CA2102208A1 - Binding domains in notch and delta proteins - Google Patents

Binding domains in notch and delta proteins

Info

Publication number
CA2102208A1
CA2102208A1 CA002102208A CA2102208A CA2102208A1 CA 2102208 A1 CA2102208 A1 CA 2102208A1 CA 002102208 A CA002102208 A CA 002102208A CA 2102208 A CA2102208 A CA 2102208A CA 2102208 A1 CA2102208 A1 CA 2102208A1
Authority
CA
Canada
Prior art keywords
proteins
genes
notch
delta
fragments
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002102208A
Other languages
French (fr)
Other versions
CA2102208C (en
Inventor
Spyridon Artavanis-Tsakonas
Marc Alan Telander Muskavitch
Richard Grant Fehon
Ilaria Rebay
Christine Marie Blaumueller
Scott Brockewell Shepard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yale University
Indiana University Research and Technology Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27105529&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2102208(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Publication of CA2102208A1 publication Critical patent/CA2102208A1/en
Application granted granted Critical
Publication of CA2102208C publication Critical patent/CA2102208C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/839—Nerves; brain

Abstract

The present invention relates to nucleotide sequences of the human Notch and Delta genes, and amino acid sequences of their encoded proteins, as well as fragments thereof containing an antigenic determinant or which are functionally active. The in-vention is also directed to fragments (termed herein "adhesive fragments"), and the sequences thereof, of the proteins ("toporyth-mic proteins") encoded by toporythmic genes which mediate homotypic or heterotypic binding to toporythmic proteins. Topor-ythmic genes, as used herein, refers to the genes Notch, Delta and Serrate, as well as other members of the Delta/Serrate family which may be identified, e.g., by the methods described herein. Antibodies to human Notch and to adhesive fragments are addi-tionally provided.
CA002102208A 1991-05-03 1992-05-01 Binding domains in notch and delta proteins Expired - Lifetime CA2102208C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US69518991A 1991-05-03 1991-05-03
US695,189 1991-05-03
US79192391A 1991-11-14 1991-11-14
US791,923 1991-11-14
PCT/US1992/003651 WO1992019734A1 (en) 1991-05-03 1992-05-01 Binding domains in notch and delta proteins

Publications (2)

Publication Number Publication Date
CA2102208A1 true CA2102208A1 (en) 1992-11-12
CA2102208C CA2102208C (en) 2003-04-29

Family

ID=27105529

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002102208A Expired - Lifetime CA2102208C (en) 1991-05-03 1992-05-01 Binding domains in notch and delta proteins

Country Status (12)

Country Link
US (1) US5849869A (en)
EP (4) EP0930365B1 (en)
JP (7) JPH07503123A (en)
AT (4) ATE473754T1 (en)
AU (1) AU675203B2 (en)
CA (1) CA2102208C (en)
DE (4) DE69233735D1 (en)
DK (4) DK0930365T3 (en)
ES (4) ES2303363T3 (en)
IE (2) IE921367A1 (en)
IL (1) IL101728A (en)
WO (1) WO1992019734A1 (en)

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US6692919B1 (en) 1997-07-23 2004-02-17 Yale University Activated forms of notch and methods based thereon
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WO2006135886A2 (en) * 2005-06-13 2006-12-21 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
CA2612021A1 (en) * 2005-06-13 2006-12-28 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
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EP1945754B1 (en) * 2005-10-31 2014-07-23 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing cancer
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US7919092B2 (en) 2006-06-13 2011-04-05 Oncomed Pharmaceuticals, Inc. Antibodies to notch receptors
CA2664738C (en) 2006-09-29 2017-03-07 Oncomed Pharmaceuticals, Inc. Compositions and methods for diagnosing and treating cancer
NO347649B1 (en) * 2006-12-14 2024-02-12 Regeneron Pharma Human antibody or antibody fragment that specifically binds human delta-like ligand 4 (hDII4), nucleic acid molecule that codes for such and vector and host-vector systems, as well as method for production, composition and use.
WO2008076960A2 (en) 2006-12-18 2008-06-26 Genentech, Inc. Antagonist anti-notch3 antibodies and their use in the prevention and treatment of notch3-related diseases
US8148147B2 (en) * 2007-01-24 2012-04-03 The Regents Of The University Of Michigan Compositions and methods for treating and diagnosing pancreatic cancer
US8088617B2 (en) 2007-01-24 2012-01-03 Oncomed Pharmaceuticals, Inc. Antibodies that bind the glutamate ligand binding region of Notch1
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Also Published As

Publication number Publication date
AU675203B2 (en) 1997-01-30
ATE386116T1 (en) 2008-03-15
DE69233724D1 (en) 2008-03-27
DK0576623T4 (en) 2008-01-02
ATE397661T1 (en) 2008-06-15
ATE226633T1 (en) 2002-11-15
JP2011135886A (en) 2011-07-14
DE69232832T3 (en) 2008-02-28
JP2007330258A (en) 2007-12-27
EP0933082B1 (en) 2010-07-14
EP0576623B1 (en) 2002-10-23
JP2004065243A (en) 2004-03-04
IE921367A1 (en) 1992-11-04
IL101728A0 (en) 1992-12-30
EP0930366B1 (en) 2008-06-04
EP0930365B1 (en) 2008-02-13
DK0576623T3 (en) 2003-02-24
JP4430891B2 (en) 2010-03-10
JP2007330259A (en) 2007-12-27
DK0930366T3 (en) 2008-10-13
ES2181674T3 (en) 2003-03-01
ES2303363T3 (en) 2008-08-01
AU1919792A (en) 1992-12-21
DE69233724T2 (en) 2009-04-02
DK0933082T3 (en) 2010-10-25
ES2310933T3 (en) 2009-01-16
WO1992019734A1 (en) 1992-11-12
EP0933082A1 (en) 1999-08-04
IE85350B1 (en) 2009-10-14
DE69233791D1 (en) 2010-08-26
JP2008005843A (en) 2008-01-17
ES2181674T5 (en) 2008-03-01
DE69233735D1 (en) 2008-07-17
EP0576623A4 (en) 1995-01-18
EP0576623B2 (en) 2007-10-03
EP0930365A3 (en) 1999-07-28
DE69232832T2 (en) 2003-06-18
IL101728A (en) 2007-08-19
ES2348919T3 (en) 2010-12-16
DK0930365T3 (en) 2008-06-02
EP0930366A2 (en) 1999-07-21
JP2011155979A (en) 2011-08-18
US5849869A (en) 1998-12-15
EP0576623A1 (en) 1994-01-05
ATE473754T1 (en) 2010-07-15
EP0930365A2 (en) 1999-07-21
DE69232832D1 (en) 2002-11-28
CA2102208C (en) 2003-04-29
JPH07503123A (en) 1995-04-06
IE20030774A1 (en) 2003-12-10
JP4604227B2 (en) 2011-01-05
EP0930366A3 (en) 1999-07-28
JP4604228B2 (en) 2011-01-05

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