CA2016521A1 - Fibronectin binding protein as well as its preparation - Google Patents

Fibronectin binding protein as well as its preparation

Info

Publication number
CA2016521A1
CA2016521A1 CA002016521A CA2016521A CA2016521A1 CA 2016521 A1 CA2016521 A1 CA 2016521A1 CA 002016521 A CA002016521 A CA 002016521A CA 2016521 A CA2016521 A CA 2016521A CA 2016521 A1 CA2016521 A1 CA 2016521A1
Authority
CA
Canada
Prior art keywords
preparation
well
fibronectin binding
binding protein
protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002016521A
Other languages
French (fr)
Other versions
CA2016521C (en
Inventor
Magnus Hook
Klas Jonsson
Kjell M. Lindberg
Lars C. Signas
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfa Laval Agri International AB
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2016521A1 publication Critical patent/CA2016521A1/en
Application granted granted Critical
Publication of CA2016521C publication Critical patent/CA2016521C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70546—Integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria

Abstract

The present invention relates to a new recombinant hybrid-DNA-molecule comprising a nucleotide sequence from S.
aureus coding for a protein, or polypeptide, having fibronectin binding properties.
CA002016521A 1989-05-11 1990-05-10 Fibronectin binding protein as well as its preparation Expired - Lifetime CA2016521C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE8901687A SE8901687D0 (en) 1989-05-11 1989-05-11 FIBRONECTIN BINDING PROTEIN AS WELL AS IT'S PREPARATION
SE8901687-7 1989-05-11

Publications (2)

Publication Number Publication Date
CA2016521A1 true CA2016521A1 (en) 1990-11-11
CA2016521C CA2016521C (en) 2002-02-05

Family

ID=20375920

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002016521A Expired - Lifetime CA2016521C (en) 1989-05-11 1990-05-10 Fibronectin binding protein as well as its preparation

Country Status (15)

Country Link
US (3) US5175096A (en)
EP (1) EP0397633B1 (en)
JP (1) JP3077993B2 (en)
AT (1) ATE125867T1 (en)
AU (1) AU630950B2 (en)
CA (1) CA2016521C (en)
DE (1) DE69021263T2 (en)
DK (1) DK0397633T3 (en)
ES (1) ES2077666T3 (en)
FI (1) FI102768B1 (en)
GR (1) GR3017946T3 (en)
IE (1) IE72968B1 (en)
NO (1) NO300069B1 (en)
NZ (1) NZ233614A (en)
SE (1) SE8901687D0 (en)

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US5440014A (en) * 1990-08-10 1995-08-08 H+E,Uml/Oo/ K; Magnus Fibronectin binding peptide
US5851794A (en) * 1990-10-22 1998-12-22 Alfa Laval Ab Collagen binding protein as well as its preparation
US7279162B1 (en) 1990-10-22 2007-10-09 Henry M. Jackson Foundation For The Advancement Of Military Medicine Isolated broadly reactive opsonic immunoglobulin for treating a pathogenic coagulase-negative staphylococcus infection
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US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5980908A (en) * 1991-12-05 1999-11-09 Alfa Laval Ab Bacterial cell surface protein with fibronectin, fibrinogen, collagen and laminin binding ability, process for the manufacture of the protein and prophylactic treatment
DE69434437T2 (en) * 1993-02-05 2006-04-06 Smithkline Beecham P.L.C., Brentford Fibronectin binding protein, monoclonal antibody and their use to restore adhesion to bacteria
US5492819A (en) * 1993-09-23 1996-02-20 Genencor International, Inc. Recovery of insoluble biosynthetic products
US7083979B1 (en) * 1994-03-25 2006-08-01 Indiana University Foundation Methods for enhanced retroviral-mediated gene transfer
US6033907A (en) * 1995-09-29 2000-03-07 Indiana University Foundation Enhanced virus-mediated DNA transfer
US6660842B1 (en) * 1994-04-28 2003-12-09 Tripep Ab Ligand/receptor specificity exchangers that redirect antibodies to receptors on a pathogen
US6933366B2 (en) * 1996-12-27 2005-08-23 Tripep Ab Specificity exchangers that redirect antibodies to bacterial adhesion receptors
US6040137A (en) * 1995-04-27 2000-03-21 Tripep Ab Antigen/antibody specification exchanger
US20040247611A1 (en) * 1994-05-23 2004-12-09 Montana State University Identification of pathogen-ligand interactions
GB9415902D0 (en) * 1994-08-05 1994-09-28 Smithkline Beecham Plc Method of treatment
DE69636124T2 (en) * 1995-09-29 2006-12-21 Indiana University Research And Technology Corp., Bloomington METHOD FOR IMPROVED VIRUS-RELATED DNA TRANSFER USING MOLECULES WITH VIRUS AND CELL BINDING DOMAINS
EP0859845A1 (en) * 1995-10-16 1998-08-26 Smithkline Beecham Plc Novel cell surface protein compounds
US5858709A (en) * 1996-10-15 1999-01-12 Smithkline Beecham P.L.C. Fibronectin binding protein B compounds
GB9521146D0 (en) * 1995-10-16 1995-12-20 Smithkline Beecham Plc Novel compounds
US6013482A (en) * 1996-10-15 2000-01-11 Smithkline Beecham Plc Cell surface protein compounds
US6274376B1 (en) * 1996-02-20 2001-08-14 Smithkline Beecham Corporation ClpL
US6348584B1 (en) * 1996-10-17 2002-02-19 John Edward Hodgson Fibronectin binding protein compounds
CA2277793A1 (en) * 1997-01-21 1998-07-23 The Texas A & M University System Fibronectin binding protein compositions and methods of use
US6685943B1 (en) 1997-01-21 2004-02-03 The Texas A&M University System Fibronectin binding protein compositions and methods of use
US6610293B1 (en) 1997-06-16 2003-08-26 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
US6270992B1 (en) * 1997-07-29 2001-08-07 Smithkline Beecham Corporation Histidine kinase of Staphylococcus aureus
GB9720633D0 (en) * 1997-09-29 1997-11-26 Univ Bristol BHV-2 vector
US7250494B2 (en) * 1998-06-15 2007-07-31 Biosynexus Incorporated Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria
US6703025B1 (en) 1998-08-31 2004-03-09 Inhibitex, Inc. Multicomponent vaccines
US6692739B1 (en) 1998-08-31 2004-02-17 Inhibitex, Inc. Staphylococcal immunotherapeutics via donor selection and donor stimulation
US20020092987A1 (en) * 1998-09-05 2002-07-18 Taehee Cho Photo detect device using quantum dots and materialization method thereof
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
CA2446294A1 (en) * 2001-05-08 2002-11-14 Yi Xu Surface proteins from gram-positive bacteria having highly conserved motifs and antibodies that recognize them
CA2447118A1 (en) 2001-05-11 2002-11-21 The Texas A & M University System Method and compositions for inhibiting thrombin-induced coagulation
CA2450939C (en) 2001-06-15 2012-11-06 Inhibitex, Inc. Cross-reactive monoclonal and polyclonal antibodies which recognize surface proteins from coagulase-negative staphylococci and staphylococcus aureus
US7115264B2 (en) * 2001-11-05 2006-10-03 Inhibitex Monoclonal antibodies to the fibronectin binding protein and method of use in treating or preventing infections
US7335359B2 (en) * 2003-02-06 2008-02-26 Tripep Ab Glycosylated specificity exchangers
WO2004069873A2 (en) * 2003-02-06 2004-08-19 Tripep Ab Antigen/antibody or ligand/receptor glycosylated specificity exchangers
NZ561879A (en) * 2003-03-07 2009-05-31 Wyeth Corp Polysaccharide - staphylococcal surface adhesin carrier protein conjugates for immunization against nosocomial infections
TWI353991B (en) 2003-05-06 2011-12-11 Syntonix Pharmaceuticals Inc Immunoglobulin chimeric monomer-dimer hybrids
US20050037947A1 (en) * 2003-05-06 2005-02-17 Bitonti Alan J. Inhibition of drug binding to serum albumin
US7348004B2 (en) * 2003-05-06 2008-03-25 Syntonix Pharmaceuticals, Inc. Immunoglobulin chimeric monomer-dimer hybrids
HUE026384T2 (en) * 2003-05-06 2016-06-28 Biogen Hemophilia Inc Clotting factor chimeric proteins for treatment of a hemostatic disorder
BRPI0511429A (en) * 2004-05-21 2007-12-11 Wyeth Corp isolated fibronectin binding protein (fnb), altered from staphylococcal aureus (s. aureus); fnb isolated, altered; immunogenic composition; method for immunizing a vertebrate against s. aureus; expression vector; recombinant host cell; method for producing an altered fnb; method for inducing an immune response in a vertebrate; isolated, altered fibronectin binding protein (fnb) from staphylococcal aureus (s. aureus); and isolated nucleic acid molecule encoding an altered fnb of s. aureus
CA2580137A1 (en) 2004-09-22 2006-03-30 Glaxosmithkline Biologicals S.A. Immunogenic composition
KR101541383B1 (en) 2006-03-30 2015-08-03 글락소스미스클라인 바이오로지칼즈 에스.에이. immunogenic composition
US20090092631A1 (en) * 2007-03-26 2009-04-09 Tripep Ab Glycosylated specificity exchangers that induce an antibody dependent cellular cytotoxicity (adcc) response
US9181329B2 (en) 2007-08-31 2015-11-10 The University Of Chicago Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions
AU2008292897B2 (en) * 2007-08-31 2015-01-22 University Of Chicago Methods and compositions related to immunizing against staphylococcal lung diseases and conditions
WO2010014304A1 (en) * 2008-07-29 2010-02-04 University Of Chicago Compositions and methods related to staphylococcal bacterium proteins
US20110262477A1 (en) 2008-10-06 2011-10-27 University Of Chicago Compositions and Methods Related to Bacterial EAP, EMP, and/or ADSA Proteins
AU2010271116B2 (en) 2009-04-03 2015-08-13 University Of Chicago Compositions and methods related to Protein A (SpA) variants
GB0913680D0 (en) 2009-08-05 2009-09-16 Glaxosmithkline Biolog Sa Immunogenic composition
WO2011097401A1 (en) 2010-02-03 2011-08-11 University Of Rochester Treatment of fibrosis-related disorders using fibronectin binding proteins and polypeptides
JP2013523818A (en) 2010-04-05 2013-06-17 ザ・ユニバーシティー・オブ・シカゴ Compositions and methods relating to protein A (SpA) antibodies as enhancers of immune responses
US8821894B2 (en) 2010-07-02 2014-09-02 The University Of Chicago Compositions and methods related to protein A (SpA) variants
EP2614074A1 (en) 2010-09-09 2013-07-17 The University of Chicago Methods and compositions involving protective staphylococcal antigens
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
US9556281B2 (en) 2011-08-15 2017-01-31 The University Of Chicago Compositions and methods related to antibodies to staphylococcal protein A
ES2806945T3 (en) 2012-04-26 2021-02-19 Univ Chicago Staphylococcal coagulase antigens and methods for their use
AU2013252888B2 (en) 2012-04-26 2018-06-14 University Of Chicago Compositions and methods related to antibodies that neutralize coagulase activity during Staphylococcus aureus disease
CA2899089C (en) 2013-03-15 2021-10-26 Biogen Ma Inc. Factor ix polypeptide formulations
CN105384800B (en) * 2015-12-07 2019-01-25 黑龙江八一农垦大学 Staphylococcus aureus TAF fusion protein preparation method and applications
EP3257862A1 (en) * 2016-06-16 2017-12-20 ETH Zürich Fibronectin-binding peptides for use in tumor or fibrosis diagnosis and therapy
EP4038091A1 (en) 2019-10-02 2022-08-10 Janssen Vaccines & Prevention B.V. Staphylococcus peptides and methods of use

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US3917818A (en) * 1970-01-14 1975-11-04 Agricura Labor Ltd Treatment of mastitis in cows, the product for this treatment and to the production of said product
DE2644622C3 (en) * 1976-10-02 1979-11-29 Behringwerke Ag, 3550 Marburg Extraction of microorganisms and diagnostic agents containing them
SE445013B (en) * 1979-06-21 1986-05-26 Landstingens Inkopscentral Means for preventing or treating infections by humans and animals
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US5189015A (en) * 1984-05-30 1993-02-23 Alfa-Laval Agri International Ab Method for prophylactic treatment of the colonization of a Staphylococcus aureus bacterial strain by bacterial cell surface protein with fibronectin and fibrinogen binding ability
SE454403B (en) * 1984-05-30 1988-05-02 Alfa Laval Agri Int USE OF A CELLYTE PROTEIN WITH FIBRONECTIN, FIBRINOGENE, COLLAGEN, AND / OR LAMIN BINDING PROPERTIES IN THE PRODUCTION OF SAR TREATMENT AGENTS
US5571514A (en) * 1987-06-01 1996-11-05 Alfa Laval Ab Fibronectin binding protein as well as its preparation
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SE8801723D0 (en) * 1988-05-06 1988-05-06 Staffan Normark FIBRONECTIN BINDING PROTEIN AS WELL AS IT'S PREPARATION
SE8801894D0 (en) * 1988-05-20 1988-05-20 Alfa Laval Agri Int FIBRONECT BINING PROTEIN
SE8901687D0 (en) * 1989-05-11 1989-05-11 Alfa Laval Agri Int FIBRONECTIN BINDING PROTEIN AS WELL AS IT'S PREPARATION
SE9002617D0 (en) * 1990-08-10 1990-08-10 Alfa Laval Agri Int A FIBRONECTIN BINDING PEPTIDE

Also Published As

Publication number Publication date
NZ233614A (en) 1991-12-23
IE72968B1 (en) 1997-05-07
NO902082L (en) 1990-11-12
GR3017946T3 (en) 1996-02-29
DE69021263D1 (en) 1995-09-07
US5652217A (en) 1997-07-29
FI102768B (en) 1999-02-15
AU5481890A (en) 1990-11-15
SE8901687D0 (en) 1989-05-11
ES2077666T3 (en) 1995-12-01
DK0397633T3 (en) 1996-01-02
JP3077993B2 (en) 2000-08-21
FI902350A0 (en) 1990-05-10
EP0397633A3 (en) 1991-07-31
NO902082D0 (en) 1990-05-10
AU630950B2 (en) 1992-11-12
DE69021263T2 (en) 1996-01-04
JPH03272687A (en) 1991-12-04
ATE125867T1 (en) 1995-08-15
CA2016521C (en) 2002-02-05
NO300069B1 (en) 1997-04-01
EP0397633A2 (en) 1990-11-14
US5175096A (en) 1992-12-29
US5840846A (en) 1998-11-24
FI102768B1 (en) 1999-02-15
IE901696L (en) 1990-11-11
EP0397633B1 (en) 1995-08-02

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