CA2076648A1 - Composition for inducing humoral anergy to an immunogen - Google Patents
Composition for inducing humoral anergy to an immunogenInfo
- Publication number
- CA2076648A1 CA2076648A1 CA2076648A CA2076648A CA2076648A1 CA 2076648 A1 CA2076648 A1 CA 2076648A1 CA 2076648 A CA2076648 A CA 2076648A CA 2076648 A CA2076648 A CA 2076648A CA 2076648 A1 CA2076648 A1 CA 2076648A1
- Authority
- CA
- Canada
- Prior art keywords
- immunogen
- composition
- inducing humoral
- immunogens
- conjugates
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/81—Drug, bio-affecting and body treating compositions involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, immunotolerance, or anergy
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/868—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Abstract
Conjugates of stable nonimmunogenic polymers and analogs of immunogens that possess the specific B cell binding ability of the immunogen but lack T cell epitopes and which, when introduced into individuals, induce humoral anergy to the immunogen are disclosed. Accordingly, these conjugates are useful for treating antibody-mediated pathologies that are caused by foreign or self immunogens.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002277724A CA2277724C (en) | 1991-02-08 | 1992-02-04 | A composition for inducing humoral anergy to an immunogen |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US652,648 | 1991-02-08 | ||
US07/652,648 US5268454A (en) | 1991-02-08 | 1991-02-08 | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
PCT/US1992/000975 WO1992013558A1 (en) | 1991-02-08 | 1992-02-04 | A composition for inducing humoral anergy |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002277724A Division CA2277724C (en) | 1991-02-08 | 1992-02-04 | A composition for inducing humoral anergy to an immunogen |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2076648A1 true CA2076648A1 (en) | 1992-08-09 |
CA2076648C CA2076648C (en) | 1999-08-17 |
Family
ID=24617613
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002076648A Expired - Fee Related CA2076648C (en) | 1991-02-08 | 1992-02-04 | Composition for inducing humoral anergy to an immunogen |
Country Status (13)
Country | Link |
---|---|
US (5) | US5268454A (en) |
EP (1) | EP0498658B1 (en) |
JP (1) | JP2544873B2 (en) |
KR (1) | KR100234678B1 (en) |
AT (1) | ATE142109T1 (en) |
AU (1) | AU646157B2 (en) |
CA (1) | CA2076648C (en) |
DE (1) | DE69213272T2 (en) |
DK (1) | DK0498658T3 (en) |
ES (1) | ES2094287T3 (en) |
GR (1) | GR3021809T3 (en) |
IE (1) | IE920419A1 (en) |
WO (1) | WO1992013558A1 (en) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6022544A (en) * | 1983-01-24 | 2000-02-08 | The John Hopkins University | Therapeutic suppression of specific immune responses by administration of oligomeric forms of antigen of controlled chemistry |
US5268454A (en) * | 1991-02-08 | 1993-12-07 | La Jolla Pharmaceutical Company | Composition for inducing humoral anergy to an immunogen comprising a t cell epitope-deficient analog of the immunogen conjugated to a nonimmunogenic carrier |
WO1993012145A1 (en) * | 1991-12-19 | 1993-06-24 | Baylor College Of Medicine | Pva or peg conjugates of peptides for epitope-specific immunosuppression |
DE4302012C1 (en) * | 1993-01-26 | 1994-07-21 | Serosearch Gmbh Entwicklung Un | Immunological test |
KR100361933B1 (en) * | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | Chemically defined nonpolymeric bonds form the platform molecule and its conjugate |
US6410775B1 (en) | 1995-06-07 | 2002-06-25 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
US5874409A (en) * | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
EP0954531A1 (en) * | 1996-06-06 | 1999-11-10 | Lajolla Pharmaceutical Company | aPL IMMUNOREACTIVE PEPTIDES, CONJUGATES THEREOF AND METHODS OF TREATMENT FOR aPL ANTIBODY-MEDIATED PATHOLOGIES |
US5817752A (en) * | 1996-06-06 | 1998-10-06 | La Jolla Pharmaceutical Company | Cyclic polypeptides comprising a thioether linkage and methods for their preparation |
JP2002511431A (en) * | 1998-04-15 | 2002-04-16 | バクスター インターナショナル インコーポレイテッド | Inhibition of heteroreactive antibodies |
US6936249B1 (en) * | 1998-04-15 | 2005-08-30 | Genencor International, Inc. | Proteins producing an altered immunogenic response and methods of making and using the same |
AU3665699A (en) * | 1998-04-27 | 1999-11-16 | Biocrystal Limited | Compositions and methods for tolerization in immune complex-mediated disease progression |
US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
DE69928995T2 (en) * | 1998-06-22 | 2006-09-07 | Affymetrix, Inc., Santa Clara | Reagent and method for solid phase synthesis |
US6399578B1 (en) * | 1998-12-09 | 2002-06-04 | La Jolla Pharmaceutical Company | Conjugates comprising galactose α1,3 galactosyl epitopes and methods of using same |
US20010010818A1 (en) * | 1998-12-09 | 2001-08-02 | Engle Steven B. | Methods and formulations for reducing circulating antibodies |
US6458953B1 (en) * | 1998-12-09 | 2002-10-01 | La Jolla Pharmaceutical Company | Valency platform molecules comprising carbamate linkages |
US7083777B1 (en) * | 1999-04-02 | 2006-08-01 | The Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
WO2000075105A1 (en) * | 1999-06-08 | 2000-12-14 | La Jolla Pharmaceutical Company | Valency platform molecules comprising aminooxy groups |
CA2391944A1 (en) * | 1999-11-28 | 2001-06-14 | Lajolla Pharmaceutical Company | Methods of treating lupus based on antibody affinity and screening methods and compositions for use thereof |
CA2414076A1 (en) | 2000-06-08 | 2001-12-13 | La Jolla Pharmaceutical Company | Multivalent platform molecules comprising high molecular weight polyethylene oxide |
US7312325B2 (en) | 2000-09-26 | 2007-12-25 | Duke University | RNA aptamers and methods for identifying the same |
SV2003000753A (en) | 2000-12-05 | 2003-06-16 | Brigham & Womens Hospital | USE OF ZWITTERIONIC POLYSACARIDS FOR THE SPECIFIC MODULATION OF IMMUNE PROGRESS |
EP1387697A4 (en) * | 2001-05-17 | 2005-04-20 | Jolla Pharma | Methods of treating antibody-mediated pathologies using agents which inhibit cd21 |
EP2070939B1 (en) * | 2001-05-25 | 2014-04-02 | Duke University | Modulators of pharmacological agents |
US20030114405A1 (en) * | 2001-08-13 | 2003-06-19 | Linnik Matthew D. | Methods of treating systemic lupus erythematosus in individuals having significantly impaired renal function |
US7105135B2 (en) * | 2001-10-16 | 2006-09-12 | Lockheed Martin Corporation | System and method for large scale detection of hazardous materials in the mail or in other objects |
AU2003303524A1 (en) * | 2002-12-27 | 2004-07-29 | La Jolla Pharmaceutical Company | Methods of improving health-related quality of life in individuals with systemic lupus erythematosus |
WO2004069174A2 (en) * | 2003-01-31 | 2004-08-19 | Slil Biomedical Corporation | Monitoring and treatment of amyotrophic lateral sclerosis |
US20040258683A1 (en) * | 2003-03-30 | 2004-12-23 | Linnik Matthew D. | Methods of treating and monitoring systemic lupus erythematosus in individuals |
WO2004089407A2 (en) * | 2003-03-31 | 2004-10-21 | The Brigham And Women's Hospital, Inc. | Zwitterionic immunomodulators for the treatment of asthma and allergy |
CA2543072A1 (en) * | 2003-11-05 | 2005-06-02 | Pevion Biotech Ltd. | Compositions comprising melittin-derived peptides and methods for the potentiation of immune responses against target antigens |
CN1980947B (en) * | 2004-04-22 | 2013-01-30 | 雷加多生物科学公司 | Improved modulators of coagulation factors |
ITPD20040159A1 (en) * | 2004-06-21 | 2004-09-21 | Univ Degli Studi Trieste | BIFUNCTIONAL DERIVATIVES OF POLYETHYLENGLYCLE THEIR PREPARATION AND USE. |
WO2007092451A2 (en) | 2006-02-06 | 2007-08-16 | The Brigham And Women's Hospital, Inc. | Zwitterionic polysaccharides for promotion of immune system maturation and health |
EP2057998A1 (en) * | 2007-10-31 | 2009-05-13 | Universitätsklinikum Hamburg-Eppendorf | Use of modified cells for the treatment of multiple sclerosis |
JP6273200B2 (en) | 2011-07-12 | 2018-01-31 | ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | Lipid-containing PSA compositions, methods of isolation and methods of use |
CN108135167B (en) | 2015-08-19 | 2021-07-09 | 哈佛学院院长及董事 | Lipidated PSA compositions and methods |
US11491181B2 (en) | 2016-07-15 | 2022-11-08 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
US10864279B2 (en) * | 2016-12-16 | 2020-12-15 | Industrial Technology Research Institute | Linker-drug and antibody-drug conjugate (ADC) employing the same |
EP3715376A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the prevention or treatment of myasthenia gravis |
EP3715374A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the sequestration of undesirable antibodies in a patient |
EP3715375A1 (en) | 2019-03-23 | 2020-09-30 | Ablevia biotech GmbH | Compound for the prevention or treatment of pre-eclampsia |
KR20230074775A (en) | 2020-09-23 | 2023-05-31 | 아블레비아 바이오테크 게엠베하 | Compounds for increasing the potency of viral vectors |
US20230381334A1 (en) | 2020-09-23 | 2023-11-30 | Ablevia Biotech Gmbh | Compound for the sequestration of undesirable antibodies in a patient |
TW202228784A (en) | 2020-09-23 | 2022-08-01 | 奧地利商艾柏力維亞生技有限公司 | Compound for the sequestration of undesirale anti-peg antibodies in a patient |
CA3192740A1 (en) | 2020-09-23 | 2022-03-31 | Oskar SMRZKA | Compound for the prevention or treatment of autoantibody-mediated conditions |
KR20230074553A (en) | 2020-09-23 | 2023-05-30 | 아블레비아 바이오테크 게엠베하 | Compounds for Increasing the Efficacy of Factor VIII Replacement Therapy |
CA3192735A1 (en) | 2020-09-24 | 2022-03-31 | Oskar SMRZKA | Compound for the prevention or treatment of myasthenia gravis |
WO2023180502A1 (en) | 2022-03-24 | 2023-09-28 | Ablevia Biotech Gmbh | Compound for increasing efficacy of oncolytic viruses |
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US4430260A (en) * | 1979-02-27 | 1984-02-07 | Lee Weng Y | Penicillin-polyvinyl alcohol conjugate and process of preparation |
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US5162515A (en) | 1990-01-16 | 1992-11-10 | La Jolla Pharmaceutical Company | Conjugates of biologically stable polymers and polynucleotides for treating systemic lupus erythematosus |
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EP0572443A1 (en) * | 1990-12-17 | 1993-12-08 | The Johns Hopkins University | Suppression of immune responses with oligomeric forms of antigen of controlled chemistry |
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KR100361933B1 (en) | 1993-09-08 | 2003-02-14 | 라 졸라 파마슈티칼 컴파니 | Chemically defined nonpolymeric bonds form the platform molecule and its conjugate |
US6410775B1 (en) | 1995-06-07 | 2002-06-25 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
US5874409A (en) | 1995-06-07 | 1999-02-23 | La Jolla Pharmaceutical Company | APL immunoreactive peptides, conjugates thereof and methods of treatment for APL antibody-mediated pathologies |
US6858210B1 (en) | 1998-06-09 | 2005-02-22 | La Jolla Pharmaceutical Co. | Therapeutic and diagnostic domain 1 β2GPI polypeptides and methods of using same |
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-
1991
- 1991-02-08 US US07/652,648 patent/US5268454A/en not_active Expired - Lifetime
-
1992
- 1992-02-04 KR KR1019920702481A patent/KR100234678B1/en not_active IP Right Cessation
- 1992-02-04 CA CA002076648A patent/CA2076648C/en not_active Expired - Fee Related
- 1992-02-04 AU AU14118/92A patent/AU646157B2/en not_active Ceased
- 1992-02-04 WO PCT/US1992/000975 patent/WO1992013558A1/en active Application Filing
- 1992-02-04 JP JP4505775A patent/JP2544873B2/en not_active Expired - Fee Related
- 1992-02-07 DE DE69213272T patent/DE69213272T2/en not_active Expired - Fee Related
- 1992-02-07 ES ES92301036T patent/ES2094287T3/en not_active Expired - Lifetime
- 1992-02-07 AT AT92301036T patent/ATE142109T1/en not_active IP Right Cessation
- 1992-02-07 DK DK92301036.7T patent/DK0498658T3/da active
- 1992-02-07 EP EP92301036A patent/EP0498658B1/en not_active Expired - Lifetime
- 1992-02-07 IE IE041992A patent/IE920419A1/en not_active IP Right Cessation
-
1993
- 1993-09-08 US US08/118,055 patent/US6060056A/en not_active Expired - Fee Related
-
1996
- 1996-11-28 GR GR960403200T patent/GR3021809T3/en unknown
-
2002
- 2002-02-20 US US10/081,076 patent/US7208156B2/en not_active Expired - Fee Related
-
2004
- 2004-07-16 US US10/892,956 patent/US7163683B2/en not_active Expired - Fee Related
- 2004-10-01 US US10/957,198 patent/US7138244B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20050031635A1 (en) | 2005-02-10 |
DK0498658T3 (en) | 1997-02-17 |
US20030103990A1 (en) | 2003-06-05 |
ATE142109T1 (en) | 1996-09-15 |
IE920419A1 (en) | 1992-08-12 |
EP0498658B1 (en) | 1996-09-04 |
DE69213272T2 (en) | 1997-01-30 |
US7208156B2 (en) | 2007-04-24 |
CA2076648C (en) | 1999-08-17 |
US6060056A (en) | 2000-05-09 |
US20050170436A1 (en) | 2005-08-04 |
US7163683B2 (en) | 2007-01-16 |
US7138244B2 (en) | 2006-11-21 |
JP2544873B2 (en) | 1996-10-16 |
US5268454A (en) | 1993-12-07 |
AU646157B2 (en) | 1994-02-10 |
KR100234678B1 (en) | 1999-12-15 |
DE69213272D1 (en) | 1996-10-10 |
EP0498658A2 (en) | 1992-08-12 |
ES2094287T3 (en) | 1997-01-16 |
GR3021809T3 (en) | 1997-02-28 |
WO1992013558A1 (en) | 1992-08-20 |
JPH05508421A (en) | 1993-11-25 |
AU1411892A (en) | 1992-09-07 |
EP0498658A3 (en) | 1993-05-12 |
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