CA2058946A1 - Formulations for the oral administration of drugs with masked taste - Google Patents

Formulations for the oral administration of drugs with masked taste

Info

Publication number
CA2058946A1
CA2058946A1 CA002058946A CA2058946A CA2058946A1 CA 2058946 A1 CA2058946 A1 CA 2058946A1 CA 002058946 A CA002058946 A CA 002058946A CA 2058946 A CA2058946 A CA 2058946A CA 2058946 A1 CA2058946 A1 CA 2058946A1
Authority
CA
Canada
Prior art keywords
drugs
formulations
oral administration
masked taste
masked
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002058946A
Other languages
French (fr)
Other versions
CA2058946C (en
Inventor
Luigi Giovanni Mapelli
Marco Giuseppe Raffaele Marconi
Marco Zema
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adare Pharmaceuticals SRL
Original Assignee
Luigi Giovanni Mapelli
Marco Giuseppe Raffaele Marconi
Marco Zema
Eurand International S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luigi Giovanni Mapelli, Marco Giuseppe Raffaele Marconi, Marco Zema, Eurand International S.P.A. filed Critical Luigi Giovanni Mapelli
Publication of CA2058946A1 publication Critical patent/CA2058946A1/en
Application granted granted Critical
Publication of CA2058946C publication Critical patent/CA2058946C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Abstract

The taste of orally administered drugs is masked by coating the drug with a polymeric membrane which is soluble only at a pH of 5 or more. An acid substance is included in the formulation containing the coated drug to reduce or prevent the dissolution of the membrane in the oral cavity.
CA002058946A 1990-04-17 1991-04-09 Formulations for the oral administration of drugs with masked taste Expired - Fee Related CA2058946C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT20055A/90 1990-04-17
IT02005590A IT1246383B (en) 1990-04-17 1990-04-17 METHOD FOR MASKING THE TASTE OF DRUGS
PCT/EP1991/000689 WO1991016043A1 (en) 1990-04-17 1991-04-09 Pharmaceutical formulations

Publications (2)

Publication Number Publication Date
CA2058946A1 true CA2058946A1 (en) 1991-10-18
CA2058946C CA2058946C (en) 2001-11-20

Family

ID=11163454

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002058946A Expired - Fee Related CA2058946C (en) 1990-04-17 1991-04-09 Formulations for the oral administration of drugs with masked taste

Country Status (19)

Country Link
US (1) US5409711A (en)
EP (1) EP0477333B1 (en)
JP (1) JP3193041B2 (en)
KR (1) KR0164863B1 (en)
AT (1) ATE99927T1 (en)
AU (1) AU635133B2 (en)
CA (1) CA2058946C (en)
DE (1) DE69100991T2 (en)
DK (1) DK0477333T3 (en)
ES (1) ES2048594T3 (en)
HK (1) HK12495A (en)
IE (1) IE64274B1 (en)
IT (1) IT1246383B (en)
NZ (1) NZ237824A (en)
PT (1) PT97369B (en)
RU (1) RU2085190C1 (en)
SA (1) SA99191025A (en)
WO (1) WO1991016043A1 (en)
ZA (1) ZA912793B (en)

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US6508954B1 (en) * 2000-01-18 2003-01-21 Albemarle Corporation 1,3-dibromo-5,5-dimethylhydantoin of enhanced properties
US7999118B2 (en) 2000-01-18 2011-08-16 Albemarle Corporation Process for producing N-halogenated hydantoins
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AU2001263812B2 (en) * 2000-03-28 2004-09-23 Sandoz Ag Granulated particles with masked taste
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US6551617B1 (en) 2000-04-20 2003-04-22 Bristol-Myers Squibb Company Taste masking coating composition
US7223421B2 (en) * 2000-06-30 2007-05-29 Mcneil-Ppc, Inc. Teste masked pharmaceutical particles
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CA2359812C (en) * 2000-11-20 2004-02-10 The Procter & Gamble Company Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures
US20020119196A1 (en) * 2000-12-21 2002-08-29 Narendra Parikh Texture masked particles containing an active ingredient
US20030070584A1 (en) * 2001-05-15 2003-04-17 Cynthia Gulian Dip coating compositions containing cellulose ethers
AU4061702A (en) * 2001-05-15 2003-04-03 Mcneil-Ppc, Inc. Dip coating compositions containing starch or dextrin
US20030077365A1 (en) * 2001-06-28 2003-04-24 Howarth Jonathan N. Environmentally-friendly microbiological and microbiocidal control in aqueous systems
US6986910B2 (en) * 2001-06-28 2006-01-17 Albemarle Corporation Microbiological control in poultry processing
US6908636B2 (en) * 2001-06-28 2005-06-21 Albermarle Corporation Microbiological control in poultry processing
US8048924B2 (en) 2001-08-29 2011-11-01 Biocon Limited Methods and compositions employing 4-aminophenylacetic acid compounds
GB0123400D0 (en) 2001-09-28 2001-11-21 Novartis Ag Organic compounds
US8309118B2 (en) * 2001-09-28 2012-11-13 Mcneil-Ppc, Inc. Film forming compositions containing sucralose
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
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US20030118329A1 (en) * 2001-12-21 2003-06-26 Pere Obrador Video indexing using high resolution still images
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US6958161B2 (en) * 2002-04-12 2005-10-25 F H Faulding & Co Limited Modified release coated drug preparation
US7429619B2 (en) * 2002-08-02 2008-09-30 Mcneil Consumer Healthcare Polyacrylic film forming compositions
EP1545468A4 (en) * 2002-09-20 2007-06-20 Alpharma Inc Sustained-release opioid formulations and methods of use
US20060073216A1 (en) * 2002-12-26 2006-04-06 Solution Biosciences, Inc. Compositions and methods for control of bovine mastitis
US8367111B2 (en) * 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
US7901276B2 (en) 2003-06-24 2011-03-08 Albemarle Corporation Microbiocidal control in the processing of meat-producing four-legged animals
US20040265445A1 (en) * 2003-06-24 2004-12-30 Liimatta Eric W. Microbiocidal control in the processing of poultry
US20040265446A1 (en) * 2003-06-24 2004-12-30 Mcnaughton James L. Microbiocidal control in the processing of poultry
US7632521B2 (en) * 2003-07-15 2009-12-15 Eurand, Inc. Controlled release potassium chloride tablets
CA2553775A1 (en) 2004-01-20 2005-08-11 Richard F. Harty Compositions and methods of treatment for inflammatory diseases
HUE028158T2 (en) 2004-07-07 2016-12-28 Biocon Ltd Synthesis of azo bonded immunoregulatory compounds
US8747895B2 (en) * 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) * 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
GB2419094A (en) 2004-10-12 2006-04-19 Sandoz Ag Pharmaceutical composition of unpleasnt tasing active substances
NZ589750A (en) 2004-10-21 2012-07-27 Aptalis Pharmatech Inc Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US20060105038A1 (en) * 2004-11-12 2006-05-18 Eurand Pharmaceuticals Limited Taste-masked pharmaceutical compositions prepared by coacervation
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
JP2007031407A (en) 2005-07-29 2007-02-08 Shin Etsu Chem Co Ltd Coating composition containing cellulose ether with low substitution degree, and film-coated preparation with concealed unpleasant taste
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US20070190141A1 (en) * 2006-02-16 2007-08-16 Aaron Dely Extended release opiate composition
AU2007309281B2 (en) * 2006-10-20 2013-10-31 Johnson & Johnson Consumer Inc. Acetaminophen / ibuprofen combinations
AU2007308986A1 (en) * 2006-10-25 2008-05-02 Mcneil-Ppc, Inc. Ibuprofen composition
CN101380474B (en) * 2007-09-06 2012-07-25 北京大学 A pH sensitive solid medicine composition for oral liquid and preparation method thereof
KR101753411B1 (en) * 2008-11-25 2017-07-03 미쓰비시 타나베 파마 코퍼레이션 Orally rapidly disintegrating tablet, and process for producing same
JP5309262B2 (en) 2009-12-02 2013-10-09 アプタリス ファーマ リミテッド Fexofenadine microcapsule and composition containing the same
TW201127375A (en) * 2010-01-08 2011-08-16 Eurand Inc Taste masked topiramate composition and an orally disintegrating tablet comprising the same
EP2719377B1 (en) * 2011-06-10 2018-04-18 Nipro Corporation Method for producing orodispersible tablets
CN104640537A (en) 2012-09-18 2015-05-20 麦克内尔-Ppc股份有限公司 Low melting propionic acid derivative particles for use in oral dosage forms
BR112015005968A2 (en) 2012-09-18 2017-07-04 Mcneil Ppc Inc sustained release oral dosage forms comprising particles of low melting propionic acid
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US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
US10828208B2 (en) 2016-11-21 2020-11-10 The Procte & Gamble Company Low-bulk, close-fitting, high-capacity disposable absorbent pant
CN111388444B (en) * 2020-03-18 2022-05-20 北京鑫开元医药科技有限公司 Roxithromycin granules and preparation method thereof

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Also Published As

Publication number Publication date
HK12495A (en) 1995-02-03
NZ237824A (en) 1992-03-26
JP3193041B2 (en) 2001-07-30
AU7681291A (en) 1991-11-11
ZA912793B (en) 1992-12-30
KR0164863B1 (en) 1999-01-15
PT97369B (en) 1998-08-31
IT9020055A0 (en) 1990-04-17
ES2048594T3 (en) 1994-03-16
ATE99927T1 (en) 1994-01-15
IE64274B1 (en) 1995-07-26
IT9020055A1 (en) 1991-10-17
CA2058946C (en) 2001-11-20
DE69100991T2 (en) 1994-05-05
SA99191025A (en) 2005-12-03
IE911272A1 (en) 1991-10-23
RU2085190C1 (en) 1997-07-27
PT97369A (en) 1991-12-31
EP0477333B1 (en) 1994-01-12
DE69100991D1 (en) 1994-02-24
US5409711A (en) 1995-04-25
JPH05500674A (en) 1993-02-12
KR920702618A (en) 1992-10-06
IT1246383B (en) 1994-11-18
DK0477333T3 (en) 1994-03-14
WO1991016043A1 (en) 1991-10-31
AU635133B2 (en) 1993-03-11
EP0477333A1 (en) 1992-04-01

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Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed