CA2023926A1 - Method for the determination of hdl cholesterol by means of a rapid diagnostic agent with an integrated fractionating step - Google Patents

Method for the determination of hdl cholesterol by means of a rapid diagnostic agent with an integrated fractionating step

Info

Publication number
CA2023926A1
CA2023926A1 CA2023926A CA2023926A CA2023926A1 CA 2023926 A1 CA2023926 A1 CA 2023926A1 CA 2023926 A CA2023926 A CA 2023926A CA 2023926 A CA2023926 A CA 2023926A CA 2023926 A1 CA2023926 A1 CA 2023926A1
Authority
CA
Canada
Prior art keywords
determination
integrated
hdl cholesterol
diagnostic agent
rapid diagnostic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2023926A
Other languages
French (fr)
Other versions
CA2023926C (en
Inventor
Walter Rittersdorf
Ulfert Deneke
Gerhard Hiller
Hartmut Merdes
Klaus Buecker
Uwe Goebbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Diagnostics GmbH
Original Assignee
Boehringer Mannheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6388410&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2023926(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH
Publication of CA2023926A1 publication Critical patent/CA2023926A1/en
Application granted granted Critical
Publication of CA2023926C publication Critical patent/CA2023926C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/60—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving cholesterol
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/525—Multi-layer analytical elements
    • G01N33/526—Multi-layer analytical elements the element being adapted for a specific analyte
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125—Digestion or removing interfering materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Abstract

A method and reagent for the separation of non-HDL
lipoproteins from biological fluids in a carrier through which liquids can flow; in particular by non-HDL lipoproteins are precipitated from the fluids in the carrier which contains a precipitating agent for non-HDL lipoproteins; after separation of the precipitated non-HDL lipoproteins the HDL cholesterol content of the fluid can be determined as a parameter for assessing coronary heart disease risk.
CA002023926A 1989-09-01 1990-08-24 Method for the determination of hdl cholesterol by means of a rapid diagnostic agent with an integrated fractionating step Expired - Lifetime CA2023926C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3929032A DE3929032C2 (en) 1989-09-01 1989-09-01 Method for the determination of HDL cholesterol by means of a rapid diagnostic with integrated fractionation step
DEP3929032.8 1989-09-01

Publications (2)

Publication Number Publication Date
CA2023926A1 true CA2023926A1 (en) 1991-03-02
CA2023926C CA2023926C (en) 1999-12-28

Family

ID=6388410

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002023926A Expired - Lifetime CA2023926C (en) 1989-09-01 1990-08-24 Method for the determination of hdl cholesterol by means of a rapid diagnostic agent with an integrated fractionating step

Country Status (10)

Country Link
US (5) US5426030A (en)
EP (1) EP0415298B1 (en)
JP (1) JPH0766001B2 (en)
AT (1) ATE130104T1 (en)
CA (1) CA2023926C (en)
DD (1) DD297515A5 (en)
DE (2) DE3929032C2 (en)
ES (1) ES2081329T3 (en)
IL (1) IL95497A (en)
RU (1) RU1799472C (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE39915E1 (en) 1989-09-01 2007-11-06 Roche Diagnostics Gmbh Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step
DE3929032C2 (en) * 1989-09-01 1998-09-03 Boehringer Mannheim Gmbh Method for the determination of HDL cholesterol by means of a rapid diagnostic with integrated fractionation step
US5783400A (en) * 1990-04-27 1998-07-21 Genzyme Corporation Method for the isolation of lipoprotein allowing for the subsequent quantification of its mass and cholesterol content
US5213965A (en) * 1990-07-16 1993-05-25 Cholestech Corporation Solid-phase precipitation assay device
US5213964A (en) * 1990-07-16 1993-05-25 Cholestech Corporation High-density lipoprotein solid-base precipitation assay method
US5460974A (en) * 1992-10-13 1995-10-24 Miles Inc. Method of assaying whole blood for HDL cholesterol
DE69528645T2 (en) * 1994-05-19 2003-06-18 Troell Martha T METHOD AND DEVICE FOR COLLECTING, STORING AND REAL-TIME ANALYSIS OF BLOOD AND OTHER BODY LIQUIDS
JP2799835B2 (en) * 1995-01-31 1998-09-21 第一化学薬品株式会社 How to determine cholesterol
US5981294A (en) * 1995-11-29 1999-11-09 Metrika, Inc. Device for blood separation in a diagnostic device
JP3869471B2 (en) * 1996-04-22 2007-01-17 株式会社三菱化学ヤトロン Method for specific measurement of HDL cholesterol and composition for measurement
US5968839A (en) * 1996-05-13 1999-10-19 Metrika, Inc. Method and device producing a predetermined distribution of detectable change in assays
US5945345A (en) * 1996-08-27 1999-08-31 Metrika, Inc. Device for preventing assay interference using silver or lead to remove the interferant
EP0849589B1 (en) * 1996-12-20 2003-04-02 Matsushita Electric Industrial Co., Ltd. Cholesterol sensor and method for producing the same
US20050101032A1 (en) * 1997-02-10 2005-05-12 Metrika, Inc. Assay device, composition, and method of optimizing assay sensitivity
US20060019404A1 (en) * 1998-05-06 2006-01-26 Blatt Joel M Quantitative assay with extended dynamic range
DE19843094A1 (en) 1998-09-21 2000-03-23 Roche Diagnostics Gmbh Method for the determination of glycated hemoglobin
JP3686326B2 (en) * 2000-11-08 2005-08-24 アークレイ株式会社 Test piece for measuring high density lipoprotein (HDL) cholesterol
EP2221621B1 (en) 2001-12-21 2014-05-28 Polymer Technology Systems, Inc. Method for determining HDL cholesterol concentration from whole blood
MXPA04006367A (en) * 2001-12-28 2005-07-13 Polymer Technology Systems Inc Test strip for determining concentration of multiple analytes in a single fluid sample.
DE10204606C1 (en) * 2002-01-18 2003-10-16 Cholestech Corp Device and method for high density lipoproteins
ES2252358T3 (en) * 2002-04-09 2006-05-16 Cholestech Corporation METHOD AND TEST DEVICE FOR THE QUANTIFICATION OF CHOLESTEROL ASSOCIATED WITH HIGH DENSITY LIPOPROTEINS.
TWI333545B (en) * 2003-04-02 2010-11-21 Cholestech Corp Adhered membranes retaining porosity and biological activity
US20050037504A1 (en) * 2003-07-17 2005-02-17 Dimagno Theodore John One-step assay for high-density lipoprotein cholesterol
US20050032141A1 (en) * 2003-07-17 2005-02-10 Dimagno Theodore John Dry analytical element for high-density lipoprotein cholesterol quantification
ATE388401T1 (en) * 2003-11-04 2008-03-15 Cholestech Corp REAGENT MEMBRANES AND LAMINATES AND METHOD FOR THE PRODUCTION THEREOF
US20050124019A1 (en) * 2003-11-04 2005-06-09 Jones Ronald M. Reagent-containing membranes and laminates and methods of their preparation
US7150995B2 (en) * 2004-01-16 2006-12-19 Metrika, Inc. Methods and systems for point of care bodily fluid analysis
US20060062688A1 (en) * 2004-02-03 2006-03-23 Polymer Technology Systems, Inc. Bodily fluid analysis system
US7435577B2 (en) 2004-02-03 2008-10-14 Polymer Technology Systems, Inc. Direct measurement of chlolesterol from low density lipoprotein with test strip
US7625721B2 (en) * 2004-02-03 2009-12-01 Polymer Technology Systems, Inc. Non-precipitating bodily fluid analysis system
US7772007B2 (en) * 2004-04-02 2010-08-10 Cholestech Corporation Assay device for direct measurement of LDL cholesterol
US20060019406A1 (en) * 2004-07-23 2006-01-26 Ning Wei Lateral flow device for the detection of large pathogens
EP1779119B1 (en) * 2004-08-17 2012-08-01 Polymer Technology Systems, Inc. Non-precipitating bodily fluid analysis method
US20060062690A1 (en) * 2004-08-17 2006-03-23 Polymer Technology Systems, Inc. Apparatus and method of manufacturing bodily fluid test strip
US20060068500A1 (en) * 2004-09-28 2006-03-30 Kimberly-Clark Worldwide, Inc. Detecting yeast infections using a lateral flow assay
US8217025B2 (en) * 2006-11-17 2012-07-10 Harbor Therapeutics, Inc. Drug screening and treatment methods
US7824879B2 (en) * 2007-01-09 2010-11-02 Cholestech Corporation Device and method for measuring LDL-associated cholesterol
JP2009013164A (en) * 2007-06-04 2009-01-22 Hitachi High-Technologies Corp Apparatus for measuring high density lipoprotein, and method for separating the same
JP5313537B2 (en) * 2008-04-10 2013-10-09 富士フイルム株式会社 Dry analytical element for high density lipoprotein cholesterol measurement
WO2009152373A1 (en) * 2008-06-13 2009-12-17 Polymer Technology Systems, Inc. Hybrid strip
US9395373B2 (en) 2008-06-13 2016-07-19 Polymer Technology Systems, Inc. Hybrid strip
WO2010085271A1 (en) 2009-01-23 2010-07-29 Polymer Technology Systems, Inc. Diagnostic multi-layer dry phase test strip with integrated biosensors
KR101058743B1 (en) * 2009-06-04 2011-08-24 주식회사 인포피아 Cholesterol Test Strip and Cholesterol Detection Method Using the Same
KR101203385B1 (en) * 2009-06-04 2012-11-21 주식회사 인포피아 Test strip improved spreadability of plasma or serum
JP5460183B2 (en) * 2009-08-28 2014-04-02 パナソニック株式会社 Analytical reagents and analytical devices
US20120107850A1 (en) * 2009-07-15 2012-05-03 Panasonic Corporation Analysis reagent and analysis device having the analysis reagent carried therein
US9926547B2 (en) 2011-04-28 2018-03-27 Novozymes, Inc. Polypeptides having endoglucanase activity and polynucleotides encoding same
GB201403790D0 (en) * 2014-03-04 2014-04-16 Ge Healthcare Ltd Microfluidic devices and arrangements for introducing reagents and biological samples to such devices
KR20230058320A (en) * 2021-10-19 2023-05-03 구글 엘엘씨 Analytical Apparatus and Method for Simultaneous Isolation of Red Blood Cells and Proteins from Blood Fluid Samples

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4414326A (en) * 1978-04-24 1983-11-08 Goldberg Jack M Diagnostic agents
DE2910134A1 (en) * 1979-03-15 1980-09-25 Boehringer Mannheim Gmbh DIAGNOSTIC AGENT FOR DETECTING COMPONENTS OF BODY LIQUIDS
DE3029579C2 (en) * 1980-08-05 1985-12-12 Boehringer Mannheim Gmbh, 6800 Mannheim Method and means for separating plasma or serum from whole blood
JPS5767860A (en) * 1980-10-15 1982-04-24 Fuji Photo Film Co Ltd Material for multilayer analysis
DE3130749C2 (en) * 1981-08-04 1984-06-07 Boehringer Mannheim Gmbh, 6800 Mannheim Rapid diagnostic agent and method for its use, in particular for quantitative determinations
DE3215310A1 (en) * 1982-04-23 1983-10-27 Boehringer Mannheim Gmbh, 6800 Mannheim METHOD FOR DETERMINING THE LOW DENSITY LIPOPROTEINE (LDL) AND REAGENT FOR ITS IMPLEMENTATION
DE3247608A1 (en) * 1982-12-23 1984-07-05 Boehringer Mannheim Gmbh, 6800 Mannheim TEST STRIP
DE3338836A1 (en) * 1983-10-26 1985-05-09 Boehringer Mannheim Gmbh METHOD FOR DETERMINING THE LOW DENSITY LIPOPROTEINE (LDL) AND REAGENT FOR ITS IMPLEMENTATION
JPS6318269A (en) * 1986-07-11 1988-01-26 Eiken Kagaku Kk Settling reagent for fractionating high specific gravity lipo protein and measurement of high specific gravity lipo protein cholesterol using the same
US5215886A (en) * 1987-06-22 1993-06-01 Patel P Jivan HDL determination in whole blood
GB8728310D0 (en) * 1987-12-03 1988-01-06 St Georges Hosp Medical School Method of estimation of systemic cholesterol concentrations from capillary blood samples
JPH02210265A (en) * 1989-02-10 1990-08-21 Konica Corp Analysis element
US5135716A (en) * 1989-07-12 1992-08-04 Kingston Diagnostics, L.P. Direct measurement of HDL cholesterol via dry chemistry strips
DE3929032C2 (en) * 1989-09-01 1998-09-03 Boehringer Mannheim Gmbh Method for the determination of HDL cholesterol by means of a rapid diagnostic with integrated fractionation step
US5213965A (en) * 1990-07-16 1993-05-25 Cholestech Corporation Solid-phase precipitation assay device
US5213964A (en) * 1990-07-16 1993-05-25 Cholestech Corporation High-density lipoprotein solid-base precipitation assay method
US5286626A (en) * 1991-12-13 1994-02-15 Actimed Laboratories, Inc. Process and apparatus for direct determination of low density lipoprotein
US5460974A (en) * 1992-10-13 1995-10-24 Miles Inc. Method of assaying whole blood for HDL cholesterol
US5401466A (en) * 1993-06-01 1995-03-28 Miles Inc. Device for the direct measurement of low density lipoprotein cholesterol

Also Published As

Publication number Publication date
ATE130104T1 (en) 1995-11-15
US6171849B1 (en) 2001-01-09
RU1799472C (en) 1993-02-28
JPH0399268A (en) 1991-04-24
IL95497A0 (en) 1991-06-30
JPH0766001B2 (en) 1995-07-19
DD297515A5 (en) 1992-01-09
CA2023926C (en) 1999-12-28
US6214570B1 (en) 2001-04-10
US5426030A (en) 1995-06-20
US5786164A (en) 1998-07-28
EP0415298A3 (en) 1992-03-11
EP0415298A2 (en) 1991-03-06
EP0415298B1 (en) 1995-11-08
ES2081329T3 (en) 1996-03-01
IL95497A (en) 1995-01-24
DE3929032C2 (en) 1998-09-03
DE3929032A1 (en) 1991-03-07
DE59009849D1 (en) 1995-12-14
US5580743A (en) 1996-12-03

Similar Documents

Publication Publication Date Title
CA2023926A1 (en) Method for the determination of hdl cholesterol by means of a rapid diagnostic agent with an integrated fractionating step
US4234317A (en) Apparatus and method for fractionation of lipoproteins
CA2435550A1 (en) System for monitoring the concentration of analytes in body fluids
US3733179A (en) Method and apparatus for the quantitative determination of blood chemicals in blood derivatives
EP1188482A3 (en) Apparatus & method for conducting assays
EP1521083A3 (en) Method for diagnosing and distinguishing stroke
AU2004256206A1 (en) Device and method for simultaneous carrying out of blood group determination, serum cross-check and antibody detection test
EP1480251A3 (en) System of analyzing complex mixtures of biological and other fluids to identify biological state information
WO2003044481A3 (en) Optical bio-discs and microfluidic devices for analysis of cells
WO2001029558A1 (en) A test strip provided device with a lid-provided pretreatment portion
EP0747105A3 (en) Plasma separation filter, plasma separation method using the same and plasma separation apparatus
DE69218981D1 (en) Procedure for the detection of free IGF-I, IGF-II, and GH levels in body fluids
US5783401A (en) Immunoenzymatic detection device
EP0341587A3 (en) Apparatus for collecting blood
WO2000026668A3 (en) S100 proteins and autoantibodies as serum markers for cancer
EP0419168A3 (en) Fluid specimen collecting and testing apparatus
WO2005006959A2 (en) Compact analyte testing cassette with true positive and negative analyte controls
EP0402846A3 (en) Fluorescence polarization immunoassay for tetrahydrocannabinoids
Delvin et al. The application of an automated hexosaminidase assay to genetic screening
CA2347553A1 (en) Method for measuring cellular adhesion
CA2172243A1 (en) Method for quantifying bpi in body fluids
WO1996015453A1 (en) Method and device for determination of proteins employing antigen/antibody reactions
EP0387027A3 (en) Endometriosis diagnosis methods and reagents
WO2000010673A8 (en) Apparatus and method for capturing particles with surface exposure of anionic phospholipids from biological fluids
WO2001086292A3 (en) Ipg assay

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry