CA2080462A1 - Therapeutic uses of actin-binding compounds - Google Patents
Therapeutic uses of actin-binding compoundsInfo
- Publication number
- CA2080462A1 CA2080462A1 CA002080462A CA2080462A CA2080462A1 CA 2080462 A1 CA2080462 A1 CA 2080462A1 CA 002080462 A CA002080462 A CA 002080462A CA 2080462 A CA2080462 A CA 2080462A CA 2080462 A1 CA2080462 A1 CA 2080462A1
- Authority
- CA
- Canada
- Prior art keywords
- actin
- therapeutic uses
- binding compounds
- native
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4716—Muscle proteins, e.g. myosin, actin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
Abstract
A method for decreasing the concentration of free actin in the plasma of an animal is described which comprises the administration of native and modified actin-binding proteins, and especially the administration of native and modified actin-binding regions of gelsolin. Diagnostic methods for identifying animals in need of such treatment are also described.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50721490A | 1990-04-11 | 1990-04-11 | |
US507,214 | 1990-04-11 | ||
PCT/US1991/002553 WO1991015770A1 (en) | 1990-04-11 | 1991-04-11 | Therapeutic uses of actin-binding compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2080462A1 true CA2080462A1 (en) | 1991-10-12 |
CA2080462C CA2080462C (en) | 2004-10-26 |
Family
ID=24017703
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002080462A Expired - Lifetime CA2080462C (en) | 1990-04-11 | 1991-04-11 | Therapeutic uses of actin-binding compounds |
Country Status (10)
Country | Link |
---|---|
US (2) | US5260224A (en) |
EP (1) | EP0526544B1 (en) |
JP (2) | JP3616392B2 (en) |
AT (1) | ATE171625T1 (en) |
AU (1) | AU663050B2 (en) |
CA (1) | CA2080462C (en) |
DE (1) | DE69130289T2 (en) |
DK (1) | DK0526544T3 (en) |
ES (1) | ES2124702T3 (en) |
WO (1) | WO1991015770A1 (en) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3616392B2 (en) * | 1990-04-11 | 2005-02-02 | ザ・ブリガム・アンド・ウイメンズ・ホスピタル・インコーポレイテッド | Therapeutic use of actin-binding compounds |
US5464817A (en) * | 1990-04-11 | 1995-11-07 | Brigham And Women's Hospital | Method for reducing the viscosity of pathological mucoid airway contents in the respiratory tract comprising administering actin-binding compounds with or without DNASE I |
US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5691160A (en) * | 1992-08-14 | 1997-11-25 | Biogen, Inc. | Effects of actin filaments of fibrin clot structure and lysis |
US6306421B1 (en) | 1992-09-25 | 2001-10-23 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6663881B2 (en) * | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5981568A (en) * | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5593964A (en) * | 1993-10-07 | 1997-01-14 | The George Washington University Medical Center | Method of treating septic shock by preventing actin polymerization |
US5578570A (en) * | 1993-10-07 | 1996-11-26 | The George Washington University Medical Center | Method of treating septic shock using thymosin β4 |
JP3914272B2 (en) | 1993-12-28 | 2007-05-16 | 中外製薬株式会社 | Gene encoding adseverin |
EP0755262A4 (en) * | 1994-03-11 | 1997-05-07 | Merck & Co Inc | Composition for the treatment of lung disease |
US7611533B2 (en) | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
GB2304047A (en) | 1995-08-09 | 1997-03-12 | Univ Manchester | Pharmaceutical compositions containing cytokines |
USRE38490E1 (en) | 1995-11-16 | 2004-04-06 | Baylor College Of Medicine | Method for identifying metastatic sequences |
USRE38392E1 (en) | 1996-01-30 | 2004-01-20 | Baylor College Of Medicine | Method for identifying metastatic sequences |
DE69716460T2 (en) | 1996-12-04 | 2003-06-26 | Renovo Ltd | Wound healing and treatment of fibrosis |
AU7578498A (en) * | 1997-05-19 | 1998-12-11 | Chiron Corporation | Apoptosis-inducing gelsolin sequences |
EP1029048A2 (en) * | 1997-11-05 | 2000-08-23 | Baylor College Of Medicine | Sequences for targeting metastatic cells |
US6545139B1 (en) | 1998-03-13 | 2003-04-08 | Baylor College Of Medicine | DNA sequence encoding the p99 gene and kits for the detection of neoplasia |
US6403766B1 (en) | 1999-10-15 | 2002-06-11 | Cornell Research Foundation, Inc. | Human actin regulatory proteins and methods for detection, diagnosis and treatment of different stages of carcinogenesis |
JP2005508892A (en) * | 2001-08-14 | 2005-04-07 | スタテンズ セーラム インスティテュート | Purification method for large-scale production of Gc-globulin, substances obtained thereby and their pharmaceutical use |
US6806355B2 (en) | 2001-08-14 | 2004-10-19 | Statens Serum Institut | Purification process for large scale production of Gc-globulin, the Gc-globulin produced hereby, a use of Gc.globulin and a Gc-globulin medicinal product |
US7462491B2 (en) * | 2002-01-31 | 2008-12-09 | Baylor College Of Medicine | Methods and compositions for diagnosis and monitoring of prostate cancer progression by detection of serum caveolin |
US20030224464A1 (en) * | 2002-01-31 | 2003-12-04 | Baylor College Of Medicine | Secreted caveolin as a marker for prostate cancer |
AU2003226401A1 (en) * | 2002-04-16 | 2003-11-03 | The Brigham And Women's Hospital, Inc. | Gelsolin as a prognostic marker of artherosclerotic diseases |
US7301020B2 (en) * | 2003-06-19 | 2007-11-27 | Wisconsin Alumni Research Foundation | Macrolide analogs and methods for identifying same |
US20070238655A1 (en) * | 2003-11-12 | 2007-10-11 | The Trustees Of The University Of Pennsylvania | Methods of Using Gelsolin to Treat or Prevent Bacterial Sepsis |
US9408891B2 (en) | 2003-11-12 | 2016-08-09 | The Trustees Of The University Of Pennsylvania | Methods of using gelsolin to treat or prevent bacterial sepsis |
ES2464444T3 (en) * | 2004-05-12 | 2014-06-02 | The Brigham And Women's Hospital, Inc. | Gelsolin for use in the treatment of infections |
CA2578478A1 (en) | 2004-08-06 | 2006-02-16 | National Jewish Medical And Research Center | Product and process for inhibition of biofilm development |
US8440622B2 (en) | 2006-03-15 | 2013-05-14 | The Brigham And Women's Hospital, Inc. | Use of gelsolin to treat multiple sclerosis and to diagnose neurologic disease (stossel) |
KR101556790B1 (en) | 2006-03-15 | 2015-10-01 | 더 브리검 앤드 우먼즈 하스피털, 인크. | Use of gelsolin to diagnose and treat inflammatory diseases |
EP2114460B1 (en) | 2007-02-15 | 2014-07-16 | National Jewish Health | Compositions for the disruption of biofilms |
PL2708603T3 (en) * | 2008-01-25 | 2017-12-29 | Beth Israel Deaconess Medical Ct Inc | Diagnostic and therapeutic uses of gelsolin in renal failure |
US10112000B2 (en) | 2010-07-08 | 2018-10-30 | Asahi Kasei Medical Co., Ltd. | Method for reducing amyloid beta concentration in blood |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1969388A (en) * | 1987-06-19 | 1989-01-19 | Syracuse University | Cytochalasin purification methods and compositions |
JP3616392B2 (en) * | 1990-04-11 | 2005-02-02 | ザ・ブリガム・アンド・ウイメンズ・ホスピタル・インコーポレイテッド | Therapeutic use of actin-binding compounds |
JPH09315440A (en) * | 1996-05-29 | 1997-12-09 | Mitsui Petrochem Ind Ltd | Container for wrapping film |
-
1991
- 1991-04-11 JP JP50836991A patent/JP3616392B2/en not_active Expired - Lifetime
- 1991-04-11 CA CA002080462A patent/CA2080462C/en not_active Expired - Lifetime
- 1991-04-11 ES ES91908685T patent/ES2124702T3/en not_active Expired - Lifetime
- 1991-04-11 DE DE69130289T patent/DE69130289T2/en not_active Expired - Lifetime
- 1991-04-11 AU AU77516/91A patent/AU663050B2/en not_active Ceased
- 1991-04-11 DK DK91908685T patent/DK0526544T3/en active
- 1991-04-11 WO PCT/US1991/002553 patent/WO1991015770A1/en active IP Right Grant
- 1991-04-11 EP EP91908685A patent/EP0526544B1/en not_active Expired - Lifetime
- 1991-04-11 AT AT91908685T patent/ATE171625T1/en not_active IP Right Cessation
- 1991-10-10 US US07/774,738 patent/US5260224A/en not_active Expired - Fee Related
-
1995
- 1995-05-30 US US08/454,403 patent/US5508265A/en not_active Expired - Lifetime
-
2004
- 2004-09-08 JP JP2004261196A patent/JP2005041881A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DE69130289D1 (en) | 1998-11-05 |
US5508265A (en) | 1996-04-16 |
JP3616392B2 (en) | 2005-02-02 |
DE69130289T2 (en) | 1999-06-02 |
DK0526544T3 (en) | 1999-06-21 |
EP0526544A4 (en) | 1993-08-11 |
ES2124702T3 (en) | 1999-02-16 |
CA2080462C (en) | 2004-10-26 |
AU7751691A (en) | 1991-10-30 |
ATE171625T1 (en) | 1998-10-15 |
US5260224A (en) | 1993-11-09 |
EP0526544B1 (en) | 1998-09-30 |
AU663050B2 (en) | 1995-09-28 |
WO1991015770A1 (en) | 1991-10-17 |
JPH05506034A (en) | 1993-09-02 |
JP2005041881A (en) | 2005-02-17 |
EP0526544A1 (en) | 1993-02-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |