CA2030551A1 - Process for producing small particles of biologically active molecules - Google Patents

Process for producing small particles of biologically active molecules

Info

Publication number
CA2030551A1
CA2030551A1 CA2030551A CA2030551A CA2030551A1 CA 2030551 A1 CA2030551 A1 CA 2030551A1 CA 2030551 A CA2030551 A CA 2030551A CA 2030551 A CA2030551 A CA 2030551A CA 2030551 A1 CA2030551 A1 CA 2030551A1
Authority
CA
Canada
Prior art keywords
molecules
biologically active
particles
active molecules
small particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2030551A
Other languages
French (fr)
Other versions
CA2030551C (en
Inventor
Wayne Gombotz
Michael S. Healy
Larry R. Brown
Henry E. Auer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkermes Controlled Therapeutics Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2030551A1 publication Critical patent/CA2030551A1/en
Application granted granted Critical
Publication of CA2030551C publication Critical patent/CA2030551C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient

Abstract

Small diameter particles of biologically active molecules are produced by atomizing solutions of the molecules through a nozzle into very cold liquified gases, which immediately freeze the atomized droplets. The resulting frozen particles having diameters of approximately 10 to 90 micrometers are lyophilized to produce porous particles, suspended in a non-solvent for the molecules, and exposed to ultrasonic energy or homogenization to produce particles having diameters of 0.1 to 10 micrometers with greater than 70 to 95% of the initial biological activity of the molecules in solution.
CA002030551A 1989-05-01 1990-05-01 Process for producing small particles of biologically active molecules Expired - Lifetime CA2030551C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34568489A 1989-05-01 1989-05-01
US07/345,684 1989-05-01

Publications (2)

Publication Number Publication Date
CA2030551A1 true CA2030551A1 (en) 1990-11-02
CA2030551C CA2030551C (en) 1998-08-25

Family

ID=23356054

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002030551A Expired - Lifetime CA2030551C (en) 1989-05-01 1990-05-01 Process for producing small particles of biologically active molecules

Country Status (10)

Country Link
US (1) US6569458B1 (en)
EP (1) EP0432232B1 (en)
JP (1) JPH0739339B2 (en)
AT (1) ATE99546T1 (en)
AU (1) AU620253B2 (en)
CA (1) CA2030551C (en)
DE (1) DE69005800T2 (en)
DK (1) DK0432232T3 (en)
ES (1) ES2062530T3 (en)
WO (1) WO1990013285A1 (en)

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Also Published As

Publication number Publication date
ATE99546T1 (en) 1994-01-15
DE69005800T2 (en) 1994-05-19
DE69005800D1 (en) 1994-02-17
WO1990013285A1 (en) 1990-11-15
JPH04500527A (en) 1992-01-30
AU620253B2 (en) 1992-02-13
AU5635990A (en) 1990-11-29
US6569458B1 (en) 2003-05-27
EP0432232B1 (en) 1994-01-05
ES2062530T3 (en) 1994-12-16
JPH0739339B2 (en) 1995-05-01
CA2030551C (en) 1998-08-25
DK0432232T3 (en) 1994-01-31
EP0432232A1 (en) 1991-06-19

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