieved by pressing the arm 22 inwardly and then withdrawing the tray. Withdrawal is assisted~by the provision of thumb grips 33j in the form of ribs, on both sides of the tray. ~he tray also has a tongue 25 which can be depressed downwardly as described belowj and which has an open slot 26.
Extending from the front of the tray~2 is a mouth-piece 27. ~ It is through this mouthpiece that medicament ~ leaves the devlce as it is inhaled by a patient. ~o ; improve airflow through the mouthpiece it may be provided :: :
with a pair of apertures 2S.
: :
~he rotatable support 3 is in the form of a disc .. . . ~ . ., ~ . . : , . . .... .. ..
.: ;
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,. . . - .~ .: : ,.
3,~.7 in which is formed a circular array of circular openings 30. A central opening 31 enables the carrier to be mounted for rotativn on the lug 21. A corresponding plurality of ribs 32 are formed on the underside of the support 3, with one rib extending between each two adjacent openings 30.
In use, the cover 4 is removed and the tray with the support 3 mounted thereon, is then removed completely from the housing 1 after the arm 22 has been depressed.
A blister pack 5 is then mounted on the support 3 with one blister extending into each of the openings 30. ~he tray, support and blister pack are then inserted together into the housing. ~he cover 4 is then replaced. When a patient desires to inhale medicament he removes the cover and raises the lid ll so as to cause the plunger 1~
to pass through the aperture 17 and puncture a respective blister loca-ted immediately below the aperture 17. ~he lid is then lowered to withdraw the plunger from the blister, leaving a hole therein, and the patient inhales the medicament through the mouthpiece 27. It should be noted that the plunger is positively withdrawn from the blister by the patlent rather than being left to withdraw under spring pressure (as in GB-A-212,9691 ~mentioned above) which avoids any risk of the plunger remaining jammed in the blister. Either before replacing .
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.
the cover, or on the next occasion when the patient deslres to use the device, the support 3 is rotated to bring the next blister beneath the aperture 17.
~his is achieved as follows. ~he tray 2 is withdrawn to its outward position and then pushed back to its inward position. During the latter movement an arm 60 which extends forwardly in the casing 1 and is secured to the base wall 13 thereof engages one of the ribs on the underside of the support 3. ~his causes the support to rotate in a clockwise direction, as viewed in Figure 4j by an amount sufficient to bring the next blister beneath the aperture 17. During this rotational movement another of the ribs bears againstj and progressively depresses, the tongue 25 until that rib 15 engages in the slot 26 which retains the support in its deslred position and prevents further rotation. It will be seen from Figure 5 that on either side of the slot 26 are a pair of sloping shouldersj the larger of which prevents anticlockwise rotation of the 20 support 3j and the smaller of which is sufficient to normally retain the rib in the slot 26 but which is not such as to prevent the rib leaving the slot on the next occasion when the support 3 is rotated as described above.
: 25 ~he upper surface of the blister pack 5 carries a series of numbers, arranged in a circlej corresponding : . ,. ~ :..
,. , .~. :
=- : ::: :.: . ..
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--ll--to the number o~ blisters in the pack (in this case the numbers 1 to 8). ~he top wall 16 of the housing l has an aperture 3~ through which a respective one of the numbers is visible to indicate the nurnber of the blister then aligned with the aperture 17j and hence to indicate how many blisters are left for use or alternatively how ~any blisters have been used.
In order to assist in providing ma~i~um efficiency of powder entrainment, r.leans are provided for ensuring an air flow path through the device which is substantially isolated from the surrounding environment. ~o this endj the tray 2 is provided adjacent the mouthpiece with a pair of upstanding walls 35 which converge towards the centre of the tray~ the radially inner ends of the walls 35 being interconnected by a wall 35a. When the support 3 is in a posi-tion in which a blister is aligned with the plungerj two adjacent ribs 32 of the support are allgned with the wall 35 and in close contact therewith. Alsoj the bllster pack 5 is in close cont~ct with the underside of the top wall 16 of the trayj at least~in the vicinlty of the aperture 17.
~hus when the patlent inhales through the mouthpiece 27 substantially the only air fIow which is produced lS one which passes through the aperture 17, through the hole~formed in the blister aligned therewithj throllgh a chamber defined by the wall 35 and the ribs 32 in ~: , ,, ,. , .~
~2729~7 , 12~
contact therewith and thence through the mouthpiece 27, optionally supplemented by air flowing into the mouthpiece through the aper-tures 28 if these are provided.
~here is thus no requirement for airtightness in other parts of the device> for example, airtightness between the housing parts 10 and ll or between the housing and the trayj and such airtightness is not provided.
Although not visible in the drawingsj the device shown in Figures l to 6 is preferably provided with a recessj located inwardly of the rear wall 15 and extending parallel thereto, for removably receiving a brush whlch the patient can use to clean the device of powdered medicament spilt therein.
~he device shown in Figures 1 to 6 may be modified in various ways. For example, the plunger 18 may be curved, asvie~vedin side elevation so that as it pierces a blister it produces ln it a hole which is smaller and more nearly circular than that which is produced if the plunger is straight as illustrated. ~his provides for lmproved entrainment of powdered medicament in the ai~r flow produced by inhalation and helps to avoid powder belng trapped ln the blister. ~his and other modifications are shown in Figures 7 and 8 which illustrate a second~embodlment~of the invention.
~ he~embodlment of Figures 7 and 8 is broadly slmllar to that of Figures 1 to 6j and the reference ' :
numerals in Figures 7 and 8 are the same as in Figures 1 to 6, where appropriate, but with the addition of a prime. Because of the similarities between the two embodiments the following description deals only with features of Figures 7 and 8 which differ from the corresponding features of Figures 1 to 6.
(a) ~he arm 22 is replaced by a pair of resilient arms 22'~ one on either side. ~he symmetry thus achieved makes it easier to slide the tray 2' in and out.
(b) ~here is no slot 26. Instead, the ribs 32 on the underside of the disc 3' engage behind the rear edge of tongue 25'.
(c) ~he walls 35 and 35a are replaced by a smoothly continuous wall 35' in which straight wall 35a is replaced by an arcuate wall portion the ends of which merge into the radially inner ends of the walls 35. A
corresponding modification is required in the ribs on the underside of the rotatable supportj and Figure 8 is an underplan view of such a modified support.
(d) ~he lug 21' is circular in cross-section, rather than being cruciform as shown in Figure 1.
(e) ~hethumb grips 33 are replaced by thumb grips 33a' on the arms 22' and additional thumb grips 33b' are provlded on the cover 4'.
(f) ~he aperture 34, through which numbers on the blister pack are visible is replaced by a slot 34'.
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Most of the slot is covered by the lid 11', but the forward portion is notj and it is through this forward portion that the numbers are visible.
(g) ~he brushj which is referred to above but is not shown in ~igures 1 to 6 is shown in Figure 7 and denoted by reference numeral 40. -Figure 9 shows a second embodiment of theinvention, which instead of using a blister pack comprising a plurality of blistersj uses a plurality of individual packs each containing a single blister.
In Figure 9 components which are comparable in function to those of Figures 1 to 6 are denoted by the same reference numerals plus 100.
~he device of ~igure 9 comprises a housing lOl a tray 102 with an integral support 103j a cover 104j and a plurality of individual blister packs 105. ~he housing 101 comprises a base member 110 and a lid 111 hinged thereto by pivots 112. ~he base member 110 includes side walls 114 and a top wall 116 which extends over only the forward portion of the base member to form a kind of bridge. Extending forwardly from the . :: , ; .: ;. .. . . .
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lid 111 is an elongate plunger 118 which is so positioned that when the lid 111 is raised the plunger passes through an aperture 117 formed in the top wall 116. I~hen the lid is in its lowered position the plunger 118 is protected from damage by ups-tanding walls 119 formed on the top walI 11~.
~ he blister packs are removably contained in a magazine 151 which is fixed or removable and is located at the rear of the housing 101 and normally covered by the lid 111. In the illustrated embodiment the magazine is arranged to contain four packsj but other sizes of magazine could be used instead.
~he tray 102 defines a recess 150 adapted to receive one of the blister packs 105. ~he recess communlcates at its forward end with a mouthpiece 127.
~he tray is slidable between the outward position illustrated and an inward position in which a flange 152 thereof rests against the forward end of the h~using 101. ~liding movement is achieved by means of a palr~ofrunners ~whlch pa~ss down the inside of the housing adjacent the side walls 114 thereof. ~he sides of the magazine 151 stop short of the side walls ll~ to permi-t the runners to pass.
In use~ the patient removes the cover 104 and, with the tray iD either its inward or outward position, , - : - ~
raises the lid 111, and removes a blister pack 10~ ~rom the magazine 151. With the tray in its out~ard position, the patient then places the blister pack on -the tray with blister thereof extending downwardly into the recess 150.
~he lid is then lowered. ~he tray is then pushed to its inward position and the lid raisedj to cause the plunger 118 to puncture the blisterj and then lowered. ~he patient then inhales through the mouthpiece 127j medicament from the blister being entrained in the air flow thus produced. ~he blister pack is in close contact with the underside of the top wall 116 so that substantially the only air flow is that which passes through the aperture 117, through the hole formed in the blister aligned therewithj through the recess 150 and thence through the mouthpiece 127.
If desiredj the mouthpiece 127 could be provided with apertures corresponding to the apertures 28 of ~igure 1.
~ he embodiment of Eigures 10 to 12 comprises a pair of ide~tical inhalation devices arranged back to back to form a single article. Each device comprises a housing 201, a tray 202, a rotatable support 203 and a cover 204. ~he support 203 is designed to receive a circular blister pack whichj for use in the embodiment illustrated in Figures I0 to 12j comprises four blisters arranged in a circle. It is to be understoodj however;
that blister packs with other numbers of blisters cou].d be used insteadj given appropriate modification to the ~, . .: , ,,,~ . , :
. ;~ ' . . ~, , :, , . , , .: .
: -.
~Z7Z~7 rotatable support 203.
Considering first the housing 201, this comprises a base mer;lber 210 which is common to each of the devices.
~he housing further comprises a lid 211 hinged to the base member 210 by pivots 212. Each device has its own lid. ~he lid 211 has a recess 211' in the upper surface thereof; the recess in one side making it easier for a patient to lift the other lid.
~he recesses of the two lids are offset from one another on opposite sides of the article. ~he base member 210 has a base wall (not visible in the drawings), upstanding side walls 214j and a pair of top walls 216j one in each devicej each top wall 216 being arranged to form a bridge between the side walls. Each top wall 216 has an aperture 217 ~ormed therein. E~-tending forwardly from the front edge of each lid 211 is an elongate plunger 218. ~his is so positioned that when the lid 211 is raised (see Figure 11) the plunger passes through the aperture 217 which also acts as an air inlet lnto the device. When the lid is in its lowered pOSitiOIl the plunger 218 is protected from damage by upstanding walls 219 formed on the upper wall 216.
As can be seenj the plunger 218 is curvedj as viewed in side elevation, for reasons set out above.
~he tray 202 ~efines a shallow chamber for receiving j , - :, ,, :
. .
: . ::. : ", .:;
the rotatable support 203. The tray 202 can be moved in the housing between an inward position~ as shown in Figure 12, and an outward positionj as shown in Figure 11. Further outward movement beyond the above mentioned outward position is possible only on releasing a lug mechanism which, when releasedj ~al~es it possible to remove the tray completely fror.l the housing. ~he lug mechanism can be the same as that described above with rei~erence to Fi~ures 1 to ~, or ~igures 7 and ~, and including a lug 23 as are details of the other internal components of the devices, and these are not therefore described in more detail here.
Extending from the front of the tray 202 is a mouth-piece 227. ~he mouthpiece is provided with a pair of apertures 22~,though these are optional.
~he remaining constructional details ~nd the Mænner of use of the devices shown in Figures lOto 12can be ascertained from the above description of Figures 1 to ~, and Figures 7~and 8.
It will be apparent that two separate blister pacl~s may be held in the article, one in each of the two devices.
~hese two blister packs may contain different medicaments, and thus a patient needing two different medicaments can use a slngle artlcle wlthout the problem of needing repeatedly to change over the blister pacl~ from one medicament to the other.
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~ he embodiment shown in ~igures13 to 15 is identical to that shown in Figures lOto 12 except as regards the lids. In the embodiment of Figures 13 to 1~ the lidsj denoted by reference numeral 311j each have the general shape of an L~ with the ster.ls of the two L's each occupying half the width of the article and being side by side with one another. ~his makes it possible for the distance between the distal end of each lid and the pivot thereof to be greater than is the case ~qith the er.lbodiment of Figures lOto 1.~, ~his in turn means that for a given upward force applied by the patient to a lid the downward force of the tip of the plunger 218 will be greater in the embodiment of Flgures 13 to 15 than it ~is in the embodiment of Figures IOto ~. This ln turn makes it easier for a patient to puncture a bllster, a fact which may be of considerable significance to some patients, particularly the elderly :
and infirm.
:: ' ~ :: :
Claims (17)
1. A device for administering medicaments in solid finely divided form to patients, comprising a housing; a tray mounted in the housing and movable rectilinearly between first and second positions relative to the housing; a support provided on the tray and adapted to receive, in use, a carrier provided with at least one medicament container; a plunger operable, in use, to penetrate a container registered therewith to open the container, movement of the tray from its first to its second position being such as to cause, in use, the support to bring a container into registration with the plunger; an air inlet through which, in use, air can enter the device, and an outlet through which a patient can inhale, whereby medicament will be released from an opened container and entrained in an air flow produced by the patient, air entering the air inlet and passing out through the outlet having entrained medicament therein.
2. A device according to claim 1, wherein the support is rotatably mounted on the tray to receive a carrier having a plurality of medicament containers arranged in a circle.
3. A device according to claim 2, wherein indexing means are provided operably by movement of the tray from its first to its second position to cause the support to be indexed to bring the next container into registration with the plunger.
4. A device according to claim 2, wherein the support is in the form of a disc having a plurality of apertures therethrough, the apertures being arranged in a circle so that each receives a respective medicament container.
5. A device according to any one of claims 2 to 4, wherein the plunger is of such a length that it completely penetrates the container aligned therewith to produce an air flow passage therethrough and wherein the support has a plurality of ribs on a face thereof, the ribs cooperating with means provided on the housing adjacent the said outlet to define, together with said passage through the container, a substantially isolated air flow path which leads from the side of the container nearer the plunger, through the container and thence to the said outlet.
6. A device according to claim 1, wherein the support is adapted to receive a carrier having a single medicament container.
7. A device according to claim 6, further comprising a magazine adapted to receive at least one further carrier.
8. A device according to claim 1, wherein the housing has a base member and a lid pivotally mounted there on for pivotal movement about an axis between a closed position and an open position.
9. A device according to claim 8, wherein the said plunger is carried by the lid.
10. A device according to claim 9, wherein the plunger is located adjacent said axis.
11. A device according to claim 9 or 10, wherein the plunger is arranged to penetrate a container when the lid is moved to its open position and to leave the container when the lid is moved from its open position towards its closed position.
12. A device according to any one of claims 8 to 10, wherein the plunger is curved in a direction such as to reduce the size of hole which it produces in the con-tainer on penetration.
13. A device according to claim 1, wherein the second tray position is such that the tray moves outwardly with respect to the housing from the first position to the second position and wherein the tray has a third position, outwardly from the second position, in which a carrier can be received by the support.
14. A device according to claim 13, wherein the third tray position is one in which the tray is completely removed from the housing.
15. A device according to claims 2, 4 or 6, wherein the carrier is a blister pack defining at least one blister as the said container.
16. A device according to claim 1 in combination with another such device to form an interval device.
17. A device according to claim 16, wherein said another such device is back-to-back in tandem with the first mentioned.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858519141A GB8519141D0 (en) | 1985-07-30 | 1985-07-30 | Administering medicaments to patients |
| GB8519141 | 1985-07-30 | ||
| GB858525067A GB8525067D0 (en) | 1985-10-10 | 1985-10-10 | Administering medicaments to patients |
| GB8525067 | 1985-10-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1272917A true CA1272917A (en) | 1990-08-21 |
Family
ID=26289568
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000514908A Expired - Lifetime CA1272917A (en) | 1985-07-30 | 1986-07-29 | Devices for administering medicaments to patients |
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| EP (1) | EP0211595B1 (en) |
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| BE (1) | BE905189A (en) |
| BR (1) | BR8603576A (en) |
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| DO (1) | DOP1989004707A (en) |
| ES (1) | ES2000781A6 (en) |
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| PT83094B (en) * | 1985-07-30 | 1993-07-30 | Glaxo Group Ltd | DEVICES PROPER FOR THE ADMINISTRATION OF MEDICINES TO PATIENTS |
| IT1222509B (en) * | 1987-08-17 | 1990-09-05 | Miat Spa | INSUFFLATOR FOR THE ADMINISTRATION OF DRUGS IN THE FORM OF PRE-DOSED POWDER IN OPERATIONS |
| US4817789A (en) * | 1987-09-23 | 1989-04-04 | Allergan, Inc. | Lens container assembly |
| FR2626500B1 (en) * | 1988-01-28 | 1990-04-27 | Valois Sa | VAPOR PUSH BUTTON AGENCY FOR MIXING AN ADDITIVE IN THE EMISSION OF THE JET |
| CH678151A5 (en) * | 1988-07-13 | 1991-08-15 | Heinz Hermann Weick | Self-medication nasal dispenser |
| GB8824804D0 (en) * | 1988-10-22 | 1988-11-30 | Fisons Plc | Device |
| SE466684B (en) * | 1989-03-07 | 1992-03-23 | Draco Ab | DEVICE INHALATOR AND PROCEDURE TO REGISTER WITH THE DEVICE INHALATOR MEDICATION |
| US5176132A (en) * | 1989-05-31 | 1993-01-05 | Fisons Plc | Medicament inhalation device and formulation |
| US5239991A (en) * | 1989-06-21 | 1993-08-31 | Fisons Plc | Disposable powder medicament inhalation device with peel-off cover |
| IT1230313B (en) * | 1989-07-07 | 1991-10-18 | Somova Spa | INHALER FOR CAPSULES MEDICATIONS. |
| DE3927170A1 (en) * | 1989-08-17 | 1991-02-21 | Boehringer Ingelheim Kg | INHALATOR |
| US5208226A (en) * | 1989-09-08 | 1993-05-04 | Glaxo Group Limited | Medicaments |
| US5270305A (en) * | 1989-09-08 | 1993-12-14 | Glaxo Group Limited | Medicaments |
| DK544589D0 (en) * | 1989-11-01 | 1989-11-01 | Novo Nordisk As | MANUALLY OPERATED DEVICE FOR DISPENSING A PRESCRIBED QUANTITY OF A POWDER-SHAPED SUBSTANCE |
| YU48707B (en) * | 1990-03-02 | 1999-07-28 | Glaxo Group Limited | Inhalation device |
| US6536427B2 (en) | 1990-03-02 | 2003-03-25 | Glaxo Group Limited | Inhalation device |
| SK280967B6 (en) * | 1990-03-02 | 2000-10-09 | Glaxo Group Limited | Inhalation device |
| GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
| GB9012870D0 (en) * | 1990-06-08 | 1990-08-01 | Glaxo Group Ltd | Device |
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| PT83094B (en) * | 1985-07-30 | 1993-07-30 | Glaxo Group Ltd | DEVICES PROPER FOR THE ADMINISTRATION OF MEDICINES TO PATIENTS |
| US4690279A (en) * | 1986-03-13 | 1987-09-01 | Charles Hochberg | Birth control pill dispenser in the form of a hair brush |
-
1986
- 1986-07-29 PT PT83094A patent/PT83094B/en not_active IP Right Cessation
- 1986-07-29 BE BE0/216987A patent/BE905189A/en not_active IP Right Cessation
- 1986-07-29 NO NO863062A patent/NO166268C/en not_active IP Right Cessation
- 1986-07-29 DE DE8686305807T patent/DE3682457D1/en not_active Expired - Lifetime
- 1986-07-29 PH PH34078A patent/PH26882A/en unknown
- 1986-07-29 NZ NZ217006A patent/NZ217006A/en unknown
- 1986-07-29 SE SE8603252A patent/SE8603252L/en not_active Application Discontinuation
- 1986-07-29 CH CH3025/86A patent/CH672600A5/de not_active IP Right Cessation
- 1986-07-29 BR BR8603576A patent/BR8603576A/en not_active IP Right Cessation
- 1986-07-29 FR FR8610955A patent/FR2585563B1/en not_active Expired - Lifetime
- 1986-07-29 IT IT48322/86A patent/IT1195984B/en active
- 1986-07-29 US US06/891,536 patent/US4811731A/en not_active Expired - Lifetime
- 1986-07-29 CA CA000514908A patent/CA1272917A/en not_active Expired - Lifetime
- 1986-07-29 ES ES8600683A patent/ES2000781A6/en not_active Expired
- 1986-07-29 IL IL79550A patent/IL79550A/en not_active IP Right Cessation
- 1986-07-29 GB GB08618466A patent/GB2178965B/en not_active Expired
- 1986-07-29 AT AT0204086A patent/AT396872B/en not_active IP Right Cessation
- 1986-07-29 FI FI863094A patent/FI88112C/en not_active IP Right Cessation
- 1986-07-29 DK DK360986A patent/DK163640C/en not_active IP Right Cessation
- 1986-07-29 NL NL8601949A patent/NL8601949A/en not_active Application Discontinuation
- 1986-07-29 EP EP86305807A patent/EP0211595B1/en not_active Expired - Lifetime
- 1986-07-29 IE IE202286A patent/IE59026B1/en not_active IP Right Cessation
- 1986-07-29 GR GR861995A patent/GR861995B/en unknown
- 1986-07-29 AU AU60655/86A patent/AU591152B2/en not_active Expired
- 1986-07-30 KR KR1019860006254A patent/KR940002247B1/en not_active IP Right Cessation
- 1986-07-30 JP JP61177917A patent/JPS6241668A/en active Granted
- 1986-07-30 DE DE19863625685 patent/DE3625685A1/en active Granted
- 1986-07-30 LU LU86534A patent/LU86534A1/en unknown
- 1986-07-30 MX MX003326A patent/MX171389B/en unknown
- 1986-07-30 PL PL1986260858A patent/PL149733B1/en unknown
- 1986-07-30 HU HU863243A patent/HU199306B/en not_active IP Right Cessation
-
1988
- 1988-12-27 US US07/290,628 patent/US5035237A/en not_active Expired - Lifetime
-
1989
- 1989-02-14 SG SG87/89A patent/SG8789G/en unknown
- 1989-02-24 KE KE3865A patent/KE3865A/en unknown
- 1989-08-24 HK HK675/89A patent/HK67589A/en not_active IP Right Cessation
- 1989-08-29 DO DO1989004707A patent/DOP1989004707A/en unknown
- 1989-12-08 CY CY1481A patent/CY1481A/en unknown
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Legal Events
| Date | Code | Title | Description |
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| MKEX | Expiry |