CA2085464A1 - Using 5,10,15,10-tetrakis (r-carboxyphenyl)porphine for detecting and treating lung cancer - Google Patents

Using 5,10,15,10-tetrakis (r-carboxyphenyl)porphine for detecting and treating lung cancer

Info

Publication number
CA2085464A1
CA2085464A1 CA002085464A CA2085464A CA2085464A1 CA 2085464 A1 CA2085464 A1 CA 2085464A1 CA 002085464 A CA002085464 A CA 002085464A CA 2085464 A CA2085464 A CA 2085464A CA 2085464 A1 CA2085464 A1 CA 2085464A1
Authority
CA
Canada
Prior art keywords
porphine
carboxyphenyl
tetrakis
detecting
radiotracer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002085464A
Other languages
French (fr)
Other versions
CA2085464C (en
Inventor
Dean A. Cole
David C. Moody, Iii
Edward L. Ellinwood
Gerard M. Klein
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
US Department of Energy
University of California
Original Assignee
Dean A. Cole
David C. Moody, Iii
Edward L. Ellinwood
Gerard M. Klein
United States Department Of Energy
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dean A. Cole, David C. Moody, Iii, Edward L. Ellinwood, Gerard M. Klein, United States Department Of Energy, The Regents Of The University Of California filed Critical Dean A. Cole
Publication of CA2085464A1 publication Critical patent/CA2085464A1/en
Application granted granted Critical
Publication of CA2085464C publication Critical patent/CA2085464C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0036—Porphyrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1206—Administration of radioactive gases, aerosols or breath tests
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/805—Optical property

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Optics & Photonics (AREA)
  • General Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Atmospheric Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Method using tetra-aryl porphyrins for and, in particular, 5,10,15,20-tetrakis(4-carboxyphenyl)porphine as a fluorescent tracer for cancers of the lung, and as a radiotracer therefor as a complex with 67Cu. The latter complex also provides a source of beta radiation for selective destruction of lung malignancies as well as gamma radiation useful for image analysis of the situs thereof by single photon emission computed tomography, as an example, both in vivo. Copper-64 may be substituted for the 67Cu if only radiotracer characteristics are of interest. This lighter isotope of copper is a positron emitter, and positron emission tomography techniques can be used to locate the malignant tissue mass.
CA002085464A 1990-06-15 1991-06-17 Using 5,10,15,10-tetrakis (r-carboxyphenyl)porphine for detecting and treating lung cancer Expired - Fee Related CA2085464C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US539,999 1990-06-15
US07/539,999 US5162231A (en) 1989-10-25 1990-06-15 Method of using 5,10,15,20-tetrakis(carboxyphenyl)porphine for detecting cancers of the lung
PCT/US1991/004132 WO1991019977A1 (en) 1990-06-15 1991-06-17 USING 5,10,15,20-TETRAKIS(r-CARBOXYPHENYL)PORPHINE FOR DETECTING AND TREATING LUNG CANCER

Publications (2)

Publication Number Publication Date
CA2085464A1 true CA2085464A1 (en) 1991-12-16
CA2085464C CA2085464C (en) 2002-12-17

Family

ID=24153544

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002085464A Expired - Fee Related CA2085464C (en) 1990-06-15 1991-06-17 Using 5,10,15,10-tetrakis (r-carboxyphenyl)porphine for detecting and treating lung cancer

Country Status (15)

Country Link
US (2) US5162231A (en)
EP (1) EP0533845B1 (en)
JP (1) JP3047468B2 (en)
KR (1) KR0171393B1 (en)
AT (1) ATE251750T1 (en)
AU (2) AU8061491A (en)
BR (1) BR9106563A (en)
CA (1) CA2085464C (en)
DE (1) DE69133325T2 (en)
DK (1) DK0533845T3 (en)
FI (1) FI925673A (en)
HU (1) HUT63499A (en)
NO (1) NO924820L (en)
RU (1) RU2114430C1 (en)
WO (2) WO1991019978A1 (en)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5622685A (en) * 1990-05-30 1997-04-22 Deutches Krebsforchunszentrum Stiftung Des Offentlichen Rechts Polyether-substituted porphyrin anti-tumor agents
US5252698A (en) * 1992-10-09 1993-10-12 Sri International Metal ion porphyrin-containing poly(azine)
US5464741A (en) * 1993-10-08 1995-11-07 Henwell, Inc. Palladium (II) octaethylporphine alpha-isothiocyanate as a phosphorescent label for immunoassays
US6490330B1 (en) * 1994-04-12 2002-12-03 The Regents Of The University Of California Production of high specific activity copper -67
US5716958A (en) * 1994-10-27 1998-02-10 Tobishi Pharmaceutical Co., Ltd. Amino acid derivative having anti-CCK activity
US5591422A (en) * 1995-06-02 1997-01-07 Pharmacyclics, Inc. Texaphyrin complexes having improved functionalization
CA2309154C (en) 1997-11-03 2010-02-16 Duke University Substituted porphyrins
US6703050B1 (en) * 1998-09-04 2004-03-09 The Regents Of The University Of Michigan Methods and compositions for the prevention or treatment of cancer
KR100753184B1 (en) 1999-01-25 2007-08-30 내셔날 쥬이쉬 메디칼 앤드 리서치 센터 Substituted Porphyrins
US6984498B2 (en) * 1999-12-27 2006-01-10 Adair Edwin L Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
US6190877B1 (en) * 1999-12-27 2001-02-20 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection and fluorescence detection techniques
US6750037B2 (en) * 1999-12-27 2004-06-15 Edwin L. Adair Method of cancer screening primarily utilizing non-invasive cell collection, fluorescence detection techniques, and radio tracing detection techniques
US6575888B2 (en) * 2000-01-25 2003-06-10 Biosurface Engineering Technologies, Inc. Bioabsorbable brachytherapy device
KR100390771B1 (en) * 2000-08-31 2003-07-10 한국화학연구원 Porphyrin derivatives as photosensitizer in PDT
ES2380261T3 (en) 2000-11-17 2012-05-10 Biomoda, Inc. Compositions and methods for the detection of precancerous conditions in cell and tissue samples using 5, 10, 15, 20-tetrakis (carboxyphenyl) porphine.
DE60233317D1 (en) * 2001-01-19 2009-09-24 Nat Jewish Med & Res Center MEDICAMENT FOR PROTECTION IN RADIO THERAPY
JP2005508864A (en) 2001-06-01 2005-04-07 ナショナル・ジュウィッシュ・メディカル・アンド・リサーチ・センター Oxidant scavengers for the treatment of diabetes or for use in transplantation or for induction of immune tolerance
US6566517B2 (en) 2001-06-06 2003-05-20 Brookhaven Science Associates, Llc Metalloporphyrins and their uses as imageable tumor-targeting agents for radiation therapy
US20050255085A1 (en) * 2002-03-01 2005-11-17 Yuman Fong Prevention of recurrence and metastasis of cancer
JP2006501163A (en) 2002-06-07 2006-01-12 デューク・ユニバーシティー Substituted porphyrin
ATE336266T1 (en) * 2002-06-21 2006-09-15 Adair Edwin Lloyd APPLICATION OF METALLOPORPHYRINS FOR THE TREATMENT OF ARTERIOSCLEROSIS
EA008683B1 (en) 2002-07-23 2007-06-29 Дзе Риджентс Оф Дзе Юниверсити Оф Мичиган Tetrapropylammonium tetrathiomolybdate and related compounds for anti-angiogenic therapies
US20070149496A1 (en) * 2003-10-31 2007-06-28 Jack Tuszynski Water-soluble compound
US6995260B2 (en) * 2004-05-20 2006-02-07 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
US6989443B2 (en) * 2004-06-28 2006-01-24 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
US20060094682A1 (en) * 2004-10-29 2006-05-04 Odyssey Thera, Inc. Kinase inhibitors for the treatment of diabetes and obesity
JP5155304B2 (en) * 2006-05-17 2013-03-06 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Retrospective sorting of 4D CT into respiratory phase based on geometric analysis of imaging criteria
US9957293B2 (en) * 2006-08-23 2018-05-01 Yeda Research And Development Company Ltd. Conjugates of RGD peptides and porphyrin or (bacterio)chlorophyll photosynthesizers and their uses
US8287839B2 (en) * 2006-12-04 2012-10-16 Brookhaven Science Associates, Llc Carboranylporphyrins and uses thereof
US8444953B2 (en) * 2007-03-22 2013-05-21 Brookhaven Science Associates, Llc Symmetric and asymmetric halogen-containing metallocarboranylporphyrins and uses thereof
US20080279781A1 (en) * 2007-05-10 2008-11-13 Brookhaven Science Associates, Llc Glycosylated Carboranylporphyrins and Uses Thereof
ES2600469T3 (en) 2008-05-23 2017-02-09 National Jewish Health A compound for use in the treatment of lesions associated with exposure to phosgene gas or chlorine gas
US8877509B2 (en) * 2009-07-17 2014-11-04 Bioaffinity Technologies, Inc. System and method for analyzing samples labeled with 5, 10, 15, 20 tetrakis (4-carboxyphenyl) porphine (TCPP)
CN109922834B (en) 2016-06-16 2022-09-23 良药治疗公司 Porphyrin compounds and compositions for the treatment of cancer
CN107589189B (en) * 2017-09-06 2018-07-10 中国农业科学院饲料研究所 A kind of detection method of the chiral enantiomer of flumequine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4930516B1 (en) * 1985-11-13 1998-08-04 Laser Diagnostic Instr Inc Method for detecting cancerous tissue using visible native luminescence
US4783529A (en) * 1985-12-03 1988-11-08 Research Corporation Technologies Rapid synthesis of radiolabeled porphyrin complexes for medical application
US4857300A (en) * 1987-07-27 1989-08-15 Cytocorp, Inc. Cytological and histological fixative formulation and methods for using same

Also Published As

Publication number Publication date
FI925673A0 (en) 1992-12-14
HU9203923D0 (en) 1993-03-29
RU2114430C1 (en) 1998-06-27
US5162231A (en) 1992-11-10
NO924820L (en) 1993-02-12
AU8190691A (en) 1992-01-07
WO1991019978A1 (en) 1991-12-26
FI925673A (en) 1992-12-14
CA2085464C (en) 2002-12-17
AU8061491A (en) 1992-01-07
AU670743B2 (en) 1996-08-01
DE69133325D1 (en) 2003-11-13
JPH06500164A (en) 1994-01-06
NO924820D0 (en) 1992-12-14
US5391547A (en) 1995-02-21
ATE251750T1 (en) 2003-10-15
DE69133325T2 (en) 2004-07-29
JP3047468B2 (en) 2000-05-29
EP0533845A4 (en) 1993-11-18
EP0533845A1 (en) 1993-03-31
DK0533845T3 (en) 2004-02-16
KR0171393B1 (en) 1999-05-15
EP0533845B1 (en) 2003-10-08
HUT63499A (en) 1993-08-30
WO1991019977A1 (en) 1991-12-26
BR9106563A (en) 1993-06-22

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