CA2023703A1 - Medical electrical lead with polymeric monolithic controlled release device and method of manufacture - Google Patents

Medical electrical lead with polymeric monolithic controlled release device and method of manufacture

Info

Publication number
CA2023703A1
CA2023703A1 CA2023703A CA2023703A CA2023703A1 CA 2023703 A1 CA2023703 A1 CA 2023703A1 CA 2023703 A CA2023703 A CA 2023703A CA 2023703 A CA2023703 A CA 2023703A CA 2023703 A1 CA2023703 A1 CA 2023703A1
Authority
CA
Canada
Prior art keywords
lead
medical electrical
electrical lead
manufacture
steroid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2023703A
Other languages
French (fr)
Other versions
CA2023703C (en
Inventor
Edward D. Di Domenico
Christopher M. Hobot
Kenneth B. Stokes
Arthur J. Coury
Phong D. Doan
Richard D. Sandstrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Publication of CA2023703A1 publication Critical patent/CA2023703A1/en
Application granted granted Critical
Publication of CA2023703C publication Critical patent/CA2023703C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems
    • A61N1/0565—Electrode heads
    • A61N1/0568—Electrode heads with drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/056—Transvascular endocardial electrode systems
    • A61N1/057—Anchoring means; Means for fixing the head inside the heart
    • A61N1/0573—Anchoring means; Means for fixing the head inside the heart chacterised by means penetrating the heart tissue, e.g. helix needle or hook

Abstract

A cardiac pacing lead or other stimulation lead carrying a steroid compounded within a polymer matrix.
The steroid is dispersed in thermoplastic or thermoset polyurethane or polyurea forming monomers or prepolymers.
The mixture is then chain extended by addition of the appropriate difunctional or multifunctional isocyanate, hydroxyl or amine curing agent to form a solid polymer.
The resulting formulation is molded or cast into a desired shape, and incorporated in the distal end of a medical electrical lead, adjacent to or within the electrode. In a preferred embodiment, the medical lead employs an extendable helix which is screwed into body tissue, and the polymer containing the drug takes the form of a generally dimensionally stable annular member mounted to the lead, encircling the helix.
CA002023703A 1989-08-23 1990-08-21 Medical electrical lead with polymeric monolithic controlled release device and method of manufacture Expired - Fee Related CA2023703C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/398,220 1989-08-23
US07/398,220 US4972848A (en) 1989-08-23 1989-08-23 Medical electrical lead with polymeric monolithic controlled release device and method of manufacture

Publications (2)

Publication Number Publication Date
CA2023703A1 true CA2023703A1 (en) 1991-02-24
CA2023703C CA2023703C (en) 1995-05-16

Family

ID=23574495

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002023703A Expired - Fee Related CA2023703C (en) 1989-08-23 1990-08-21 Medical electrical lead with polymeric monolithic controlled release device and method of manufacture

Country Status (6)

Country Link
US (1) US4972848A (en)
EP (1) EP0414233B1 (en)
JP (1) JP2893472B2 (en)
AU (1) AU636906B2 (en)
CA (1) CA2023703C (en)
DE (1) DE69028966T2 (en)

Families Citing this family (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5003992A (en) * 1989-08-23 1991-04-02 Holleman Timothy W Atraumatic screw-in lead
US5255693A (en) * 1989-11-02 1993-10-26 Possis Medical, Inc. Cardiac lead
US5217028A (en) * 1989-11-02 1993-06-08 Possis Medical, Inc. Bipolar cardiac lead with drug eluting device
DE4219083C1 (en) * 1992-06-11 1993-10-07 Vasco Med Inst Fuer Katheterte Fluid dispensing electrode for cardiology, neurology or gynaecology - has anchoring element provided by hollow helix allowing storage of dispensed medicament
US5447533A (en) * 1992-09-03 1995-09-05 Pacesetter, Inc. Implantable stimulation lead having an advanceable therapeutic drug delivery system
US5431681A (en) * 1993-09-22 1995-07-11 Pacesetter, Inc. Combination pacing and defibrillating lead having sensing capability
US5456708A (en) * 1993-10-28 1995-10-10 Pacesetter, Inc. Rotatable pin, screw-in pacing and sensing lead having improved tip and fluidic seal
US5397343A (en) * 1993-12-09 1995-03-14 Medtronic, Inc. Medical electrical lead having counter fixation anchoring system
US5489294A (en) * 1994-02-01 1996-02-06 Medtronic, Inc. Steroid eluting stitch-in chronic cardiac lead
US5496360A (en) * 1994-04-12 1996-03-05 Ventritex, Inc. Implantable cardiac electrode with rate controlled drug delivery
US5522875A (en) 1994-07-28 1996-06-04 Medtronic, Inc. Medical electrical lead system having a torque transfer stylet
US5522874A (en) * 1994-07-28 1996-06-04 Gates; James T. Medical lead having segmented electrode
US5545207A (en) * 1994-08-24 1996-08-13 Medtronic, Inc. Medical electrical lead having stable fixation system
US5593433A (en) * 1994-12-19 1997-01-14 Intermedics, Inc. Implantable endocardial lead with self-healing retractable fixation apparatus
US5545201A (en) * 1995-03-29 1996-08-13 Pacesetter, Inc. Bipolar active fixation lead for sensing and pacing the heart
US5741321A (en) 1996-01-11 1998-04-21 Medtronic, Inc. Active fixation medical electrical lead having improved turning tool
US5987746A (en) * 1996-02-21 1999-11-23 Medtronic, Inc. Method of making medical electrical lead
US6285910B1 (en) 1997-04-21 2001-09-04 Medtronic, Inc. Medical electrical lead
US6489562B1 (en) 1997-04-01 2002-12-03 Medtronic, Inc Medical electrical lead having variable stiffness tip-ring spacer
US6785576B2 (en) 1997-04-21 2004-08-31 Medtronic, Inc. Medical electrical lead
AU7705798A (en) 1997-08-29 1999-03-22 Medtronic, Inc. Medical electrical lead
US5922014A (en) * 1997-09-02 1999-07-13 Medtronic, Inc. Single pass lead and method of use
US6038463A (en) * 1997-09-26 2000-03-14 Medtronic, Inc. Medical electrical lead
US6016436A (en) * 1997-09-26 2000-01-18 Medtronic, Inc. Medical electrical lead
US6212434B1 (en) 1998-07-22 2001-04-03 Cardiac Pacemakers, Inc. Single pass lead system
US5942276A (en) * 1998-01-16 1999-08-24 Medtronic, Inc. Method of manufacturing x-ray visible soluble covering
US6256541B1 (en) 1998-04-17 2001-07-03 Cardiac Pacemakers, Inc. Endocardial lead having defibrillation and sensing electrodes with septal anchoring
US7658727B1 (en) 1998-04-20 2010-02-09 Medtronic, Inc Implantable medical device with enhanced biocompatibility and biostability
WO1999053994A1 (en) * 1998-04-20 1999-10-28 Medtronic, Inc. Medical leads with enhanced biocompatibility and biostability
US6501990B1 (en) 1999-12-23 2002-12-31 Cardiac Pacemakers, Inc. Extendable and retractable lead having a snap-fit terminal connector
US6463334B1 (en) 1998-11-02 2002-10-08 Cardiac Pacemakers, Inc. Extendable and retractable lead
US6038482A (en) * 1998-10-30 2000-03-14 Pacesetter, Inc. Open bore electrode with a tiered drug therapy delivery system
US6052625A (en) * 1998-11-09 2000-04-18 Medtronic, Inc. Extractable implantable medical lead
US20050004642A1 (en) * 1998-11-09 2005-01-06 Medtronic, Inc. Implantable medical lead including overlay
US6801809B2 (en) 2000-02-22 2004-10-05 Medtronic, Inc. Extractable implantable medical lead
AU3788900A (en) * 1998-11-10 2000-05-29 Intermedics Inc. Cardiac lead with ETFE coated DBS coil
US6321123B1 (en) 1999-03-08 2001-11-20 Medtronic Inc. J-shaped coronary sinus lead
US6304786B1 (en) 1999-03-29 2001-10-16 Cardiac Pacemakers, Inc. Implantable lead with dissolvable coating for improved fixation and extraction
US6253110B1 (en) 1999-04-27 2001-06-26 Medtronic Inc Method for tissue stimulation and fabrication of low polarization implantable stimulation electrode
US6363287B1 (en) 1999-10-27 2002-03-26 Medtronic, Inc. Steroid elution electrodes LVCV, left atrial medical/elecrical leads
US6478776B1 (en) 2000-04-05 2002-11-12 Biocardia, Inc. Implant delivery catheter system and methods for its use
US7499742B2 (en) 2001-09-26 2009-03-03 Cvrx, Inc. Electrode structures and methods for their use in cardiovascular reflex control
US7840271B2 (en) 2000-09-27 2010-11-23 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US7623926B2 (en) 2000-09-27 2009-11-24 Cvrx, Inc. Stimulus regimens for cardiovascular reflex control
US8086314B1 (en) 2000-09-27 2011-12-27 Cvrx, Inc. Devices and methods for cardiovascular reflex control
US7616997B2 (en) 2000-09-27 2009-11-10 Kieval Robert S Devices and methods for cardiovascular reflex control via coupled electrodes
US9089450B2 (en) * 2000-11-14 2015-07-28 Cochlear Limited Implantatable component having an accessible lumen and a drug release capsule for introduction into same
AUPR148400A0 (en) 2000-11-14 2000-12-07 Cochlear Limited Apparatus for delivery of pharmaceuticals to the cochlea
US6512959B1 (en) 2000-11-28 2003-01-28 Pacesetter, Inc. Double threaded stylet for extraction of leads with a threaded electrode
US6611710B2 (en) 2000-11-29 2003-08-26 Pacesetter, Inc. Double threaded stylet for extraction of leads with a threaded electrode
US6567704B2 (en) 2000-12-20 2003-05-20 Medtronic, Inc. Medical electrical lead and method of use
SE0101154D0 (en) * 2001-03-29 2001-03-29 St Jude Medical An electrically conductive lead and a method of producing such a lead
US6763270B1 (en) 2001-08-07 2004-07-13 Pacesetter, Inc. Lead extraction mechanism for active fixation leads
US6671562B2 (en) 2001-11-09 2003-12-30 Oscor Inc. High impedance drug eluting cardiac lead
AUPR879201A0 (en) * 2001-11-09 2001-12-06 Cochlear Limited Subthreshold stimulation of a cochlea
US6978185B2 (en) * 2001-11-09 2005-12-20 Oscor Inc. Multifilar conductor for cardiac leads
JP4295627B2 (en) 2002-03-27 2009-07-15 シーブイアールエックス， インコーポレイテッド Electrode structure and its use in controlling circulatory system reflection
US7313445B2 (en) * 2002-09-26 2007-12-25 Medtronic, Inc. Medical lead with flexible distal guidewire extension
US7031777B2 (en) * 2002-09-27 2006-04-18 Medtronic, Inc. Cardiac vein lead with flexible anode and method for forming same
US7082335B2 (en) 2002-09-30 2006-07-25 Medtronic, Inc. Multipolar pacing method and apparatus
US7282213B2 (en) 2002-09-30 2007-10-16 Medtronic, Inc. Method for applying a drug coating to a medical device
US8010207B2 (en) * 2002-10-31 2011-08-30 Medtronic, Inc. Implantable medical lead designs
US7189204B2 (en) 2002-12-04 2007-03-13 Cardiac Pacemakers, Inc. Sleep detection using an adjustable threshold
EP1633320A2 (en) 2003-05-02 2006-03-15 SurModics, Inc. Implantable controlled release bioactive agent delivery device
US8246974B2 (en) 2003-05-02 2012-08-21 Surmodics, Inc. Medical devices and methods for producing the same
US8606356B2 (en) 2003-09-18 2013-12-10 Cardiac Pacemakers, Inc. Autonomic arousal detection system and method
US7155292B2 (en) 2003-09-25 2006-12-26 Cardiac Pacemakers, Inc. Active fixation assembly for an implantable device
US7953499B2 (en) * 2003-09-30 2011-05-31 Cardiac Pacemakers, Inc. Drug-eluting electrode
US7092766B1 (en) 2003-11-19 2006-08-15 Pacesetter, Inc. Active fixation lead with multiple density
EP1685085A2 (en) * 2003-11-20 2006-08-02 Angiotech International Ag Implantable sensors and implantable pumps and anti-scarring agents
US7245973B2 (en) 2003-12-23 2007-07-17 Cardiac Pacemakers, Inc. His bundle mapping, pacing, and injection lead
US7747323B2 (en) 2004-06-08 2010-06-29 Cardiac Pacemakers, Inc. Adaptive baroreflex stimulation therapy for disordered breathing
US7596413B2 (en) 2004-06-08 2009-09-29 Cardiac Pacemakers, Inc. Coordinated therapy for disordered breathing including baroreflex modulation
US8423139B2 (en) 2004-12-20 2013-04-16 Cardiac Pacemakers, Inc. Methods, devices and systems for cardiac rhythm management using an electrode arrangement
US8290586B2 (en) 2004-12-20 2012-10-16 Cardiac Pacemakers, Inc. Methods, devices and systems for single-chamber pacing using a dual-chamber pacing device
AR047851A1 (en) 2004-12-20 2006-03-01 Giniger Alberto German A NEW MARCAPASOS THAT RESTORES OR PRESERVES THE PHYSIOLOGICAL ELECTRIC DRIVING OF THE HEART AND A METHOD OF APPLICATION
US8005544B2 (en) 2004-12-20 2011-08-23 Cardiac Pacemakers, Inc. Endocardial pacing devices and methods useful for resynchronization and defibrillation
US8010192B2 (en) 2004-12-20 2011-08-30 Cardiac Pacemakers, Inc. Endocardial pacing relating to conduction abnormalities
US8326423B2 (en) 2004-12-20 2012-12-04 Cardiac Pacemakers, Inc. Devices and methods for steering electrical stimulation in cardiac rhythm management
US8010191B2 (en) 2004-12-20 2011-08-30 Cardiac Pacemakers, Inc. Systems, devices and methods for monitoring efficiency of pacing
US20060241000A1 (en) * 2005-04-22 2006-10-26 Cardiac Pacemakers, Inc. Lubricious compound and medical device made of the same
US20060240253A1 (en) * 2005-04-22 2006-10-26 Cardiac Pacemakers, Inc. Guidewire and tube with lubricious coating
US20060240059A1 (en) * 2005-04-22 2006-10-26 Cardiac Pacemakers, Inc. Lubricious eluting polymer blend and coating made from the same
US20060240060A1 (en) * 2005-04-22 2006-10-26 Cardiac Pacemakers, Inc. Lubricious compound and medical device made of the same
WO2007064251A1 (en) * 2005-11-29 2007-06-07 St. Jude Medical Ab An implantable lead
US8109879B2 (en) 2006-01-10 2012-02-07 Cardiac Pacemakers, Inc. Assessing autonomic activity using baroreflex analysis
AR059786A1 (en) * 2006-03-09 2008-04-30 Med El Elektromed Geraete Gmbh CONFIGURATION OF COCLEAR IMPLANT ELECTRODE TO ELECT PHARMACOS
US20080288017A1 (en) * 2007-02-27 2008-11-20 Cvrx, Inc. External Baroreflex Activation
US8594794B2 (en) 2007-07-24 2013-11-26 Cvrx, Inc. Baroreflex activation therapy with incrementally changing intensity
US8133215B2 (en) * 2007-08-13 2012-03-13 Cochlear Limited Independently-manufactured drug delivery module and corresponding receptacle in an implantable medical device
US9943614B2 (en) 2008-06-17 2018-04-17 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
US20100189765A1 (en) * 2008-11-26 2010-07-29 Erickson Signe R Implantable ocular drug delivery device and methods
WO2010071494A1 (en) * 2008-12-19 2010-06-24 St.Jude Medical Ab A medical implantable lead and a method for ensuring proper and safe attachment of such a lead to an organ
WO2010071849A2 (en) 2008-12-19 2010-06-24 Action Medical, Inc. Devices, methods, and systems including cardiac pacing
US8108054B2 (en) * 2009-02-04 2012-01-31 Pacesetter, Inc. Active fixation implantable medical lead configured to indicate via fluoroscopy embedment of helical anchor in cardiac tissue
US20100228330A1 (en) * 2009-03-05 2010-09-09 Pacesetter, Inc. Lead configured for hisian, para-hisian, rv septum and rv outflow tract pacing
ES2550034T3 (en) * 2009-09-23 2015-11-04 Lake Region Manufacturing, Inc. D/B/A/ Lake Regional Medical Lead wire electrostimulation conductor cable
US8565880B2 (en) 2010-04-27 2013-10-22 Cardiac Pacemakers, Inc. His-bundle capture verification and monitoring
US8617097B2 (en) 2010-05-24 2013-12-31 Cochlear Limited Drug-delivery accessory for an implantable medical device
WO2011150958A1 (en) * 2010-05-31 2011-12-08 St. Jude Medical Ab Medical implantable lead
US8532792B2 (en) 2010-06-30 2013-09-10 Cardiac Pacemakers, Inc. Helix retraction assist mechanism
AU2012285818B2 (en) 2011-07-20 2015-07-02 Brigham Young University Hydrogel materials incorporating eluting ceragenin compound
US8932614B2 (en) 2011-08-25 2015-01-13 Paul B. Savage Incorporation of particulate ceragenins in polymers
WO2013029055A1 (en) * 2011-08-25 2013-02-28 Brigham Young University Incorporation of particulate ceragenins in polymers
CN104080459B (en) 2011-09-13 2018-07-03 布莱阿姆青年大学 For treating the composition of bone disease and knochenbruch
US9603859B2 (en) 2011-09-13 2017-03-28 Brigham Young University Methods and products for increasing the rate of healing of tissue wounds
KR101966293B1 (en) 2011-09-13 2019-04-08 브라이엄 영 유니버시티 Products for healing of tissue wounds
US9694019B2 (en) 2011-09-13 2017-07-04 Brigham Young University Compositions and methods for treating bone diseases and broken bones
EP3449900A1 (en) 2011-12-21 2019-03-06 Brigham Young University Oral care compositions
US9533063B1 (en) 2012-03-01 2017-01-03 Brigham Young University Aerosols incorporating ceragenin compounds and methods of use thereof
EP3225113B1 (en) 2012-05-02 2020-09-02 Brigham Young University Methods for making ceragenin particulate materials
MX351261B (en) 2012-06-01 2017-10-06 Surmodics Inc Apparatus and method for coating balloon catheters.
US9827401B2 (en) 2012-06-01 2017-11-28 Surmodics, Inc. Apparatus and methods for coating medical devices
BR112015008804A2 (en) 2012-10-17 2017-07-04 Univ Brigham Young mastitis treatment and prevention
US11090468B2 (en) 2012-10-25 2021-08-17 Surmodics, Inc. Apparatus and methods for coating medical devices
JP6294352B2 (en) 2013-01-07 2018-03-14 ブリガム・ヤング・ユニバーシティＢｒｉｇｈａｍ Ｙｏｕｎｇ Ｕｎｉｖｅｒｓｉｔｙ Methods for reducing cell proliferation and treating certain diseases
US11524015B2 (en) 2013-03-15 2022-12-13 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
US10568893B2 (en) 2013-03-15 2020-02-25 Brigham Young University Methods for treating inflammation, autoimmune disorders and pain
CN110420211A (en) 2013-03-15 2019-11-08 布莱阿姆青年大学 The method for treating inflammation, autoimmune disease and pain
US9387215B2 (en) 2013-04-22 2016-07-12 Brigham Young University Animal feed including cationic cholesterol additive and related methods
FR3006594A1 (en) * 2013-06-11 2014-12-12 Sorin Crm Sas IMPLANTABLE MICROSONDE FOR DETECTION / STIMULATION INCORPORATING AN ANTI-INFLAMMATORY AGENT
US11690855B2 (en) 2013-10-17 2023-07-04 Brigham Young University Methods for treating lung infections and inflammation
US20150203527A1 (en) 2014-01-23 2015-07-23 Brigham Young University Cationic steroidal antimicrobials
CA2844321C (en) 2014-02-27 2021-03-16 Brigham Young University Cationic steroidal antimicrobial compounds
US10220045B2 (en) 2014-03-13 2019-03-05 Brigham Young University Compositions and methods for forming stabilized compositions with reduced CSA agglomeration
US9867836B2 (en) 2014-03-13 2018-01-16 Brigham Young University Lavage and/or infusion using CSA compounds for increasing fertility in a mammal
US9931350B2 (en) 2014-03-14 2018-04-03 Brigham Young University Anti-infective and osteogenic compositions and methods of use
US9686966B2 (en) 2014-04-30 2017-06-27 Brigham Young University Methods and apparatus for cleaning or disinfecting a water delivery system
US10238665B2 (en) 2014-06-26 2019-03-26 Brigham Young University Methods for treating fungal infections
US10441595B2 (en) 2014-06-26 2019-10-15 Brigham Young University Methods for treating fungal infections
US10227376B2 (en) 2014-08-22 2019-03-12 Brigham Young University Radiolabeled cationic steroid antimicrobials and diagnostic methods
US10155788B2 (en) 2014-10-07 2018-12-18 Brigham Young University Cationic steroidal antimicrobial prodrug compositions and uses thereof
WO2016172543A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
WO2016172553A1 (en) 2015-04-22 2016-10-27 Savage Paul B Methods for the synthesis of ceragenins
US9434759B1 (en) 2015-05-18 2016-09-06 Brigham Young University Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds
US10226550B2 (en) 2016-03-11 2019-03-12 Brigham Young University Cationic steroidal antimicrobial compositions for the treatment of dermal tissue
CN106553774B (en) * 2016-11-14 2019-05-24 北京空间机电研究所 A kind of fuel gas pipeline network type catapult-launching gear of the integrated ejection of multiple spot
US10959433B2 (en) 2017-03-21 2021-03-30 Brigham Young University Use of cationic steroidal antimicrobials for sporicidal activity
EP3950053B1 (en) 2017-11-06 2023-06-21 Pacesetter, Inc. Biostimulator having fixation element
US11577086B2 (en) 2018-08-20 2023-02-14 Pacesetter, Inc. Fixation mechanisms for a leadless cardiac biostimulator
WO2020112816A1 (en) 2018-11-29 2020-06-04 Surmodics, Inc. Apparatus and methods for coating medical devices
USD894396S1 (en) 2019-03-08 2020-08-25 Pacesetter, Inc. Leadless biostimulator attachment feature
US11541243B2 (en) 2019-03-15 2023-01-03 Pacesetter, Inc. Biostimulator having coaxial fixation elements
US11819590B2 (en) 2019-05-13 2023-11-21 Surmodics, Inc. Apparatus and methods for coating medical devices
CN113983864B (en) * 2021-09-30 2023-08-29 北京空间机电研究所 Bullet is cut high-efficient fire frock of integration

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4191818A (en) * 1975-10-25 1980-03-04 Basf Wyandotte Corporation Process for preparing heat-resistant polyurethane elastomers having no secondary softening range
US4106512A (en) * 1976-12-16 1978-08-15 Medtronic, Inc. Transvenously implantable lead
US4217913A (en) * 1977-10-10 1980-08-19 Medtronic, Inc. Body-implantable lead with protected, extendable tissue securing means
NL8004629A (en) * 1979-08-27 1981-03-03 Medtronic Inc ENDO-CARDIAL HEART STIMULATOR PIPE.
EP0047013B1 (en) * 1980-09-02 1986-01-22 Medtronic, Inc. Subcutaneously implantable lead with drug dispenser means
AU558611B2 (en) * 1981-02-03 1987-02-05 Bayer Aktiengesellschaft Polyurethane gel
IT1153909B (en) * 1982-12-17 1987-01-21 Sogimi Srl REACTIVE POLYMERS FOR THE TREATMENT OF SKIN DISEASES
US4506680A (en) * 1983-03-17 1985-03-26 Medtronic, Inc. Drug dispensing body implantable lead
US4577642A (en) * 1985-02-27 1986-03-25 Medtronic, Inc. Drug dispensing body implantable lead employing molecular sieves and methods of fabrication
US4606118A (en) * 1985-02-27 1986-08-19 Medtronic, Inc. Method of making a drug dispensing body
USH356H (en) * 1985-02-27 1987-11-03 Medtronic, Inc. Epicardial lead having low threshold, low polarization myocardial electrode
DE3708133A1 (en) * 1987-03-13 1988-09-22 Bisping Hans Juergen IMPLANTABLE ELECTRODE PROBE WITH EXTENDABLE SCREW ELECTRODE
US4819661A (en) * 1987-10-26 1989-04-11 Cardiac Pacemakers, Inc. Positive fixation cardiac electrode with drug elution capabilities

Also Published As

Publication number Publication date
US4972848A (en) 1990-11-27
JPH03170169A (en) 1991-07-23
EP0414233B1 (en) 1996-10-23
CA2023703C (en) 1995-05-16
EP0414233A3 (en) 1992-05-13
AU636906B2 (en) 1993-05-13
DE69028966T2 (en) 1997-05-07
JP2893472B2 (en) 1999-05-24
EP0414233A2 (en) 1991-02-27
DE69028966D1 (en) 1996-11-28
AU6123690A (en) 1991-02-28

Similar Documents

Publication Publication Date Title
CA2023703A1 (en) Medical electrical lead with polymeric monolithic controlled release device and method of manufacture
CA2313642C (en) Pharmaceutical hydrogel formulations, drug delivery devices and methods
US5265608A (en) Steroid eluting electrode for peripheral nerve stimulation
US5525356A (en) Amphoteric N-substituted acrylamide hydrogel and method
US4820263A (en) Apparatus and method for iontophoretic drug delivery
CA2187355A1 (en) An adjunctive polymer system for use with medical device
GR3005190T3 (en)
EP0280737A4 (en) Steroidal drug-containing preparation for external use.
CA2230595A1 (en) Bioresorbable polymer use in cochlear and other implants
BR8804370A (en) LOW FREQUENCY ELECTRO-THERAPY DEVICE
ES2093625T3 (en) EXTENDED PHARMACEUTICAL ADMINISTRATION OF SMALL MOLECULES SOLUBLE IN WATER.
CA2044791A1 (en) Myocardial Iontophoresis
CA2233043A1 (en) Port body for the administration of drugs
IL91850A0 (en) Biodegradable in-situ forming implants and methods of producing the same
IE880533L (en) Pharmaceutical delivery device
ES8403720A1 (en) Pharmaceutical mixture.
EP0228448A4 (en) Use of biologically active copolymers for the manufacture of a medicament for stimulating the growth of an animal.
EP0268421A3 (en) An implant composition and a method of preparing the same
AU2493588A (en) Pad for use as a living body stimulus electrode
AU623241B2 (en) An implantable medical instrument for stimulating a physiological function of a living thing with adjustable intensity of stimulation, and process of adjusting the intensity of stimulation
CN1047621A (en) Chemicals curing piles
CN85205378U (en) Medicine-holding magnetic plaster
DE58905060D1 (en) Pain reliever and anti-inflammatory drug.
EP0202917A3 (en) Implant device
CN2075968U (en) Spiral electrode

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed