CA2002559A1 - In vivo fluorescence photometer - Google Patents

In vivo fluorescence photometer

Info

Publication number
CA2002559A1
CA2002559A1 CA2002559A CA2002559A CA2002559A1 CA 2002559 A1 CA2002559 A1 CA 2002559A1 CA 2002559 A CA2002559 A CA 2002559A CA 2002559 A CA2002559 A CA 2002559A CA 2002559 A1 CA2002559 A1 CA 2002559A1
Authority
CA
Canada
Prior art keywords
light
beams
abnormal tissue
incident
resulting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2002559A
Other languages
French (fr)
Other versions
CA2002559C (en
Inventor
William R. Potter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Health Research Inc
Original Assignee
William R. Potter
Health Research Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by William R. Potter, Health Research Inc. filed Critical William R. Potter
Publication of CA2002559A1 publication Critical patent/CA2002559A1/en
Application granted granted Critical
Publication of CA2002559C publication Critical patent/CA2002559C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/415Evaluating particular organs or parts of the immune or lymphatic systems the glands, e.g. tonsils, adenoids or thymus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/41Detecting, measuring or recording for evaluating the immune or lymphatic systems
    • A61B5/414Evaluating particular organs or parts of the immune or lymphatic systems
    • A61B5/418Evaluating particular organs or parts of the immune or lymphatic systems lymph vessels, ducts or nodes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0601Apparatus for use inside the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/06Radiation therapy using light
    • A61N5/0613Apparatus adapted for a specific treatment
    • A61N5/062Photodynamic therapy, i.e. excitation of an agent

Abstract

A method and apparatus for in vivo detection of abnormal tissue in patients by irradiating a diagnostic region simultaneously with at least two wavelengths of incident light, and detecting the resulting fluorescence of normal and abnormal tissue. The patient is provided with a photosensitizer which preferentially collects in abnormal tissue, and beams of light--preferably at about 612 and 632.8 nm--are directed to the diagnostic region.
The beams of light are chopped at 90 and 135 Hz, respectively. Fluorescent light from the diagnostic region is then detected, and an electronic signal is generated relating to the intensity of the fluorescence.
Because of the chopping of the incident beams, the fluorescent light and the resulting electronic signal are also chopped. The electronic signal is provided as input to phase-locked amplifier circuitry, which differentiates between the contribution to the signal resulting from each of the 612 and 632.8 nm incident beams. A difference signal is provided as output to headphones, and the operator of the apparatus is notified of presence of abnormal tissue by changes in pitch of the difference signal. The source for the light may be lasers or an arc lamp, and there may be three or more incident wavelengths used.
CA002002559A 1988-11-08 1989-11-08 In vivo fluorescence photometer Expired - Fee Related CA2002559C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US268,723 1988-11-08
US07/268,723 US5111821A (en) 1988-11-08 1988-11-08 Fluorometric method for detecting abnormal tissue using dual long-wavelength excitation

Publications (2)

Publication Number Publication Date
CA2002559A1 true CA2002559A1 (en) 1990-05-08
CA2002559C CA2002559C (en) 1999-07-06

Family

ID=23024191

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002002559A Expired - Fee Related CA2002559C (en) 1988-11-08 1989-11-08 In vivo fluorescence photometer

Country Status (2)

Country Link
US (2) US5111821A (en)
CA (1) CA2002559C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5348018A (en) * 1991-11-25 1994-09-20 Alfano Robert R Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy

Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5873821A (en) * 1992-05-18 1999-02-23 Non-Invasive Technology, Inc. Lateralization spectrophotometer
US5205291A (en) * 1988-11-08 1993-04-27 Health Research, Inc. In vivo fluorescence photometer
US5555885A (en) * 1988-12-21 1996-09-17 Non-Invasive Technology, Inc. Examination of breast tissue using time-resolved spectroscopy
US5419323A (en) * 1988-12-21 1995-05-30 Massachusetts Institute Of Technology Method for laser induced fluorescence of tissue
US5353799A (en) * 1991-01-22 1994-10-11 Non Invasive Technology, Inc. Examination of subjects using photon migration with high directionality techniques
US5792051A (en) * 1988-12-21 1998-08-11 Non-Invasive Technology, Inc. Optical probe for non-invasive monitoring of neural activity
US5201318A (en) * 1989-04-24 1993-04-13 Rava Richard P Contour mapping of spectral diagnostics
US5699798A (en) * 1990-08-10 1997-12-23 University Of Washington Method for optically imaging solid tumor tissue
US5687730A (en) * 1991-01-22 1997-11-18 Pdt Systems, Inc. Apparatus for detecting the presence of abnormal tissue within a target tissue beneath the skin of a patient
US5318023A (en) * 1991-04-03 1994-06-07 Cedars-Sinai Medical Center Apparatus and method of use for a photosensitizer enhanced fluorescence based biopsy needle
US5377676A (en) * 1991-04-03 1995-01-03 Cedars-Sinai Medical Center Method for determining the biodistribution of substances using fluorescence spectroscopy
US6549795B1 (en) 1991-05-16 2003-04-15 Non-Invasive Technology, Inc. Spectrophotometer for tissue examination
US5377686A (en) * 1991-10-11 1995-01-03 The University Of Connecticut Apparatus for detecting leakage from vascular tissue
US5533508A (en) * 1991-10-31 1996-07-09 Pdt Systems, Inc. Vivo dosimeter for photodynamic therapy
US5309912A (en) * 1991-11-08 1994-05-10 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Multidimensional imaging using a single point detector for a phase encoded modulated optical carrier
US6785568B2 (en) * 1992-05-18 2004-08-31 Non-Invasive Technology Inc. Transcranial examination of the brain
US5954053A (en) * 1995-06-06 1999-09-21 Non-Invasive Technology, Inc. Detection of brain hematoma
US5452723A (en) * 1992-07-24 1995-09-26 Massachusetts Institute Of Technology Calibrated spectrographic imaging
WO1994003470A1 (en) * 1992-08-10 1994-02-17 Davies Richard J Method and apparatus for screening and diagnosing for cancers
US5673701A (en) * 1994-10-07 1997-10-07 Non Invasive Technology, Inc. Optical techniques for examination of biological tissue
US6058324A (en) * 1993-06-17 2000-05-02 Non-Invasive Technology, Inc. Examination and imaging of biological tissue
US5820558A (en) * 1994-12-02 1998-10-13 Non-Invasive Technology, Inc. Optical techniques for examination of biological tissue
US7255851B2 (en) * 1994-07-01 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US5803909A (en) * 1994-10-06 1998-09-08 Hitachi, Ltd. Optical system for measuring metabolism in a body and imaging method
US6542772B1 (en) * 1994-12-02 2003-04-01 Non-Invasive Technology, Inc. Examination and imaging of biological tissue
US6258576B1 (en) 1996-06-19 2001-07-10 Board Of Regents, The University Of Texas System Diagnostic method and apparatus for cervical squamous intraepithelial lesions in vitro and in vivo using fluorescence spectroscopy
US5697373A (en) * 1995-03-14 1997-12-16 Board Of Regents, The University Of Texas System Optical method and apparatus for the diagnosis of cervical precancers using raman and fluorescence spectroscopies
US5991653A (en) * 1995-03-14 1999-11-23 Board Of Regents, The University Of Texas System Near-infrared raman spectroscopy for in vitro and in vivo detection of cervical precancers
DE19541686B4 (en) * 1995-11-08 2009-08-06 Kaltenbach & Voigt Gmbh & Co. Kg Device for detecting caries, plaque or bacterial infestation of teeth
US5842995A (en) * 1996-06-28 1998-12-01 Board Of Regents, The Univerisity Of Texas System Spectroscopic probe for in vivo measurement of raman signals
US5995857A (en) * 1996-07-01 1999-11-30 Toomim; I. Hershel Biofeedback of human central nervous system activity using radiation detection
US5845640A (en) * 1997-01-24 1998-12-08 Spectra Science Corporation Chemiluminescent sources for photodynamic therapy and photomedicine
US6233481B1 (en) 1997-10-09 2001-05-15 Spectra Science Corporation Diagnostic application of sono-chemical excitation of fluorescent photosensitizers
US20030135122A1 (en) * 1997-12-12 2003-07-17 Spectrx, Inc. Multi-modal optical tissue diagnostic system
US6055451A (en) * 1997-12-12 2000-04-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
EP1054619B1 (en) 1998-02-11 2007-11-21 Non-Invasive Technology, Inc. Imaging and characterization of brain tissue
DE69934482T2 (en) 1998-02-11 2007-09-27 Non-Invasive Technology, Inc. PROOF, PICTURE AND IDENTIFICATION OF BREAST ENVELOPES
AU2945799A (en) * 1998-03-30 1999-10-18 Packard Instrument Company, Inc. Improvements in and relating to biomedical assays
JP4474050B2 (en) * 1998-09-11 2010-06-02 スペクトルックス・インコーポレイテッド Multi-mode optical tissue diagnosis system
US6256530B1 (en) 1998-09-15 2001-07-03 Denvu, L.L.C. Optical instrument and technique for cancer diagnosis using in-vivo fluorescence emission of test tissue
US6377842B1 (en) 1998-09-22 2002-04-23 Aurora Optics, Inc. Method for quantitative measurement of fluorescent and phosphorescent drugs within tissue utilizing a fiber optic probe
JP2000262460A (en) * 1999-03-18 2000-09-26 Inst Of Physical & Chemical Res Method for detecting specified location, method for biological measurement, device for detecting specified location of biological sample, and optical fiber holding device
US20040147843A1 (en) * 1999-11-05 2004-07-29 Shabbir Bambot System and method for determining tissue characteristics
US6697666B1 (en) 1999-06-22 2004-02-24 Board Of Regents, The University Of Texas System Apparatus for the characterization of tissue of epithelial lined viscus
US7840257B2 (en) 2003-01-04 2010-11-23 Non Invasive Technology, Inc. Examination of biological tissue using non-contact optical probes
US7904139B2 (en) 1999-08-26 2011-03-08 Non-Invasive Technology Inc. Optical examination of biological tissue using non-contact irradiation and detection
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
AU2001239835A1 (en) 2000-02-26 2001-09-03 Advanced Photodynamic Technologies, Inc. Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and surfactant
US6624187B1 (en) 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
WO2004002476A2 (en) 2002-06-27 2004-01-08 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
WO2004005289A2 (en) * 2002-07-02 2004-01-15 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
US20040064053A1 (en) * 2002-09-30 2004-04-01 Chang Sung K. Diagnostic fluorescence and reflectance
US7057100B2 (en) * 2003-06-26 2006-06-06 The J.C. Robinson Seed Co. Inbred corn line W23129
EP1688083B1 (en) 2003-11-20 2018-09-12 Hamamatsu Photonics K.K. Lymph node detector
JP2006014868A (en) * 2004-06-30 2006-01-19 Hamamatsu Photonics Kk Lymph node detecting apparatus
JP5028008B2 (en) * 2004-12-08 2012-09-19 オリンパス株式会社 Fluorescence endoscope device
US7865223B1 (en) 2005-03-14 2011-01-04 Peter Bernreuter In vivo blood spectrometry
US8055321B2 (en) 2005-03-14 2011-11-08 Peter Bernreuter Tissue oximetry apparatus and method
US8140141B2 (en) * 2006-05-17 2012-03-20 University Of Utah Research Foundation Devices and methods for fluorescent inspection and/or removal of material in a sample
BRPI0815322B8 (en) * 2007-08-31 2018-10-16 3M Innovative Properties Co "respirator and respiratory protective mask connection component"
KR20100075459A (en) * 2007-08-31 2010-07-02 쓰리엠 이노베이티브 프로퍼티즈 컴파니 Unitary respirator with molded thermoset elastomeric elements
CN104524707B (en) * 2007-08-31 2018-11-13 3M创新有限公司 Respiratory protection combines mask and forming method thereof
US8725226B2 (en) 2008-11-14 2014-05-13 Nonin Medical, Inc. Optical sensor path selection
JP5608871B2 (en) * 2010-03-09 2014-10-15 学校法人慶應義塾 System for preventing blood burn at the laser catheter emitting part
BR112013014084A2 (en) 2010-12-09 2016-09-20 Alcon Res Ltd optical coherence tomography and illumination using a common light source
WO2012083206A1 (en) * 2010-12-17 2012-06-21 Elizabeth Marjorie Clare Hillman Concurrent multi-region optical imaging
US20120203075A1 (en) * 2011-02-08 2012-08-09 Christopher Horvath White coherent laser light launched into nano fibers for surgical illumination
US10589120B1 (en) 2012-12-31 2020-03-17 Gary John Bellinger High-intensity laser therapy method and apparatus
JP6132731B2 (en) * 2013-09-27 2017-05-24 富士フイルム株式会社 Optical measuring device
US11172811B2 (en) * 2019-06-20 2021-11-16 Cilag Gmbh International Image rotation in an endoscopic fluorescence imaging system
US11671691B2 (en) 2019-06-20 2023-06-06 Cilag Gmbh International Image rotation in an endoscopic laser mapping imaging system
US11147436B2 (en) * 2019-06-20 2021-10-19 Cilag Gmbh International Image rotation in an endoscopic fluorescence imaging system

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2521727A2 (en) * 1981-03-25 1983-08-19 Cilas DEVICE FOR MEASURING THE STATE OF OXYDO-REDUCTION OF A LIVING ORGAN IN SITU
JPS5940830A (en) * 1982-08-31 1984-03-06 浜松ホトニクス株式会社 Apparatus for diagnosis of cancer using laser beam pulse
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US4576178A (en) * 1983-03-28 1986-03-18 David Johnson Audio signal generator
US4541438A (en) * 1983-06-02 1985-09-17 The Johns Hopkins University Localization of cancerous tissue by monitoring infrared fluorescence emitted by intravenously injected porphyrin tumor-specific markers excited by long wavelength light
US4718417A (en) * 1985-03-22 1988-01-12 Massachusetts Institute Of Technology Visible fluorescence spectral diagnostic for laser angiosurgery
US4930516B1 (en) * 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5348018A (en) * 1991-11-25 1994-09-20 Alfano Robert R Method for determining if tissue is malignant as opposed to non-malignant using time-resolved fluorescence spectroscopy

Also Published As

Publication number Publication date
US5111821A (en) 1992-05-12
US5062431A (en) 1991-11-05
CA2002559C (en) 1999-07-06

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