CA2101942A1 - Technetium-99m labeled polypeptides for imaging - Google Patents

Technetium-99m labeled polypeptides for imaging

Info

Publication number
CA2101942A1
CA2101942A1 CA2101942A CA2101942A CA2101942A1 CA 2101942 A1 CA2101942 A1 CA 2101942A1 CA 2101942 A CA2101942 A CA 2101942A CA 2101942 A CA2101942 A CA 2101942A CA 2101942 A1 CA2101942 A1 CA 2101942A1
Authority
CA
Canada
Prior art keywords
technetium
imaging
labeled polypeptides
mammalian body
labeled
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA2101942A
Other languages
French (fr)
Other versions
CA2101942C (en
Inventor
Richard T. Dean
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CIS Bio International SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2101942A1 publication Critical patent/CA2101942A1/en
Application granted granted Critical
Publication of CA2101942C publication Critical patent/CA2101942C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m far such imaging. The invention provides peptides which bind technetium-99m and which can be targeted to specific sites within a mammalian body.
CA002101942A 1991-02-08 1992-02-07 Technetium-99m labeled polypeptides for imaging Expired - Fee Related CA2101942C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65301291A 1991-02-08 1991-02-08
US653,012 1991-02-08
PCT/US1992/000757 WO1992013572A1 (en) 1991-02-08 1992-02-07 TECHNETIUM-99m LABELED POLYPEPTIDES FOR IMAGING

Publications (2)

Publication Number Publication Date
CA2101942A1 true CA2101942A1 (en) 1992-08-09
CA2101942C CA2101942C (en) 2001-01-30

Family

ID=24619134

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002101942A Expired - Fee Related CA2101942C (en) 1991-02-08 1992-02-07 Technetium-99m labeled polypeptides for imaging

Country Status (12)

Country Link
US (7) US5654272A (en)
EP (1) EP0570493B1 (en)
JP (1) JP2774378B2 (en)
KR (1) KR930703024A (en)
AT (1) ATE188387T1 (en)
BR (1) BR1100906A (en)
CA (1) CA2101942C (en)
DE (1) DE69230525T2 (en)
DK (1) DK0570493T3 (en)
ES (1) ES2141102T3 (en)
GR (1) GR3032851T3 (en)
WO (1) WO1992013572A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7018615B2 (en) 1995-09-11 2006-03-28 The Burnham Institute Method of identifying molecules that home to a selected organ in vivo

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US7018615B2 (en) 1995-09-11 2006-03-28 The Burnham Institute Method of identifying molecules that home to a selected organ in vivo
US7341710B2 (en) 1995-09-11 2008-03-11 The Burnham Institute Method of identifying molecules that home to a selected organ in vivo

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US5888474A (en) 1999-03-30
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AU658617B2 (en) 1995-04-27
US5681541A (en) 1997-10-28
US5811394A (en) 1998-09-22
JP2774378B2 (en) 1998-07-09
WO1992013572A1 (en) 1992-08-20
DK0570493T3 (en) 2000-06-26
DE69230525T2 (en) 2000-06-21
ES2141102T3 (en) 2000-03-16
KR930703024A (en) 1993-11-29
AU1411792A (en) 1992-09-07
US5788960A (en) 1998-08-04
JPH06503352A (en) 1994-04-14
US5849260A (en) 1998-12-15
EP0570493B1 (en) 2000-01-05
DE69230525D1 (en) 2000-02-10
US5654272A (en) 1997-08-05
EP0570493A1 (en) 1993-11-24
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