CA2029383A1 - Swelling modulated polymeric drug delivery device - Google Patents

Swelling modulated polymeric drug delivery device

Info

Publication number
CA2029383A1
CA2029383A1 CA2029383A CA2029383A CA2029383A1 CA 2029383 A1 CA2029383 A1 CA 2029383A1 CA 2029383 A CA2029383 A CA 2029383A CA 2029383 A CA2029383 A CA 2029383A CA 2029383 A1 CA2029383 A1 CA 2029383A1
Authority
CA
Canada
Prior art keywords
swelling
delivery device
drug delivery
polymeric drug
modulators
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2029383A
Other languages
French (fr)
Other versions
CA2029383C (en
Inventor
Gregory A. Mcclelland
Gaylen M. Zentner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of CA2029383A1 publication Critical patent/CA2029383A1/en
Application granted granted Critical
Publication of CA2029383C publication Critical patent/CA2029383C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

A controlled release drug delivery device, comprised of swellable polymers, whose degree of swelling in an environment of use is controlled by swelling modulators blended within the polymers, is disclosed. The swelling modulators can include buffers, osmagents, surfactants or combinations thereof surrounded by a microporous coating or interspersed within individual matrices. The combination of controlled release swelling modulators with swellable polymers may be applied to regulate patterns of beneficial agent (typically a drug) release.
CA002029383A 1989-11-07 1990-11-06 Swelling modulated polymeric drug delivery device Expired - Fee Related CA2029383C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/433,056 US5120548A (en) 1989-11-07 1989-11-07 Swelling modulated polymeric drug delivery device
US433,056 1989-11-07

Publications (2)

Publication Number Publication Date
CA2029383A1 true CA2029383A1 (en) 1991-05-08
CA2029383C CA2029383C (en) 2000-12-12

Family

ID=23718684

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002029383A Expired - Fee Related CA2029383C (en) 1989-11-07 1990-11-06 Swelling modulated polymeric drug delivery device

Country Status (7)

Country Link
US (1) US5120548A (en)
EP (1) EP0427519B1 (en)
JP (1) JPH082778B2 (en)
CA (1) CA2029383C (en)
CY (1) CY1964A (en)
DE (1) DE69011045T2 (en)
HK (1) HK199696A (en)

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DE69011045T2 (en) 1995-02-23
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DE69011045D1 (en) 1994-09-01
JPH03206030A (en) 1991-09-09

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