CA2084891A1 - Methods and formulations for use in inhibiting conception and in treating benign gynecological disorders - Google Patents

Methods and formulations for use in inhibiting conception and in treating benign gynecological disorders

Info

Publication number
CA2084891A1
CA2084891A1 CA2084891A CA2084891A CA2084891A1 CA 2084891 A1 CA2084891 A1 CA 2084891A1 CA 2084891 A CA2084891 A CA 2084891A CA 2084891 A CA2084891 A CA 2084891A CA 2084891 A1 CA2084891 A1 CA 2084891A1
Authority
CA
Canada
Prior art keywords
time
period
composition
progestogen
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2084891A
Other languages
French (fr)
Other versions
CA2084891C (en
Inventor
Darcy V. Spicer
Malcolm C. Pike
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Southern California USC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2084891A1 publication Critical patent/CA2084891A1/en
Application granted granted Critical
Publication of CA2084891C publication Critical patent/CA2084891C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/14—Topical contraceptives and spermacides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/85—Reproductive organs or embryos
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/85—Reproductive organs or embryos
    • Y10S530/852—Sperm
    • Y10S530/853—Ovary; eggs; embryos

Abstract

PCT No. PCT/US92/02973 Sec. 371 Date Feb. 1, 1993 Sec. 102(e) Date Feb. 1, 1993 PCT Filed Apr. 10, 1992.Compositions and methods which are effective to inhibit conception and to treat benign gynecological disorders for extended periods of time are described, wherein an effective amount of a gonadotropin hormone releasing hormone composition and an effective amount of an estrogenic composition are provided over a first period of time, in addition to a progestogen and optionally an androgenic composition. According to one protocol, the progestogen is provided for a second, shorter period of time; the progestogen is provided at a higher level for at least 5 to about 20 days, and then at a lower level for the remainder, if any, of the second period of time. In an alternative protocol, the progestogen is provided at a lower level substantially throughout the period of administration of gonadotropin hormone releasing hormone composition and estrogenic composition. An effective amount of the androgenic hormone is optionally provided over the first period of time.
CA002084891A 1991-04-12 1992-04-10 Methods and formulations for use in inhibiting conception and in treating benign gynecological disorders Expired - Fee Related CA2084891C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US684,612 1991-04-12
US07/684,612 US5211952A (en) 1991-04-12 1991-04-12 Contraceptive methods and formulations for use therein

Publications (2)

Publication Number Publication Date
CA2084891A1 true CA2084891A1 (en) 1992-10-13
CA2084891C CA2084891C (en) 1999-01-05

Family

ID=24748794

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002084891A Expired - Fee Related CA2084891C (en) 1991-04-12 1992-04-10 Methods and formulations for use in inhibiting conception and in treating benign gynecological disorders

Country Status (10)

Country Link
US (2) US5211952A (en)
EP (1) EP0538443B1 (en)
AT (1) ATE158717T1 (en)
CA (1) CA2084891C (en)
DE (1) DE69222500T2 (en)
DK (1) DK0538443T3 (en)
ES (1) ES2109995T3 (en)
FI (1) FI104789B (en)
NO (1) NO309410B1 (en)
WO (1) WO1992018107A1 (en)

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Also Published As

Publication number Publication date
NO924755D0 (en) 1992-12-09
DK0538443T3 (en) 1998-04-14
FI925652A (en) 1992-12-11
ES2109995T3 (en) 1998-02-01
EP0538443A1 (en) 1993-04-28
ATE158717T1 (en) 1997-10-15
FI104789B (en) 2000-04-14
NO924755L (en) 1993-02-09
NO309410B1 (en) 2001-01-29
US5340584A (en) 1994-08-23
US5211952A (en) 1993-05-18
CA2084891C (en) 1999-01-05
EP0538443B1 (en) 1997-10-01
DE69222500D1 (en) 1997-11-06
DE69222500T2 (en) 1998-02-05
WO1992018107A1 (en) 1992-10-29
FI925652A0 (en) 1992-12-11
EP0538443A4 (en) 1993-12-08

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