CA2067754A1 - Preparation for the application of agents in mini-droplets - Google Patents
Preparation for the application of agents in mini-dropletsInfo
- Publication number
- CA2067754A1 CA2067754A1 CA002067754A CA2067754A CA2067754A1 CA 2067754 A1 CA2067754 A1 CA 2067754A1 CA 002067754 A CA002067754 A CA 002067754A CA 2067754 A CA2067754 A CA 2067754A CA 2067754 A1 CA2067754 A1 CA 2067754A1
- Authority
- CA
- Canada
- Prior art keywords
- preparation
- agents
- application
- droplets
- mini
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Abstract
The invention relates to a preparation for the application of agents in the form of minuscule droplets of fluid, in particular provided with membrane-like structures consisting of one or several layers of amphiphilic molecules, or an amphiphilic carrier substance, in particular for transporting the agent into and through natural barriers such as skin and similar materials. The preparation contains a concentration of edge active substances which amounts to up to 99 mol-% of the agent concentration which is required for the induction of droplet solubilization. Such preparations are suitable, for example, for the non-invasive applications of antidiabetics, in particular of insulin. The invention, moreover, relates to the methods for the preparation of such formulations.
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP4026834.9 | 1990-08-24 | ||
DEP4026833.0 | 1990-08-24 | ||
DE4026834 | 1990-08-24 | ||
DE4026833 | 1990-08-24 | ||
DEP4107153.0 | 1991-03-06 | ||
DEP4107152.2 | 1991-03-06 | ||
DE19914107152 DE4107152C2 (en) | 1991-03-06 | 1991-03-06 | Preparations for non-invasive administration of antidiabetics |
DE19914107153 DE4107153A1 (en) | 1991-03-06 | 1991-03-06 | Compsns. for application of active agents |
PCT/EP1991/001596 WO1992003122A1 (en) | 1990-08-24 | 1991-08-22 | Preparation for application of active substances in the form of minimum-sized droplets |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2067754A1 true CA2067754A1 (en) | 1992-02-25 |
CA2067754C CA2067754C (en) | 2002-06-04 |
Family
ID=27435001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002067754A Expired - Lifetime CA2067754C (en) | 1990-08-24 | 1991-08-22 | Preparation for the application of agents in mini-droplets |
Country Status (9)
Country | Link |
---|---|
US (1) | US20070042030A1 (en) |
EP (1) | EP0475160B8 (en) |
JP (1) | JP3765579B2 (en) |
AT (1) | ATE134133T1 (en) |
CA (1) | CA2067754C (en) |
DE (1) | DE59107402D1 (en) |
DK (1) | DK0475160T4 (en) |
ES (1) | ES2085936T5 (en) |
WO (1) | WO1992003122A1 (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU770803B2 (en) * | 1998-12-23 | 2004-03-04 | Idea Ag | Improved formulation for topical non-invasive application in vivo |
AU772429B2 (en) * | 1999-01-27 | 2004-04-29 | Idea Ag | Transnasal transport/immunisation with highly adaptable carriers |
US7008638B2 (en) | 1998-05-11 | 2006-03-07 | Ciba Specialty Chemicals Corporation | Use of nanodispersions in cosmetic end formulations |
US7381423B2 (en) | 1998-05-11 | 2008-06-03 | Ciba Specialty Chemicals Corp. | Use of nanodispersions in cosmetic end formulations |
US7459171B2 (en) | 1999-07-05 | 2008-12-02 | Idea Ag | Method for the improvement of transport across adaptable semi-permeable barriers |
US7473432B2 (en) | 2002-10-11 | 2009-01-06 | Idea Ag | NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery |
US9724299B2 (en) | 2006-12-01 | 2017-08-08 | Anterios, Inc. | Amphiphilic entity nanoparticles |
US10016451B2 (en) | 2007-05-31 | 2018-07-10 | Anterios, Inc. | Nucleic acid nanoparticles and uses therefor |
US10532019B2 (en) | 2005-12-01 | 2020-01-14 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
US10905637B2 (en) | 2006-12-01 | 2021-02-02 | Anterios, Inc. | Peptide nanoparticles and uses therefor |
US11311496B2 (en) | 2016-11-21 | 2022-04-26 | Eirion Therapeutics, Inc. | Transdermal delivery of large agents |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6165500A (en) * | 1990-08-24 | 2000-12-26 | Idea Ag | Preparation for the application of agents in mini-droplets |
CA2139757C (en) * | 1992-07-08 | 2009-04-14 | Gunther Maierhofer | Liposomes, method of preparing the same and use thereof in the preparation of drugs |
DE4306475A1 (en) * | 1993-03-02 | 1994-09-08 | Ensenat Pedro Gonzalez | Liposomes containing chlorhexidine diacetate or chlorhexidine digluconate |
DE4308121A1 (en) * | 1993-03-15 | 1994-09-22 | Rhone Poulenc Rorer Gmbh | Aqueous liposome system and method for producing such a liposome system |
US6663885B1 (en) * | 1993-03-15 | 2003-12-16 | A. Natterman & Cie Gmbh | Aqueous liposome system and a method for the preparation of such a liposome system |
DE4447287C1 (en) * | 1994-12-30 | 1996-11-07 | Cevc Gregor | Droplet-in-fluid composition to transport agent e.g. through skin |
JP3136352B2 (en) * | 1996-01-22 | 2001-02-19 | 参天製薬株式会社 | Keratoconjunctival disease therapeutic agent |
US5910306A (en) * | 1996-11-14 | 1999-06-08 | The United States Of America As Represented By The Secretary Of The Army | Transdermal delivery system for antigen |
US20060002949A1 (en) | 1996-11-14 | 2006-01-05 | Army Govt. Of The Usa, As Rep. By Secretary Of The Office Of The Command Judge Advocate, Hq Usamrmc. | Transcutaneous immunization without heterologous adjuvant |
US5980898A (en) * | 1996-11-14 | 1999-11-09 | The United States Of America As Represented By The U.S. Army Medical Research & Material Command | Adjuvant for transcutaneous immunization |
US7585645B2 (en) | 1997-05-27 | 2009-09-08 | Sembiosys Genetics Inc. | Thioredoxin and thioredoxin reductase containing oil body based products |
US6302863B1 (en) | 1998-06-16 | 2001-10-16 | Nikolai Tankovich | Method for removal of lipids via a perfluorocarbon tumescent solution |
MXPA01002149A (en) * | 1998-09-01 | 2003-03-27 | Idea Ag | Electrically controlled transport of charged penetrants across barriers. |
US6193997B1 (en) * | 1998-09-27 | 2001-02-27 | Generex Pharmaceuticals Inc. | Proteinic drug delivery system using membrane mimetics |
US6290987B1 (en) * | 1998-09-27 | 2001-09-18 | Generex Pharmaceuticals, Inc. | Mixed liposome pharmaceutical formulation with amphiphiles and phospholipids |
CA2309633C (en) * | 1998-10-23 | 2010-12-14 | Idea Innovative Dermale Applikationen Gmbh | Method for developing, testing and using associates of macromolecules and complex aggregates for improved payload and controllable de/association rates |
SI1031346T1 (en) | 1999-01-27 | 2002-08-31 | Idea Ag | Noninvasive vaccination through the skin |
EP1265638A1 (en) * | 1999-11-12 | 2002-12-18 | Pharmaderm Laboratories Ltd. | Compositions for transdermal and transmucosal administration of therapeutic agents |
BR0001144B1 (en) * | 2000-02-21 | 2013-10-22 | PHARMACEUTICAL COMPOSITION OF VITAMIN-E, PAPAINE AND HYALURONIDASE-BASED DICLOPHENAC | |
ATE382333T1 (en) * | 2000-04-12 | 2008-01-15 | Liplasome Pharma As | LIPIDE-BASED DRUG DELIVERY SYSTEMS AGAINST PARASITIC INFECTIONS |
US6451808B1 (en) * | 2000-10-17 | 2002-09-17 | Depomed, Inc. | Inhibition of emetic effect of metformin with 5-HT3 receptor antagonists |
IL139177A0 (en) * | 2000-10-20 | 2001-11-25 | S C Republic Dev S R L | Sustained release drug delivery system |
GB0028706D0 (en) * | 2000-11-24 | 2001-01-10 | Unilever Plc | Cosmetic composition |
US20020177626A1 (en) | 2001-01-19 | 2002-11-28 | Cook Graham D. | Treatment of sleep disturbances |
EP1230917A1 (en) | 2001-02-08 | 2002-08-14 | Vectron Therapeutics AG | Invasomes for the therapy of illnesses, their manufacture and use |
CA2476859C (en) * | 2002-03-13 | 2011-09-20 | Collagenex Pharmaceuticals, Inc. | Water-based delivery systems |
US20040018237A1 (en) * | 2002-05-31 | 2004-01-29 | Perricone Nicholas V. | Topical drug delivery using phosphatidylcholine |
US20040009180A1 (en) * | 2002-07-11 | 2004-01-15 | Allergan, Inc. | Transdermal botulinum toxin compositions |
AU2002950713A0 (en) | 2002-08-09 | 2002-09-12 | Vital Health Sciences Pty Ltd | Carrier |
ES2298566T3 (en) * | 2002-10-11 | 2008-05-16 | Idea Ag | ADDED WITH INCREASED DEFORMABILITY, WHICH INCLUDES AT LEAST THREE AMPHIPATIC COMPONENTS, FOR IMPROVED TRANSPORTATION THROUGH SEMIPERMEABLE BARRIERS AND FOR THE APPLICATION OF NON-INVASIVE PHARMACES IN VIVID, ESPECIALLY THROUGH THE SKIN. |
CA2584475A1 (en) * | 2004-11-12 | 2006-05-18 | Idea Ag | Extended surface aggregates in the treatment of skin conditions |
MX2007015949A (en) | 2005-06-17 | 2008-03-07 | Vital Health Sciences Pty Ltd | A carrier comprising one or more di and/or mono-(electron transfer agent) phosphate derivatives or complexes thereof. |
US20070042998A1 (en) * | 2005-08-19 | 2007-02-22 | Annica Karkkainen | Medical cosmetic method for reducing adipose tissue and for initiating lipolysis through subcutaneous and intracutaneous injections and customized composition compounded from pharmaceutical agents for use therein |
DE102006013623A1 (en) * | 2005-11-23 | 2007-05-24 | Pro Natura Gesellschaft für gesunde Ernährung mbH | New 5-D-fructose-dehydrogenase useful e.g. as a medicament, food, dietetic food, food additives or a balanced diet and for the therapy of adiposity |
US20070154403A1 (en) * | 2006-01-05 | 2007-07-05 | Thomas Skold | Oral, Pulmonary and Transmucosal Delivery Composition |
CN104224704A (en) * | 2006-03-13 | 2014-12-24 | 株式会社·R-技术上野 | Aqueous composition |
EP2522343A1 (en) | 2006-03-28 | 2012-11-14 | Javelin Pharmaceuticals, Inc. | Formulations of Low Dose Diclofenac and Beta-Cyclodextrin |
US10512644B2 (en) | 2007-03-12 | 2019-12-24 | Inheris Pharmaceuticals, Inc. | Oligomer-opioid agonist conjugates |
US8173666B2 (en) | 2007-03-12 | 2012-05-08 | Nektar Therapeutics | Oligomer-opioid agonist conjugates |
DE102007028360B4 (en) | 2007-06-15 | 2016-04-14 | Marcus Asam | Combination of active ingredients for cosmetic preparations |
JP2012528846A (en) | 2009-06-03 | 2012-11-15 | マヨ、ジョン、チャールズ | Formulations for treating deep tissue pain |
US20120232034A1 (en) | 2009-08-21 | 2012-09-13 | Henk-Andre Kroon | Vesicular formulations |
CN102480938A (en) * | 2009-08-21 | 2012-05-30 | 阿斯制药株式会社 | Method for incorporating medicine into a plant |
AU2011213557B2 (en) | 2010-02-05 | 2015-05-07 | Phosphagenics Limited | Carrier comprising non-neutralised tocopheryl phosphate |
CA2794734C (en) | 2010-03-30 | 2017-12-12 | Phosphagenics Limited | Transdermal delivery patch |
US20120190609A1 (en) * | 2010-08-30 | 2012-07-26 | Martin Bader | Method for producing a lipid particle, the lipid particle itself and its use |
EP2685992A4 (en) | 2011-03-15 | 2014-09-10 | Phosphagenics Ltd | Amino-quinolines as kinase inhibitors |
US8668937B2 (en) | 2011-03-17 | 2014-03-11 | Transdermal Biotechnology, Inc. | Topical nitric oxide systems and methods of use thereof |
WO2013057208A1 (en) | 2011-10-18 | 2013-04-25 | Targeted Delivery Technologies Limited | Compositions and methods for reducing the proliferation and viability of microbial agents |
GB201205642D0 (en) | 2012-03-29 | 2012-05-16 | Sequessome Technology Holdings Ltd | Vesicular formulations |
GB201208409D0 (en) | 2012-05-14 | 2012-06-27 | Sequessome Technology Holdings Ltd | Vesicular formulations, kits and uses |
GB201208384D0 (en) | 2012-05-14 | 2012-06-27 | Sequessome Technology Holdings Ltd | Vesicular formulations, uses and methods |
US8871259B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Techniques and systems for treatment of neuropathic pain and other indications |
US8871261B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Cancer treatments and compositions for use thereof |
US8871254B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Systems and methods for treatment of acne vulgaris and other conditions with a topical nitric oxide delivery system |
US8871256B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Methods and systems for treatment of inflammatory diseases with nitric oxide |
US8871258B2 (en) | 2012-09-19 | 2014-10-28 | Transdermal Biotechnology, Inc. | Treatment and prevention of learning and memory disorders |
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US9314423B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Hair treatment systems and methods using peptides and other compositions |
US20140271731A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Cardiovascular disease treatment and prevention |
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US9241899B2 (en) | 2013-03-13 | 2016-01-26 | Transdermal Biotechnology, Inc. | Topical systems and methods for treating sexual dysfunction |
US9387159B2 (en) | 2013-03-13 | 2016-07-12 | Transdermal Biotechnology, Inc. | Treatment of skin, including aging skin, to improve appearance |
US9750787B2 (en) | 2013-03-13 | 2017-09-05 | Transdermal Biotechnology, Inc. | Memory or learning improvement using peptide and other compositions |
US9314433B2 (en) | 2013-03-13 | 2016-04-19 | Transdermal Biotechnology, Inc. | Methods and systems for treating or preventing cancer |
US9295636B2 (en) | 2013-03-13 | 2016-03-29 | Transdermal Biotechnology, Inc. | Wound healing using topical systems and methods |
US20140271938A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Systems and methods for delivery of peptides |
US9393264B2 (en) | 2013-03-13 | 2016-07-19 | Transdermal Biotechnology, Inc. | Immune modulation using peptides and other compositions |
US20140271937A1 (en) | 2013-03-13 | 2014-09-18 | Transdermal Biotechnology, Inc. | Brain and neural treatments comprising peptides and other compositions |
US9533951B2 (en) | 2014-10-20 | 2017-01-03 | Eastman Chemical Company | Heterocyclic amphoteric compounds |
US9381147B2 (en) * | 2014-10-20 | 2016-07-05 | Johnson & Johnson Consumer Inc. | Compositions comprising zwitterionic ester ammonioalkanoates |
US9943816B2 (en) | 2014-10-20 | 2018-04-17 | Eastman Chemical Company | Amphoteric ester sulfonates |
CA2974196C (en) | 2015-01-20 | 2023-12-12 | TetraDerm Group LLC | Versatile topical drug delivery vehicle and multifactorial tissue moisturizer that provides mucosal and skin barrier restoration |
US10744090B2 (en) | 2015-06-30 | 2020-08-18 | Sequessome Technology Holdings Limited | Multiphasic compositions |
US11414380B2 (en) | 2015-09-17 | 2022-08-16 | Eastman Chemical Company | Amphoteric compounds |
US9993408B2 (en) | 2015-09-17 | 2018-06-12 | Johnson & Johnson Consumer Inc. | Compositions comprising zwitterionic alkyl-alkanoylamides and/or alkyl alkanoates |
CA3007587C (en) | 2015-12-09 | 2023-12-05 | Phosphagenics Limited | Pharmaceutical formulation |
BR112019012946A2 (en) | 2016-12-21 | 2019-11-26 | Avecho Biotechnology Ltd | process |
WO2019213101A1 (en) * | 2018-04-30 | 2019-11-07 | Purdue Research Foundation | Liposomal nano formulation of combinational antibiotics and the uses thereof |
CN111904932B (en) * | 2019-05-08 | 2023-06-20 | 北京德立福瑞医药科技有限公司 | Micelle preparation containing glucocorticoid and preparation method thereof |
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Family Cites Families (9)
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---|---|---|---|---|
IL64397A0 (en) * | 1981-01-07 | 1982-02-28 | Weder Hans G | Process for the preparation of liposomal medicaments |
EP0102324A3 (en) * | 1982-07-29 | 1984-11-07 | Ciba-Geigy Ag | Lipids and surfactants in an aqueous medium |
GB8321913D0 (en) * | 1983-08-15 | 1983-09-14 | Acacia Chem Ltd | Spray method |
IL79114A (en) * | 1985-08-07 | 1990-09-17 | Allergan Pharma | Method and composition for making liposomes |
JPS6295134A (en) * | 1985-10-21 | 1987-05-01 | Nippon Saafuakutanto Kogyo Kk | Production of liposome |
DK86988A (en) * | 1987-02-25 | 1988-08-26 | Takeda Chemical Industries Ltd | LIPOSOM PREPARATION AND APPLICATION THEREOF |
US4828837A (en) * | 1987-03-30 | 1989-05-09 | Liposome Technology, Inc. | Non-crystalline minoxidil composition, its production and application |
US4937078A (en) * | 1988-08-26 | 1990-06-26 | Mezei Associates Limited | Liposomal local anesthetic and analgesic products |
US5104661A (en) * | 1989-08-14 | 1992-04-14 | Technology Unlimited, Inc. | Reverse loading of liposomes |
-
1991
- 1991-08-22 CA CA002067754A patent/CA2067754C/en not_active Expired - Lifetime
- 1991-08-22 WO PCT/EP1991/001596 patent/WO1992003122A1/en active Application Filing
- 1991-08-22 JP JP51357091A patent/JP3765579B2/en not_active Expired - Fee Related
- 1991-08-23 AT AT91114163T patent/ATE134133T1/en not_active IP Right Cessation
- 1991-08-23 DE DE59107402T patent/DE59107402D1/en not_active Expired - Lifetime
- 1991-08-23 ES ES91114163T patent/ES2085936T5/en not_active Expired - Lifetime
- 1991-08-23 EP EP91114163A patent/EP0475160B8/en not_active Expired - Lifetime
- 1991-08-23 DK DK91114163T patent/DK0475160T4/en active
-
2006
- 2006-07-05 US US11/481,804 patent/US20070042030A1/en not_active Abandoned
Cited By (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7008638B2 (en) | 1998-05-11 | 2006-03-07 | Ciba Specialty Chemicals Corporation | Use of nanodispersions in cosmetic end formulations |
US7381423B2 (en) | 1998-05-11 | 2008-06-03 | Ciba Specialty Chemicals Corp. | Use of nanodispersions in cosmetic end formulations |
AU770803B2 (en) * | 1998-12-23 | 2004-03-04 | Idea Ag | Improved formulation for topical non-invasive application in vivo |
AU772429B2 (en) * | 1999-01-27 | 2004-04-29 | Idea Ag | Transnasal transport/immunisation with highly adaptable carriers |
US7591949B2 (en) | 1999-07-05 | 2009-09-22 | Idea Ag | Method for the improvement of transport across adaptable semi-permeable barriers |
US7459171B2 (en) | 1999-07-05 | 2008-12-02 | Idea Ag | Method for the improvement of transport across adaptable semi-permeable barriers |
US7473432B2 (en) | 2002-10-11 | 2009-01-06 | Idea Ag | NSAID formulations, based on highly adaptable aggregates, for improved transport through barriers and topical drug delivery |
US10532019B2 (en) | 2005-12-01 | 2020-01-14 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
US10576034B2 (en) | 2005-12-01 | 2020-03-03 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
US9724299B2 (en) | 2006-12-01 | 2017-08-08 | Anterios, Inc. | Amphiphilic entity nanoparticles |
US10285941B2 (en) | 2006-12-01 | 2019-05-14 | Anterios, Inc. | Amphiphilic entity nanoparticles |
US10758485B2 (en) | 2006-12-01 | 2020-09-01 | Anterios, Inc. | Amphiphilic entity nanoparticles |
US10905637B2 (en) | 2006-12-01 | 2021-02-02 | Anterios, Inc. | Peptide nanoparticles and uses therefor |
US10016451B2 (en) | 2007-05-31 | 2018-07-10 | Anterios, Inc. | Nucleic acid nanoparticles and uses therefor |
US11311496B2 (en) | 2016-11-21 | 2022-04-26 | Eirion Therapeutics, Inc. | Transdermal delivery of large agents |
Also Published As
Publication number | Publication date |
---|---|
EP0475160A1 (en) | 1992-03-18 |
JPH05502042A (en) | 1993-04-15 |
ATE134133T1 (en) | 1996-02-15 |
DK0475160T3 (en) | 1996-07-08 |
EP0475160B1 (en) | 1996-02-14 |
JP3765579B2 (en) | 2006-04-12 |
CA2067754C (en) | 2002-06-04 |
ES2085936T5 (en) | 2005-03-01 |
US20070042030A1 (en) | 2007-02-22 |
DE59107402D1 (en) | 1996-03-28 |
DK0475160T4 (en) | 2004-11-22 |
EP0475160B8 (en) | 2004-11-03 |
EP0475160B2 (en) | 2004-07-14 |
ES2085936T3 (en) | 1996-06-16 |
WO1992003122A1 (en) | 1992-03-05 |
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