CA1289026C - Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola - Google Patents
Insufflator for the administration of drugs in the form of a powder pre-dosed into opercolaInfo
- Publication number
- CA1289026C CA1289026C CA000574144A CA574144A CA1289026C CA 1289026 C CA1289026 C CA 1289026C CA 000574144 A CA000574144 A CA 000574144A CA 574144 A CA574144 A CA 574144A CA 1289026 C CA1289026 C CA 1289026C
- Authority
- CA
- Canada
- Prior art keywords
- operculum
- insufflator
- turnable member
- seat
- air
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0028—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up
- A61M15/003—Inhalators using prepacked dosages, one for each application, e.g. capsules to be perforated or broken-up using capsules, e.g. to be perforated or broken-up
- A61M15/0033—Details of the piercing or cutting means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/06—Solids
- A61M2202/064—Powder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/07—General characteristics of the apparatus having air pumping means
- A61M2205/071—General characteristics of the apparatus having air pumping means hand operated
- A61M2205/075—Bulb type
Abstract
ABSTRACT
Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola An insufflator for administering pre-dosed powder drugs contained into opercola, which comprises a body having an air-inlet opening and a substantially vertical outlet channel for the air carring the powder drug, and a device with opposite pins of a known kind for puncturing the operculum, said operculum being placed in a suitable seat. The latter is provided in a member that is turnable relative to said body. Said turnable member can take at least two different positions: a first position, where the operculum can be axially punctured by the above-mentioned opposite, substantially horizontal pins; and a second position, turned 90° relative to said first position, where the opposite holes that have been pierced in the operculum are coaxial with said air-outlet channel.
Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola An insufflator for administering pre-dosed powder drugs contained into opercola, which comprises a body having an air-inlet opening and a substantially vertical outlet channel for the air carring the powder drug, and a device with opposite pins of a known kind for puncturing the operculum, said operculum being placed in a suitable seat. The latter is provided in a member that is turnable relative to said body. Said turnable member can take at least two different positions: a first position, where the operculum can be axially punctured by the above-mentioned opposite, substantially horizontal pins; and a second position, turned 90° relative to said first position, where the opposite holes that have been pierced in the operculum are coaxial with said air-outlet channel.
Description
DESCRIPTION
The present invention relates to insufflators for administering drugs which are in the form of finest (micronized) powder pre-dosed into opercula of hard gelatine or other non-toxic material. Said insufflators have a device for puncturing the operculum through which an air stream is then passed that removes the powder from the operculum and acts as an administering vehicle. The air stream is produced by means of a suitable hand-driven pump.
V~rious kind of insuff lators are known in which the operculum containing the drug in the form of a micronized powder which usually takes about 1/3 of the internal vo~ume of the operculum, is placed in a suitable seat provided in the device and is then punctured or otherwise opened for the air stream that is passed through said seat to drag the powder drug.
The above-mentioned puncturing device comprises one or more needles or pins, usually two opposite coaxial pins suitable to pierce in the operculum two corresponding opposite openings for the air stream that flows through said opposite openings to drag the powder contained in the operculum. See for example U.S. Patent 3 906 950 in which the pins are vertically oriented. Ho~ever, such insufflator, besldes being quite complicated, also shows the draw--bacl~ that when the operculum is punctured by the two opposite, vertically oriented pins of the puncturing device, due to the combined effect of the gravity force acting onto the powder containPd in the operculum and of the drag exerted on the powder by the lower pin when this is drawn out of the operculum, a perceptihle amount of powder falls out of the operculum. The action of the air stream, that in this case is produced by a lower hand-'~ , `
. ~' ~l2 ~3~3'~
-pump, is not in the position to completely eject the amount of powder that has fallen from the operculum, thus giv~ng rise to waste of powder drug. Moreover, in the long run, powder piles up especially in the pump, thus giving rise to the need of periodically cleaning the insufflator.
A similar but much simpler insufflator is the one produced by the FISONS LIMITED, England, under the trade mark RINOFLATORE. It comprises a single vertical, upwardly oriented puncturing pin coaxial with the operculum and flow pipe of the air stream. The pin i~s long enough to ac~ually pierce the operculum from one end tP the other. This insufflat~r shows howeYer the same, or even worse~
draw-bac~s as the former one, concerning the powder coming out of the lower hole and piling up inside the apparatus. This is confirmed by the fac' that said insufflator is marketed with a brush included for removing the powder that piles up inside.
A further known apparatus is described in US Patent 4 D13 075, and can be used both as an inhaler and as an insufflator. Also in this apparatus the operculum is vertically oriented parallel with the outlet pipe of the air stream. The operculum is opened by cutting ,its two terminal ca~s. This apparatus is complicated and expensive to ~anufacture becaus2 it co~prises rather elaborated pieces which include two metal blades having a special shape. Moreover, also with this apparatus a percepti~le amount of powder is lost at the moment of cutting the two end caps of the operculum.
It is an ob~er~ of the in~/ention to ?rovide an insufflator for administering drugs in the form of a powder pre-dosed into opercola; which insuf~lator is simple to manufacture and affords the possibilit~ of utilizi~g in practice all the powder contained - .
.: ~
.in the opercola.
The above-mentloned objects are achived by means of a body .insufflator for administering drugs which are in the form of a powder pre-dosed into opercola, said insufflator comprising a body having an air--inlet opening coaxial wi-th a substantially vertical outle-t channel for carryinginle-t air mixed with the powder drug, and a device with opposite substantially horizontal reci.procating pins for puncturing an ,operculum, said operculum being placed in a seat having two axially opposite holes, and characterized in tha-t the seat for the operculum is provided in a member that is turnable relative to said body, and in that said -turnable member can take at least two differen-t positions: a first 1~ position, or operculum puncturing position, where the operculum is axially puncturable by said opposite, substantially horizontal reciprocating pins through said two axially opposite holes in said seat; and a second position, or delivery position, that is substantially -turned 90 relative to said first position, in which one of said axially opposite holes is coaxial wi-th said air-ou-tlet channel and the other one of said axially opposite holes is in communication with the air-inlet opening.
With the insufflator according -to the invention, the operculum is punctuxed while the turnable member is in its :Eiræt position, thus preventing the powder from falling out oE -the operculum while it is punctured due to -the drag of the puncturing pins acting onto the powder tha-t is contained in it.
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~ . ' - 3a -The turnable member is then -turned 90 to bring it into said second position, so that -the opposite holes in the operculum are coaxial with the air-outlet channel. The seat of the operculum, and -therefore khe inside thereof (the operculum i5 now punctured), is in communication with the air-inlet opening and with the air-outlet channel.
Actually, a small amount of powder can come out of the lower hole of the operculum when the turnable member is turned 90 and brou~ht into its second position. This amount of powder is however very small because in the mass of the powder particles over the lower hole of the operculum the "arch effect" is displayed. Therefore only those powder particles can come out which are below said "ar'ch" or, more exactly, "dome" that is formed above said lower opening. The diameter of the holes will obviously be the narrowest possible consistent with the need of affording an air flow enough to remove the powder from the operculum. Therefore, the amount of powder that come out is in practice negligible and however much lower that the amount coming out when the operculum is punctured by vertically directed pins.
From the above it can be recognized how simple the insufflator according to the invention is to manufacture and use.
In particular, the turnable member containing the seat of the operculum can profitabl~ have a circular shape and be fitted in a suitable circular cavity provided in the body of the insufflator.
The various parts of the latter can all be made of a non-toxic heat-mouldable plastic material.
Tn the insufflator according to the invention, the air-inlet openins will be in communication with a conventional hand pump suitably consisting of a non-toxic elastomer container whose interior is in co~munication with the air-inlet opening. Said s container is provided with a one-way or check valve for the intake of the external air.
A similar valve may be provided at the air-inlet opening, so that also the above mentioned small amount of powder is prevented to fall down into the elastomer container.
The body of the insufflator according to the invention can be suitably provided with an ejection device For ejecting the turnable member from said body so as to ease loading of an operculum into said seat provided in the turnable member. Said ejection device can simply consist of a pusher that can be operated from the outside, for example by means of a knob, said pusher acting onto the internal ~ace of th~ turnable member. A finger pressure on said knob is enough to push out the turnable member and ease its removal.
The turnable member can in turn comprise a similar ejection device to eject the empty operculum from its seat.
The loading of the operculum can also be carried out without the need of making the turnable member detachable from the body of the insufflator. In fact it can be provided that the operculum be loaded when the turnable member is in a third position in which the seat of the operculum is coaxial with a radial loading opening provided in the body of the insufflator. The diameter of said openins is wide enough for the operculum to be inserted into its seat. In this case, the ejection of the empty operculum can be eased by providing an ejection device of the above mentioned type and suitable to radially eject the e~pty operculum through said loading opening after bringing the turnable member again into said ' ' ' ~ ':
third position.
The invention wi71 be better understood from the following description of an illustrative, non-limiting embodiment thereof, taken in conjunction with the enclosed drawings in which:
- Figure I is a front view of the insufflator according to the invention provided with a protective cover;
- Figure 2 is a side view of the same insufflator;
- Figure 3 is a top view of the same insufflator;
- Figure 4 is a partial enlarged cross-section taken along line IV-IV of Figure 3;
- Figure S is a partial, enlarged cross-section taken along line V-V of Figure l; and - Figure 6 is a less enlarged cross-section taken along line VI-VI
of Figure 1.
From Figures 1, 2 and 3 the exterior appearance of the insufflator according to the invention can be seen. In particular, 1 is a container made of non-toxic elastomer that makes up the pump which can be hand-operated by pressing said container 1. The latter is provided with a one-way or check valve 2 that is sketched in the figures and allows the resilient container I to be filled with air after having been pressed. By pressing the resilient container I an air stream is generated that is needed for the operation oF the insufflator.
From Figures 1, 2 and 3 the removable cover 3 that covers the body of the insuFflator can also be seen. In said cover 3 there is provided a slit 4 fro~ ~/hich a fin 5 projects whose function will be explained below.
' 3~ 2 ~i From figures ~, 5 and 6 it can be seen how the insufflator is internally made. It comprises a body 6 having an air-inlet channel 7 communicating with the interior of the container 1. Body 6 also comprises an outlet channel 8 for the air that is char~ed with drug powder. In the illustrated embodiment the outlet channel 8 is provided with an adapter 9 havin~ an anatomic shape in its upper part to allow the powder drug to be delivered through the nostrils.
Both the air-inlet channel 7 and the air-outlet channel 8 communicate respectively through openin~s 10, 11 with a central cyl,indrical cavity 12 (Figures 5 and 6) provided in body 6 and into which from outside a circular member 13 can be inserted that can turn within said cavity 12. The turnable member 13 has a diametral seat 14 in which the hard gelatine operculum 15 can be inserted.
The operculum contains the drug in the form of a ~icronized powder.
Seat 14 shows in axially opposite positions t~o holes 16, 17 respectively matching said openings 10 and 11 when said turnable member 13 is in the position shown in Figures 4, 5 and 6, that is in its socalled second position. In this way, when the turnable member 13 is in its second position, seat 14 is in communication ~ith both the air inlet channel 7, and there-through with pump 1, and with the air-outlet channel 8.
The turnable m2mber 13 can be rotated between two positions, namely the position we already called the second position and a position that is rotated 90 relative to said second position, and that w will refer to as first position. When the turnable member 13 is in its flrst position, holes 16, 17 are coa,cial ~ith t~o opposite pins 1~, 19 secured to knobs 20, 21 respectively, which can be horizontally reciprocated through opposite slide openings 22, 23 provided in body 6. The knobs 20, 21 are provided with return :. :
, 3~3~ 6 springs 24, 25 respectively.
When the turnable member 13 is in its first position, by pressing knobs 20 and 21 inwardly pins 18, 19 pass through corresponding openings 26, 27 provided in the wall of cavity 12 and through said corresponding holes 16, 17 respectively, thus puncturing the operculum 15 previously inserted into its seat 14 at the top of both spherical caps of said operculum. Two opposite, substantially coaxial holes are thus provided in the operculum. After turning the turnable member 13 in its second position, said holes lay on the same axis as both holes 16 and 17 of the seat 14 and the corresponding openings 10 and 11 co~municating with air-inlet 7 and outlet 8 channels respectively. A straight, vert;cal path for the air stream is thus obtained~ said path being coaxial with the operculum 15.
On the bottom of the circular cavity 12 a plate pusher 28 is provided (Figures 5 and 6). Said pusher is secured to one end of a stem 29 that passes through an opening 31 provided in the back of body 6. The stem 29 has a knob 30 secured to the other end thereof.
The --ssembly consist~ng of plate 28, stem 2a and knob 30 makes up an e~ocl1on devic~ for the easy removal of turnable member 13 fro~
cavit~ 12. In fact, by pressing knob 30, the turnable member 13 will be pushed outside, thus easing its removal ~rom body 5. With the turnable member 13 renloved, an operculum 15 can be easily , inser ed int~ seat 14.
From igures 4 and 5 it can be seen that seat 14 preferably has, on both side walls, some protrusions 32 by means of ~hich operculum 15 can ~e maintained in its eosition into seat l4. The protrusions 32 cause operculum 15 to be inserted into said seat 14 with a small pressure. Thereby it is prevented from accidentally falling out during the loading of the insufflator.
The insufflator is also provided with a device for ejecting the operculum from the turnable member 13 (see Figures 5 and 6~ after having been used. Said ejection device consists of a pusher 34 in form of a saddle placed on the bottom of the seat 14 (see Figures 6 and 5). The saddle 34 is connected with an external fin 5 protruding through a slit 36 provided in the outside face of the turnable member 13. Said fin is secured to the saddle 34. When turnable member 13 is ejected from circular cavity 12, it is possible to eject, in turn3 the empty operculum l~ by means of a little pressure on the vertical edge 35 of fin 5. Fin 5 is also used both to rotate the turnable member 13 to bring it into the desired positions and as a grasping device for the turnable member 13.
As already mentioned, the insufflator according to the invention will be suitably made of a non-toxic heat-mouldable plastic material whilst the resilient container l, that ~lorks as a pump, will ~e made of a non-toxic elastomer. Springs 24 and 25 and pins 18 and 19 ~ill be made of a suitable non-toxic plastic material or metal.
Although the operation of the insufflator should be already evident from the above description and the enc10sed Figures, it will be briefl~ described in the following for the sake of a better understanding.
The first step will obviously consist of taking off the protective - -' , ' " ' ' ' '~ ' cover 3. Next one will: pull out the turnable member 13 from cavity12 of body 6; insert operculum 15 into its seat 14 in the turnable member 13; fit the turnable member 13 into cavity 12, meanwhile bringing the member 13, by means of fin 5, into its first position ~here holes 16 and 17 of turnable member 13 are coaxial with pins 18 and 19; push knobs 20, 21 to axially puncture operculum 15 at both ends thereof; bring, by means of fin 5, the turnable member 13 into its second position (that is, turn it 90) thus bringing holes 16 and 17 to match openings 10 and 11 respectively; introduce adapter 9 into the concerned cavity (for example in a nostril) or place its outlet opening near the area to be treated; repeatedly press the resilient container l; pull out again the turnable member 13; eject the empty operculum 15 by lightly pressing edge 35 of fin 5; insert the turnable member 13 into cavity 12; and put on again protective cover 3.
It can be recognized from the above that the insufflator according to the present invention has a quite simple structure and can be easily manufactured. It can also be used in simple and reliable way and does not give rise to the above-mentioned draw-backs of the prior art apparatuses.
The present invention relates to insufflators for administering drugs which are in the form of finest (micronized) powder pre-dosed into opercula of hard gelatine or other non-toxic material. Said insufflators have a device for puncturing the operculum through which an air stream is then passed that removes the powder from the operculum and acts as an administering vehicle. The air stream is produced by means of a suitable hand-driven pump.
V~rious kind of insuff lators are known in which the operculum containing the drug in the form of a micronized powder which usually takes about 1/3 of the internal vo~ume of the operculum, is placed in a suitable seat provided in the device and is then punctured or otherwise opened for the air stream that is passed through said seat to drag the powder drug.
The above-mentioned puncturing device comprises one or more needles or pins, usually two opposite coaxial pins suitable to pierce in the operculum two corresponding opposite openings for the air stream that flows through said opposite openings to drag the powder contained in the operculum. See for example U.S. Patent 3 906 950 in which the pins are vertically oriented. Ho~ever, such insufflator, besldes being quite complicated, also shows the draw--bacl~ that when the operculum is punctured by the two opposite, vertically oriented pins of the puncturing device, due to the combined effect of the gravity force acting onto the powder containPd in the operculum and of the drag exerted on the powder by the lower pin when this is drawn out of the operculum, a perceptihle amount of powder falls out of the operculum. The action of the air stream, that in this case is produced by a lower hand-'~ , `
. ~' ~l2 ~3~3'~
-pump, is not in the position to completely eject the amount of powder that has fallen from the operculum, thus giv~ng rise to waste of powder drug. Moreover, in the long run, powder piles up especially in the pump, thus giving rise to the need of periodically cleaning the insufflator.
A similar but much simpler insufflator is the one produced by the FISONS LIMITED, England, under the trade mark RINOFLATORE. It comprises a single vertical, upwardly oriented puncturing pin coaxial with the operculum and flow pipe of the air stream. The pin i~s long enough to ac~ually pierce the operculum from one end tP the other. This insufflat~r shows howeYer the same, or even worse~
draw-bac~s as the former one, concerning the powder coming out of the lower hole and piling up inside the apparatus. This is confirmed by the fac' that said insufflator is marketed with a brush included for removing the powder that piles up inside.
A further known apparatus is described in US Patent 4 D13 075, and can be used both as an inhaler and as an insufflator. Also in this apparatus the operculum is vertically oriented parallel with the outlet pipe of the air stream. The operculum is opened by cutting ,its two terminal ca~s. This apparatus is complicated and expensive to ~anufacture becaus2 it co~prises rather elaborated pieces which include two metal blades having a special shape. Moreover, also with this apparatus a percepti~le amount of powder is lost at the moment of cutting the two end caps of the operculum.
It is an ob~er~ of the in~/ention to ?rovide an insufflator for administering drugs in the form of a powder pre-dosed into opercola; which insuf~lator is simple to manufacture and affords the possibilit~ of utilizi~g in practice all the powder contained - .
.: ~
.in the opercola.
The above-mentloned objects are achived by means of a body .insufflator for administering drugs which are in the form of a powder pre-dosed into opercola, said insufflator comprising a body having an air--inlet opening coaxial wi-th a substantially vertical outle-t channel for carryinginle-t air mixed with the powder drug, and a device with opposite substantially horizontal reci.procating pins for puncturing an ,operculum, said operculum being placed in a seat having two axially opposite holes, and characterized in tha-t the seat for the operculum is provided in a member that is turnable relative to said body, and in that said -turnable member can take at least two differen-t positions: a first 1~ position, or operculum puncturing position, where the operculum is axially puncturable by said opposite, substantially horizontal reciprocating pins through said two axially opposite holes in said seat; and a second position, or delivery position, that is substantially -turned 90 relative to said first position, in which one of said axially opposite holes is coaxial wi-th said air-ou-tlet channel and the other one of said axially opposite holes is in communication with the air-inlet opening.
With the insufflator according -to the invention, the operculum is punctuxed while the turnable member is in its :Eiræt position, thus preventing the powder from falling out oE -the operculum while it is punctured due to -the drag of the puncturing pins acting onto the powder tha-t is contained in it.
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~ . ' - 3a -The turnable member is then -turned 90 to bring it into said second position, so that -the opposite holes in the operculum are coaxial with the air-outlet channel. The seat of the operculum, and -therefore khe inside thereof (the operculum i5 now punctured), is in communication with the air-inlet opening and with the air-outlet channel.
Actually, a small amount of powder can come out of the lower hole of the operculum when the turnable member is turned 90 and brou~ht into its second position. This amount of powder is however very small because in the mass of the powder particles over the lower hole of the operculum the "arch effect" is displayed. Therefore only those powder particles can come out which are below said "ar'ch" or, more exactly, "dome" that is formed above said lower opening. The diameter of the holes will obviously be the narrowest possible consistent with the need of affording an air flow enough to remove the powder from the operculum. Therefore, the amount of powder that come out is in practice negligible and however much lower that the amount coming out when the operculum is punctured by vertically directed pins.
From the above it can be recognized how simple the insufflator according to the invention is to manufacture and use.
In particular, the turnable member containing the seat of the operculum can profitabl~ have a circular shape and be fitted in a suitable circular cavity provided in the body of the insufflator.
The various parts of the latter can all be made of a non-toxic heat-mouldable plastic material.
Tn the insufflator according to the invention, the air-inlet openins will be in communication with a conventional hand pump suitably consisting of a non-toxic elastomer container whose interior is in co~munication with the air-inlet opening. Said s container is provided with a one-way or check valve for the intake of the external air.
A similar valve may be provided at the air-inlet opening, so that also the above mentioned small amount of powder is prevented to fall down into the elastomer container.
The body of the insufflator according to the invention can be suitably provided with an ejection device For ejecting the turnable member from said body so as to ease loading of an operculum into said seat provided in the turnable member. Said ejection device can simply consist of a pusher that can be operated from the outside, for example by means of a knob, said pusher acting onto the internal ~ace of th~ turnable member. A finger pressure on said knob is enough to push out the turnable member and ease its removal.
The turnable member can in turn comprise a similar ejection device to eject the empty operculum from its seat.
The loading of the operculum can also be carried out without the need of making the turnable member detachable from the body of the insufflator. In fact it can be provided that the operculum be loaded when the turnable member is in a third position in which the seat of the operculum is coaxial with a radial loading opening provided in the body of the insufflator. The diameter of said openins is wide enough for the operculum to be inserted into its seat. In this case, the ejection of the empty operculum can be eased by providing an ejection device of the above mentioned type and suitable to radially eject the e~pty operculum through said loading opening after bringing the turnable member again into said ' ' ' ~ ':
third position.
The invention wi71 be better understood from the following description of an illustrative, non-limiting embodiment thereof, taken in conjunction with the enclosed drawings in which:
- Figure I is a front view of the insufflator according to the invention provided with a protective cover;
- Figure 2 is a side view of the same insufflator;
- Figure 3 is a top view of the same insufflator;
- Figure 4 is a partial enlarged cross-section taken along line IV-IV of Figure 3;
- Figure S is a partial, enlarged cross-section taken along line V-V of Figure l; and - Figure 6 is a less enlarged cross-section taken along line VI-VI
of Figure 1.
From Figures 1, 2 and 3 the exterior appearance of the insufflator according to the invention can be seen. In particular, 1 is a container made of non-toxic elastomer that makes up the pump which can be hand-operated by pressing said container 1. The latter is provided with a one-way or check valve 2 that is sketched in the figures and allows the resilient container I to be filled with air after having been pressed. By pressing the resilient container I an air stream is generated that is needed for the operation oF the insufflator.
From Figures 1, 2 and 3 the removable cover 3 that covers the body of the insuFflator can also be seen. In said cover 3 there is provided a slit 4 fro~ ~/hich a fin 5 projects whose function will be explained below.
' 3~ 2 ~i From figures ~, 5 and 6 it can be seen how the insufflator is internally made. It comprises a body 6 having an air-inlet channel 7 communicating with the interior of the container 1. Body 6 also comprises an outlet channel 8 for the air that is char~ed with drug powder. In the illustrated embodiment the outlet channel 8 is provided with an adapter 9 havin~ an anatomic shape in its upper part to allow the powder drug to be delivered through the nostrils.
Both the air-inlet channel 7 and the air-outlet channel 8 communicate respectively through openin~s 10, 11 with a central cyl,indrical cavity 12 (Figures 5 and 6) provided in body 6 and into which from outside a circular member 13 can be inserted that can turn within said cavity 12. The turnable member 13 has a diametral seat 14 in which the hard gelatine operculum 15 can be inserted.
The operculum contains the drug in the form of a ~icronized powder.
Seat 14 shows in axially opposite positions t~o holes 16, 17 respectively matching said openings 10 and 11 when said turnable member 13 is in the position shown in Figures 4, 5 and 6, that is in its socalled second position. In this way, when the turnable member 13 is in its second position, seat 14 is in communication ~ith both the air inlet channel 7, and there-through with pump 1, and with the air-outlet channel 8.
The turnable m2mber 13 can be rotated between two positions, namely the position we already called the second position and a position that is rotated 90 relative to said second position, and that w will refer to as first position. When the turnable member 13 is in its flrst position, holes 16, 17 are coa,cial ~ith t~o opposite pins 1~, 19 secured to knobs 20, 21 respectively, which can be horizontally reciprocated through opposite slide openings 22, 23 provided in body 6. The knobs 20, 21 are provided with return :. :
, 3~3~ 6 springs 24, 25 respectively.
When the turnable member 13 is in its first position, by pressing knobs 20 and 21 inwardly pins 18, 19 pass through corresponding openings 26, 27 provided in the wall of cavity 12 and through said corresponding holes 16, 17 respectively, thus puncturing the operculum 15 previously inserted into its seat 14 at the top of both spherical caps of said operculum. Two opposite, substantially coaxial holes are thus provided in the operculum. After turning the turnable member 13 in its second position, said holes lay on the same axis as both holes 16 and 17 of the seat 14 and the corresponding openings 10 and 11 co~municating with air-inlet 7 and outlet 8 channels respectively. A straight, vert;cal path for the air stream is thus obtained~ said path being coaxial with the operculum 15.
On the bottom of the circular cavity 12 a plate pusher 28 is provided (Figures 5 and 6). Said pusher is secured to one end of a stem 29 that passes through an opening 31 provided in the back of body 6. The stem 29 has a knob 30 secured to the other end thereof.
The --ssembly consist~ng of plate 28, stem 2a and knob 30 makes up an e~ocl1on devic~ for the easy removal of turnable member 13 fro~
cavit~ 12. In fact, by pressing knob 30, the turnable member 13 will be pushed outside, thus easing its removal ~rom body 5. With the turnable member 13 renloved, an operculum 15 can be easily , inser ed int~ seat 14.
From igures 4 and 5 it can be seen that seat 14 preferably has, on both side walls, some protrusions 32 by means of ~hich operculum 15 can ~e maintained in its eosition into seat l4. The protrusions 32 cause operculum 15 to be inserted into said seat 14 with a small pressure. Thereby it is prevented from accidentally falling out during the loading of the insufflator.
The insufflator is also provided with a device for ejecting the operculum from the turnable member 13 (see Figures 5 and 6~ after having been used. Said ejection device consists of a pusher 34 in form of a saddle placed on the bottom of the seat 14 (see Figures 6 and 5). The saddle 34 is connected with an external fin 5 protruding through a slit 36 provided in the outside face of the turnable member 13. Said fin is secured to the saddle 34. When turnable member 13 is ejected from circular cavity 12, it is possible to eject, in turn3 the empty operculum l~ by means of a little pressure on the vertical edge 35 of fin 5. Fin 5 is also used both to rotate the turnable member 13 to bring it into the desired positions and as a grasping device for the turnable member 13.
As already mentioned, the insufflator according to the invention will be suitably made of a non-toxic heat-mouldable plastic material whilst the resilient container l, that ~lorks as a pump, will ~e made of a non-toxic elastomer. Springs 24 and 25 and pins 18 and 19 ~ill be made of a suitable non-toxic plastic material or metal.
Although the operation of the insufflator should be already evident from the above description and the enc10sed Figures, it will be briefl~ described in the following for the sake of a better understanding.
The first step will obviously consist of taking off the protective - -' , ' " ' ' ' '~ ' cover 3. Next one will: pull out the turnable member 13 from cavity12 of body 6; insert operculum 15 into its seat 14 in the turnable member 13; fit the turnable member 13 into cavity 12, meanwhile bringing the member 13, by means of fin 5, into its first position ~here holes 16 and 17 of turnable member 13 are coaxial with pins 18 and 19; push knobs 20, 21 to axially puncture operculum 15 at both ends thereof; bring, by means of fin 5, the turnable member 13 into its second position (that is, turn it 90) thus bringing holes 16 and 17 to match openings 10 and 11 respectively; introduce adapter 9 into the concerned cavity (for example in a nostril) or place its outlet opening near the area to be treated; repeatedly press the resilient container l; pull out again the turnable member 13; eject the empty operculum 15 by lightly pressing edge 35 of fin 5; insert the turnable member 13 into cavity 12; and put on again protective cover 3.
It can be recognized from the above that the insufflator according to the present invention has a quite simple structure and can be easily manufactured. It can also be used in simple and reliable way and does not give rise to the above-mentioned draw-backs of the prior art apparatuses.
Claims (11)
1. Insufflator for administering drugs which are in the form of a powder pre-dosed into opercola, said insufflator comprising a body having an air-inlet opening coaxial with a substantially vertical outlet channel for carrying inlet air mixed with the powder drug, and a device with opposite substantially horizontal reciprocating pins for puncturing an operculum, said operculum being placed in a seat having two axially opposite holes, and characterized in that the seat for the operculum is provided in a member that is turnable relative to said body, and in that said turnable member can take at least two different positions: a first position, or operculum puncturing position, where the operculum is axially puncturable by said opposite, substantially horizontal reciprocating pins through said two axially opposite holes in said seat; and a second position, or delivery position, that is substantially turned 90° relative to said first position, in which one of said axially opposite holes is coaxial with said air-outlet channel and the other one of said axially opposite holes is in communication with the air-inlet opening.
2. Insufflator as claimed in claim 1, characterized in that the turnable member is detachable from said body.
3. Insufflator as claimed in claim 2, characterized in that the turnable member is housed in a cylindrical cavity provided in said body and coaxial therewith.
4. Insufflator as claimed in claim 3, characterized in that on the bottom of the cylindrical. cavity there is provided a pusher that can be reciprocated parallel to the axis of rotation of the turnable member and can be operated from outside the body to ease the separation of the turnable member from said body.
5. Insufflator as claimed in claim 2, characterized in that on the bottom of the operculum seat there is provided a pusher that can be reciprocated parallel to the axis of rotation of the turnable member and can be operated from outside said turnable member for the ejection of the empty operculum from its seat when the turnable member is separated from said body.
6. Insufflator as claimed in claim 5, characterized in that the turnable member is provided with an outwardly projecting fin to ease the turning of said turnable member.
7. Insufflator as claimed in claim 6, characterized in that said fin is secured to said pusher for the ejection of the operculum from its seat.
8. Insufflator as claimed in claim 1, characterized in that the turnable member can take a third position in which the seat of the operculum is coaxial with a radial loading opening that is provided in the body of the insufflator, the diameter of said loading opening being large enough to allow the insertion of the operculum into its seat.
9. Insufflator as claimed in claim 8, characterized in that in the body of the insufflator there is provided a pusher that can be reciprocated perpendicular to the axis of rotation of the turnable member and that can be operated from the outside of said body to ease the ejection of the empty operculum through said loading opening when the turnable member is in said third position.
10. Insufflator as claimed in claim 1, characterized in that a one-way or check valve is provided at the air-inlet opening to prevent the powder from falling down through said opening.
11. Insufflator as claimed in claim 1, characterized in that the turnable member is provided with an outwardly projecting fin to ease the turning of said turnable member.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT21668/87A IT1222509B (en) | 1987-08-17 | 1987-08-17 | INSUFFLATOR FOR THE ADMINISTRATION OF DRUGS IN THE FORM OF PRE-DOSED POWDER IN OPERATIONS |
| IT21668A/87 | 1987-08-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1289026C true CA1289026C (en) | 1991-09-17 |
Family
ID=11185106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000574144A Expired - Fee Related CA1289026C (en) | 1987-08-17 | 1988-08-08 | Insufflator for the administration of drugs in the form of a powder pre-dosed into opercola |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4884565A (en) |
| EP (1) | EP0303844B1 (en) |
| JP (1) | JPS6470072A (en) |
| AT (1) | ATE63698T1 (en) |
| AU (1) | AU602603B2 (en) |
| CA (1) | CA1289026C (en) |
| DE (1) | DE3862907D1 (en) |
| ES (1) | ES2022548B3 (en) |
| FI (1) | FI92978C (en) |
| GR (1) | GR3002092T3 (en) |
| IL (1) | IL87169A (en) |
| IT (1) | IT1222509B (en) |
| NZ (1) | NZ225682A (en) |
| PT (1) | PT88281B (en) |
| RU (1) | RU1771420C (en) |
| TR (1) | TR23304A (en) |
| YU (1) | YU47416B (en) |
| ZA (1) | ZA886058B (en) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1237118B (en) * | 1989-10-27 | 1993-05-18 | Miat Spa | MULTI-DOSE INHALER FOR POWDER DRUGS. |
| IL98441A (en) * | 1990-06-14 | 1995-12-31 | Rhone Poulenc Rorer Ltd | Powder inhalers |
| NL9002706A (en) * | 1990-12-10 | 1992-07-01 | Pharmachemie Bv | Apparatus for use when inhaling powdered materials packaged in rod capsules. |
| AU650953B2 (en) * | 1991-03-21 | 1994-07-07 | Novartis Ag | Inhaler |
| US5797391A (en) * | 1991-03-28 | 1998-08-25 | Rhone-Poulenc Rorer Limited | Inhaler |
| GB9106648D0 (en) * | 1991-03-28 | 1991-05-15 | Rhone Poulenc Rorer Ltd | New inhaler |
| IT1248059B (en) * | 1991-06-14 | 1995-01-05 | Miat Spa | MULTI-DOSE INSUFFLATOR FOR POWDER DRUGS |
| US6681767B1 (en) | 1991-07-02 | 2004-01-27 | Nektar Therapeutics | Method and device for delivering aerosolized medicaments |
| US5161524A (en) * | 1991-08-02 | 1992-11-10 | Glaxo Inc. | Dosage inhalator with air flow velocity regulating means |
| DE69214243T2 (en) * | 1991-09-23 | 1997-02-06 | Pfizer | Methods for the detection of specific mRNA and DNA in cells |
| US5476093A (en) * | 1992-02-14 | 1995-12-19 | Huhtamaki Oy | Device for more effective pulverization of a powdered inhalation medicament |
| US5785049A (en) * | 1994-09-21 | 1998-07-28 | Inhale Therapeutic Systems | Method and apparatus for dispersion of dry powder medicaments |
| US6509006B1 (en) | 1992-07-08 | 2003-01-21 | Inhale Therapeutic Systems, Inc. | Devices compositions and methods for the pulmonary delivery of aerosolized medicaments |
| US6582728B1 (en) | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| US6024090A (en) | 1993-01-29 | 2000-02-15 | Aradigm Corporation | Method of treating a diabetic patient by aerosolized administration of insulin lispro |
| US7448375B2 (en) | 1993-01-29 | 2008-11-11 | Aradigm Corporation | Method of treating diabetes mellitus in a patient |
| CN1119833A (en) * | 1993-03-03 | 1996-04-03 | 泰纳克斯公司 | Dry powder inhalator medicament carrier |
| US5372128A (en) * | 1993-04-14 | 1994-12-13 | Habley Medical Technology Corporation | Fluidizing powder inhaler |
| US5533502A (en) * | 1993-05-28 | 1996-07-09 | Vortran Medical Technology, Inc. | Powder inhaler with aerosolization occurring within each individual powder receptacle |
| DE4318455A1 (en) * | 1993-06-03 | 1994-12-08 | Boehringer Ingelheim Kg | Capsule holder |
| US5388572A (en) * | 1993-10-26 | 1995-02-14 | Tenax Corporation (A Connecticut Corp.) | Dry powder medicament inhalator having an inhalation-activated piston to aerosolize dose and deliver same |
| US5388573A (en) * | 1993-12-02 | 1995-02-14 | Tenax Corporation | Dry powder inhalator medicament carrier |
| EP0748213B1 (en) | 1994-03-07 | 2004-04-14 | Nektar Therapeutics | Methods and compositions for pulmonary delivery of insulin |
| US6051256A (en) * | 1994-03-07 | 2000-04-18 | Inhale Therapeutic Systems | Dispersible macromolecule compositions and methods for their preparation and use |
| JP3372105B2 (en) * | 1994-05-26 | 2003-01-27 | 株式会社日立ユニシアオートモティブ | Inhalation type dispenser |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| JP3388896B2 (en) * | 1994-08-08 | 2003-03-24 | 株式会社日立ユニシアオートモティブ | Inhalation type dispenser |
| AU697676B2 (en) * | 1994-09-21 | 1998-10-15 | Nektar Therapeutics | Apparatus and methods for dispersing dry powder medicaments |
| DE19502725B4 (en) * | 1995-01-28 | 2004-03-04 | Ing. Erich Pfeiffer Gmbh & Co Kg | Discharge device for media |
| US5901703A (en) * | 1995-02-06 | 1999-05-11 | Unisia Jecs Corporation | Medicine administering device for nasal cavities |
| US5780014A (en) * | 1995-04-14 | 1998-07-14 | Inhale Therapeutic Systems | Method and apparatus for pulmonary administration of dry powder alpha 1-antitrypsin |
| JP3317827B2 (en) * | 1995-10-09 | 2002-08-26 | 株式会社ユニシアジェックス | Dosing device |
| US5669378A (en) * | 1995-12-21 | 1997-09-23 | Pera; Ivo | Inhaling device |
| AUPN976496A0 (en) * | 1996-05-10 | 1996-05-30 | Glaxo Wellcome Australia Ltd | Unit dose dispensing device |
| US20030203036A1 (en) | 2000-03-17 | 2003-10-30 | Gordon Marc S. | Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients |
| CA2212430A1 (en) | 1997-08-07 | 1999-02-07 | George Volgyesi | Inhalation device |
| US6257233B1 (en) | 1998-06-04 | 2001-07-10 | Inhale Therapeutic Systems | Dry powder dispersing apparatus and methods for their use |
| GB2353222B (en) | 1999-06-23 | 2001-09-19 | Cambridge Consultants | Inhalers |
| US20010029947A1 (en) | 1999-12-17 | 2001-10-18 | Steve Paboojian | Receptacles to facilitate the extraction of powders |
| US6457471B1 (en) * | 2000-06-30 | 2002-10-01 | Medihale Ltd. | Dual-purpose medical device for upper airway treatment and methods for using same |
| US7575761B2 (en) | 2000-06-30 | 2009-08-18 | Novartis Pharma Ag | Spray drying process control of drying kinetics |
| EP1381417A4 (en) | 2001-04-26 | 2009-12-30 | New England Pharm Inc | Metered dose delivery device for liquid and powder agents |
| ITMI20010357U1 (en) * | 2001-06-28 | 2002-12-30 | Plastiape Spa | INHALER DEVICE |
| GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
| ITMI20020078A1 (en) * | 2002-01-16 | 2003-07-16 | Fabrizio Niccolai | DEVICE USABLE IN THE TREATMENT OF RESPIRATORY TRACT AFFECTIONS |
| US7582284B2 (en) | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
| GB0216562D0 (en) | 2002-04-25 | 2002-08-28 | Bradford Particle Design Ltd | Particulate materials |
| US9339459B2 (en) | 2003-04-24 | 2016-05-17 | Nektar Therapeutics | Particulate materials |
| WO2004039415A2 (en) | 2002-10-28 | 2004-05-13 | Northgate Technologies Inc. | Dual-capacity insufflator tube |
| DE10258360A1 (en) * | 2002-12-12 | 2004-06-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Chamber for accommodation of disposable capsules for powder inhalers has an inner surface with protruding elements serving as distance pieces between the capsules |
| US7284553B2 (en) | 2002-12-12 | 2007-10-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Powder inhaler comprising a chamber for a capsule for taking up a non-returnable capsule being filled with an active ingredient |
| US20040206350A1 (en) * | 2002-12-19 | 2004-10-21 | Nektar Therapeutics | Aerosolization apparatus with non-circular aerosolization chamber |
| PL1615689T3 (en) * | 2003-04-09 | 2016-06-30 | Novartis Ag | Aerosolization apparatus with capsule puncture alignment guide |
| US8869794B1 (en) * | 2003-04-09 | 2014-10-28 | Novartis Pharma Ag | Aerosolization apparatus with capsule puncturing member |
| WO2004091705A1 (en) * | 2003-04-09 | 2004-10-28 | Nektar Therapeutics | Aerosolization apparatus with air inlet shield |
| US7654975B2 (en) * | 2003-04-24 | 2010-02-02 | Northgate Technologies, Inc. | Mixed-gas insufflation system |
| WO2004112702A2 (en) * | 2003-06-13 | 2004-12-29 | Advanced Inhalation Research, Inc. | Low dose pharmaceutical powders for inhalation |
| WO2005035035A1 (en) * | 2003-10-07 | 2005-04-21 | Northgate Technologies Inc. | System and method for delivering a substance to a body cavity |
| EP1680173B1 (en) | 2003-10-31 | 2011-01-12 | Trudell Medical International | System for manipulating a catheter for delivering a substance to a body cavity |
| DE10352277A1 (en) * | 2003-11-08 | 2005-06-02 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | powder inhaler |
| US20070178141A1 (en) * | 2005-09-07 | 2007-08-02 | Bebaas, Inc. | Vitamin B12 compositions |
| US20130131007A1 (en) | 2005-09-07 | 2013-05-23 | Bebaas, Inc. | Vitamin b12 compositions |
| CA2933737C (en) | 2006-08-04 | 2020-12-29 | Northgate Technologies Inc. | In-dwelling port for access into a body |
| US8360056B2 (en) * | 2006-08-31 | 2013-01-29 | Hitachi, Ltd. | Medicine sprayer |
| MX2009004349A (en) * | 2006-10-25 | 2009-07-22 | Novartis Ag | Powder dispersion apparatus, method of making and using the apparatus, and components that can be used on the apparatus and other devices. |
| CN104188907A (en) | 2007-02-11 | 2014-12-10 | Map药物公司 | Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile |
| US8496002B2 (en) * | 2007-06-12 | 2013-07-30 | Civitas Therapeutics, Inc. | Powder inhaler devices |
| WO2009046215A2 (en) * | 2007-10-02 | 2009-04-09 | Lab International Srl | Safety and abuse deterrent improved device |
| US8327610B1 (en) | 2011-12-16 | 2012-12-11 | JCDS Holdings, LLC | Capsule opener and emptier |
| US9572595B1 (en) | 2014-03-05 | 2017-02-21 | Northgate Technologies Inc. | In-dwelling port for access into a body |
| USD752204S1 (en) | 2014-03-10 | 2016-03-22 | Civitas Therapeutics, Inc. | Indicator for an inhaler |
| USD752734S1 (en) | 2014-03-10 | 2016-03-29 | Civitas Therapeutics, Inc. | Inhaler grip |
| USD755367S1 (en) | 2014-03-10 | 2016-05-03 | Civitas Therapeutics, Inc. | Indicator for an inhaler |
| US11517686B2 (en) * | 2016-12-20 | 2022-12-06 | Emphasys Importadora Exportadora E Distribuidora Ltda. | Dry powder inhaler |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2517482A (en) * | 1949-04-09 | 1950-08-01 | Sharp & Dohme Inc | Inhaler |
| US3507277A (en) * | 1966-09-17 | 1970-04-21 | Fisons Pharmaceuticals Ltd | Inhalation device |
| IT941426B (en) * | 1971-07-17 | 1973-03-01 | Isf Spa | SWIRL-CHAMBER INHALER FOR POWDER-SHAPING MEDICINAL SUBSTANCES |
| FR2224175B1 (en) * | 1973-04-04 | 1978-04-14 | Isf Spa | |
| GB1387954A (en) * | 1973-05-08 | 1975-03-19 | Miles Lab | Insufflator |
| IT1016489B (en) * | 1974-03-18 | 1977-05-30 | Isf Spa | INHALER |
| US3971377A (en) * | 1974-06-10 | 1976-07-27 | Alza Corporation | Medicament dispensing process for inhalation therapy |
| IT1017153B (en) * | 1974-07-15 | 1977-07-20 | Isf Spa | APPARATUS FOR INHALATIONS |
| DE2960616D1 (en) * | 1978-05-03 | 1981-11-12 | Fisons Plc | Inhalation device |
| EP0041783B1 (en) * | 1980-06-06 | 1984-12-05 | FISONS plc | Inhalation device for powdered medicaments |
| PT83094B (en) * | 1985-07-30 | 1993-07-30 | Glaxo Group Ltd | DEVICES PROPER FOR THE ADMINISTRATION OF MEDICINES TO PATIENTS |
-
1987
- 1987-08-17 IT IT21668/87A patent/IT1222509B/en active
-
1988
- 1988-07-20 AT AT88111680T patent/ATE63698T1/en not_active IP Right Cessation
- 1988-07-20 IL IL87169A patent/IL87169A/en not_active IP Right Cessation
- 1988-07-20 DE DE8888111680T patent/DE3862907D1/en not_active Expired - Fee Related
- 1988-07-20 ES ES88111680T patent/ES2022548B3/en not_active Expired - Lifetime
- 1988-07-20 EP EP88111680A patent/EP0303844B1/en not_active Expired - Lifetime
- 1988-07-27 US US07/224,816 patent/US4884565A/en not_active Expired - Lifetime
- 1988-08-03 NZ NZ225682A patent/NZ225682A/en unknown
- 1988-08-05 JP JP63195946A patent/JPS6470072A/en active Granted
- 1988-08-08 CA CA000574144A patent/CA1289026C/en not_active Expired - Fee Related
- 1988-08-10 TR TR595/88A patent/TR23304A/en unknown
- 1988-08-15 FI FI883767A patent/FI92978C/en not_active IP Right Cessation
- 1988-08-15 YU YU157488A patent/YU47416B/en unknown
- 1988-08-15 AU AU21009/88A patent/AU602603B2/en not_active Ceased
- 1988-08-16 ZA ZA886058A patent/ZA886058B/en unknown
- 1988-08-17 PT PT88281A patent/PT88281B/en not_active IP Right Cessation
- 1988-08-17 RU SU884356377A patent/RU1771420C/en active
-
1991
- 1991-06-07 GR GR91400770T patent/GR3002092T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FI92978C (en) | 1995-02-10 |
| EP0303844B1 (en) | 1991-05-22 |
| EP0303844A1 (en) | 1989-02-22 |
| GR3002092T3 (en) | 1992-12-30 |
| NZ225682A (en) | 1990-08-28 |
| FI883767A (en) | 1989-02-18 |
| ES2022548B3 (en) | 1991-12-01 |
| FI883767A0 (en) | 1988-08-15 |
| JPH0558349B2 (en) | 1993-08-26 |
| AU2100988A (en) | 1989-02-23 |
| US4884565A (en) | 1989-12-05 |
| PT88281B (en) | 1993-09-30 |
| AU602603B2 (en) | 1990-10-18 |
| YU157488A (en) | 1990-10-31 |
| FI92978B (en) | 1994-10-31 |
| IL87169A (en) | 1992-05-25 |
| ATE63698T1 (en) | 1991-06-15 |
| PT88281A (en) | 1990-06-29 |
| JPS6470072A (en) | 1989-03-15 |
| YU47416B (en) | 1995-03-27 |
| IT1222509B (en) | 1990-09-05 |
| ZA886058B (en) | 1989-04-26 |
| DE3862907D1 (en) | 1991-06-27 |
| IT8721668A0 (en) | 1987-08-17 |
| IL87169A0 (en) | 1988-12-30 |
| RU1771420C (en) | 1992-10-23 |
| TR23304A (en) | 1989-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKLA | Lapsed |