CA2018714A1 - Hypothalamic polypeptides with adenylate cyclase stimulating activity - Google Patents

Hypothalamic polypeptides with adenylate cyclase stimulating activity

Info

Publication number
CA2018714A1
CA2018714A1 CA002018714A CA2018714A CA2018714A1 CA 2018714 A1 CA2018714 A1 CA 2018714A1 CA 002018714 A CA002018714 A CA 002018714A CA 2018714 A CA2018714 A CA 2018714A CA 2018714 A1 CA2018714 A1 CA 2018714A1
Authority
CA
Canada
Prior art keywords
adenylate cyclase
stimulating activity
hypothalamic
polypeptides
cyclase stimulating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002018714A
Other languages
French (fr)
Other versions
CA2018714C (en
Inventor
Akira Arimura
Atsuro Miyata
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tulane University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2018714A1 publication Critical patent/CA2018714A1/en
Application granted granted Critical
Publication of CA2018714C publication Critical patent/CA2018714C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/17—Vasoactive intestinal peptides; related peptides

Abstract

The present invention relates to novel peptides having adenylate cyclase stimulating activity. The novel peptides all contain at least the sequeunce His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-.
CA002018714A 1989-06-19 1990-06-11 Hypothalamic polypeptides with adenylate cyclase stimulating activity Expired - Lifetime CA2018714C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/367,817 US5128242A (en) 1989-06-19 1989-06-19 Hypothalamic polypeptides with adenylate cyclase stimulating activity
US07/367,817 1989-06-19

Publications (2)

Publication Number Publication Date
CA2018714A1 true CA2018714A1 (en) 1990-12-19
CA2018714C CA2018714C (en) 2001-12-25

Family

ID=23448744

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002018714A Expired - Lifetime CA2018714C (en) 1989-06-19 1990-06-11 Hypothalamic polypeptides with adenylate cyclase stimulating activity

Country Status (4)

Country Link
US (1) US5128242A (en)
EP (1) EP0404652A1 (en)
JP (1) JP2897169B2 (en)
CA (1) CA2018714C (en)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198542A (en) * 1989-06-20 1993-03-30 Takeda Chemical Industries, Inc. Dna encoding a pitvitary adenylate cyclase activating protein and use thereof
AU651596B2 (en) * 1990-06-05 1994-07-28 Immunex Corporation Type II interleukin-1 receptors
EP0467279A3 (en) * 1990-07-18 1992-08-05 Takeda Chemical Industries, Ltd. Polypeptides having c-amp producing activity
US5521069A (en) * 1990-08-10 1996-05-28 Takeda Chemical Industries, Ltd. Genomic DNA exons having exons encoding human pituitary adenylate cyclase activity peptide with 38 amino acids residues(PACAP38) and a promoter thereof
EP0470604A3 (en) * 1990-08-10 1992-12-09 Takeda Chemical Industries, Ltd. Pacap38, proteine with adenylate cyclase activity
US5623050A (en) * 1991-08-22 1997-04-22 Takeda Chemical Industries, Ltd. Stable polypeptides having c-AMP production enhancing activity and the use thereof
EP0618291A3 (en) * 1993-02-26 1997-12-03 Takeda Chemical Industries, Ltd. PACAP receptor protein, method for preparing said protein, and use thereof
US5695954A (en) * 1993-05-14 1997-12-09 University Of Victoria Innovation & Development Corporation DNA encoding two fish neuropeptides
JPH10505863A (en) * 1994-09-22 1998-06-09 ジ・アドミニストレーターズ・オブ・ザ・チューレン・エデュケイショナル・ファンド Methods and pharmaceutical compositions for the prevention and treatment of brain disorders
US6680295B1 (en) 1994-09-22 2004-01-20 The Administrators Of The Tulane Educational Fund Method and pharmaceutical composition for prevention and treatment of brain damage
US5763402A (en) * 1996-07-26 1998-06-09 The Administrators Of The Tulane Educational Fund Promotion or inhibition of spermatogenesis
ATE256739T1 (en) * 1996-08-02 2004-01-15 Scripps Research Inst HYPOTHALAMUS-SPECIFIC POLYPEPTIDES
US6165755A (en) * 1997-01-23 2000-12-26 University Of Victoria Innovation And Development Corporation Chicken neuropeptide gene useful for improved poultry production
US6242563B1 (en) 1998-07-20 2001-06-05 Societe De Conseils De Recherches Et D'applications Scientifiques, Sas Peptide analogues
HUP0104934A3 (en) * 1998-07-20 2002-05-28 Sod Conseils Rech Applic Peptide analogues of pacap, pharmaceutical compositions comprising thereof and their use
US20020155533A1 (en) * 1998-11-30 2002-10-24 Takeda Chemical PACAP receptor protein, method for preparing said protein, and use thereof
US20020182729A1 (en) * 2001-01-11 2002-12-05 Dicicco-Bloom Emanuel Pituitary adenylate cyclase-activating polypeptide (PACAP) is an anti-mitogenic signal for selected neuronal precursors in vivo
EP1423509A2 (en) * 2001-08-30 2004-06-02 Stem Cell Therapeutics Inc. Differentiation of neural stem cells and therapeutic use thereof
EP1430114B1 (en) * 2001-09-14 2012-01-18 Stem Cell Therapeutics Inc. Prolactin induced increase in neural stem cell numbers and therapeutical use thereof
WO2003024471A2 (en) * 2001-09-18 2003-03-27 Stem Cell Therapeutics Inc. Effect of growth hormone and igf-1 on neural stem cells and therapeutic application
AU2003250697B2 (en) * 2002-07-30 2008-05-01 Stem Cell Therapeutics Inc. Oligodendrocyte production from multipotent neural stem cells
WO2004011497A1 (en) * 2002-07-31 2004-02-05 Stem Cell Therapeutics Inc. Method of enhancing neural stem cell proliferation, differentiation, and survival using pituitary adenylate cyclase activating polypeptide (pacap)
ES2320754T3 (en) * 2002-10-22 2009-05-28 Waratah Pharmaceuticals, Inc. TREATMENT OF DIABETES.
EP1562626B1 (en) * 2002-10-29 2007-11-28 ALZA Corporation Stabilized, solid-state polypeptide particles
JP4990634B2 (en) * 2004-02-13 2012-08-01 ステム セル セラピューティクス コーポレイション Use of luteinizing hormone (LH) and chorionic gonadotropin (hCG) for neural stem cell proliferation and neurogenesis
EP1778268B1 (en) 2004-07-21 2016-05-04 Tulane University Health Sciences Center Treatment of renal dysfunction and multiple myeloma using pacap compounds
JP2008515818A (en) * 2004-10-07 2008-05-15 ステム セル セラピューティクス コーポレイション Stimulation of proliferation of pluripotent stem cells by administration of compounds related to pregnancy
CA2664629A1 (en) 2005-09-27 2007-04-05 Christopher Gregg Oligodendrocyte precursor cell proliferation regulated by prolactin
WO2007106986A1 (en) * 2006-03-17 2007-09-27 Stem Cell Therapeutics Corp. Dosing regimes for lh or hcg and epo for treatment of neurological disorders
WO2011054001A2 (en) 2009-11-02 2011-05-05 The Administrators Of The Tulane Analogs of pitutary adenylate cyclase-activating polypeptide (pacap) and methods for their use
CA2788835A1 (en) * 2010-02-05 2011-08-11 The Administrators Of The Tulane Educational Fund The use of pituitary adenylate cyclase-activating polypeptide (pacap) and pacap analogs as adjunctive treatments with inhibitors of calcineurin or inhibitors of the mammalian target of rapamycin (mtor) complexes
EP3019184A4 (en) * 2013-06-07 2017-04-05 The Administrators of the Tulane Educational Fund Analogs of pituitary adenylate cyclase-activating polypeptide (pacap) and methods for their use
GB201601492D0 (en) 2016-01-27 2016-03-09 Airbus Operations Ltd Aircraft fuel system
GB2615755A (en) * 2022-02-15 2023-08-23 Airbus Operations Ltd Fuel tank stringer with flow passage

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8427651D0 (en) * 1984-11-01 1984-12-05 Beecham Group Plc Compounds
SE454514B (en) * 1985-03-11 1988-05-09 Kabigen Ab INTESTINAL Mammalian Hormone Precursor AND COMPOSITIONS CONTAINING THIS
JPS62246595A (en) * 1986-04-17 1987-10-27 Eisai Co Ltd Peptide having bronchodilative action and depressive action
US4939224A (en) * 1987-02-26 1990-07-03 The Salk Institute Biotechnology/Industrial Associates, Inc. Vasoactive intestinal peptide analogs
SE8702520D0 (en) * 1987-06-16 1987-06-16 Kabigen Ab MAMMAL INTESTINE HORMONE PRECURSOR

Also Published As

Publication number Publication date
JP2897169B2 (en) 1999-05-31
CA2018714C (en) 2001-12-25
JPH03123798A (en) 1991-05-27
US5128242A (en) 1992-07-07
EP0404652A1 (en) 1990-12-27

Similar Documents

Publication Publication Date Title
CA2018714A1 (en) Hypothalamic polypeptides with adenylate cyclase stimulating activity
DE68912268D1 (en) Elastomere polypeptide als vaskulare prothesematerialien.
GB2223389B (en) Combine harvester
GB2216529B (en) Peptides useful as tachykinin antagonists
YU162789A (en) 2-aza-4-(alcoxycarbonyl) spiro/4,5/decan-3-ones
AU5229690A (en) Polyamide 4.6 composition
PH30818A (en) Novel substituted thienopyrans as antihpertensive agents.
IL94487A0 (en) Atrial peptide derivatives
GB8801281D0 (en) I c piston engine
AU4162089A (en) Polyamide blends by reactive processing
GB8811636D0 (en) I c engine
ZA916918B (en) Amino acid analogs as CCK antagonists.
ZA899630B (en) Toughened polyamide compositions
AU6916987A (en) Vasopressin-like polypeptides (alpha-methyl amino-acid at positions 4 or 7)
EP0255394A3 (en) Immunosuppressive peptides
EP0261239A4 (en) Fsh-releasing peptide.
Helmsing El Desarrollo de la producción de algodón: 1950-1978
GB8810573D0 (en) I c engines
CS698486A1 (en) Zpusob pripravy 1 amino 8 naftol 3,6 disulfonove kyseliny
ZA895454B (en) 2,2-dihalogenocy-clopropyl-hydroxy-ethyltriazoles
Silverman Bertolucci by Bertolucci
GB8809184D0 (en) Heptapeptide
GB8908029D0 (en) Oxaspriro(2,5)octane derivative
ZA891059B (en) 1-aminomethyl-3-(2,4-difluoro-3-chlorophenyl)-4-cyano-pyrroles
IE892748L (en) Aminomethyl peptides

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed
MKEC Expiry (correction)
MKEC Expiry (correction)

Effective date: 20121202