CA1334366C - Animal marker implanting system - Google Patents
Animal marker implanting systemInfo
- Publication number
- CA1334366C CA1334366C CA000548144A CA548144A CA1334366C CA 1334366 C CA1334366 C CA 1334366C CA 000548144 A CA000548144 A CA 000548144A CA 548144 A CA548144 A CA 548144A CA 1334366 C CA1334366 C CA 1334366C
- Authority
- CA
- Canada
- Prior art keywords
- marker
- implanting
- housing
- tubular means
- plunger
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0069—Devices for implanting pellets, e.g. markers or solid medicaments
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K11/00—Marking of animals
- A01K11/006—Automatic identification systems for animals, e.g. electronic devices, transponders for animals
Abstract
A system for implanting a solid marker in an animal is provided. The apparatus includes a hollow tube having an entrance and an exit opening. A support is provided for supporting a hollow tube. A plunger is slideably disposed between a first position and a second position within the support. The plunger cooperates with the support and the tube. The plunger engages the marker proximate to the entrance opening of the tube, and ejects the marker through the tube when the plunger is moved from a first position to a second position.
Description
~ ANIMAL MARKER IMPL~NTING SYSTEM
1 33~3~
B~CKGROUND OF THE INVENTION
This invention relates, in general, to a system for implanting an identification marker in an animal and, in particular, to a system for facilitating implantation and retention of an iden-tification marker into a laboratory animal.
Heretofore, the marking of animals for tracking and testing purposes has involved marking the animal externally, i.e., tatooing, branding or tagging. These external markers are difficult to read when identifying the animal and are extremely limited in the amount of information about the animal that can be carried by the external marker.
In order to overcome the disadvantages noted above with external markers, a system has been proposed whereby markers carry-ing information that can be read by an external detector can be implanted in a test animal. However, such a system requires an instrument that permits a marker to be delivered into the animal without difficulty and wherein the marker will remain securely embedded in the lab animal for a considerable length of time.
SUMMARY OF THE lNv~NlION
Generally speaking, in accordance with the invention, an improved apparatus for implanting a marker into an animal is pro-vided. The apparatus includes a hollow tube having an opening at each end. An entrance end of the hollow tube is supported within a housing. An exit end of the tube is sharp to allow subcutaneous penetration of the tube underneath the skin of a laboratory animal.
A plunger is slideably mounted within the housing. The plunger is adapted to displace the marker from a first position in the tube out of the exit end of the tube.
In an exemplary embodiment, an electronic transponder containing information about the animal, such as identification numbers, is placed in the marker. When the tube is inserted below the skin of the animal and the plunger is displaced, the marker ,1 ~
~ 2- 1 334366 containing the electronic transponder is forced through the tube, lodging it underneath the skin of the animal.
An object of this invention is to provide an improved appar-atus for implanting markers in laboratory animals.
A further object of this invention is to provide an implant-ing system for facilitating identification of laboratory animals.
Still a further object of this invention is to provide an easy to use implanting instrument for implanting a marker into a laboratory animal.
Yet a further object of the invention is to provide an implanting system for implanting a marker subcutaneously in the animal so that the marker will be retained within the animal.
Still other objects and advantages of the invention will in part be obvious and will in part be apparent from the specification and the drawings.
The invention accordingly comprises features of construc-tion, combination of elements and arrangement of parts which will be exemplified in the construction hereinafter set forth and the scope of the invention will be indicated in the claims.
BRIEF DESCRIPTION OF THE DRAWINGS
For a fuller understanding of the invention, reference is had to the following description taken in connection with the accompanying drawings, in which:
FIG. 1 is a perspective view of an animal marker implanting instrument constructed in accordance with a preferred embodiment of the instant invention;
FIG. 2 is a partial sectional view taken along line 2-2 of FIG. l;
FIG. 3 is a partial sectional view taken along line 2-2 of FIG. l;
FIG. 4 is a partial sectional view taken along line 4-4 of FIG. 3;
FIG. 5 is a partial sectional view taken along line 5-5 of FIG. 3;
_3_ ~ 33436~
FIG. 6 is a partial sectional view taken along line 2-2 of FIG. 1, when the needle assembly is inserted therein;
FIG. 7 is a sectional view taken along line 7-7 of FIG. 6;
FIG. 8 is a perspective view of the implanting instrument illustrated in FIG. 1 in use;
FIG. 9 is a plan view of the implanting instrument illus-trated in FIG. 1 in use;
FIG. 10 is a sectional view taken along line 10-10 of FIG.
9;
FIG. 11 is an enlarged partial sectional view of the implan-ter instrument illustred in FIG. 10;
FIG. 12 is a sectional view of the implanting instrument taken along line 12-12 of FIG. 11;
FIG. 13 is a perspective view of the needle assembly;
FIG. 14 is a sectional view of the marker depicted in FIG.
11;
FIG. 15 is a sectional view depicting a sectional view taken along line 15-15 of FIG. 13; and Fig. 16 is a perspective view of a cylinder to be used as part of the instant invention.
DETAILED DESCRIPTION OF THE PREFERRRED EMBODIMENTS
Reference is initially made to FIGS. 1 through 15, wherein an animal marking system including an implanting instrument, gener-ally indicated at 10 (FIG. 1), a needle assembly, generally indicated as 19 (FIG. 13) and an animal marker, generally indicated as 30 (FIGS. 11, 12 and 14) is depicted. As is explained in greater detail below, the cooperation of the needle assembly, marker and implanting instrument permits the facile implantation of a marker into a laboratory animal and the retention of the marker within the animal during long periods of laboratory monitoring and testing.
Reference is now particularly made to FIGS. 1 through 5, wherein instrument 10 is illustrated in detail. Instrument 10 defines two opposed half walls 27 which are molded in mirror image and secured together to define a unitary housing in the shape of a handle 31. Each opposed wall 27 is defined by a substantially parallelogram shaped configuration including lengthwise mating ~4~ 1 3 3 4 3 6 6 walls 27a and lateral mating walls 27b and 27c. As is explained in greater detail below, mating walls 27a are inclined with respect to lateral mating walls 27b to define handle 31 and to facilitate storage therein of a plurality of needle assemblies. A cap 34 is slideably mounted to the housing defined in opposed wall 27. In an exemplary embodiment, at least one of the opposed walls 27 can be transparent or translucent to allow the user to view the needle assemblies 19 disposed within the handle.
Cap 34 is normally disposed in a closed position, and can be displaced in the direction A (FIG. 2) from a closed position (solid lines in FIG. 2) to an open position (phantom lines in FIG.
1 33~3~
B~CKGROUND OF THE INVENTION
This invention relates, in general, to a system for implanting an identification marker in an animal and, in particular, to a system for facilitating implantation and retention of an iden-tification marker into a laboratory animal.
Heretofore, the marking of animals for tracking and testing purposes has involved marking the animal externally, i.e., tatooing, branding or tagging. These external markers are difficult to read when identifying the animal and are extremely limited in the amount of information about the animal that can be carried by the external marker.
In order to overcome the disadvantages noted above with external markers, a system has been proposed whereby markers carry-ing information that can be read by an external detector can be implanted in a test animal. However, such a system requires an instrument that permits a marker to be delivered into the animal without difficulty and wherein the marker will remain securely embedded in the lab animal for a considerable length of time.
SUMMARY OF THE lNv~NlION
Generally speaking, in accordance with the invention, an improved apparatus for implanting a marker into an animal is pro-vided. The apparatus includes a hollow tube having an opening at each end. An entrance end of the hollow tube is supported within a housing. An exit end of the tube is sharp to allow subcutaneous penetration of the tube underneath the skin of a laboratory animal.
A plunger is slideably mounted within the housing. The plunger is adapted to displace the marker from a first position in the tube out of the exit end of the tube.
In an exemplary embodiment, an electronic transponder containing information about the animal, such as identification numbers, is placed in the marker. When the tube is inserted below the skin of the animal and the plunger is displaced, the marker ,1 ~
~ 2- 1 334366 containing the electronic transponder is forced through the tube, lodging it underneath the skin of the animal.
An object of this invention is to provide an improved appar-atus for implanting markers in laboratory animals.
A further object of this invention is to provide an implant-ing system for facilitating identification of laboratory animals.
Still a further object of this invention is to provide an easy to use implanting instrument for implanting a marker into a laboratory animal.
Yet a further object of the invention is to provide an implanting system for implanting a marker subcutaneously in the animal so that the marker will be retained within the animal.
Still other objects and advantages of the invention will in part be obvious and will in part be apparent from the specification and the drawings.
The invention accordingly comprises features of construc-tion, combination of elements and arrangement of parts which will be exemplified in the construction hereinafter set forth and the scope of the invention will be indicated in the claims.
BRIEF DESCRIPTION OF THE DRAWINGS
For a fuller understanding of the invention, reference is had to the following description taken in connection with the accompanying drawings, in which:
FIG. 1 is a perspective view of an animal marker implanting instrument constructed in accordance with a preferred embodiment of the instant invention;
FIG. 2 is a partial sectional view taken along line 2-2 of FIG. l;
FIG. 3 is a partial sectional view taken along line 2-2 of FIG. l;
FIG. 4 is a partial sectional view taken along line 4-4 of FIG. 3;
FIG. 5 is a partial sectional view taken along line 5-5 of FIG. 3;
_3_ ~ 33436~
FIG. 6 is a partial sectional view taken along line 2-2 of FIG. 1, when the needle assembly is inserted therein;
FIG. 7 is a sectional view taken along line 7-7 of FIG. 6;
FIG. 8 is a perspective view of the implanting instrument illustrated in FIG. 1 in use;
FIG. 9 is a plan view of the implanting instrument illus-trated in FIG. 1 in use;
FIG. 10 is a sectional view taken along line 10-10 of FIG.
9;
FIG. 11 is an enlarged partial sectional view of the implan-ter instrument illustred in FIG. 10;
FIG. 12 is a sectional view of the implanting instrument taken along line 12-12 of FIG. 11;
FIG. 13 is a perspective view of the needle assembly;
FIG. 14 is a sectional view of the marker depicted in FIG.
11;
FIG. 15 is a sectional view depicting a sectional view taken along line 15-15 of FIG. 13; and Fig. 16 is a perspective view of a cylinder to be used as part of the instant invention.
DETAILED DESCRIPTION OF THE PREFERRRED EMBODIMENTS
Reference is initially made to FIGS. 1 through 15, wherein an animal marking system including an implanting instrument, gener-ally indicated at 10 (FIG. 1), a needle assembly, generally indicated as 19 (FIG. 13) and an animal marker, generally indicated as 30 (FIGS. 11, 12 and 14) is depicted. As is explained in greater detail below, the cooperation of the needle assembly, marker and implanting instrument permits the facile implantation of a marker into a laboratory animal and the retention of the marker within the animal during long periods of laboratory monitoring and testing.
Reference is now particularly made to FIGS. 1 through 5, wherein instrument 10 is illustrated in detail. Instrument 10 defines two opposed half walls 27 which are molded in mirror image and secured together to define a unitary housing in the shape of a handle 31. Each opposed wall 27 is defined by a substantially parallelogram shaped configuration including lengthwise mating ~4~ 1 3 3 4 3 6 6 walls 27a and lateral mating walls 27b and 27c. As is explained in greater detail below, mating walls 27a are inclined with respect to lateral mating walls 27b to define handle 31 and to facilitate storage therein of a plurality of needle assemblies. A cap 34 is slideably mounted to the housing defined in opposed wall 27. In an exemplary embodiment, at least one of the opposed walls 27 can be transparent or translucent to allow the user to view the needle assemblies 19 disposed within the handle.
Cap 34 is normally disposed in a closed position, and can be displaced in the direction A (FIG. 2) from a closed position (solid lines in FIG. 2) to an open position (phantom lines in FIG.
2). As is illustrated in FIG. 7, cap 34 includes side walls 34a and gripping walls 34b which are disposed in elongated slots 27' formed in opposed walls 27. Cap 34 includes ribs 35 on the side for permitting the cap to be easily gripped and can be displaced between an open and closed position. An arrow 37 or other indicia can be imprinted on cap 34 to indicate the proper directions for sliding.
Opposed lateral walls 27b are covered by cap 34 when cap 34 is in a closed position. Opposed lateral walls 27b are configured to define opposed recessed walls 38a and an open chamber, generally indicated at 38, for receiving a needle assembly and for permitting each needle assembly to be dispensed through the opening from the interior of the housing when cap 34 is displaced to an open position.
Opposed lateral walls 27b are further configured to define a channel 39 which orients the needle assembly when it is positioned in chamber 38.
Referring particularly to FIGS. 10 through 15, needle assembly 19 is formed from a stainless steel hollow tube 20 having an exit opening 21 and an entrance opening 23. Exit opening 21 is formed in the shape of an inclined edge 22 which forms a sharp point for permitting the tube to easily penetrate an animal's skin. The side of tube 20 having entrance opening 23 is molded in a plug 24.
Plug 24 includes a sleeve 25 integrally formed therewith and pro-jecting about tube 20 to extend along a portion of the tube's length.
Plug 24 includes arcuate end walls 24a for facilitating the posi-_5_ 1 334366 tioning of the plugs in chamber 38 in a manner that will be discussedin detail below. As is particularly illustrated in FIG. 15, marker 30 is positioned in tube 20 near the exit opening 21 thereof. A drive pin 16 is used to position the marker within the tube. Drive pin 16 includes a sealing disc 17 that is integrally molded therewith.
Sealing disc 17 has an outside diameter that is sufficient to interference fit with the inside diameter of the tube 20 and prevent displacement of the drive pin during normal stoage and handling of the needle assembly. Drive pin 16 aids in positioning the marker in the tube. However, it has been found necessary to facilitate positioning of the marker in tube 20 particularly when the marker is a glass capsule in order to prevent the marker from slipping out of the exit opening of the tube.
Reference is now made to FIGS. 11 and 12 wherein a projec-tion 29 integral with sleeve 25 extends through opening 28 in order to prevent the marker from slipping or moving in the tube prior to the discharge of same into the animal. This projection can be easily formed during assembly of the hollow tube within plug 24 by molding the plug about the tube and permitting the resin used to form the tube to enter aperture 28. Projection 29 is intended to frictionally engage marker 30 when the marker is positioned within tube 20 to prevent the marker from sliding in the tube. Projection 29 will hold the marker in place until a force sufficient to push marker 30 through tube 20 is applied to a plunger and, in turn, to the marker.
In an exemplary embodiment, tube 20 is stainless steel.
However, tube 20 may be made from other rigid FDA approved materials, such as Ultem, manufactured by General Electric. Also, as afore-noted, sleeve 25 and plug 24 can be integrally formed by injection molding a plastic resin about the entrance opening of tube 20. Also, the sleeve and plug may be formed of rigid materials other than plastic.
Needle assembly 19 is easily positioned in chamber 38 when cap 34 is displaced into an open position. Moreover, needle assembly 19 is tightly secured within chamber 38 by returning cap 34 to a closed position. This prevents any wobbling of the needle 19 assembly during use.
_ -6- 1 3 3 4 3 6 6 Plunger 18 includes a rod 41 and a knurled surface 43 inte-grally formed at one end of rod 41. Plunger 18 is slideably mounted within elongated channel 39 formed by lateral walls 27b formed in the top of the housing. Knurled surface 43 projects through elongated opening 44 in cap 34 and permits the plunger to be displaced between a start position and an implanting position. Channel 39 is coaxially aligned with the entrance opening 23 of tube 20 of the needle assembly 19 and alignment channel 49 to form a continuous pathway for rod 41 when needle assembly 19 is retained in chamber 38. Knurled surface 43 extends through elongated opening 44 (FIG. 9) in cap 34, allowing displacement of the plunger 18 by pushing knurled surface 43 from a start position to an implanting position. Plunger 18 also includes seats 18a projecting therefrom which rests against stops 27e formed by opposed half walls 27. Stops 27e and seats 18a cooperate to normally maintain the plunger at the start position depicted in FIG. 6.
The distance of the placement of the marker in the tube from the exit opening and the length of elongated opening 44 have relative lengths with respect to each other. When cap 34 is displaced in the direction A into an open position, it will capture knurled surface 43 if it is not already in a start position and displace the plunger to a start position so that rod 41 is entirely displaced outside of the entrance opening 23 of the needle assembly 19. Furthermore, the distance of the placement of the marker from the exit opening determines the distance through which the rod will be displaced and, hence, the preferred distance of elongaged opening 44. Moreover, this distance further assumes that rod 41 is entirely displaced without the entrance opening of the tube when plunger 18 is in a start position. This permits placement of needle assembly 19 in chamber 38.
When cap 34 is returned to a closed position, stop 27e helps maintain plunger 18 at its start position so that the plunger is not unintentionally pushed forward. If slideable cap 34 is not pushed entirely into a closed position, knurled surface 43 is prevented from being pushed forward sufficiently to cause plunger 18 to eject the marker 28 from the needle assembly 19. This configuration prevents use of the instrument unless the needle assembly 19 is fully secured within chamber 38 and is securely captured by cap 34 being displaced into a closed position. Also, since knurled surface 43 of the plunger 18 comes in contact with the cap at the limits of elongated opening 44, the plunger 18 is automatically positioned by manipulat-ing the cap.
Reference is now also made to FIG. 8, wherein operation of the instant invention is depicted. In an exemplary embodiment, marker 30 is stored within tube 20 and is retained therein by a projection 25. Cap 34 is then slid into an open position. Needle assembly 19 is then pivotably displaced into chamber 38. Cap 34 is then displaced forward into a closed position supporting and anchor-ing needle assembly 19 securely in place within chamber 38 and channel 49.
Next, a test animal, such as a mouse 46, must be stabilized.
As illustrated in FIG. 8, a mouse can be picked up in the user's one hand and the implanting instrument held in the user's other hand.
However, as is illustrated in FIG. 16, in an exemplary embodiment, a cylinder 80 that is open at both ends can be utilized to render the head of the mouse immobile. By inserting the mouse's head in a cylinder the mouse cannot turn its head and bite the user's hand or otherwise interfere with the procedure. Furthermore, once the mouse's head is immobilized in the cylinder it permits the hand of the user to be used to stretch the animal's skin and thereby facilitate manipulation of the mouse during subcutaneous implanta-tion. Accordingly, the implanter systems of the instant invention contemplates the use of different sized tubes to accommodate the distinct differences in the size of the laboratory animals. Once the animal is immobilized, the user is prepared to insert tube 20 into the laboratory animal.
Exit end 21 of tube 20 is inserted subcutaneously into mouse 46 until the animal's skin 48 reaches the edge of sleeve 25. This automatically places marker 30 at the desired position beneath the skin. Knurled surface 43 of the plunger 18 is then pushed forward, `~ -8- 1 3 3 4 3 6 6 preferably with the user's thumb 50, with enough force such that plunger 18 engages drive pin 16. Knurled surface 43 is displaced until knurled surface 43 is disposed into an implanting position so that rod 43 comes in contact with the end of opening 44 in cap 34.
At this point, plunger rod 41 of plunger 18 has engaged drive pin 16 and extends far enough within tube 20 to have forced drive pin 16 to eject marker 30 from tube 20 underneath the animal's skin. Next, the implanting apparatus is removed from animal skin 48, cap 34 is pulled back and needle assembly 19 is removed and discarded. The process may then be repeated for another animal.
In an exemplary embodiment, marker 30 is a glass capsule having therein an electronic transponder containing identification information about the animal. This is used by way of example only.
This process is adaptable to the implantation of any type of marker.
Marker 30 is formed by embedding an electronic transponder (not shown) in a glass capsule. By using an electronic transponder, the amount of storable information is greatly increased, especially when transponder information can be directly linked to computer systems containing further information and processing software. Because the capsule is glass, it tends to slide easily in stainless tube 20. It is for this reason that projection 29 is used to interference fit the capsule in the tube and prevent same from moving within the tube during storage and handling of the needle assembly.
Each needle assembly 19 is sealed within a sanitary sleeve 33 which can be easily removed when the needle assembly is displaced into chamber 38 for use in the manner described above. Moreover, after sanitary sleeve 33 is used to cover the exit opening of the tube, a sterilant gas can be injected into a chamber defined by tube 20, drive pin 16 and sealing disc 17 and the sleeve 33. By introducing a sterliant gas, the marker can be sterilized and remain sterilized until the needle assembly is ready for use. Furthermore, as is illustrated particularly in FIGS. 2 through 5 and 13, the opposed side walls 27 of the housing and the plug 24 of each needle assembly are configured in a manner discussed below to permit each needle assembly to be stored in the handle and removed therefrom for easy use.
Specifically, a pair of opposed ramps 45 are formed in each wall 27. Ramps 45 are formed in mirror image on each wall so that they are disposed in registry with each other when walls 27 are brought together to form the housing defining handle 31. Further-more, each ramp is disposed in parallel with lateral wall 37c and at an angle with respect to the lengthwise extent of the handle. Ramps 45 are spread a sufficient distance apart to permit two rows of needle assemblies to be stored in the handle.
The plug of each needle assembly includes positioning grooves 26 found in opposed surfaces, the grooves being disposed on an angle with respect to the lengthwise extent of the plug and diagonally opposed with each other to facilitate placement of each needle assembly in the housing during assembly of the product. As is illustrated with some particularity in FIGS. 3 through 5, each needle assembly can be positioned within handle by racking the plug onto a first ramp 45 so that the ramp is positioned within the positioning groove 26. The groove 26 and ramp 45 prevent any substantial lengthwise displacement of each needle assembly during storage and use of the instrument. The opposing ramp assists in positioning the plug by pressing against the plug. Each ramp 45 includes a positioning ramp 45a that is parallel with the lengthwise side walls 27a of handle 31. Positioning ramp 45a does not protrude as far as ramp 45 and is provided to assist in preventing the plug from sliding laterally and to further assist in guiding the needle assembly through the opening in chamber 38 when a needle assembly is to be removed from the handle.
In an exemplary embodiment, ten needle assemblies are stored on each ramp 45. As noted above, wall 27a and ramp 45a facilitate delivery of each needle assembly to the operator.
As is illustrated in FIG. 2, the opening in chamber 38 is sufficiently large to permit the needle assembly to be removed therethrough. Accordingly, when a needle assembly is needed, cap 34 is displaced from a closed position to an open position. By manipulating the orientation of the housing, a needle assembly positioned closest to chamber 38 will then slide out of the housing -lo- 1 3 3 4 3 6 6 through opening 38. As aforenoted, such manipulation can be facili-tated by forming one of the opposed walls 27 forming handle 31 out of a transparent or translucent material. It is then a simple matter to position plug 24 of the needle assembiy in chamber 38, slide cap 34 to a closed position and remove the sanitary sleeve 33, so that the user is ready to begin implantation of the marker in the manner discussed above.
Reference is now made to FIG. 14, wherein a marker 30 is formed of a smooth material 81, such as glass. As aforenoted, the use of a glass marker can be problematical. First, when the needle assembly does not include a projection 29, marker 30 is not secured in the tube and, hence, the marker may slide out of the tube of the needle assemlby. Also, it has been observed that when a glass encapsulated transponder is implanted in a laboratory animal, migra-tion of the transponder out of the wound of the animal can occur.
Accordingly, in a preferred embodiment, one-half of marker 30 is coated with a layer 83 having a high coefficient of friction. For example, Silastic~, manufactured by Dow Corning, has been success-fully used. Also, polypropylene has been used as a coating. By utilizing a layer coating marker 30, projection 29 can be eliminated, thereby allowing for a thinner tube 20 having a greater inner diameter than the embodiments containing projection 29.
The instant invention further contemplates a method of forming layer 38 about a glass marker. Specifically, markers are partially inserted into a mold cavity. Thereaftrer, a polypropylene resin is injected into the mold cavities and cured about the marker to define a suitable non-slippery surface.
In a further embodiment, the outer surface of glass of marker 30 can be etched. Although etching of the outer glass coating prevents migration in the animal, projection 29 is still needed to hold marker 30 in place in the tube 20. However, etching has been found to weaken the marker and although experimentally viable, does not appear to offer the same efficiency as the use of a coating on the glass capsule.
1 3343b~
It will thus be seen that the objects set forth above, and those made apparent from the preceding description, are efficiently attained and, since certain changes may be made in the above construction without departing from the spirit and scope of the invention, it is intended that all matter contained in the above description or shown in the accompanying drawings shall be interpre-ted as illustrative and not in a limiting sense.
It is also to be understood that the following claims are intended to cap all of the generic and specific features of the invention herein described, and all statements of the scope of the invention which, as a matter of language, might be said to fall therebetween.
Opposed lateral walls 27b are covered by cap 34 when cap 34 is in a closed position. Opposed lateral walls 27b are configured to define opposed recessed walls 38a and an open chamber, generally indicated at 38, for receiving a needle assembly and for permitting each needle assembly to be dispensed through the opening from the interior of the housing when cap 34 is displaced to an open position.
Opposed lateral walls 27b are further configured to define a channel 39 which orients the needle assembly when it is positioned in chamber 38.
Referring particularly to FIGS. 10 through 15, needle assembly 19 is formed from a stainless steel hollow tube 20 having an exit opening 21 and an entrance opening 23. Exit opening 21 is formed in the shape of an inclined edge 22 which forms a sharp point for permitting the tube to easily penetrate an animal's skin. The side of tube 20 having entrance opening 23 is molded in a plug 24.
Plug 24 includes a sleeve 25 integrally formed therewith and pro-jecting about tube 20 to extend along a portion of the tube's length.
Plug 24 includes arcuate end walls 24a for facilitating the posi-_5_ 1 334366 tioning of the plugs in chamber 38 in a manner that will be discussedin detail below. As is particularly illustrated in FIG. 15, marker 30 is positioned in tube 20 near the exit opening 21 thereof. A drive pin 16 is used to position the marker within the tube. Drive pin 16 includes a sealing disc 17 that is integrally molded therewith.
Sealing disc 17 has an outside diameter that is sufficient to interference fit with the inside diameter of the tube 20 and prevent displacement of the drive pin during normal stoage and handling of the needle assembly. Drive pin 16 aids in positioning the marker in the tube. However, it has been found necessary to facilitate positioning of the marker in tube 20 particularly when the marker is a glass capsule in order to prevent the marker from slipping out of the exit opening of the tube.
Reference is now made to FIGS. 11 and 12 wherein a projec-tion 29 integral with sleeve 25 extends through opening 28 in order to prevent the marker from slipping or moving in the tube prior to the discharge of same into the animal. This projection can be easily formed during assembly of the hollow tube within plug 24 by molding the plug about the tube and permitting the resin used to form the tube to enter aperture 28. Projection 29 is intended to frictionally engage marker 30 when the marker is positioned within tube 20 to prevent the marker from sliding in the tube. Projection 29 will hold the marker in place until a force sufficient to push marker 30 through tube 20 is applied to a plunger and, in turn, to the marker.
In an exemplary embodiment, tube 20 is stainless steel.
However, tube 20 may be made from other rigid FDA approved materials, such as Ultem, manufactured by General Electric. Also, as afore-noted, sleeve 25 and plug 24 can be integrally formed by injection molding a plastic resin about the entrance opening of tube 20. Also, the sleeve and plug may be formed of rigid materials other than plastic.
Needle assembly 19 is easily positioned in chamber 38 when cap 34 is displaced into an open position. Moreover, needle assembly 19 is tightly secured within chamber 38 by returning cap 34 to a closed position. This prevents any wobbling of the needle 19 assembly during use.
_ -6- 1 3 3 4 3 6 6 Plunger 18 includes a rod 41 and a knurled surface 43 inte-grally formed at one end of rod 41. Plunger 18 is slideably mounted within elongated channel 39 formed by lateral walls 27b formed in the top of the housing. Knurled surface 43 projects through elongated opening 44 in cap 34 and permits the plunger to be displaced between a start position and an implanting position. Channel 39 is coaxially aligned with the entrance opening 23 of tube 20 of the needle assembly 19 and alignment channel 49 to form a continuous pathway for rod 41 when needle assembly 19 is retained in chamber 38. Knurled surface 43 extends through elongated opening 44 (FIG. 9) in cap 34, allowing displacement of the plunger 18 by pushing knurled surface 43 from a start position to an implanting position. Plunger 18 also includes seats 18a projecting therefrom which rests against stops 27e formed by opposed half walls 27. Stops 27e and seats 18a cooperate to normally maintain the plunger at the start position depicted in FIG. 6.
The distance of the placement of the marker in the tube from the exit opening and the length of elongated opening 44 have relative lengths with respect to each other. When cap 34 is displaced in the direction A into an open position, it will capture knurled surface 43 if it is not already in a start position and displace the plunger to a start position so that rod 41 is entirely displaced outside of the entrance opening 23 of the needle assembly 19. Furthermore, the distance of the placement of the marker from the exit opening determines the distance through which the rod will be displaced and, hence, the preferred distance of elongaged opening 44. Moreover, this distance further assumes that rod 41 is entirely displaced without the entrance opening of the tube when plunger 18 is in a start position. This permits placement of needle assembly 19 in chamber 38.
When cap 34 is returned to a closed position, stop 27e helps maintain plunger 18 at its start position so that the plunger is not unintentionally pushed forward. If slideable cap 34 is not pushed entirely into a closed position, knurled surface 43 is prevented from being pushed forward sufficiently to cause plunger 18 to eject the marker 28 from the needle assembly 19. This configuration prevents use of the instrument unless the needle assembly 19 is fully secured within chamber 38 and is securely captured by cap 34 being displaced into a closed position. Also, since knurled surface 43 of the plunger 18 comes in contact with the cap at the limits of elongated opening 44, the plunger 18 is automatically positioned by manipulat-ing the cap.
Reference is now also made to FIG. 8, wherein operation of the instant invention is depicted. In an exemplary embodiment, marker 30 is stored within tube 20 and is retained therein by a projection 25. Cap 34 is then slid into an open position. Needle assembly 19 is then pivotably displaced into chamber 38. Cap 34 is then displaced forward into a closed position supporting and anchor-ing needle assembly 19 securely in place within chamber 38 and channel 49.
Next, a test animal, such as a mouse 46, must be stabilized.
As illustrated in FIG. 8, a mouse can be picked up in the user's one hand and the implanting instrument held in the user's other hand.
However, as is illustrated in FIG. 16, in an exemplary embodiment, a cylinder 80 that is open at both ends can be utilized to render the head of the mouse immobile. By inserting the mouse's head in a cylinder the mouse cannot turn its head and bite the user's hand or otherwise interfere with the procedure. Furthermore, once the mouse's head is immobilized in the cylinder it permits the hand of the user to be used to stretch the animal's skin and thereby facilitate manipulation of the mouse during subcutaneous implanta-tion. Accordingly, the implanter systems of the instant invention contemplates the use of different sized tubes to accommodate the distinct differences in the size of the laboratory animals. Once the animal is immobilized, the user is prepared to insert tube 20 into the laboratory animal.
Exit end 21 of tube 20 is inserted subcutaneously into mouse 46 until the animal's skin 48 reaches the edge of sleeve 25. This automatically places marker 30 at the desired position beneath the skin. Knurled surface 43 of the plunger 18 is then pushed forward, `~ -8- 1 3 3 4 3 6 6 preferably with the user's thumb 50, with enough force such that plunger 18 engages drive pin 16. Knurled surface 43 is displaced until knurled surface 43 is disposed into an implanting position so that rod 43 comes in contact with the end of opening 44 in cap 34.
At this point, plunger rod 41 of plunger 18 has engaged drive pin 16 and extends far enough within tube 20 to have forced drive pin 16 to eject marker 30 from tube 20 underneath the animal's skin. Next, the implanting apparatus is removed from animal skin 48, cap 34 is pulled back and needle assembly 19 is removed and discarded. The process may then be repeated for another animal.
In an exemplary embodiment, marker 30 is a glass capsule having therein an electronic transponder containing identification information about the animal. This is used by way of example only.
This process is adaptable to the implantation of any type of marker.
Marker 30 is formed by embedding an electronic transponder (not shown) in a glass capsule. By using an electronic transponder, the amount of storable information is greatly increased, especially when transponder information can be directly linked to computer systems containing further information and processing software. Because the capsule is glass, it tends to slide easily in stainless tube 20. It is for this reason that projection 29 is used to interference fit the capsule in the tube and prevent same from moving within the tube during storage and handling of the needle assembly.
Each needle assembly 19 is sealed within a sanitary sleeve 33 which can be easily removed when the needle assembly is displaced into chamber 38 for use in the manner described above. Moreover, after sanitary sleeve 33 is used to cover the exit opening of the tube, a sterilant gas can be injected into a chamber defined by tube 20, drive pin 16 and sealing disc 17 and the sleeve 33. By introducing a sterliant gas, the marker can be sterilized and remain sterilized until the needle assembly is ready for use. Furthermore, as is illustrated particularly in FIGS. 2 through 5 and 13, the opposed side walls 27 of the housing and the plug 24 of each needle assembly are configured in a manner discussed below to permit each needle assembly to be stored in the handle and removed therefrom for easy use.
Specifically, a pair of opposed ramps 45 are formed in each wall 27. Ramps 45 are formed in mirror image on each wall so that they are disposed in registry with each other when walls 27 are brought together to form the housing defining handle 31. Further-more, each ramp is disposed in parallel with lateral wall 37c and at an angle with respect to the lengthwise extent of the handle. Ramps 45 are spread a sufficient distance apart to permit two rows of needle assemblies to be stored in the handle.
The plug of each needle assembly includes positioning grooves 26 found in opposed surfaces, the grooves being disposed on an angle with respect to the lengthwise extent of the plug and diagonally opposed with each other to facilitate placement of each needle assembly in the housing during assembly of the product. As is illustrated with some particularity in FIGS. 3 through 5, each needle assembly can be positioned within handle by racking the plug onto a first ramp 45 so that the ramp is positioned within the positioning groove 26. The groove 26 and ramp 45 prevent any substantial lengthwise displacement of each needle assembly during storage and use of the instrument. The opposing ramp assists in positioning the plug by pressing against the plug. Each ramp 45 includes a positioning ramp 45a that is parallel with the lengthwise side walls 27a of handle 31. Positioning ramp 45a does not protrude as far as ramp 45 and is provided to assist in preventing the plug from sliding laterally and to further assist in guiding the needle assembly through the opening in chamber 38 when a needle assembly is to be removed from the handle.
In an exemplary embodiment, ten needle assemblies are stored on each ramp 45. As noted above, wall 27a and ramp 45a facilitate delivery of each needle assembly to the operator.
As is illustrated in FIG. 2, the opening in chamber 38 is sufficiently large to permit the needle assembly to be removed therethrough. Accordingly, when a needle assembly is needed, cap 34 is displaced from a closed position to an open position. By manipulating the orientation of the housing, a needle assembly positioned closest to chamber 38 will then slide out of the housing -lo- 1 3 3 4 3 6 6 through opening 38. As aforenoted, such manipulation can be facili-tated by forming one of the opposed walls 27 forming handle 31 out of a transparent or translucent material. It is then a simple matter to position plug 24 of the needle assembiy in chamber 38, slide cap 34 to a closed position and remove the sanitary sleeve 33, so that the user is ready to begin implantation of the marker in the manner discussed above.
Reference is now made to FIG. 14, wherein a marker 30 is formed of a smooth material 81, such as glass. As aforenoted, the use of a glass marker can be problematical. First, when the needle assembly does not include a projection 29, marker 30 is not secured in the tube and, hence, the marker may slide out of the tube of the needle assemlby. Also, it has been observed that when a glass encapsulated transponder is implanted in a laboratory animal, migra-tion of the transponder out of the wound of the animal can occur.
Accordingly, in a preferred embodiment, one-half of marker 30 is coated with a layer 83 having a high coefficient of friction. For example, Silastic~, manufactured by Dow Corning, has been success-fully used. Also, polypropylene has been used as a coating. By utilizing a layer coating marker 30, projection 29 can be eliminated, thereby allowing for a thinner tube 20 having a greater inner diameter than the embodiments containing projection 29.
The instant invention further contemplates a method of forming layer 38 about a glass marker. Specifically, markers are partially inserted into a mold cavity. Thereaftrer, a polypropylene resin is injected into the mold cavities and cured about the marker to define a suitable non-slippery surface.
In a further embodiment, the outer surface of glass of marker 30 can be etched. Although etching of the outer glass coating prevents migration in the animal, projection 29 is still needed to hold marker 30 in place in the tube 20. However, etching has been found to weaken the marker and although experimentally viable, does not appear to offer the same efficiency as the use of a coating on the glass capsule.
1 3343b~
It will thus be seen that the objects set forth above, and those made apparent from the preceding description, are efficiently attained and, since certain changes may be made in the above construction without departing from the spirit and scope of the invention, it is intended that all matter contained in the above description or shown in the accompanying drawings shall be interpre-ted as illustrative and not in a limiting sense.
It is also to be understood that the following claims are intended to cap all of the generic and specific features of the invention herein described, and all statements of the scope of the invention which, as a matter of language, might be said to fall therebetween.
Claims (18)
1. An apparatus for implanting a marker in an animal, comprising a hollow tubular means having an entrance opening and an exit opening, support means configured to permit said tubular means to be releasably mounted in said support means, the support means including a housing and a chamber in the housing, the chamber being adapted to receive the tubular means, and a cover slideably mounted to the housing and adapted to be disposed between a first position in which the tubular means can be inserted into the chamber and a second position wherein the tubular means is maintained securely within the chamber and projects from the housing, the tubular means being releasably mounted in the housing; and plunger means, slideably disposed between a first position and a second position, said plunger means being cooperatively supported by said housing and adapted to enter the tubular means when displaced from a first position to a second position to engage said marker proximate to the exit opening of the tubular means for ejecting said marker through the exit opening in response to said plunger means being accordingly displaced from the first position to said second position.
2. An apparatus for implanting a marker in an animal, comprising a plurality of hollow tubular means each having an entrance opening and an exit opening, a housing configured to permit said tubular means to be stored and releasably held in said housing and including an opening for permitting each said tubular means stored in said housing to be dispensed therethrough, wherein said housing comprises at least a pair of opposed ramp means projecting from said housing, each said tubular means containing a pair of diagonally opposed slots formed therein, said slots being dimensioned to receive said ramps and position each of said tubular means in place in said housing and permit said tubular means to be dispensed through said opening one at a time, and a plunger means slideably disposed between a first position and a second position, said plunger means cooperatively supported by said housing and adapted to enter a tubular means dispensed through said opening when displaced from a first position to a second position and to engage said marker for ejecting said marker through said exit opening in response to said plunger means being coordinately displaced from said first position to said second position.
3. An apparatus for implanting a marker as claimed in claim 1 or 2 further comprising a sharp edge at the exit opening of the tubular means.
4. An apparatus for implanting a marker as claimed in claim 1, wherein said housing is configured to store said tubular means therein, said chamber including an opening for permitting each said tubular means stored in said housing to be dispensed therethrough.
5. An apparatus for implanting a marker as claimed in claim 4, wherein the storage means comprises at least a pair of opposed ramp means projecting from said housing, each said tubular means containing a pair of diagonally opposed slots therein, said slots being dimensioned to cooperate with said ramp means to position each said tubular means in place in said housing and permit said tubular means to slide along one of said ramp means.
6. An apparatus for implanting a marker as claimed in claim 1, wherein said plunger means including a rod and a knurled surface integrally formed at one end of said rod, said knurled surface projecting through said cover to permit said plunger means to be displaced.
7. An apparatus for implanting a marker as claimed in claim 6, wherein said cover has an elongated opening and said knurled surface extends through said elongated opening in said cover to allow displacement of said knurled surface within said opening.
8. An apparatus for implanting a marker as claimed in claim 7, wherein the rod is of a first predetermined length and said opening in said cover is a second predetermined length so that said cover displaces said knurled surface and rod to a position without said chamber when said cover is displaced into an open position so that said tubular means can be releasably inserted in said chamber.
9. An apparatus for implanting a marker as claimed in claim 3, wherein said tubular means includes a friction means projecting therein for frictionally engaging a marker within said tubular means and preventing said marker from movement therein during storage and handling of the tubular means.
10. An apparatus for implanting a marker as claimed in claim 9, wherein said means for retaining the marker in place comprises an opening in a side of said tubular means, a projection extending through said opening and projecting in contact with said marker with sufficient force to secure said marker within said tubular means during storage and handling thereof.
11. An apparatus for implanting a marker as claimed in claim 10, wherein said marker is contained within said tubular means proximate to said exit opening.
12. An apparatus for implanting a marker as claimed in claim 3, wherein a layer of material surrounds at least a portion of said marker and provides a friction surface for preventing movement of said marker in said tubular means during storage and handling of said tubular means.
13. An apparatus for implanting a marker as claimed in claim 1, wherein said support means comprises an elongated housing having a pair of finger retainers projecting therefrom, said tubular means being fixedly mounted therein to project from said support means.
14. An apparatus for implanting a marker as claimed in claim 13, wherein said elongated housing includes a chamber, said chamber opening being axially positioned in alignment between said tubular means and said plunger means, and said plunger means being adapted to enter said channel when said plunger means is displaced to a second position.
15. An apparatus for implanting a marker as claimed in claim 14, and further comprising holding means for holding at least one marker, said holding means being configured to cooperate with said chamber wherein said holding means positions said marker in said chamber so that said marker can be displaced through said tubular means when said plunger means is displaced from said first position to said second position.
16. An apparatus for implanting a marker as claimed in claim 14, wherein said plunger means is further disposed through a third position between said first position and said second position.
17. An apparatus for implanting a marker as claimed in claim 16, wherein said plunger means is without said chamber when said plunger means is in said first position and said plunger is disposed in contact with said marker when said plunger means is disposed in said third position, said plunger means engaging said marker and displacing said marker out of the exit opening of said tubular means when displaced from said third position to said second position.
18. A system for implanting a marker in a laboratory animal comprising an apparatus as defined in claim 1, 2, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 or 17, that can be grasped in an operators's hand, and an open cylinder adapted to receive and immobilize the head of an animal so that said instrument can be operated without difficulty.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/919,152 US4787384A (en) | 1986-10-06 | 1986-10-06 | Animal marker implanting system |
| US06/919,152 | 1986-10-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1334366C true CA1334366C (en) | 1995-02-14 |
Family
ID=25441597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000548144A Expired - Lifetime CA1334366C (en) | 1986-10-06 | 1987-09-29 | Animal marker implanting system |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US4787384A (en) |
| JP (5) | JPS6391023A (en) |
| AU (3) | AU624647B2 (en) |
| CA (1) | CA1334366C (en) |
| CH (2) | CH680555A5 (en) |
| DE (1) | DE3745071C2 (en) |
| FR (3) | FR2604601B1 (en) |
| GB (6) | GB2196827B (en) |
| IT (1) | IT1211825B (en) |
| NL (1) | NL191480C (en) |
| NZ (1) | NZ221983A (en) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6603988B2 (en) * | 2001-04-13 | 2003-08-05 | Kelsey, Inc. | Apparatus and method for delivering ablative laser energy and determining the volume of tumor mass destroyed |
| US4787384A (en) * | 1986-10-06 | 1988-11-29 | Bio Medic Data System, Inc. | Animal marker implanting system |
| NZ223074A (en) * | 1987-12-23 | 1990-08-28 | Magri Holland | Ear tag applicator, rotary magazine |
| US4936827A (en) * | 1988-04-11 | 1990-06-26 | Ivy Laboratories, Inc. | Implanter applicator |
| NL8802482A (en) * | 1988-10-10 | 1990-05-01 | Texas Instruments Holland | METHOD FOR PLANNING AN OBJECT AND GUN. |
| NL8802481A (en) * | 1988-10-10 | 1990-05-01 | Texas Instruments Holland | TRANSPONDER AND METHOD FOR MAKING THE SAME |
| GB2240718A (en) * | 1990-02-09 | 1991-08-14 | Hundon Forge Ltd | Implanting device with needle cover |
| US5439475A (en) * | 1990-07-03 | 1995-08-08 | Bennett; David M. | Tissue grafting method using an apparatus with multiple tissue receiving receptacles |
| US5135493A (en) * | 1990-09-10 | 1992-08-04 | Pitman-Moore, Inc. | Strip cartridge adapter and strip cartridge for implant device |
| NL9002183A (en) * | 1990-10-08 | 1992-05-06 | Texas Instruments Holland | METHOD FOR INSERTING A TRANSPONDER IN A LIVELY. |
| US5266926A (en) * | 1991-05-31 | 1993-11-30 | Avid Marketing, Inc. | Signal transmission and tag power consumption measurement circuit for an inductive reader |
| SE9103660L (en) * | 1991-12-11 | 1993-06-07 | Ragnar Winberg | MARKING MARKET FOR MARKING ANIMALS |
| US5288291A (en) * | 1992-08-12 | 1994-02-22 | Datapet, Inc. | Method and apparatus for simultaneously injecting a liquid and a transponder into an animal |
| US5330951A (en) * | 1992-12-09 | 1994-07-19 | Mobil Oil Corporation | Catalyst composition for polymerizing alpha-olefin |
| DE4320754A1 (en) * | 1993-06-23 | 1995-01-05 | Hoechst Ag | Device for applying implants |
| US5595752A (en) * | 1994-07-01 | 1997-01-21 | Monsanto Company | Increasing dressing percentage and carcass weight in finishing beef cattle |
| US5672357A (en) * | 1994-07-01 | 1997-09-30 | Monsanto Company | Method and device for implantation of large diameter objects in bovines |
| JPH10508504A (en) * | 1994-09-16 | 1998-08-25 | バイオプシス メディカル インコーポレイテッド | Method and apparatus for identifying and marking tissue |
| US5522797A (en) * | 1995-01-03 | 1996-06-04 | Ivy Laboratories, Inc. | Slide action veterinary implanter |
| US6017496A (en) * | 1995-06-07 | 2000-01-25 | Irori | Matrices with memories and uses thereof |
| US6331273B1 (en) | 1995-04-25 | 2001-12-18 | Discovery Partners International | Remotely programmable matrices with memories |
| US6416714B1 (en) | 1995-04-25 | 2002-07-09 | Discovery Partners International, Inc. | Remotely programmable matrices with memories |
| US5751629A (en) * | 1995-04-25 | 1998-05-12 | Irori | Remotely programmable matrices with memories |
| US6329139B1 (en) | 1995-04-25 | 2001-12-11 | Discovery Partners International | Automated sorting system for matrices with memory |
| US5874214A (en) * | 1995-04-25 | 1999-02-23 | Irori | Remotely programmable matrices with memories |
| GB9612014D0 (en) * | 1996-06-08 | 1996-08-07 | Kelvincision Surgical Engineer | Animal tag system |
| US5853366A (en) * | 1996-07-08 | 1998-12-29 | Kelsey, Inc. | Marker element for interstitial treatment and localizing device and method using same |
| US5902310A (en) * | 1996-08-12 | 1999-05-11 | Ethicon Endo-Surgery, Inc. | Apparatus and method for marking tissue |
| US5817054A (en) * | 1996-11-12 | 1998-10-06 | Ivy Laboratories, Inc. | Veterinary implanter with disinfectant dispenser |
| US6270464B1 (en) * | 1998-06-22 | 2001-08-07 | Artemis Medical, Inc. | Biopsy localization method and device |
| US6251418B1 (en) * | 1997-12-18 | 2001-06-26 | C.R. Bard, Inc. | Systems and methods for local delivery of an agent |
| NZ525373A (en) * | 1997-12-29 | 2004-12-24 | Alza Corp | Implanter device for subcutaneous implants with retractable cannula to release implant |
| DK1300129T3 (en) * | 1997-12-29 | 2005-06-20 | Alza Corp | Implant vial |
| US6175760B1 (en) | 1998-02-17 | 2001-01-16 | University Of Iowa Research Foundation | Lesion localizer for nuclear medicine |
| US7063681B1 (en) * | 1998-04-23 | 2006-06-20 | Alza Corporation | Trocar for inserting implants |
| US20020058882A1 (en) * | 1998-06-22 | 2002-05-16 | Artemis Medical, Incorporated | Biopsy localization method and device |
| US6307468B1 (en) * | 1999-07-20 | 2001-10-23 | Avid Identification Systems, Inc. | Impedance matching network and multidimensional electromagnetic field coil for a transponder interrogator |
| JP2002042078A (en) * | 2000-07-21 | 2002-02-08 | Leading Information Technology Institute | Electronic tag device |
| DE10110513A1 (en) * | 2001-01-29 | 2002-12-12 | Ulrich Werth | Implant and method and device for inserting the implant into living tissue |
| US7377276B2 (en) * | 2001-01-31 | 2008-05-27 | United States Of America As Represented By The Secretary Of The Army | Automated inhalation toxicology exposure system and method |
| US6904912B2 (en) | 2001-01-31 | 2005-06-14 | The United States Of America As Represented By The Secretary Of The Army | Automated inhalation toxicology exposure system |
| US8221329B2 (en) * | 2001-07-31 | 2012-07-17 | The United State Of America As Represented By The Secretary Of The Army | Inhalation system and method |
| ES2214119B1 (en) * | 2002-11-25 | 2005-11-01 | Rumitag, S.L. | PROCEDURE FOR THE IDENTIFICATION AND FOLLOW-UP OF ANIMALS THROUGH THE USE OF ELECTRONIC IDENTIFICATION DEVICES (TRANSPONDERS). |
| US7247160B2 (en) * | 2002-12-30 | 2007-07-24 | Calypso Medical Technologies, Inc. | Apparatuses and methods for percutaneously implanting objects in patients |
| IL157984A (en) | 2003-09-17 | 2015-02-26 | Dali Medical Devices Ltd | Autoneedle |
| IL157981A (en) | 2003-09-17 | 2014-01-30 | Elcam Medical Agricultural Cooperative Ass Ltd | Auto-injector |
| US9623208B2 (en) * | 2004-01-12 | 2017-04-18 | Varian Medical Systems, Inc. | Instruments with location markers and methods for tracking instruments through anatomical passageways |
| US20050234475A1 (en) * | 2004-03-04 | 2005-10-20 | Cordes Christopher J | Transponder implanter |
| IL160891A0 (en) | 2004-03-16 | 2004-08-31 | Auto-mix needle | |
| US20050234336A1 (en) * | 2004-03-26 | 2005-10-20 | Beckman Andrew T | Apparatus and method for marking tissue |
| EP1771223A4 (en) * | 2004-07-23 | 2009-04-22 | Calypso Med Technologies Inc | Apparatuses and methods for percutaneously implanting objects in patients |
| US20060282042A1 (en) | 2005-06-08 | 2006-12-14 | Sensors For Medicine And Science, Inc. | Insertion device and method |
| US20070016226A1 (en) * | 2005-07-13 | 2007-01-18 | Bio Medic Data Systems, Inc. | Implanter |
| US8092507B2 (en) * | 2007-02-05 | 2012-01-10 | Novian Health, Inc. | Interstitial energy treatment probe holders |
| US8979829B2 (en) * | 2007-02-05 | 2015-03-17 | Novian Health, Inc. | Interstitial laser therapy kits |
| KR100867724B1 (en) * | 2007-05-15 | 2008-11-10 | 이완섭 | Apparatus for inserting the electronic chip for cattles and methode using the same |
| US8068895B2 (en) * | 2008-02-25 | 2011-11-29 | Devicor Medical Products, Inc. | Biopsy site marker deployment instrument |
| US8079964B2 (en) * | 2008-02-25 | 2011-12-20 | Devicor Medical Products, Inc. | Method and apparatus for inserting biopsy site marker in marker body |
| US7824359B2 (en) * | 2008-07-24 | 2010-11-02 | Solomon Clifford T | Bioinjection device |
| ES2389683T3 (en) * | 2009-10-23 | 2012-10-30 | Forteq Nidau Ag | Device for the injection of a solid substance |
| DE102010013898A1 (en) | 2010-04-01 | 2011-10-06 | Acino Ag | Implant cannula with implant and method for attaching implants in an injection cannula |
| USD733873S1 (en) | 2013-05-07 | 2015-07-07 | Novian Health Inc. | Probe holder |
| EP3030193B1 (en) * | 2013-08-07 | 2022-09-21 | Imaginus Limited | Dosing apparatus |
| US20150085243A1 (en) * | 2013-09-24 | 2015-03-26 | Gazelle Corporation | Arm of spectacles |
| RU2728195C2 (en) | 2014-02-26 | 2020-07-28 | Аллерган, Инк. | Device for delivery of intraocular implant and methods of its use |
| JP6914932B2 (en) | 2015-11-11 | 2021-08-04 | デビコー・メディカル・プロダクツ・インコーポレイテッドＤｅｖｉｃｏｒ Ｍｅｄｉｃａｌ Ｐｒｏｄｕｃｔｓ， Ｉｎｃ． | Marker sending device and how to deploy markers |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB472560A (en) * | 1936-06-15 | 1937-09-27 | Bevan Graham Horsimann | Improvements in instruments for implanting radon seeds and other small objects in body tissues |
| DE806702C (en) * | 1948-10-02 | 1951-06-18 | Dr Med Hermann Brune | Device for introducing solid medicaments into the human body or under the skin of the same |
| US2907327A (en) * | 1957-02-08 | 1959-10-06 | Pfizer & Co C | Pellet implanter |
| US3016895A (en) * | 1958-08-01 | 1962-01-16 | Pan American Lab Inc | Injector for subcutaneous implantation of solids |
| US3128744A (en) * | 1963-01-02 | 1964-04-14 | Keith B Jefferts | Method for investigating the migratory habits of macro-organisms |
| US3572335A (en) * | 1969-01-10 | 1971-03-23 | Ralph R Robinson | Cervical implant method and device |
| US3620216A (en) * | 1969-06-25 | 1971-11-16 | Abbott Lab | Implant trocar |
| US3744493A (en) * | 1972-01-10 | 1973-07-10 | Syntex Corp | Implanter having an improved cartridge ejector |
| US3820545A (en) * | 1973-03-26 | 1974-06-28 | K Jefferts | Tag implanting machine |
| FR2242064A1 (en) * | 1973-08-28 | 1975-03-28 | Dynachim Sarl | Implantation device for introduction of hormone pellets - into connective tissue of cattle |
| US4262632A (en) * | 1974-01-03 | 1981-04-21 | Hanton John P | Electronic livestock identification system |
| GB1525841A (en) * | 1976-05-18 | 1978-09-20 | Hundon Forge Ltd | Drug implanters |
| US4233964A (en) * | 1978-05-12 | 1980-11-18 | Jefferts Keith B | Internally readable identifying tag |
| JPS6059850B2 (en) * | 1978-07-15 | 1985-12-27 | 松下電工株式会社 | Synthetic resin coating method for approximately U-shaped material |
| US4263910A (en) * | 1978-09-27 | 1981-04-28 | Eli Lilly And Company | Implantate package, system and method |
| NZ197426A (en) * | 1980-06-19 | 1984-07-06 | Phillips Pty Ltd N J | Pellet gun:magazine indexed for next injection on retraction of indexing rod |
| US4451253A (en) * | 1980-12-18 | 1984-05-29 | Harman Sherman M | Means and method for administering medicinals |
| JPS5870860A (en) * | 1981-10-23 | 1983-04-27 | Mitsubishi Heavy Ind Ltd | Coating method |
| US4451254A (en) * | 1982-03-15 | 1984-05-29 | Eli Lilly And Company | Implant system |
| US4518384A (en) * | 1983-06-17 | 1985-05-21 | Survival Technology, Inc. | Multiple medicament cartridge clip and medicament discharging device therefor |
| JPS60129057A (en) * | 1983-12-14 | 1985-07-10 | 住友化学工業株式会社 | Needle like solid drug administering needle |
| GB8408656D0 (en) * | 1984-04-04 | 1984-05-16 | Semple C | Animal identification |
| JPS60224428A (en) * | 1984-04-23 | 1985-11-08 | 高橋 英正 | Method and apparatus for discriminating indivisual of domestic animal |
| GB2159414A (en) * | 1984-05-25 | 1985-12-04 | S Mitchell Harman | Means and method for administering medicinals |
| JPS6115767A (en) * | 1984-06-29 | 1986-01-23 | Mita Ind Co Ltd | Method and apparatus for coating drum |
| GB2188028A (en) * | 1986-03-17 | 1987-09-23 | Brien Hugh O | Electronic identification ear implant |
| US4672967A (en) * | 1986-04-18 | 1987-06-16 | Smith David V | Tag implantation system and method |
| US4787384A (en) * | 1986-10-06 | 1988-11-29 | Bio Medic Data System, Inc. | Animal marker implanting system |
| US4679559A (en) * | 1986-10-07 | 1987-07-14 | Northwest Marine Technology Inc. | Method and device for tagging a macro-organism |
-
1986
- 1986-10-06 US US06/919,152 patent/US4787384A/en not_active Ceased
-
1987
- 1987-09-29 NZ NZ221983A patent/NZ221983A/en unknown
- 1987-09-29 CA CA000548144A patent/CA1334366C/en not_active Expired - Lifetime
- 1987-09-30 FR FR878713531A patent/FR2604601B1/en not_active Expired - Lifetime
- 1987-10-02 IT IT8748450A patent/IT1211825B/en active
- 1987-10-03 JP JP62249121A patent/JPS6391023A/en active Granted
- 1987-10-05 CH CH3877/87A patent/CH680555A5/de not_active IP Right Cessation
- 1987-10-05 GB GB8723356A patent/GB2196827B/en not_active Expired - Lifetime
- 1987-10-05 NL NL8702369A patent/NL191480C/en not_active IP Right Cessation
- 1987-10-05 CH CH263/92A patent/CH685044A5/en not_active IP Right Cessation
- 1987-10-06 DE DE3745071A patent/DE3745071C2/en not_active Expired - Lifetime
-
1989
- 1989-10-17 GB GB898923356A patent/GB8923356D0/en active Pending
- 1989-10-20 FR FR8913792A patent/FR2641159A1/en active Granted
- 1989-10-30 AU AU43835/89A patent/AU624647B2/en not_active Expired
- 1989-11-21 GB GB8926256A patent/GB2231477B/en not_active Expired - Lifetime
- 1989-12-29 FR FR8917498A patent/FR2639510B1/en not_active Expired - Lifetime
-
1990
- 1990-09-04 GB GB9019256A patent/GB2237174B/en not_active Expired - Lifetime
- 1990-09-04 GB GB9019257A patent/GB2237175B/en not_active Expired - Lifetime
- 1990-09-04 GB GB9019258A patent/GB2237176B/en not_active Expired - Lifetime
-
1991
- 1991-06-04 JP JP3159560A patent/JPH0817644B2/en not_active Expired - Lifetime
- 1991-06-04 JP JP3159561A patent/JPH0817645B2/en not_active Expired - Lifetime
- 1991-06-04 JP JP3159563A patent/JPH0646907B2/en not_active Expired - Lifetime
- 1991-06-04 JP JP3159562A patent/JPH0738767B2/en not_active Expired - Lifetime
-
1992
- 1992-03-27 AU AU13903/92A patent/AU653998B2/en not_active Expired
-
1993
- 1993-07-22 US US08/096,075 patent/USRE34936E/en not_active Expired - Lifetime
-
1994
- 1994-06-27 AU AU65984/94A patent/AU669071B2/en not_active Expired
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA1334366C (en) | Animal marker implanting system | |
| US5002548A (en) | Animal marker implanting system | |
| US5074318A (en) | Animal marker | |
| US5024727A (en) | Method of forming an animal marker implanting system | |
| US11040184B2 (en) | Kit for and method of assembling an applicator for inserting an implant | |
| US9757552B2 (en) | Applicator for inserting an implant | |
| EP0090899A1 (en) | Improvements in or relating to implant devices | |
| NL194223C (en) | Method for forming a marker, to be entered into an animal. | |
| IT9047753A1 (en) | PERFECTED SYSTEM FOR IMPLANTING A MARK ON AN ANIMAL. | |
| AU2007206957B2 (en) | Kit for and method of assembling an applicator for inserting an implant |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |