CA2009198A1 - Monoclonal antibody for differentiating hiv-2 from hiv-1 seropositive individuals - Google Patents

Monoclonal antibody for differentiating hiv-2 from hiv-1 seropositive individuals

Info

Publication number
CA2009198A1
CA2009198A1 CA2009198A CA2009198A CA2009198A1 CA 2009198 A1 CA2009198 A1 CA 2009198A1 CA 2009198 A CA2009198 A CA 2009198A CA 2009198 A CA2009198 A CA 2009198A CA 2009198 A1 CA2009198 A1 CA 2009198A1
Authority
CA
Canada
Prior art keywords
hiv
monoclonal antibody
seropositive individuals
differentiating
seropositive
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2009198A
Other languages
French (fr)
Other versions
CA2009198C (en
Inventor
Jeffrey C. Hunt
Virender K. Sarin
Sushil G. Devare
Ilse I. E. Tribby
Suresh M. Desai
James M. Casey
Jill Johnson-Paepke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Jeffrey C. Hunt
Virender K. Sarin
Sushil G. Devare
Ilse I. E. Tribby
Suresh M. Desai
James M. Casey
Jill Johnson-Paepke
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jeffrey C. Hunt, Virender K. Sarin, Sushil G. Devare, Ilse I. E. Tribby, Suresh M. Desai, James M. Casey, Jill Johnson-Paepke, Abbott Laboratories filed Critical Jeffrey C. Hunt
Publication of CA2009198A1 publication Critical patent/CA2009198A1/en
Application granted granted Critical
Publication of CA2009198C publication Critical patent/CA2009198C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
    • C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/974—Aids related test
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/22—Viral peptide or viral protein
    • Y10S930/221—Retrovirus related, or human immunodeficiency virus related, or simian immunodeficiency virus related

Abstract

A mouse monoclonal antibody is provided which detects HIV-2 seropositive individuals and differentiates them from HIV-1 seropositive individuals. The monoclonal antibody is specific for an epitope of HIV-2 gp41 which lies outside the characterized immunodominant region. The epitope recognized by the monoclonal antibody has the amino acid sequence HTTVPW.
CA002009198A 1989-02-03 1990-02-02 Monoclonal antibody for differentiating hiv-2 from hiv-1 seropositive individuals Expired - Lifetime CA2009198C (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30636689A 1989-02-03 1989-02-03
US306,366 1989-02-03
US36173989A 1989-06-02 1989-06-02
US361,739 1989-06-02

Publications (2)

Publication Number Publication Date
CA2009198A1 true CA2009198A1 (en) 1990-08-03
CA2009198C CA2009198C (en) 2000-02-01

Family

ID=26975121

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002009198A Expired - Lifetime CA2009198C (en) 1989-02-03 1990-02-02 Monoclonal antibody for differentiating hiv-2 from hiv-1 seropositive individuals

Country Status (8)

Country Link
US (1) US5374518A (en)
EP (1) EP0388602B1 (en)
JP (1) JP2958346B2 (en)
AT (1) ATE113989T1 (en)
AU (1) AU4906590A (en)
CA (1) CA2009198C (en)
DE (1) DE69013950T2 (en)
ES (1) ES2066887T3 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0564460A1 (en) * 1990-08-16 1993-10-13 Diagnostic Biotechnology, Inc. An augmented western blot format and immunoassay for detection of viral antibodies

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4839288A (en) * 1986-01-22 1989-06-13 Institut Pasteur Retrovirus capable of causing AIDS, antigens obtained from this retrovirus and corresponding antibodies and their application for diagnostic purposes
US6514691B1 (en) 1986-01-22 2003-02-04 Institut Pasteur Peptides of human immunodeficiency virus type 2 (HIV-2), antibodies against peptides of HIV-2, and methods and kits for detecting HIV-2
ATE164853T1 (en) * 1990-01-16 1998-04-15 Orgenics Ltd PEPTIDES DERIVED FROM VIRUS HIV ENVEL GLYCOPROTEINS, THEIR USE FOR DETECTING INFECTION OF THESE VIRUSES AND FOR VACCINATION AGAINST AIDS
US5256561A (en) * 1991-12-20 1993-10-26 Abbott Laboratories Monoclonal antibody to HIV-2 and uses thereof
US6074646A (en) * 1993-10-26 2000-06-13 Board Of Regents, The University Of Texas System Nondenatured HIV envelope antigens for detecting early HIV-specific antibodies
WO1996040763A2 (en) * 1995-06-07 1996-12-19 Abbott Laboratories Peptides for hiv-1 detection
DE19622088A1 (en) * 1996-05-31 1997-12-04 Boehringer Mannheim Gmbh Anti-HIV antibodies as control samples
EP0993615A1 (en) * 1998-03-04 2000-04-19 Universal Healthwatch, Inc. Rapid confirmatory test for microbial infections
US6852491B2 (en) * 2001-09-04 2005-02-08 Abbott Laboratories Amplification and detection reagents for HIV-1
WO2003073992A2 (en) * 2002-02-28 2003-09-12 Board Of Regents, The University Of Texas System Method and composition for detecting early hiv antibody
CA2793959C (en) 2010-03-25 2019-06-04 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
SI2691530T1 (en) 2011-06-10 2018-08-31 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
US20130189754A1 (en) 2011-09-12 2013-07-25 International Aids Vaccine Initiative Immunoselection of recombinant vesicular stomatitis virus expressing hiv-1 proteins by broadly neutralizing antibodies
EP2586461A1 (en) 2011-10-27 2013-05-01 Christopher L. Parks Viral particles derived from an enveloped virus
ES2631608T3 (en) 2012-06-27 2017-09-01 International Aids Vaccine Initiative Env-glycoprotein variant of HIV-1
EP2848937A1 (en) 2013-09-05 2015-03-18 International Aids Vaccine Initiative Methods of identifying novel HIV-1 immunogens
US10058604B2 (en) 2013-10-07 2018-08-28 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
US10174292B2 (en) 2015-03-20 2019-01-08 International Aids Vaccine Initiative Soluble HIV-1 envelope glycoprotein trimers
EP3072901A1 (en) 2015-03-23 2016-09-28 International Aids Vaccine Initiative Soluble hiv-1 envelope glycoprotein trimers

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341482C (en) * 1984-10-31 2005-05-10 Paul A. Luciw Process for preparing fragments of aids-associated retroviruses

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0564460A1 (en) * 1990-08-16 1993-10-13 Diagnostic Biotechnology, Inc. An augmented western blot format and immunoassay for detection of viral antibodies
US5721095A (en) * 1990-08-16 1998-02-24 Genelabs Diagnostics Pte Ltd. HIV-1/HIV-2 viral detection kit and method
EP0564460B1 (en) * 1990-08-16 1998-10-21 Diagnostic Biotechnology, Inc. An augmented western blot format and immunoassay for detection of viral antibodies

Also Published As

Publication number Publication date
DE69013950D1 (en) 1994-12-15
EP0388602B1 (en) 1994-11-09
CA2009198C (en) 2000-02-01
JPH02268696A (en) 1990-11-02
DE69013950T2 (en) 1995-03-30
ATE113989T1 (en) 1994-11-15
EP0388602A1 (en) 1990-09-26
ES2066887T3 (en) 1995-03-16
AU4906590A (en) 1990-09-20
JP2958346B2 (en) 1999-10-06
US5374518A (en) 1994-12-20

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Legal Events

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EEER Examination request
MKEX Expiry