CA2038968A1 - Iontophoretic delivery device - Google Patents

Iontophoretic delivery device

Info

Publication number
CA2038968A1
CA2038968A1 CA002038968A CA2038968A CA2038968A1 CA 2038968 A1 CA2038968 A1 CA 2038968A1 CA 002038968 A CA002038968 A CA 002038968A CA 2038968 A CA2038968 A CA 2038968A CA 2038968 A1 CA2038968 A1 CA 2038968A1
Authority
CA
Canada
Prior art keywords
reservoir
agent
hydrophobic polymer
electrolyte
delivery device
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002038968A
Other languages
French (fr)
Other versions
CA2038968C (en
Inventor
Patrick J. Lew
J. Richard Gyory
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of CA2038968A1 publication Critical patent/CA2038968A1/en
Application granted granted Critical
Publication of CA2038968C publication Critical patent/CA2038968C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0448—Drug reservoir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0428—Specially adapted for iontophoresis, e.g. AC, DC or including drug reservoirs
    • A61N1/0432—Anode and cathode
    • A61N1/0436—Material of the electrode

Abstract

An iontophoretic agent delivery device (10) having donor and counter electrodes (11, 12) comprised of either metal or a hydrophobic polymer loaded with a conductive filler is provided. The agent reservoir (15) in the donor electrode assembly (8) contains about 10 to 60 wt% hydrophobic polymer, about 10 to 60 wt%
hydrophilic polymer, and up to 50% agent. Similarly, the electrolyte reservoir (16) contains about 10 to 60 wt% hydrophobic polymer, about to 60 wt% hydrophilic polymer, and up to 50% electrolyte. The agent reservoir (15), the electrolyte reservoir (16) and the electrodes (11, 12) are preferably in the form of films which are laminated to one another. The hydrophobic polymer component in the agent/electrolyte reservoir (15, 16) prevents the reservoir from delaminating from the metal/hydrophobic polymer based electrode (11, 12) even after hydration of the reservoirs (15, 16).
CA002038968A 1990-03-30 1991-03-25 Iontophoretic delivery device Expired - Lifetime CA2038968C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/502,608 US5084006A (en) 1990-03-30 1990-03-30 Iontopheretic delivery device
US502,608 1990-03-30

Publications (2)

Publication Number Publication Date
CA2038968A1 true CA2038968A1 (en) 1991-10-01
CA2038968C CA2038968C (en) 2001-07-24

Family

ID=23998583

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002038968A Expired - Lifetime CA2038968C (en) 1990-03-30 1991-03-25 Iontophoretic delivery device

Country Status (18)

Country Link
US (2) US5084006A (en)
EP (1) EP0522011B1 (en)
JP (1) JP2924922B2 (en)
KR (1) KR0159909B1 (en)
AT (1) ATE107866T1 (en)
AU (1) AU636744B2 (en)
CA (1) CA2038968C (en)
DE (1) DE69102699T2 (en)
DK (1) DK0522011T3 (en)
ES (1) ES2056646T3 (en)
FI (1) FI924343A (en)
IE (1) IE64973B1 (en)
MX (1) MX172532B (en)
NO (1) NO923591L (en)
NZ (1) NZ237560A (en)
PT (1) PT97140B (en)
WO (1) WO1991015259A1 (en)
ZA (1) ZA912227B (en)

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CA2038968C (en) 2001-07-24
US5326341A (en) 1994-07-05
PT97140B (en) 1998-07-31
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EP0522011A1 (en) 1993-01-13
KR0159909B1 (en) 1999-02-18

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