CA2004739A1 - Hemostatic collagen paste composition - Google Patents

Hemostatic collagen paste composition

Info

Publication number
CA2004739A1
CA2004739A1 CA2004739A CA2004739A CA2004739A1 CA 2004739 A1 CA2004739 A1 CA 2004739A1 CA 2004739 A CA2004739 A CA 2004739A CA 2004739 A CA2004739 A CA 2004739A CA 2004739 A1 CA2004739 A1 CA 2004739A1
Authority
CA
Canada
Prior art keywords
hemostatic
paste composition
collagen paste
hemostatic collagen
collagen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2004739A
Other languages
French (fr)
Other versions
CA2004739C (en
Inventor
Lowell Saferstein
Stephen J. Wolf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ethicon Inc
Original Assignee
Johnson and Johnson Patient Care Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Johnson and Johnson Patient Care Inc filed Critical Johnson and Johnson Patient Care Inc
Publication of CA2004739A1 publication Critical patent/CA2004739A1/en
Application granted granted Critical
Publication of CA2004739C publication Critical patent/CA2004739C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/001—Use of materials characterised by their function or physical properties
    • A61L24/0015—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0033—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/418—Agents promoting blood coagulation, blood-clotting agents, embolising agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Surgery (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

ABSTRACT

A hemostatic collagen paste composition comprising a mixture, by weight of the total composition, sf 2 to 30%
of crosslinked collagen powder of 10 to 100 mesh particle size and 30 to 98% of water or an aqueous saline solution and hemostatic paste compositions that also comprise a hemostatic enhancing amount of thrombin, as well as metpods of making and using such hemostatic collagen paste compositions.
CA002004739A 1988-12-08 1989-12-06 Hemostatic collagen paste composition Expired - Lifetime CA2004739C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US282,224 1988-12-08
US07/282,224 US4891359A (en) 1988-12-08 1988-12-08 Hemostatic collagen paste composition

Publications (2)

Publication Number Publication Date
CA2004739A1 true CA2004739A1 (en) 1990-06-08
CA2004739C CA2004739C (en) 2000-03-28

Family

ID=23080569

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002004739A Expired - Lifetime CA2004739C (en) 1988-12-08 1989-12-06 Hemostatic collagen paste composition

Country Status (10)

Country Link
US (1) US4891359A (en)
EP (1) EP0372966B1 (en)
JP (1) JP3195335B2 (en)
AT (1) ATE103187T1 (en)
AU (1) AU623456B2 (en)
CA (1) CA2004739C (en)
DE (1) DE68914110T2 (en)
ES (1) ES2062041T3 (en)
IE (1) IE62927B1 (en)
ZA (1) ZA899372B (en)

Families Citing this family (99)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0466383A1 (en) * 1990-07-09 1992-01-15 BAUSCH & LOMB INCORPORATED A collagen medical adhesive and its uses
US5326350A (en) * 1992-05-11 1994-07-05 Li Shu Tung Soft tissue closure systems
US6350274B1 (en) 1992-05-11 2002-02-26 Regen Biologics, Inc. Soft tissue closure systems
US5868778A (en) * 1995-10-27 1999-02-09 Vascular Solutions, Inc. Vascular sealing apparatus and method
AU1086795A (en) * 1993-11-03 1995-05-23 Clarion Pharmaceuticals, Inc. Hemostatic patch
US6302898B1 (en) 1994-06-24 2001-10-16 Advanced Closure Systems, Inc. Devices for sealing punctures in body vessels
US6033401A (en) * 1997-03-12 2000-03-07 Advanced Closure Systems, Inc. Vascular sealing device with microwave antenna
US5562946A (en) * 1994-11-02 1996-10-08 Tissue Engineering, Inc. Apparatus and method for spinning and processing collagen fiber
US5709934A (en) * 1994-11-22 1998-01-20 Tissue Engineering, Inc. Bipolymer foams having extracellular matrix particulates
US5891558A (en) * 1994-11-22 1999-04-06 Tissue Engineering, Inc. Biopolymer foams for use in tissue repair and reconstruction
AU5638096A (en) * 1995-06-07 1996-12-30 Clarion Pharmaceuticals, Inc. Non-biological patch for hemostasis
US5911942A (en) * 1995-11-02 1999-06-15 Tissue Engineering, Inc. Method for spinning and processing collagen fiber
CZ318998A3 (en) 1996-04-04 1999-09-15 Baxter Aktiengesellschaft Haemostatic sponge based on collagen, process of its preparation, cover on a frame and kit for preparing such cover
US6492508B1 (en) * 1996-06-03 2002-12-10 United States Surgical Corp. A Division Of Tyco Healthcare Group Nucleic acids encoding extracellular matrix proteins
US6927287B1 (en) * 1996-06-03 2005-08-09 United States Surgical Corporation Nucleic acid encoding extracellular matrix protein or fragment thereof
US8716227B2 (en) * 1996-08-23 2014-05-06 Cook Biotech Incorporated Graft prosthesis, materials and methods
EP0925077B1 (en) * 1996-08-23 2003-10-15 Cook Biotech, Inc. Method for obtaining a purified collagen-based matrix from submucosa tissue
US6666892B2 (en) * 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US8603511B2 (en) 1996-08-27 2013-12-10 Baxter International, Inc. Fragmented polymeric compositions and methods for their use
US6706690B2 (en) 1999-06-10 2004-03-16 Baxter Healthcare Corporation Hemoactive compositions and methods for their manufacture and use
US8303981B2 (en) 1996-08-27 2012-11-06 Baxter International Inc. Fragmented polymeric compositions and methods for their use
US7435425B2 (en) * 2001-07-17 2008-10-14 Baxter International, Inc. Dry hemostatic compositions and methods for their preparation
US7871637B2 (en) 1996-08-27 2011-01-18 Baxter International Inc. Dry hemostatic compositions and methods for their preparation
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6063061A (en) * 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US7320962B2 (en) 1996-08-27 2008-01-22 Baxter International Inc. Hemoactive compositions and methods for their manufacture and use
US6743248B2 (en) 1996-12-18 2004-06-01 Neomend, Inc. Pretreatment method for enhancing tissue adhesion
EP1019106A1 (en) * 1997-01-16 2000-07-19 Cohesion Corporation Lyophilized collagen-based biomaterials, process of preparation and uses thereof
US20030191496A1 (en) * 1997-03-12 2003-10-09 Neomend, Inc. Vascular sealing device with microwave antenna
US6475182B1 (en) 1997-03-12 2002-11-05 Olexander Hnojewyj Fluidic media introduction apparatus
US20040176801A1 (en) * 1997-03-12 2004-09-09 Neomend, Inc. Pretreatment method for enhancing tissue adhesion
US6733515B1 (en) 1997-03-12 2004-05-11 Neomend, Inc. Universal introducer
AU7977298A (en) * 1997-06-18 1999-01-04 Cohesion Technologies, Inc. Compositions containing thrombin and microfibrillar collagen, and methods for preparation and use thereof
GB2345638A (en) * 1998-09-11 2000-07-19 Tissue Science Lab Limited Injectable collagen compositions
US8882850B2 (en) * 1998-12-01 2014-11-11 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
DK1051116T3 (en) 1998-12-01 2009-02-02 Univ Washington Embolization device
US6361551B1 (en) 1998-12-11 2002-03-26 C. R. Bard, Inc. Collagen hemostatic fibers
US6454787B1 (en) * 1998-12-11 2002-09-24 C. R. Bard, Inc. Collagen hemostatic foam
US7094428B2 (en) * 2000-06-16 2006-08-22 The University Of Medicine And Dentistry Of New Jersey Hemostatic compositions, devices and methods
US20020114795A1 (en) * 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
CA2433850A1 (en) * 2001-01-04 2002-09-12 Osteotech, Inc. Method for sterilizing bioactive materials
US20030211793A1 (en) * 2001-03-05 2003-11-13 Eugene Bell Injectable bio-compatible material and methods of use
CA2470684A1 (en) * 2001-12-21 2003-07-10 Ferrosan A/S A haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
US7923431B2 (en) * 2001-12-21 2011-04-12 Ferrosan Medical Devices A/S Haemostatic kit, a method of preparing a haemostatic agent and a method of promoting haemostatis
EP1573295A2 (en) * 2002-12-11 2005-09-14 Ferrosan A/S Gelatine-based materials as swabs
US8834864B2 (en) * 2003-06-05 2014-09-16 Baxter International Inc. Methods for repairing and regenerating human dura mater
US20060019868A1 (en) * 2004-01-30 2006-01-26 Pendharkar Sanyog M Hemostatic compositions and devices
US7927626B2 (en) * 2003-08-07 2011-04-19 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
US8440225B2 (en) * 2003-08-07 2013-05-14 Ethicon, Inc. Process of making flowable hemostatic compositions and devices containing such compositions
ATE475434T1 (en) * 2004-01-30 2010-08-15 Ferrosan As HEMOSTATIC SPRAYS AND COMPOSITIONS
KR20050086324A (en) * 2004-02-25 2005-08-30 김아란 3%,4%,5%,9% Saline
US8119160B2 (en) 2004-06-29 2012-02-21 Ethicon, Inc. Hemostatic compositions and devices
CN101001649B (en) * 2004-07-09 2011-08-31 弗罗桑医疗设备公司 Haemostatic composition comprising hyaluronic acid and its preparation method
GB2409162B (en) * 2004-10-06 2005-12-14 Bhk Holding Ltd Materials,methods,and apparatus for treating a body cavity
AU2005315876A1 (en) * 2004-12-14 2006-06-22 Fidia Advanced Biopolymers S.R.L. Process for the preparation of two and three dimensional polymer scaffolds
ES2575933T3 (en) * 2006-05-31 2016-07-04 Baxter International Inc. Collagen for use in the prevention of epidural fibrosis formation after spinal surgery
US20080004431A1 (en) * 2006-06-30 2008-01-03 Warsaw Orthopedic Inc Method of manufacturing an injectable collagen material
TWI436793B (en) * 2006-08-02 2014-05-11 Baxter Int Rapidly acting dry sealant and methods for use and manufacture
US7718616B2 (en) * 2006-12-21 2010-05-18 Zimmer Orthobiologics, Inc. Bone growth particles and osteoinductive composition thereof
TWI461227B (en) 2007-10-30 2014-11-21 Baxter Int Use of a regenerative biofunctional collagen biomatrix for treating visceral or parietal defects
EP2259803B2 (en) * 2008-02-29 2019-03-13 Ferrosan Medical Devices A/S Device for promotion of hemostasis and/or wound healing
US8840913B2 (en) * 2008-03-27 2014-09-23 Warsaw Orthopedic, Inc. Malleable multi-component implants and materials therefor
AU2009232000B2 (en) 2008-04-03 2014-12-11 Baxter International Inc. Hemostatic microspheres
JP5747370B2 (en) * 2009-03-31 2015-07-15 国立大学法人浜松医科大学 Highly sensitive detection method for highly pathogenic oral bacteria
US9039783B2 (en) * 2009-05-18 2015-05-26 Baxter International, Inc. Method for the improvement of mesh implant biocompatibility
PT2442835E (en) * 2009-06-16 2015-03-23 Baxter Healthcare Sa Hemostatic sponge
US9629913B2 (en) * 2009-07-21 2017-04-25 Aidance Skincare And Topical Solutions, Llc Silver oxide formulations
GB2487773B (en) * 2011-02-04 2014-09-17 Aidance Skincare & Topical Solutions Llc Topical antibiotic formulations
US8652509B2 (en) * 2009-11-02 2014-02-18 Moshe Rogosnitzky Method of wound hemostasis using liquid gallium nitrate
KR101811070B1 (en) * 2009-12-16 2017-12-20 백스터 인터내셔널 인코포레이티드 Hemostatic sponge
RU2012143739A (en) 2010-03-15 2014-04-20 Ферросан Медикал Дивайсиз А/С METHOD FOR ACCELERATING THE STOP OF BLEEDING AND / OR HEALING OF THE RAS
SA111320355B1 (en) 2010-04-07 2015-01-08 Baxter Heathcare S A Hemostatic sponge
JP5973997B2 (en) 2010-06-01 2016-08-23 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ Process for making a dry and stable hemostatic composition
KR101865427B1 (en) 2010-06-01 2018-06-07 백스터 인터내셔널 인코포레이티드 Process for making dry and stable hemostatic compositions
CN103037845B (en) 2010-06-01 2015-11-25 巴克斯特国际公司 For the preparation of the method for dry, stable hemostatic composition
JP2013542837A (en) 2010-11-15 2013-11-28 ジンマー オーソバイオロジクス，インコーポレイティド Bone void filler
US10022410B2 (en) 2010-12-22 2018-07-17 Ethicon, Inc. Hemostatic preparation containing an extract of golden moss
WO2012122044A2 (en) 2011-03-04 2012-09-13 Orthovita, Inc. Flowable collagen-based hemostat and methods of use
WO2013053755A2 (en) 2011-10-11 2013-04-18 Baxter International Inc. Hemostatic compositions
EP2766059B1 (en) 2011-10-11 2022-11-23 Baxter International Inc. Hemostatic compositions
AR088531A1 (en) 2011-10-27 2014-06-18 Baxter Int HEMOSTATIC COMPOSITIONS
JP6241624B2 (en) 2012-03-06 2017-12-06 フェロサン メディカル デバイシーズ エイ／エス Pressurized container containing hemostatic paste
EP2825216B1 (en) 2012-06-12 2015-08-19 Ferrosan Medical Devices A/S Dry haemostatic composition
WO2014202760A2 (en) 2013-06-21 2014-12-24 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
EP3470094B1 (en) 2013-12-11 2020-07-22 Ferrosan Medical Devices A/S Dry composition comprising an extrusion enhancer
JP6726852B2 (en) 2014-10-13 2020-07-22 フェッローサン メディカル ディバイス エー／エス Dry composition for use in hemostasis and wound healing
AU2015371184B2 (en) 2014-12-24 2020-06-25 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
CA2986981A1 (en) 2015-07-03 2017-01-12 Ferrosan Medical Devices A/S Syringe for mixing two components and for retaining a vacuum in a storage condition
KR101649450B1 (en) * 2015-08-19 2016-08-18 이상철 Skin wound healing composition
EP3496770B1 (en) * 2016-08-12 2021-05-19 Biom'up France Sas Hemostatic flowable
US11464888B2 (en) 2017-06-12 2022-10-11 Warsaw Orthopedic, Inc. Moldable formulations containing an oxysterol in an acellular tissue matrix
US11007299B2 (en) 2017-11-08 2021-05-18 Ethicon, Inc. Hemostatic paste having surface enriched with hemostasis-promoting agents and devices for delivery
CA3090405A1 (en) 2018-02-15 2019-08-22 Biom'up France SAS Multi-dimensional hemostatic product and method for producing the same
EP4321182A2 (en) 2018-05-09 2024-02-14 Ferrosan Medical Devices A/S Method for preparing a haemostatic composition
CN109674496B (en) * 2018-08-01 2019-11-15 浙江三创生物科技有限公司 The device and its device and component of conveying medicament
KR102093839B1 (en) * 2019-05-28 2020-05-04 (주)다림티센 Hemostatic agent and container containing the same
US20230047711A1 (en) * 2021-08-13 2023-02-16 Sasan Najibi Flowable collagen colloid and method of forming
US20230079760A1 (en) * 2021-09-13 2023-03-16 Medtronic Inc. Surgical system and methods of use
CN114288463B (en) * 2021-12-13 2022-07-05 鹏拓生物科技(杭州)有限公司 Development method of fluid collagen hemostatic material

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2579367A (en) * 1950-11-24 1951-12-18 Hynson Westcott & Dunning Inc Bandage
US3742955A (en) * 1970-09-29 1973-07-03 Fmc Corp Fibrous collagen derived product having hemostatic and wound binding properties
JPS5837330B2 (en) * 1975-05-01 1983-08-16 カブシキガイシヤ ニツピ Shiketsu Yokora Genfun Matsuno Seizou Hohou
GB1584080A (en) * 1977-12-05 1981-02-04 Ethicon Inc Absorbable hemostatic composition
US4215200A (en) * 1978-10-02 1980-07-29 Cornell Research Foundation, Inc. Chemically and enzymatically modified collagen hemostatic agent
JPS5625113A (en) * 1979-08-07 1981-03-10 Kureha Chem Ind Co Ltd Preparation of hemostatic collagen powder
US4374830A (en) * 1979-10-04 1983-02-22 Research Corp. Platelet aggregating material from equine arterial tissue
DE2943520C2 (en) * 1979-10-27 1982-05-19 Fa. Carl Freudenberg, 6940 Weinheim Process for the production of collagen sponge for medical or cosmetic purposes
ATE13810T1 (en) * 1981-06-25 1985-07-15 Serapharm Gmbh & Co Kg ENRICHED PLASMA DERIVES TO ASSIST WOUND CLOSURE AND COVERAGE.
JPS6144825A (en) * 1984-08-09 1986-03-04 Unitika Ltd Hemostatic agent
US4696812A (en) * 1985-10-28 1987-09-29 Warner-Lambert Company Thrombin preparations
CA1294546C (en) * 1986-04-23 1992-01-21 John S. Sundsmo Wound healing composition containing collagen

Also Published As

Publication number Publication date
DE68914110D1 (en) 1994-04-28
JP3195335B2 (en) 2001-08-06
IE893928L (en) 1990-06-08
AU4603789A (en) 1990-06-14
AU623456B2 (en) 1992-05-14
DE68914110T2 (en) 1994-07-07
US4891359A (en) 1990-01-02
EP0372966B1 (en) 1994-03-23
IE62927B1 (en) 1995-03-08
CA2004739C (en) 2000-03-28
ATE103187T1 (en) 1994-04-15
ES2062041T3 (en) 1994-12-16
EP0372966A2 (en) 1990-06-13
JPH02218616A (en) 1990-08-31
EP0372966A3 (en) 1990-12-27
ZA899372B (en) 1991-08-28

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