CA2064712A1 - Method and apparatus for administration of anticoagulant to red cell suspension output of a blood separator - Google Patents
Method and apparatus for administration of anticoagulant to red cell suspension output of a blood separatorInfo
- Publication number
- CA2064712A1 CA2064712A1 CA2064712A CA2064712A CA2064712A1 CA 2064712 A1 CA2064712 A1 CA 2064712A1 CA 2064712 A CA2064712 A CA 2064712A CA 2064712 A CA2064712 A CA 2064712A CA 2064712 A1 CA2064712 A1 CA 2064712A1
- Authority
- CA
- Canada
- Prior art keywords
- anticoagulant
- cell suspension
- red cell
- blood
- separator
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
- A61M1/301—Details
- A61M1/302—Details having a reservoir for withdrawn untreated blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
- A61M1/301—Details
- A61M1/303—Details having a reservoir for treated blood to be returned
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/30—Single needle dialysis ; Reciprocating systems, alternately withdrawing blood from and returning it to the patient, e.g. single-lumen-needle dialysis or single needle systems for hemofiltration or pheresis
- A61M1/301—Details
- A61M1/305—Control of inversion point between collection and re-infusion phase
- A61M1/308—Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3672—Means preventing coagulation
Abstract
Method and apparatus for machine separation of blood and blood components that utilizes improved administration of anticoagulant to the red cell suspension output. Anticoagulant (20) is added to incoming whole blood (13) in an amount sufficient to prevent clotting of the whole blood in the flow path upstream of the blood component separator (46), but in an amount insufficient to prevent clotting of the red cell suspension created by the separator. Anticoagulant (20) is added to the red cell suspension downstream (50) of the separator (46) in order to prevent clotting. By adding an additional aliquot of anticoagulant to the red cell suspension, the amount of anticoagulant added to whole blood before separation can be reduced or eliminated, resulting in an increase in platelet yield during the blood component separation step.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/538,306 US5135667A (en) | 1990-06-14 | 1990-06-14 | Method and apparatus for administration of anticoagulant to red cell suspension output of a blood separator |
US7/538,306 | 1990-06-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2064712A1 true CA2064712A1 (en) | 1991-12-15 |
CA2064712C CA2064712C (en) | 1999-04-06 |
Family
ID=24146354
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002064712A Expired - Lifetime CA2064712C (en) | 1990-06-14 | 1991-06-12 | Method and apparatus for administration of anticoagulant to red cell suspension output of a blood separator |
Country Status (6)
Country | Link |
---|---|
US (1) | US5135667A (en) |
EP (3) | EP0968731A1 (en) |
JP (1) | JP3062662B2 (en) |
CA (1) | CA2064712C (en) |
DE (2) | DE69132172T2 (en) |
WO (1) | WO1991019561A1 (en) |
Families Citing this family (66)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5792372A (en) * | 1987-01-30 | 1998-08-11 | Baxter International, Inc. | Enhanced yield collection systems and methods for obtaining concentrated platelets from platelet-rich plasma |
US5656163A (en) | 1987-01-30 | 1997-08-12 | Baxter International Inc. | Chamber for use in a rotating field to separate blood components |
US5370802A (en) | 1987-01-30 | 1994-12-06 | Baxter International Inc. | Enhanced yield platelet collection systems and methods |
DE69223042T2 (en) * | 1991-12-23 | 1998-06-10 | Baxter Int | CENTRIFUGE WOBEI BASKET AND COIL IS SEPARABLE TO PROVIDE ACCESS TO THE SEPARATION CHAMBER |
US5549834A (en) | 1991-12-23 | 1996-08-27 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
US5833866A (en) * | 1991-12-23 | 1998-11-10 | Baxter International Inc. | Blood collection systems and methods which derive instantaneous blood component yield information during blood processing |
US5681273A (en) * | 1991-12-23 | 1997-10-28 | Baxter International Inc. | Systems and methods for predicting blood processing parameters |
US5676841A (en) * | 1991-12-23 | 1997-10-14 | Baxter International Inc. | Blood processing systems and methods which monitor citrate return to the donor |
US5690835A (en) | 1991-12-23 | 1997-11-25 | Baxter International Inc. | Systems and methods for on line collection of cellular blood components that assure donor comfort |
US6007725A (en) | 1991-12-23 | 1999-12-28 | Baxter International Inc. | Systems and methods for on line collection of cellular blood components that assure donor comfort |
DE4227695C1 (en) * | 1992-08-21 | 1993-10-07 | Fresenius Ag | Centrifuge to separate blood into its components |
WO1994012223A1 (en) * | 1992-12-01 | 1994-06-09 | Haemonetics Corporation | Red blood cell apheresis apparatus and method |
JPH08506977A (en) * | 1993-02-18 | 1996-07-30 | バクスター インターナショナル インコーポレーテッド | Apheresis system including alternative locations for anticoagulant injection |
US5614106A (en) * | 1993-03-12 | 1997-03-25 | Baxter International Inc. | Method and apparatus for collection of platelets |
DE69433933T2 (en) * | 1993-03-23 | 2005-07-21 | CBR Laboratories, Inc., Boston | METHOD AND DEVICE FOR INCLUSION OF BIOLOGICALLY ACTIVE SUBSTANCES IN CELLS |
CA2143832A1 (en) * | 1993-07-26 | 1995-02-02 | Richard I. Brown | Systems and methods for collecting blood components |
US5427695A (en) | 1993-07-26 | 1995-06-27 | Baxter International Inc. | Systems and methods for on line collecting and resuspending cellular-rich blood products like platelet concentrate |
JPH08506984A (en) * | 1993-12-22 | 1996-07-30 | バクスター、インターナショナル、インコーポレイテッド | Self-priming drip chamber with improved visibility |
EP0744892B1 (en) | 1994-12-16 | 2003-12-03 | Baxter International Inc. | Anticoagulant compositions for platelets |
US6773669B1 (en) | 1995-03-10 | 2004-08-10 | Maxcyte, Inc. | Flow electroporation chamber and method |
US5720921A (en) * | 1995-03-10 | 1998-02-24 | Entremed, Inc. | Flow electroporation chamber and method |
US6074605A (en) * | 1995-03-10 | 2000-06-13 | Entremed, Inc. | Flow electroporation chamber and method |
US6251284B1 (en) | 1995-08-09 | 2001-06-26 | Baxter International Inc. | Systems and methods which obtain a uniform targeted volume of concentrated red blood cells in diverse donor populations |
US6527957B1 (en) | 1995-08-09 | 2003-03-04 | Baxter International Inc. | Methods for separating, collecting and storing red blood cells |
US5762791A (en) * | 1995-08-09 | 1998-06-09 | Baxter International Inc. | Systems for separating high hematocrit red blood cell concentrations |
US5637082A (en) * | 1996-02-22 | 1997-06-10 | Haemonetics Corporation | Adaptive apheresis apparatus |
US5783093A (en) * | 1997-01-02 | 1998-07-21 | Haemonetics Corporation | Blood cell concentrates using a single solution for anticoagulation and preservation |
US6200287B1 (en) | 1997-09-05 | 2001-03-13 | Gambro, Inc. | Extracorporeal blood processing methods and apparatus |
ATE523217T1 (en) | 2000-03-09 | 2011-09-15 | Caridianbct Inc | EXTRACORPORAL DEVICE FOR BLOOD PROCESSING |
AU2002253801A1 (en) | 2000-11-02 | 2002-08-19 | Gambro, Inc. | Fluid separation devices, systems and methods |
US6471855B1 (en) * | 2000-11-22 | 2002-10-29 | Baxter International Inc. | Cassette with integral separation device |
US7029916B2 (en) * | 2001-02-21 | 2006-04-18 | Maxcyte, Inc. | Apparatus and method for flow electroporation of biological samples |
US20030141260A1 (en) * | 2001-12-28 | 2003-07-31 | Frank Corbin | Oxygen-enhanced pathogen inactivation |
EP1456345B1 (en) | 2001-08-22 | 2016-07-20 | Maxcyte, Inc. | Apparatus and method for electroporation of biological samples |
WO2003026599A1 (en) * | 2001-09-26 | 2003-04-03 | The Procter & Gamble Company | Personal cleansing compositions comprising silicone resin-containing adhesives |
US6863821B2 (en) | 2002-02-02 | 2005-03-08 | Baxter International Inc. | Shear-enhanced systems and methods for removing waste materials and liquid from the blood |
AU2003220295B2 (en) | 2002-03-14 | 2007-10-18 | Fenwal, Inc. | Biological fluid sampling apparatus |
WO2004031353A2 (en) * | 2002-09-30 | 2004-04-15 | Maxcyte, Inc. | Apparatus and method for streaming electroporation |
FR2850581B1 (en) * | 2003-02-03 | 2005-09-09 | Maco Pharma Sa | PRECAUTIONED LOOP PICKUP SYSTEM |
CN101426929B (en) * | 2004-05-12 | 2011-06-08 | 麦克赛特股份有限公司 | Methods and devices related to a regulated flow electroporation chamber |
DE102005040518B4 (en) * | 2005-08-26 | 2008-04-24 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Apparatus and method for monitoring the filtration of stored blood |
JP5215412B2 (en) * | 2007-12-26 | 2013-06-19 | テルモ ビーシーティー、インコーポレーテッド | Apparatus for the controlled addition of solvents to blood components |
US8628489B2 (en) | 2008-04-14 | 2014-01-14 | Haemonetics Corporation | Three-line apheresis system and method |
US8454548B2 (en) | 2008-04-14 | 2013-06-04 | Haemonetics Corporation | System and method for plasma reduced platelet collection |
US8702637B2 (en) | 2008-04-14 | 2014-04-22 | Haemonetics Corporation | System and method for optimized apheresis draw and return |
US8961789B2 (en) | 2008-10-31 | 2015-02-24 | Baxter International Inc. | Systems and methods for performing hemodialysis |
US8834402B2 (en) | 2009-03-12 | 2014-09-16 | Haemonetics Corporation | System and method for the re-anticoagulation of platelet rich plasma |
CN103221078B (en) | 2010-11-05 | 2015-09-16 | 赫摩耐提克斯公司 | For the system and method for automatization's platelet washing |
US9302042B2 (en) | 2010-12-30 | 2016-04-05 | Haemonetics Corporation | System and method for collecting platelets and anticipating plasma return |
US8469916B2 (en) | 2011-02-28 | 2013-06-25 | Fenwal, Inc. | Systems and methods for single needle continuous plasma processing |
EP2683457B1 (en) | 2011-03-11 | 2018-06-20 | Fenwal, Inc. | Membrane separation devices, systems and methods employing same, and data management systems and methods |
US10130751B2 (en) | 2011-03-11 | 2018-11-20 | Fenwal, Inc. | Membrane separation and washing devices, systems and methods employing same, and data management systems and methods |
US9164079B2 (en) | 2011-03-17 | 2015-10-20 | Greyledge Technologies Llc | Systems for autologous biological therapeutics |
WO2019226654A1 (en) | 2018-05-21 | 2019-11-28 | Fenwal, Inc. | Systems and methods for optimization of plasma collection volumes |
US11386993B2 (en) | 2011-05-18 | 2022-07-12 | Fenwal, Inc. | Plasma collection with remote programming |
WO2014021917A1 (en) | 2012-07-30 | 2014-02-06 | Fenwal, Inc. | Optical detection of lipids |
JP6158930B2 (en) | 2012-09-10 | 2017-07-05 | フェンウォール、インコーポレイテッド | Membrane separator and system and method using the same, and data management system and method |
US20150328388A1 (en) * | 2012-12-13 | 2015-11-19 | Jms Co., Ltd. | Device for separating/housing blood components and method for preparing platelet-rich plasma |
US10376620B2 (en) | 2015-04-02 | 2019-08-13 | Fenwal, Inc. | Systems and methods for leukoreducing a red blood cell-containing fluid and concentrated red blood cells |
JP2018533384A (en) | 2015-09-14 | 2018-11-15 | フェンウォール、インコーポレイテッド | Device, system and method for storage, treatment and / or treatment of blood and blood components |
US10758652B2 (en) | 2017-05-30 | 2020-09-01 | Haemonetics Corporation | System and method for collecting plasma |
US10792416B2 (en) | 2017-05-30 | 2020-10-06 | Haemonetics Corporation | System and method for collecting plasma |
WO2019195414A1 (en) * | 2018-04-03 | 2019-10-10 | Fenwal, Inc. | Plasmapheresis methods |
US11412967B2 (en) | 2018-05-21 | 2022-08-16 | Fenwal, Inc. | Systems and methods for plasma collection |
CA3206090A1 (en) * | 2021-01-22 | 2022-07-28 | Amit J. Patel | Systems and methods for plasma collection |
CN115025828B (en) * | 2022-05-19 | 2024-03-29 | 费森尤斯卡比(广州)医疗用品有限公司 | Anticoagulant adding device for hematology department |
Family Cites Families (20)
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---|---|---|---|---|
US4680025A (en) * | 1982-08-24 | 1987-07-14 | Baxter Travenol Laboratories, Inc. | Blood component collection systems and methods |
SE451946B (en) * | 1982-12-10 | 1987-11-09 | Gambro Lundia Ab | DEVICE FOR THE DISPOSAL OF ONE OR MORE FRACTIONS OF WHOLE BLOOD, PLASMA OR SIMILAR BODY WASHES |
US5034135A (en) * | 1982-12-13 | 1991-07-23 | William F. McLaughlin | Blood fractionation system and method |
DE3302804C2 (en) * | 1983-01-28 | 1985-03-14 | Fresenius AG, 6380 Bad Homburg | Device for removing water from blood |
US4605503A (en) * | 1983-05-26 | 1986-08-12 | Baxter Travenol Laboratories, Inc. | Single needle blood fractionation system having adjustable recirculation through filter |
EP0156496B1 (en) * | 1984-02-24 | 1989-05-17 | Kuraray Co., Ltd. | Apparatus for the treatment of plasma |
EP0310205B1 (en) * | 1984-03-21 | 1994-07-20 | McLaughlin, William Francis | Filtering a liquid suspension |
US4776964A (en) * | 1984-08-24 | 1988-10-11 | William F. McLaughlin | Closed hemapheresis system and method |
US4806247A (en) * | 1985-04-12 | 1989-02-21 | Baxter International Inc. | Plasmapheresis system and method |
US4713176A (en) * | 1985-04-12 | 1987-12-15 | Hemascience Laboratories, Inc. | Plasmapheresis system and method |
US4871462A (en) * | 1985-12-23 | 1989-10-03 | Haemonetics Corporation | Enhanced separation of blood components |
US4842576A (en) * | 1986-10-15 | 1989-06-27 | Baxter International Inc. | System for generating substantially constant fluid pressure |
AU604843B2 (en) * | 1987-01-13 | 1991-01-03 | Mclaughlin, William F. | Continuous centrifugation system and method for directly deriving intermediate density material from a suspension |
AU600711B2 (en) * | 1987-02-25 | 1990-08-23 | Baxter International Inc. | Purging system for a blood tubing network |
US4769001A (en) * | 1987-02-25 | 1988-09-06 | Baxter International Inc. | Method and apparatus for calibrating plural pump fluid flow system |
US4850998A (en) * | 1987-10-07 | 1989-07-25 | Baxter International Inc. | Method for wetting a plasmapheresis filter with anticoagulant |
US4851126A (en) * | 1987-11-25 | 1989-07-25 | Baxter International Inc. | Apparatus and methods for generating platelet concentrate |
US4954128A (en) * | 1988-08-23 | 1990-09-04 | Baxter International Inc. | Therapeutics plasma exchange system |
US4897185A (en) * | 1988-10-06 | 1990-01-30 | Cobe Laboratories, Inc. | Cell processing apparatus and method |
DE3837298C1 (en) * | 1988-11-03 | 1990-03-29 | Fresenius Ag, 6380 Bad Homburg, De |
-
1990
- 1990-06-14 US US07/538,306 patent/US5135667A/en not_active Expired - Lifetime
-
1991
- 1991-06-12 WO PCT/US1991/004192 patent/WO1991019561A1/en active IP Right Grant
- 1991-06-12 JP JP3512419A patent/JP3062662B2/en not_active Expired - Fee Related
- 1991-06-12 EP EP99203026A patent/EP0968731A1/en not_active Withdrawn
- 1991-06-12 CA CA002064712A patent/CA2064712C/en not_active Expired - Lifetime
- 1991-06-12 EP EP95200461A patent/EP0664135B1/en not_active Expired - Lifetime
- 1991-06-12 EP EP91913571A patent/EP0486681B1/en not_active Expired - Lifetime
- 1991-06-12 DE DE69132172T patent/DE69132172T2/en not_active Expired - Fee Related
- 1991-06-12 DE DE69122042T patent/DE69122042T2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2064712C (en) | 1999-04-06 |
DE69132172D1 (en) | 2000-06-08 |
DE69132172T2 (en) | 2001-01-25 |
US5135667A (en) | 1992-08-04 |
EP0486681A4 (en) | 1993-01-27 |
WO1991019561A1 (en) | 1991-12-26 |
JP3062662B2 (en) | 2000-07-12 |
DE69122042T2 (en) | 1997-04-10 |
EP0486681B1 (en) | 1996-09-11 |
EP0664135B1 (en) | 2000-05-03 |
DE69122042D1 (en) | 1996-10-17 |
JPH05502609A (en) | 1993-05-13 |
EP0968731A1 (en) | 2000-01-05 |
EP0486681A1 (en) | 1992-05-27 |
EP0664135A1 (en) | 1995-07-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed | ||
MKEC | Expiry (correction) |
Effective date: 20121202 |